Frequently asked questions regarding SARS-CoV-2 in cancer patients—recommendations for clinicians caring for patients with malignant diseases
Open accessAbstract
Since early 2020, the SARS-CoV-2 pandemic has a massive impact on health care systems worldwide. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. Here, we provide recommendations for the management of patients with malignant disease in the times of COVID-19. These recommendations were prepared by an international panel of experts and then consented by the EHA Scientific Working Group on Infection in Hematology. The primary aim is to enable clinicians to provide optimal cancer care as safely as possible, since the most important protection for patients with malignant disease is the best-possible control of the underlying disease.
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For frail or older patients with metastatic gastric cancer, reducing the oxaliplatin and capecitabine dose by 40% maintains similar efficacy.
“utilizing a 40% dose reduction of combined oxaliplatin and capecitabine chemotherapy for frail or older patients with metastatic gastric cancer [82]”
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- Authors
- EHA Infectious Disease Scientific Working Group, von Lilienfeld-Toal, M., Vehreschild, J. J., Cornely, O., Pagano, L., Compagno, F., & Hirsch, H. H.
- Affiliations
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Goethe University Frankfurt (DE)
- Università Cattolica del Sacro Cuore (IT)
- University Hospital of Basel (CH)
- University of Basel (CH)
- Venue
- Leukemia
- Published
- 2020-05-01
- Volume
- 34
- Issue
- 6
- Pages
- 1487-1494
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC7194246
- OpenAlex
- W3022629633
- Cited by
- 55
- References
- 50
- Citations by year
- 2023: 3 · 2022: 6 · 2021: 14 · 2020: 32
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Leukemia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Lirias (submittedVersion, cc-by)
- Biblos-e Archivo (Universidad Autónoma de Madrid) (submittedVersion, public-domain)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Hispana (submittedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
- Common Library Network (Der Gemeinsame Bibliotheksverbund) (submittedVersion, cc-by)
- Funders
- Ankara Universitesi
- King's College Hospital NHS Foundation Trust
- King's College London
- KU Leuven
- Topics
- Health Sciences › Medicine › Oncology › COVID-19 and healthcare impacts
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, cancer patients, hematologic malignancies, infection control, clinical guidelines, infection management
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Patient Care, Humans, Neoplasms, Pneumonia, Viral, Infection Control, Practice Guidelines as Topic, Infectious Disease Transmission, Patient-to-Professional, Coronavirus Infections, Pandemics
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