The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

The Inflammasomes

Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,121 · see citing works

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Shi, J., Gao, W., & Shao, F. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.004 · Cited by 3,088 · see citing works

Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

Activation and regulation of the inflammasomes

Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works

Mechanism and Regulation of NLRP3 Inflammasome Activation

He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

Inflammation, metaflammation and immunometabolic disorders

Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008 · see citing works

The interleukin-1 family: back to the future

Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · see citing works

NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Tschopp, J., & Schroder, K. (2010) · Nature reviews. Immunology · doi:10.1038/nri2725 · Cited by 1,859 · see citing works

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G. (2009) · Nature Immunology · doi:10.1038/ni.1703 · Cited by 1,834 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia

Guralnik, J. M., Eisenstaedt, R. S., Ferrucci, L., Klein, H. G., & Woodman, R. C. (2004) · Blood · doi:10.1182/blood-2004-05-1812 · Cited by 1,450 · see citing works

Molecular mechanisms regulating NLRP3 inflammasome activation

Jo, E.-K., Kim, J. K., Shin, D.-M., & Sasakawa, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.95 · Cited by 1,378 · see citing works

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353 · see citing works

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

Yang, Y., Wang, H., Kouadir, M., Song, H., & Shi, F. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1413-8 · Cited by 1,285 · see citing works

Senescent cells: an emerging target for diseases of ageing

Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284 · see citing works

Homeostatic Immunity and the Microbiota

Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261 · see citing works

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

Schroder, K., Zhou, R., & Tschopp, J. (2010) · Science · doi:10.1126/science.1184003 · Cited by 1,131 · see citing works

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works

Sensing and reacting to microbes through the inflammasomes

Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,013 · see citing works

The NLR Gene Family: A Standard Nomenclature

Ting, J. P. ‐., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A., Girardin, S. E., Godzik, A., Harton, J. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.005 · Cited by 958 · see citing works

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935 · see citing works

Keeping It All Going—Complement Meets Metabolism

Kolev, M. V., & Kemper, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00001 · Cited by 818 · see citing works

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

Netea, M. G., Nold‐Petry, C. A., Nold, M. F., Joosten, L. A. B., Opitz, B., van der Meer, J. H. M., van de Veerdonk, F. L., Ferwerda, G., Heinhuis, B., Devesa, I., et al. (2008) · Blood · doi:10.1182/blood-2008-03-146720 · Cited by 787 · see citing works

Purinergic regulation of the immune system

Cekic, C., & Linden, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.4 · Cited by 787 · see citing works

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

Bruchard, M., Mignot, G., Dérangère, V., Chalmin, F., Chevriaux, A., Végran, F., Boireau, W., Simon, B., Ryffel, B., Connat, J., et al. (2012) · Nature Medicine · doi:10.1038/nm.2999 · Cited by 775 · see citing works

New Comprehensive Cytogenetic Scoring System for Primary Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia After MDS Derived From an International Database Merge

Schanz, J., Tüchler, H., Solé, F. G., Mallo, M., Luño, E., Cervera, J., Granada, I., Hildebrandt, B., Slovak, M. L., Ohyashiki, K., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.6394 · Cited by 688 · see citing works

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells

Phan, T. G., Grigorova, I., Okada, T., & Cyster, J. G. (2007) · Nature Immunology · doi:10.1038/ni1494 · Cited by 644 · see citing works

The ageing haematopoietic stem cell compartment

Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604 · see citing works

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Liszewski, M. K., Kolev, M. V., Friec, G. L., Leung, M. K., Bertram, P. G., Fara, A. F., Subías, M., Pickering, M. C., Drouet, C., Meri, S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.018 · Cited by 585 · see citing works

Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

Franchi, L., Eigenbrod, T., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900173 · Cited by 574 · see citing works

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Xie, M., Yu, Y., Kang, R., Zhu, S., Yang, L., Zeng, L., Sun, X., Yang, M., Billiar, T. R., Wang, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms13280 · Cited by 567 · see citing works

Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis

Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533 · see citing works

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells

Arbore, G., West, E. E., Spolski, R. J., Robertson, A. A. B., Klos, A., Rheinheimer, C., Dutow, P., Woodruff, T. M., Yu, Z., O'Neill, L. A. J., et al. (2016) · Science · doi:10.1126/science.aad1210 · Cited by 513 · see citing works

NLRP3 inflammasomes link inflammation and metabolic disease

De Nardo, D., & Latz, E. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.004 · Cited by 425 · see citing works

Proinflammatory Cytokines Lowering Erythropoietin Production

JELKMANN, W. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.555 · Cited by 422 · see citing works

ASC filament formation serves as a signal amplification mechanism for inflammasomes

Dick, M. S., Sborgi, L., Rühl, S., Hiller, S., & Brož, P. (2016) · Nature Communications · doi:10.1038/ncomms11929 · Cited by 405 · see citing works

The P2X7 receptor: A main player in inflammation

Adinolfi, E., Giuliani, A. L., De Marchi, E., Pegoraro, A., Orioli, E., & Di Virgilio, F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.021 · Cited by 385 · see citing works

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

Hu, B., Jin, C., Li, H., Tong, J., Ouyang, X., Cetinbas, N. M., Zhu, S., Strowig, T., Lam, F. C., Zhao, C. N., et al. (2016) · Science · doi:10.1126/science.aaf7532 · Cited by 375 · see citing works

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Basiorka, A. A., McGraw, K. L., Eksioglu, E. A., Chen, X., Johnson, J., Zhang, L., Zhang, Q., Irvine, B. A., Cluzeau, T., Sallman, D. A., et al. (2016) · Blood · doi:10.1182/blood-2016-07-730556 · Cited by 356 · see citing works

Recent advances in inflammasome biology

Place, D. E., & Kanneganti, T. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.10.011 · Cited by 331 · see citing works

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

Cardone, J., Friec, G. L., Vantourout, P., Roberts, A., Fuchs, A. G., Jackson, I., Suddason, T., Lord, G. M., Atkinson, J. P., Cope, A. P., et al. (2010) · Nature Immunology · doi:10.1038/ni.1917 · Cited by 284 · see citing works

DAMPs as mediators of sterile inflammation in aging-related pathologies

Feldman, N., Rotter-Maskowitz, A., & Okun, E. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.003 · Cited by 283 · see citing works

Spotlight on the NLRP3 inflammasome pathway

Groslambert, M., & Py, B. F. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141220 · Cited by 267 · see citing works

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

Kolev, M. V., Dimeloe, S., Friec, G. L., Navarini, A. A., Arbore, G., Povoleri, G. A. M., Fischer, M., Belle, R., Loeliger, J., Develioglu, L., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.024 · Cited by 257 · see citing works

Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient

Wysoczynski, M., Reca, R., Ratajczak, J., Kucia, M., Shirvaikar, N., Honczarenko, M., Mills, M., Wanzeck, J., Janowska‐Wieczorek, A., & Ratajczak, M. Z. (2004) · Blood · doi:10.1182/blood-2004-04-1430 · Cited by 252 · see citing works

Inflammasome Priming in Sterile Inflammatory Disease

Patel, M. N., Carroll, R. G., Galván-Peña, S., Mills, E. L., Olden, R., Triantafilou, M., Wolf, A. I., Bryant, C. E., Triantafilou, K., & Masters, S. L. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.12.007 · Cited by 241 · see citing works

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

Gurung, P., Malireddi, R. K. S., Anand, P., Demon, D., Walle, L. V., Liu, Z., Vogel, P., Lamkanfi, M., & Kanneganti, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401406 · Cited by 239 · see citing works

The Nlrp3 inflammasome regulates acute graft-versus-host disease

Jankovic, D. L., Ganesan, J., Bscheider, M., Stickel, N., Weber, F. C., Guarda, G., Follo, M., Pfeifer, D., Tardivel, A., Ludigs, K., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130084 · Cited by 236 · see citing works

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

Brydges, S. D., Broderick, L., McGeough, M. D., Peña, C. A., Mueller, J. L., & Hoffman, H. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71543 · Cited by 228 · see citing works

Intracellular complement − the complosome − in immune cell regulation

Arbore, G., Kemper, C., & Kolev, M. V. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.05.012 · Cited by 211 · see citing works

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes

Hess, C., & Kemper, C. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.003 · Cited by 176 · see citing works

Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression

Fettelschoss‐Gabriel, A., Kistowska, M., LeibundGut‐Landmann, S., Beer, H., Johansen, P., Senti, G., Contassot, E., Bachmann, M. F., French, L. E., Oxenius, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109176108 · Cited by 169 · see citing works

T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

Martin, B. N., Wang, C., Zhang, C.-J., Kang, Z., Gulen, M. F., Zepp, J. A., Zhao, J., Bian, G., Do, J., Min, B., et al. (2016) · Nature Immunology · doi:10.1038/ni.3389 · Cited by 154 · see citing works

A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function

Arbore, G., & Kemper, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201546131 · Cited by 141 · see citing works

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K + efflux and Ca 2+ influx

Katsnelson, M. A., Lozada‐Soto, K. M., Russo, H. M., Miller, B. A., & Dubyak, G. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00298.2015 · Cited by 140 · see citing works

IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia

Ueda, Y., Cain, D. W., Kuraoka, M., Kondo, M., & Kelsoe, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803961 · Cited by 138 · see citing works

Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes

Carstensen, M., Herder, C., Kivimäki, M., Jokela, M., Roden, M., Shipley, M. J., Witte, D. R., Brunner, E. J., & Tabák, A. G. (2010) · Diabetes · doi:10.2337/db09-1199 · Cited by 137 · see citing works

Inflammation and myeloproliferative neoplasms

Lussana, F., & Rambaldi, A. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.06.010 · Cited by 136 · see citing works

Biochemical regulation of the inflammasome

Dowling, J. K., & O'Neill, L. A. J. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.694844 · Cited by 135 · see citing works

Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor

Carruth, L. M., Demczuk, S., & Mizel, S. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98874-5 · Cited by 133 · see citing works

Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development

Geyer, H. L., Dueck, A. C., Scherber, R. M., & Mesa, R. A. (2015) · Mediators of Inflammation · doi:10.1155/2015/284706 · Cited by 124 · see citing works

Human NLRP3 inflammasome senses multiple types of bacterial RNAs

Sha, W., Mitoma, H., Hanabuchi, S., Bao, M., Weng, L., Sugimoto, N., Liu, Y., Zhang, Z., Zhong, J., Sun, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412487111 · Cited by 122 · see citing works

A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking

Ratajczak, M. Z. (2014) · Leukemia · doi:10.1038/leu.2014.346 · Cited by 118 · see citing works

Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation

Yabal, M., Calleja, D. J., Simpson, D. S., & Lawlor, K. E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0318-124r · Cited by 109 · see citing works

Danger signals activating innate immunity in graft-versus-host disease

Zeiser, R., Penack, O., Holler, E., & Idzko, M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0767-x · Cited by 105 · see citing works

Novel roles of complement in T effector cell regulation

Heeger, P. S., & Kemper, C. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.06.004 · Cited by 100 · see citing works

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Erlich, Z., Shlomovitz, I., Edry‐Botzer, L., Cohen, H., Frank, D. O., Wang, H., Lew, A. M., Lawlor, K. E., Zhan, Y., Vince, J. E., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0313-5 · Cited by 100 · see citing works

Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes

Kim, Y., Wang, W., Okla, M., Kang, I., Moreau, R. F., & Chung, S. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m062828 · Cited by 98 · see citing works

Interleukin-18 genetics and inflammatory disease susceptibility

Thompson, S. R., & Humphries, S. E. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364366 · Cited by 93 · see citing works

IL-18 Bridges Innate and Adaptive Immunity through IFN-γ and the CD134 Pathway

Maxwell, J. R., Yadav, R., Rossi, R. J., Ruby, C. E., Weinberg, A. D., Aguila, H. L., & Vella, A. T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.234 · Cited by 89 · see citing works

Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-β1 enhanced IL-18 expression in human renal proximal tubular epithelial cells

Miyauchi, K., Takiyama, Y., Honjo, J., Tateno, M., & Haneda, M. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.11.018 · Cited by 88 · see citing works

Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators

Liu, D., Zeng, X., Li, X., Cui, C., Hou, R., Guo, Z., Mehta, J. L., & Wang, X. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113863 · Cited by 87 · see citing works

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence

Jing, L., Tamplin, O. J., Chen, M. J., Deng, Q., Patterson, S., Kim, P. G., Durand, E. M., McNeil, A., Green, J. M., Matsuura, S., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141528 · Cited by 86 · see citing works

The sixth sense: hematopoietic stem cells detect danger through purinergic signaling

Rossi, L., Salvestrini, V., Ferrari, D., Virgilio, F. D., & Lemoli, R. M. (2012) · Blood · doi:10.1182/blood-2012-04-422378 · Cited by 80 · see citing works

Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking

Ratajczak, M. Z., & Adamiak, M. (2015) · Leukemia · doi:10.1038/leu.2015.66 · Cited by 76 · see citing works

Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes

Lee, H. M., Wysoczynski, M., Liu, R., Shin, D.-M., Kucia, M., Botto, M., Ratajczak, J., & Ratajczak, M. Z. (2009) · Leukemia · doi:10.1038/leu.2009.271 · Cited by 72 · see citing works

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C. S., Loschi, M. L., Thangavelu, G., Ma, L., Zaiken, M. C., Dysthe, J., Krepps, W., Panthera, J., et al. (2019) · Blood · doi:10.1182/blood.2019001950 · Cited by 67 · see citing works

Aging and erythropoiesis: Current state of knowledge

Price, E. A. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.04.005 · Cited by 64 · see citing works

NLRP3 inflammasome couples purinergic signaling with activation of the complement cascade for the optimal release of cells from bone marrow

Ratajczak, M. Z., Adamiak, M., Thapa, A. K., Bujko, K., Brzeźniakiewicz‐Janus, K., & Lenkiewicz, A. M. (2019) · Leukemia · doi:10.1038/s41375-019-0436-6 · Cited by 64 · see citing works

The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood

Lenkiewicz, A. M., Adamiak, M., Thapa, A. K., Bujko, K., Pędziwiatr, D., Abdel‐Latif, A., Kucia, M., Ratajczak, J., & Ratajczak, M. Z. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09890-7 · Cited by 63 · see citing works

Sustained engraftment of mice transplanted with IL-1-primed blood-derived stem cells

Fibbe, W. E., Hamilton, M. S., Laterveer, L., Kibbelaar, R. E., Falkenburg, J. H. F., Visser, J. W. M., & Willemze, R. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.2.417 · Cited by 61 · see citing works

Mobilization of hematopoietic stem cells as a result of innate immunity-mediated sterile inflammation in the bone marrow microenvironment—the involvement of extracellular nucleotides and purinergic signaling

Ratajczak, M. Z., Adamiak, M., Plonka, M., Abdel‐Latif, A., & Ratajczak, J. (2018) · Leukemia · doi:10.1038/s41375-018-0087-z · Cited by 57 · see citing works

Identification of Heme Oxygenase 1 (HO-1) as a Novel Negative Regulator of Mobilization of Hematopoietic Stem/Progenitor Cells

Wysoczynski, M., Ratajczak, J., Pędziwiatr, D., Rokosh, G. D., Bolli, R., & Ratajczak, M. Z. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9547-7 · Cited by 55 · see citing works

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

Cacemiro, M. D. C., Cominal, J. G., Tognon, R., Nunes, N. D. S., Simões, B. P., Figueiredo-Pontes, L. L. D., Catto, L. F. B., Traina, F., Souto, E. X., Zambuzi, F. A., et al. (2018) · Hematology, Transfusion and Cell Therapy · doi:10.1016/j.htct.2017.12.003 · Cited by 55 · see citing works

Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization

Velders, G. A., van Os, R. P., Hagoort, H., Verzaal, P., Guiot, H. F. L., Lindley, I. J. D., Willemze, R., Opdenakker, G., & Fibbe, W. E. (2003) · Blood · doi:10.1182/blood-2002-07-2270 · Cited by 50 · see citing works

The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine

Adamiak, M., Bujko, K., Brzeźniakiewicz‐Janus, K., Kucia, M., Ratajczak, J., & Ratajczak, M. Z. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09918-y · Cited by 42 · see citing works

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

Adamiak, M., Abdelbaset‐Ismail, A., Suszyńska, M., Abdel‐Latif, A., Ratajczak, J., & Ratajczak, M. Z. (2016) · Leukemia · doi:10.1038/leu.2016.278 · Cited by 39 · see citing works

The Role of Purine Metabolites as DAMPs in Acute Graft-versus-Host Disease

Apostolova, P., & Zeiser, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00439 · Cited by 38 · see citing works

Unlocking the Potential of Purinergic Signaling in Transplantation

Zeiser, R., Robson, S. C., Vaikunthanathan, T., Dworak, M., & Burnstock, G. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13801 · Cited by 33 · see citing works

Fight or flight

Croker, B. A., Silke, J., & Gerlic, M. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000148 · Cited by 32 · see citing works

Novel pleiotropic effects of bioactive phospholipids in human lung cancer metastasis

Schneider, G., Sellers, Z. P., Bujko, K., Kakar, S. S., Kucia, M., & Ratajczak, M. Z. (2017) · Oncotarget · doi:10.18632/oncotarget.17461 · Cited by 30 · see citing works

The Emerging Link Between the Complement Cascade and Purinergic Signaling in Stress Hematopoiesis

Ratajczak, M. Z., Adamiak, M., Kucia, M., Tse, W. T., Ratajczak, J., & Wiktor-Jędrzejczak, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01295 · Cited by 29 · see citing works

Monocytes Take Their Own Path to IL-1β

Elliott, E. I., & Sutterwala, F. S. (2016) · Immunity · doi:10.1016/j.immuni.2016.03.015 · Cited by 25 · see citing works

Complement and T Cell Metabolism: Food for Thought

West, E. E., & Kemper, C. (2019) · Immunometabolism · doi:10.20900/immunometab20190006 · Cited by 25 · see citing works

Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells into Peripheral Blood

Borkowska, S., Suszyńska, M., Ratajczak, J., & Ratajczak, M. Z. (2016) · Cell Transplantation · doi:10.3727/096368915x688489 · Cited by 24 · see citing works

Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis

Linz, B., Neely, C. J., Kartchner, L. B., Mendoza, A. E., Khoury, A., Truax, A. D., Sempowski, G. D., Eitas, T. K., Brickey, W. J., Ting, J. P. ‐., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601048 · Cited by 21 · see citing works

Interleukin-18-mediated interferon-gamma secretion is regulated by thymosin beta 4 in human NK cells

Lee, H., Yoon, S. Y., Song, S. B., Park, Y., Kim, T. S., Kim, S., Hur, D. Y., Song, H. K., Park, H.-J., & Cho, D. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.04.002 · Cited by 16 · see citing works

Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner

Adamiak, M., Lenkiewicz, A. M., Cymer, M., Kucia, M., Ratajczak, J., & Ratajczak, M. Z. (2019) · Leukemia · doi:10.1038/s41375-019-0530-9 · Cited by 13 · see citing works

Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells

Borkowska, S., Suszyńska, M., Wysoczynski, M., & Ratajczak, M. Z. (2013) · Leukemia · doi:10.1038/leu.2013.84 · Cited by 11 · see citing works

Purinergic signaling regulates mobilization of hematopoietic stem cells

Adamiak, M., Abdel‐Latif, A., & Ratajczak, M. Z. (2018) · Oncotarget · doi:10.18632/oncotarget.26290 · Cited by 10 · see citing works

Inflammasome-Mediated Regulation of Hematopoiesis in the Vertebrate Embryo

Frame, J. M., Long, T. L., Schuster-Kubaczka, C., Esain, V., Lim, S. E., Daley, G. Q., & North, T. E. (2018) · Blood · doi:10.1182/blood-2018-99-117076 · Cited by 10 · see citing works

Complement proteins in unexpected places: why we should be excited, not concerned!

Ghebrehiwet, B. (2020) · F1000Research · doi:10.12688/f1000research.21690.1 · Cited by 9 · see citing works

Plausible Links Between Metabolic Networks, Stem Cells, and Longevity

Kucia, M., & Ratajczak, M. Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-31206-0_15 · Cited by 6 · see citing works

Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?

Ratajczak, M. Z., & Ratajczak, J. (2020) · Leukemia · doi:10.1038/s41375-020-01041-z · Cited by 297 · see citing works

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine “storm” and risk factor for damage of hematopoietic stem cells

Ratajczak, M. Z., & Kucia, M. (2020) · Leukemia · doi:10.1038/s41375-020-0887-9 · Cited by 235 · see citing works

NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword

Hamarsheh, S., & Zeiser, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01444 · Cited by 227 · see citing works

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

Trowbridge, J. J., & Starczynowski, D. T. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201544 · Cited by 189 · see citing works

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45− Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Ratajczak, M. Z., Bujko, K., Ciechanowicz, A. K., Sielatycka, K., Cymer, M., Marlicz, W. M., & Kucia, M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10010-z · Cited by 170 · see citing works

NF-κB: a double-edged sword controlling inflammation

Liu, D., Zhong, Z., & Karin, M. (2022) · Biomedicines · doi:10.3390/biomedicines10061250 · Cited by 157 · see citing works

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works

Pyroptosis-Induced Inflammation and Tissue Damage

Wei, Y., Yang, L., Pandeya, A., Cui, J., Zhang, Y., & Li, Z. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167301 · Cited by 127 · see citing works

Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity

Meier, D. T., Souza, J. D. P., & Donath, M. Y. (2024) · Diabetologia · doi:10.1007/s00125-024-06306-1 · Cited by 113 · see citing works

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies

Bennett, J., & Starczynowski, D. T. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000693 · Cited by 100 · see citing works

Myelodysplastic syndromes

Li, H., Hu, F., Gale, R. P., Sekeres, M. A., & Liang, Y. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00402-5 · Cited by 89 · see citing works

Hematopoietic stem and progenitor cell signaling in the niche

Hurwitz, S. N., Jung, S. K., & Kurre, P. (2020) · Leukemia · doi:10.1038/s41375-020-01062-8 · Cited by 61 · see citing works

Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)

Zhang, X., Zeng, W., Zhang, Y., Yu, Q., Zeng, M., Gan, J., Zhang, W., Jiang, X., & Li, H. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5130 · Cited by 56 · see citing works

Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation

Fang, D., Cui, K., Cao, Y., Zheng, M., Kawabe, T., Hu, G., Khillan, J. S., Li, D., Zhong, C., Jankovic, D. L., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.005 · Cited by 50 · see citing works

Nlrp3 Inflammasome Signaling Regulates the Homing and Engraftment of Hematopoietic Stem Cells (HSPCs) by Enhancing Incorporation of CXCR4 Receptor into Membrane Lipid Rafts

Adamiak, M., Abdel‐Latif, A., Bujko, K., Thapa, A. K., Anusz, K., Tracz, M. J., Brzeźniakiewicz‐Janus, K., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10005-w · Cited by 50 · see citing works

Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship

Ratajczak, M. Z., & Kucia, M. (2021) · Leukemia · doi:10.1038/s41375-021-01482-0 · Cited by 48 · see citing works

Circadian Clock and Complement Immune System—Complementary Control of Physiology and Pathology?

Shivshankar, P., Fekry, B., Eckel‐Mahan, K. L., & Wetsel, R. A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00418 · Cited by 40 · see citing works

Scutellarin protects against diabetic cardiomyopathy via inhibiting oxidative stress and inflammatory response in mice

Xu, L., Chen, R., Zhang, X., Zhu, Y., Ma, X., Sun, G., & Sun, X. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-19-516 · Cited by 38 · see citing works

Novel insights into NOD-like receptors in renal diseases

Jin, J., Zhou, T.-J., Ren, G., Cai, L., & Meng, X. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00886-7 · Cited by 37 · see citing works

Thromboinflammation in Myeloproliferative Neoplasms (MPN)—A Puzzle Still to Be Solved

Bhuria, V., Baldauf, C. K., Schraven, B. L., & Fischer, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063206 · Cited by 38 · see citing works

The NLRP3 Inflammasome and Its Role in the Pathogenicity of Leukemia

Urwanisch, L., Luciano, M., & Horejs‐Hoeck, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031271 · Cited by 36 · see citing works

Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression

Papafragkos, I., Grigoriou, M., Boon, L., Kloetgen, A., Hatzioannou, A., & Verginis, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889075 · Cited by 34 · see citing works

Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner

Ratajczak, M. Z., Adamiak, M., Abdelbaset‐Ismail, A., Bujko, K., Thapa, A. K., Chumak, V., Franczak, S., Brzeźniakiewicz‐Janus, K., Ratajczak, J., & Kucia, M. (2023) · Leukemia · doi:10.1038/s41375-023-01894-0 · Cited by 32 · see citing works

Danger-associated molecular pattern molecules take unexpectedly a central stage in Nlrp3 inflammasome–caspase-1-mediated trafficking of hematopoietic stem/progenitor cells

Thapa, A. K., Adamiak, M., Bujko, K., Ratajczak, J., Abdel‐Latif, A., Kucia, M., & Ratajczak, M. Z. (2021) · Leukemia · doi:10.1038/s41375-021-01158-9 · Cited by 31 · see citing works

Implication of lncRNA MSTRG.81401 in Hippocampal Pyroptosis Induced by P2X7 Receptor in Type 2 Diabetic Rats with Neuropathic Pain Combined with Depression

Zhan, T., Tang, S., Du, J., Liu, J., Yu, B., Yang, Y., Xie, Y., Qiu, Y., Li, G., & Gao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021186 · Cited by 30 · see citing works

Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis

Balahura, L., Șelaru, A., Dinescu, S., & Costache, M. (2020) · Journal of Immunological Research · doi:10.1155/2020/2549763 · Cited by 30 · see citing works

Time restricted feeding modifies leukocyte responsiveness and improves inflammation outcome

Ella, K., Sűdy, Á. R., Búr, Z., Koós, B., Kisiczki, Á. S., Mócsai, A., & Káldi, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.924541 · Cited by 29 · see citing works

Mesenchymal stem cells ( MSCs ) and MSC ‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome

Nazari, S., Pourmand, S. M., Motevaseli, E., & Hassanzadeh, G. (2023) · IUBMB Life · doi:10.1002/iub.2759 · Cited by 28 · see citing works

Intracellular complement and immunometabolism: The advantages of compartmentalization

King, B. C., & Blom, A. M. (2024) · European Journal of Immunology · doi:10.1002/eji.202350813 · Cited by 28 · see citing works

Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review

Battista, V. D., Bochicchio, M. T., Giordano, G., Napolitano, M., & Lucchesi, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020561 · Cited by 26 · see citing works

Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease

Guo, H., Li, R., Wang, M., Hou, Y., Liu, S., Peng, T., Zhao, X., Lu, L., Han, Y., Shao, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202200978 · Cited by 25 · see citing works

p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress

Tung, L. T., Wang, H., Belle, J. I., Petrov, J. C., Langlais, D., & Nijnik, A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04202-9 · Cited by 24 · see citing works

Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition

Zhao, Y., Huang, J., Li, T., Zhang, S.-J., Wen, C., & Wang, L. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17158 · Cited by 24 · see citing works

Immune Dysfunction, Cytokine Disruption, and Stromal Changes in Myelodysplastic Syndrome: A Review

Lynch, O. F., & Calvi, L. M. (2022) · Cells · doi:10.3390/cells11030580 · Cited by 26 · see citing works

The NLRP3 Inflammasome: Relevance in Solid Organ Transplantation

Burke, R. M., Dale, B. L., & Dholakia, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910721 · Cited by 22 · see citing works

The P2X4 purinergic receptor has emerged as a potent regulator of hematopoietic stem/progenitor cell mobilization and homing—a novel view of P2X4 and P2X7 receptor interaction in orchestrating stem cell trafficking

Adamiak, M., Bujko, K., Thapa, A. K., Pensato, V., Brzeźniakiewicz‐Janus, K., Ratajczak, J., Davies, D. L., Ulrich, H., Kucia, M., & Ratajczak, M. Z. (2021) · Leukemia · doi:10.1038/s41375-021-01352-9 · Cited by 22 · see citing works

Inflammation as a Mechanism and Therapeutic Target in Peripheral Artery Disease

Chan, N., Xu, K., de Vries, T. A. C., Eikelboom, J. W., & Hirsh, J. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.01.026 · Cited by 21 · see citing works

Immune dysregulation and potential targeted therapy in myelodysplastic syndrome

Zhang, X., Yang, X., Ma, L., Zhang, Y., & Wei, J. (2023) · Therapeutic Advances in Hematology · doi:10.1177/20406207231183330 · Cited by 19 · see citing works

ATF3 Reprograms the Bone Marrow Niche in Response to Early Breast Cancer Transformation

Perrone, M., Chiodoni, C., Lecchi, M., Botti, L., Bassani, B., Piva, A., Jachetti, E., Milani, M., Lecis, D., Tagliabue, E., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0651 · Cited by 17 · see citing works

Increased Inflammasome Activation Is Associated with Aging and Chronic Myelomonocytic Leukemia Disease Severity

Andina, N. D., de Meuron, L., Schnegg-Kaufmann, A. S., Sarangdhar, M. A., Ansermet, C., Bombaci, G., Batta, K., Keller, N., Porret, N. A., Angelillo‐Scherrer, A., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200412 · Cited by 17 · see citing works

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities

Yang, L., Hu, M., Lu, Y., Han, S., & Wang, J. (2021) · Molecules · doi:10.3390/molecules26020309 · Cited by 17 · see citing works

The Nox2-ROS-Nlrp3 Inflammasome Signaling Stimulates in the Hematopoietic Stem/Progenitor Cells Lipogenesis to Facilitate Membrane Lipid Raft Formation

Abdelbaset‐Ismail, A., Ciechanowicz, A. K., Bujko, K., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10481-2 · Cited by 17 · see citing works

STING-inflammasome axis in autoimmune diseases and inflammation-related disease

Chai, S., Xu, H., Liu, R., & Cai, C. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103898 · Cited by 16 · see citing works

The Nlrp3 inflammasome – the evolving story of its positive and negative effects on hematopoiesis

Ratajczak, M. Z., & Kucia, M. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000658 · Cited by 16 · see citing works

Hematopoietic stem cell mobilization

Chang, H., Liou, Y.-S., & Sun, D. (2021) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_98_21 · Cited by 16 · see citing works

Inflammasome Activation in Myeloid Malignancies—Friend or Foe?

Andina, N. D., Bonadies, N., & Allam, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.825611 · Cited by 15 · see citing works

High BM plasma S100A8/A9 is associated with a perturbed microenvironment and poor prognosis in myelodysplastic syndromes

Wang, Y., Lin, C., Yao, C., Amaral, F. M. R., Yu, S., Kao, C., Shih, P., Hou, H., Chou, W., & Tien, H. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008958 · Cited by 14 · see citing works

Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19

Majolo, F., da Silva, G. L., Vieira, L., Timmers, L. F. S. M., Laufer, S., & Goettert, M. I. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10033-6 · Cited by 14 · see citing works

Mechanism of N-0385 blocking SARS-CoV-2 to treat COVID-19 based on molecular docking and molecular dynamics

Cao, J., Yang, X., Xiong, L., Wu, M., Chen, S., Xiong, C., He, P., Zong, Y., Zhang, L., Fu, H., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1013911 · Cited by 14 · see citing works

Extracellular Adenosine Triphosphate (eATP) and Its Metabolite, Extracellular Adenosine (eAdo), as Opposing “Yin–Yang” Regulators of Nlrp3 Inflammasome in the Trafficking of Hematopoietic Stem/Progenitor Cells

Ratajczak, M. Z., & Kucia, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.603942 · Cited by 14 · see citing works

Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer

Chen, C., Man, N., Liu, F., Martín, G. M., Itonaga, H., Sun, J., & Nimer, S. D. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3503 · Cited by 13 · see citing works

Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity

Franczak, S., Ulrich, H., & Ratajczak, M. Z. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09943-0 · Cited by 13 · see citing works

Analysis of prognostic biomarker models of TXNIP/NLRP3/IL1B inflammasome pathway in patients with acute myeloid leukemia

Chen, J., Hou, Q., Chang, T., Zheng, J., Yao, C., He, J., Chen, S., Wu, X., & Jin, Z. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.96627 · Cited by 12 · see citing works

Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes

Issa, W., Njeim, R., Carrazco, A., Burke, G. W., & Mitrofanova, A. V. (2024) · Cells · doi:10.3390/cells13131157 · Cited by 12 · see citing works

Defect in Migration of HSPCs in Nox-2 Deficient Mice Explained by Impaired Activation of Nlrp3 Inflammasome and Impaired Formation of Membrane Lipid Rafts

Bujko, K., Adamiak, M., Konopko, A., Chumak, V., Ratajczak, J., Brzeźniakiewicz‐Janus, K., Kucia, M., & Ratajczak, M. Z. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10775-7 · Cited by 12 · see citing works

Complosome as a new intracellular regulatory network in both normal and malignant hematopoiesis

Ratajczak, M. Z., Konopko, A., Jarczak, J., Kazek, M., Ratajczak, J., & Kucia, M. (2025) · Leukemia · doi:10.1038/s41375-025-02613-7 · Cited by 12 · see citing works

Unraveling the Role of the NLRP3 Inflammasome in Lymphoma: Implications in Pathogenesis and Therapeutic Strategies

Stergiou, I. Ε., Tsironis, C., Papadakos, S. P., Tsitsilonis, O., Dimopoulos, M. A., & Theocharis, S. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042369 · Cited by 11 · see citing works

Mitochondria Express Functional Signaling Ligand-Binding Receptors that Regulate their Biological Responses – the Novel Role of Mitochondria as Stress-Response Sentinels

Brzeźniakiewicz‐Janus, K., Jarczak, J., Konopko, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10847-2 · Cited by 11 · see citing works

The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation

Espinoza, J. L., Kamio, K., Lam, V. Q., & Takami, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111845 · Cited by 11 · see citing works

External Liver-Derived Complement and Intrinsic Present in Hematopoietic Stem/Progenitor Cells Complosome Modulate Cell Metabolism and Response to Stress

Thapa, A. K., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10533-1 · Cited by 11 · see citing works

The triad inflammation-microenvironment-tumor initiating cells in leukemia progression

Vilchis-Ordóñez, A., Ramírez-Ramírez, D., & Pelayo, R. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.10.010 · Cited by 11 · see citing works

From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review

Comont, T., Treiner, E., & Vergez, F. (2021) · Diagnostics · doi:10.3390/diagnostics11111982 · Cited by 10 · see citing works

Diagnosis of Myelodysplastic Syndromes: From Immunological Observations to Clinical Applications

Simoni, Y., & Chapuis, N. (2022) · Diagnostics · doi:10.3390/diagnostics12071659 · Cited by 9 · see citing works

Inflammatory signaling in the pathogenesis of acute myeloid leukemia

Baumann, A., & Ellegast, J. M. (2025) · HemaSphere · doi:10.1002/hem3.70188 · Cited by 9 · see citing works

Heme Oxygenase 1 (HO-1) as an Inhibitor of Trafficking of Normal and Malignant Hematopoietic Stem Cells – Clinical and Translational Implications

Ratajczak, M. Z., Adamiak, M., Ratajczak, J., & Kucia, M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10083-w · Cited by 9 · see citing works

The NLRP3 Inflammasome Transmits Sterile Inflammation Signals to Sustain Proper Mitochondrial Electron Transport Chain Function and Influences Cellular Metabolism

Konopko, A., Kazek, M., Waraksa-Zasada, E., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10948-y · Cited by 8 · see citing works

Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells

Adamiak, M., Ciechanowicz, A. K., Chumak, V., Bujko, K., Ratajczak, J., Brzezniakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10318-4 · Cited by 8 · see citing works

Insight to Pyroptosis in Viral Infectious Diseases

Li, J., Chen, L., Zhou, C., Bai, Y., Zhao, R., Zhang, J., Xu, X., Ge, X., & Qiu, Y. (2021) · Health · doi:10.4236/health.2021.135043 · Cited by 7 · see citing works

The Role of NLRP3, a Star of Excellence in Myeloproliferative Neoplasms

Parciante, E., Cumbo, C., Anelli, L., Zagaria, A., Redavid, I., Minervini, A., Conserva, M. R., Tota, G., Coccaro, N., Tarantini, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054860 · Cited by 6 · see citing works

Unraveling the interplay between inflammation and stem cell mobilization or homing: Implications for tissue repair and therapeutics

Chang, H., Liou, Y.-S., & Sun, D. (2024) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_100_24 · Cited by 6 · see citing works

Environmental pollutant N‐N′ethylnitrosourea‐induced leukemic NLRP3 inflammasome activation and its amelioration by Eclipta prostrata and its active compound wedelolactone

Bhattacharyya, S., & Law, S. (2021) · Environmental Toxicology · doi:10.1002/tox.23400 · Cited by 6 · see citing works

A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs)

Adamiak, M., Cymer, M., Anusz, K., Tracz, M. J., & Ratajczak, M. Z. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-09983-8 · Cited by 6 · see citing works

Cross-talk between aging resilience pathways and autoimmunity onset

Mittal, R., Saavedra, D., Mittal, M., & Hirani, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1712575 · Cited by 5 · see citing works

Complement and inflammasome crosstalk in chronic inflammation

Janžič, L., & Kouter, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1778759 · Cited by 5 · see citing works

Purinergic Signaling and Its Role in Mobilization of Bone Marrow Stem Cells

Suszyńska, M., Adamiak, M., Thapa, A. K., Cymer, M., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2679-5_17 · Cited by 5 · see citing works

Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?

Zhao, X.-C., Sun, X.-Y., Ju, B., Meng, F., & Zhao, H. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i11.1429 · Cited by 5 · see citing works

IL-1 signaling and inflammasomes in acute myeloid leukemia: mechanisms and therapeutic opportunities

Mortellaro, A., Mastaglio, S., & Muzio, M. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05966-5 · Cited by 4 · see citing works

Expression of innate immunity genes in human hematopoietic stem/progenitor cells – single cell RNA-seq analysis

Jarczak, J., Thetchinamoorthy, K., Wierzbicka, D., Bujko, K., Ratajczak, M. Z., & Kucia, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1515856 · Cited by 4 · see citing works

The inflammasomes: crosstalk between innate immunity and hematology

Dutra, V. D. F., Leal, V. N. C., & Pontillo, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01646-3 · Cited by 4 · see citing works

Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?

Alves-Hanna, F. S., Crespo-Neto, J. A., Nogueira, G. M., Pereira, D. S., Lima, A. B., Pereira-Ribeiro, T. L., Santos, V. G. R., Fonseca, J. R. F., Magalhães-Gama, F., Sadahiro, A., et al. (2023) · Journal of Immunology Research · doi:10.1155/2023/5584492 · Cited by 4 · see citing works

Multifaceted regulation of thymic tolerance by pattern recognition cascades

Mukherjee, S., Paul, P., Kar, A., & Barik, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1814309 · Cited by 3 · see citing works

Effects of glucose on the proliferation of human umbilical cord blood hematopoietic stem cells

Dadkhah, M., Sharifi, M., Sharifi, M. J., & Tehrani, R. M. (2022) · Cell and Tissue Banking · doi:10.1007/s10561-022-10048-y · Cited by 3 · see citing works

The genetic advantage of healthy centenarians: unraveling the central role of NLRP3 in exceptional healthspan

Verlinden, S. F. F. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1452453 · Cited by 3 · see citing works

Relative mRNA expression signature of PBMC-derived NLRP3 inflammasomes in progression of type 2 diabetic kidney disease

Jayashree, K., Senthilkumar, G. P., Parameswaran, S., & Mehalingam, V. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156999 · Cited by 2 · see citing works

A traditional Cameroonian spice, Syzygium guineense curtails leukemia tumor growth through G2-M cell cycle arrest and predicted NLRP3 inflammasome pathway

Nzufo, F. T., Pieme, C. A., Meher, R. K., Jouda, J., Etsassala, N. G. E. R., Pradhan, T. N., Kasinathan, N. K., Sen, S., Barkume, M. S., Kumar, S., et al. (2025) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2025.101202 · Cited by 2 · see citing works

Euphorbia factor L2 suppresses the generation of liver metastatic ascites in breast cancer via inhibiting NLRP3 inflammasome activation

Jiang, D., Liu, X., Tan, R., Zhu, Y., & Li, Z. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5332 · Cited by 2 · see citing works

When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmune hematopoietic failure and myeloid neoplasms

Zhao, X.-C., Ju, B., Xiu, N.-N., Sun, X.-Y., & Meng, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1339971 · Cited by 3 · see citing works

Aplastic Anemia in the light of the COVID-19 pandemic: infection, vaccination, and pathophysiologic mechanisms

Cahuapaza-Gutierrez, N. L. (2024) · Annals of Hematology · doi:10.1007/s00277-024-06052-9 · Cited by 2 · see citing works

Leukemic transformation during anti-tuberculosis treatment in aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome: A case report and review of literature

Xiu, N.-N., Yang, X.-D., Xu, J. M. S., Ju, B., Sun, X.-Y., & Zhao, X.-C. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i28.6908 · Cited by 2 · see citing works

Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severityPreprint

Andina, N. D., de Meuron, L., Schnegg-Kaufmann, A. S., Ansermet, C., Bomaci, G., Keller, N., Porret, N. A., Angelillo‐Scherrer, A., Bonadies, N., & Allam, R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.27.477992 · Cited by 2 · see citing works

Integrative multi-omic analysis of NLRP3 inflammasome dysregulation and subtyping for personalized treatment in acute myeloid leukemia

Zhang, H., Yang, L., Liu, Y., Wang, D., Shi, L., & Tian, C. (2025) · Discover Oncology · doi:10.1007/s12672-025-02383-9 · Cited by 1 · see citing works

TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome

Gil, J. M. L., Rodríguez‐Ruiz, L., Palacios, M., Peral, J., Navarro, S., Fuster, J. L., Beléndez, C., Jerez, A., Murillo, L., de Heredia, C. D., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00368-3 · Cited by 1 · see citing works

Potential Diagnostic Value of Abnormal Pyroptosis Genes Expression in Myelodysplastic Syndromes (MDS): A Primary Observational Cohort Study

Soltani, M., Sharifi, M. J., Khalilian, P., Sharifi, M., Nematollahi, P., Shapourian, H., & Ganjalıkhani-Hakemi, M. (2024) · International Journal of Hematology-Oncology and Stem Cell Research · doi:10.18502/ijhoscr.v18i2.15371 · Cited by 1 · see citing works

Inflamasoma, piroptosis y su posible relación con la fisiopatología de la COVID-19

Pedreáñez, A. B., Mosquera, J., & Muñóz, N. (2020) · Investigación Clínica · doi:10.22209/ic.v61n3a07 · Cited by 1 · see citing works

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemiaPreprint

Luciano, M., Blöchl, C., Vetter, J., Urwanisch, L., Neuper, T., Elmer, D. P., Bauer, R., Dang, H.-H., Strandt, H., Neureiter, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.25.449862 · Cited by 1 · see citing works

Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia SyndromePreprint

Gil, J. M. L., Rodríguez‐Ruiz, L., Palacios, M., Peral, J., Navarro, S., Fuster, J. L., Beléndez, C., Jerez, A., Murillo, L., de Heredia, C. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.20.639294 · Cited by 1 · see citing works

[Mechanisms by which the bone marrow microenvironment of myelodysplastic neoplasms contributes to disease progression].

Hong, M., & Chang, C. (2023) · PubMed Central · doi:10.3760/cma.j.issn.0253-2727.2023.04.018

Role of NLRP3 Inflammasome in Pathogenesis of Ischemic Stroke

Дмитриевич, К. С., Kamenskih, E. M., & Удут, Е. В. (2024) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093024030098

The Role of NLRP3 Inflammasome in the Pathogenesis of Ischemic Stroke

Дмитриевич, К. С., Kamenskih, E. M., & Удут, Е. В. (2024) · Российский физиологический журнал им  И  М  Сеченова · doi:10.31857/s0869813924050014

Advances in the Regulation of Hematopoietic Homeostasis by Programmed Cell Death Under Radiation Conditions

Shu, M., Zhang, J., Huang, H., Chen, Y., Shi, Y., Zeng, H., & Shao, L. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10863-2

The Nlrp3 inflammasome – the evolving story of its positive and negative effects on hematopoiesis

Ratajczak, M. Z., & Kucia, M. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000658 · Cited by 16 · see citing works

Nlrp3 Inflammasome Signaling Regulates the Homing and Engraftment of Hematopoietic Stem Cells (HSPCs) by Enhancing Incorporation of CXCR4 Receptor into Membrane Lipid Rafts

Adamiak, M., Abdel‐Latif, A., Bujko, K., Thapa, A. K., Anusz, K., Tracz, M. J., Brzeźniakiewicz‐Janus, K., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10005-w · Cited by 50 · see citing works

The NLRP3 Inflammasome Transmits Sterile Inflammation Signals to Sustain Proper Mitochondrial Electron Transport Chain Function and Influences Cellular Metabolism

Konopko, A., Kazek, M., Waraksa-Zasada, E., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10948-y · Cited by 8 · see citing works

The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation

Espinoza, J. L., Kamio, K., Lam, V. Q., & Takami, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111845 · Cited by 11 · see citing works

New evidence indicates that the NLRP3 inflammasome in hematopoietic stem and progenitor cells (HSPCs) maintains proper mitochondrial electron transport chain function and affects both cellular trafficking and metabolism through a gasdermin pore-mediated, alarmin-release-dependent mechanism

Kucia, M., Kazek, M., Jarczak, J., Waraksa-Zasada, E., Kieszek, P., & Ratajczak, M. Z. (2025) · Blood · doi:10.1182/blood-2025-2314