Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome
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Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and associated with fibrostenosing Crohn's disease. Tl1a-overexpression in mice lead to spontaneous ileitis, and exacerbated induced proximal colitis and fibrosis. IBD is associated with shifts in the gut microbiome, but the effect of differing microbial populations and their interaction with TL1A on fibrosis has not been investigated. We demonstrate that the pro-fibrotic and inflammatory phenotype resulting from Tl1a-overexpression is abrogated in the absence of resident microbiota. To evaluate if this is due to the absence of a unique bacterial population, as opposed to any bacteria per se, we gavaged germ-free (GF) wild-type and Tl1a-transgenic (Tl1a-Tg) mice with stool from specific pathogen free (SPF) mice and a healthy human donor (Hu). Reconstitution with SPF, but not Hu microbiota, resulted in increased intestinal collagen deposition and fibroblast activation in Tl1a-Tg mice. Notably, there was reduced fibroblast migration and activation under GF conditions compared to native conditions. We then identified several candidate organisms that correlated directly with increased fibrosis in reconstituted mice and showed that these organisms directly impact fibroblast function in vitro. Thus, Tl1a-mediated intestinal fibrosis and fibroblast activation are dependent on specific microbial populations.
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Increased liver ECM deposition was observed in germ-free mice compared to conventionally housed mice, and also in MyD88/TRIF-deficient mice.
“Increased liver ECM deposition was observed in germ free mice compared to conventionally housed mice166, which was also observed in MyD88/TRIF deficient mice.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [166]
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Self-citationThe Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works
Johansson, M., Larsson, J. M. H., & Hansson, G. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006451107 · Cited by 1,459 · see citing works
Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S. (2011) · Gut · doi:10.1136/gut.2010.223263 · Cited by 1,063 · see citing works
Willing, B. P., Dicksved, J., Halfvarson, J., Andersson, A. F., Lucio, M., Zheng, Z., Järnerot, G., Tysk, C., Jansson, J. K., & Engstrand, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.049 · Cited by 1,032 · see citing works
Meta‐analyses of human gut microbes associated with obesity and IBD
Walters, W. A., Xu, Z., & Knight, R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.09.039 · Cited by 836 · see citing works
Rath, H. C., Herfarth, H. H., Ikeda, J. S., Grenther, W. B., Hamm, T. E., Balish, E., Taurog, J. D., Hammer, R. E., Wilson, K. H., & Sartor, R. B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118878 · Cited by 833 · see citing works
Self-citationSartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works
Self-citationSignal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95
Chinnaiyan, A. M., O’Rourke, K. M., Yu, G.-L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., & Dixit, V. M. (1996) · Science · doi:10.1126/science.274.5289.990 · Cited by 653 · see citing works
Kugathasan, S., Denson, L. A., Walters, T. D., Kim, M., Marigorta, U. M., Schirmer, M., Mondal, K., Liu, C., Griffiths, A. M., Noe, J. D., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30317-3 · Cited by 632 · see citing works
CoNet app: inference of biological association networks using Cytoscape
Faust, K., & Raes, J. (2016) · F1000Research · doi:10.12688/f1000research.9050.1 · Cited by 599 · see citing works
The outer mucus layer hosts a distinct intestinal microbial niche
Li, H., Limenitakis, J. P., Fuhrer, T., Geuking, M. B., Lawson, M. A., Wyss, M., Brugiroux, S., Keller, I., Macpherson, J. A., Rupp, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9292 · Cited by 511 · see citing works
Schaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S. B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., Bergen, M. V., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309333 · Cited by 447 · see citing works
CoNet app: inference of biological association networks using Cytoscape
Faust, K., & Raes, J. (2016) · F1000Research · doi:10.12688/f1000research.9050.2 · Cited by 437 · see citing works
Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
Sabino, J., Vieira-Silva, S., Machiels, K., Joossens, M., Falony, G., Ballet, V., Ferrante, M., Van Assche, G., Van der Merwe, S., Vermeire, S., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-311004 · Cited by 413 · see citing works
Rooks, M. G., Veiga, P., Wardwell-Scott, L., Tickle, T. L., Segata, N., Michaud, M., Gallini, C. A., Beal, C., van Hylckama-Vlieg, J. E. T., Ballal, S. A., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.3 · Cited by 386 · see citing works
A death-domain-containing receptor that mediates apoptosis
Kitson, J., Raven, T., Jiang, Y., Goeddel, D. V., Giles, K. M., Pun, K., Grinham, C. J., Brown, R., & Farrow, S. N. (1996) · Nature · doi:10.1038/384372a0 · Cited by 335 · see citing works
Tan, K. B., Harrop, J., Reddy, M. P., Young, P. R., Terrett, J. A., Emery, J. G., Moore, G. P., & Truneh, A. (1997) · Gene · doi:10.1016/s0378-1119(97)00509-x · Cited by 277 · see citing works
Bodmer, J.-L., Burns, K., Schneider, P., Hofmann, K., Steiner, V., Thome, M., Bornand, T., Hahne, M., Schröter, M., Becker, K., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80244-7 · Cited by 262 · see citing works
Intestinal myofibroblasts in innate immune responses of the intestine
Otte, J.-M., Rosenberg, I. M., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00403-7 · Cited by 242 · see citing works
Bibiloni, R., Mangold, M., Madsen, K. L., Fedorak, R. N., & Tannock, G. W. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46498-0 · Cited by 226 · see citing works
Screaton, G. R., Xu, X.-N., Olsen, A. L., Cowper, A. E., Tan, R., McMichael, A. J., & Bell, J. I. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4615 · Cited by 210 · see citing works
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis
Bamias, G., Mishina, M., Nyce, M. R., Ross, W. G., Kollias, G., Rivera–Nieves, J., Pizarro, T. T., & Cominelli, F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510903103 · Cited by 169 · see citing works
Dextran Sodium Sulfate-Induced Colitis in Germ-Free IQI/Jic Mice.
Kitajima, S., MORIMOTO, M., Sagara, E., SHIMIZU, C., & IKEDA, Y. (2001) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.50.387 · Cited by 168 · see citing works
The T Cell Costimulator TL1A Is Induced by FcγR Signaling in Human Monocytes and Dendritic Cells
Prehn, J., Thomas, L. S., Landers, C. J., Yu, Q., Michelsen, K. S., & Targan, S. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4033 · Cited by 160 · see citing works
Self-citationThe TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation
Meylan, F., Song, Y.-J., Fuss, I. J., Villarreal, S., Kahle, E., Malm, I.-J., Acharya, K., Ramos, H. L., Lo, L., Mentink‐Kane, M. M., et al. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.67 · Cited by 154 · see citing works
Microbial Dysbiosis in Pediatric Patients with Crohn's Disease
Kaakoush, N. O., Day, A. S., Huinao, K. D., Leach, S. T., Lemberg, D. A., Dowd, S. E., & Mitchell, H. M. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.01396-12 · Cited by 147 · see citing works
Eun, C. S., Mishima, Y., Wohlgemuth, S., Liu, B., Bower, M., Carroll, I. M., & Sartor, R. B. (2014) · Infection and Immunity · doi:10.1128/iai.01513-13 · Cited by 124 · see citing works
Self-citationCrucial steps in the natural history of inflammatory bowel disease
Latella, G. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i29.3790 · Cited by 115 · see citing works
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis
Shih, D. Q., Zheng, L., Zhang, X., Zhang, H., Kanazawa, Y., Ichikawa, R., Wallace, K. L., Chen, J., Pothoulakis, C., Koon, H. W., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.37 · Cited by 106 · see citing works
Self-citationShih, D. Q., Barrett, R. J., Zhang, X., Yeager, N., Koon, H. W., Phaosawasdi, P., Song, Y., Ko, B., Wong, M. H., Michelsen, K. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016090 · Cited by 103 · see citing works
Self-citationIBD-Associated TL1A Gene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein
Michelsen, K. S., Thomas, L. S., Taylor, K. D., Yu, Q., Mei, L., Landers, C. J., Derkowski, C. A., McGovern, D. P. B., Rotter, J. I., & Targan, S. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004719 · Cited by 103 · see citing works
Self-citationTaraban, V. Y., Ślebioda, T. J., Willoughby, J. E., Buchan, S. L., James, S., Sheth, B., Smyth, N. R., Thomas, G. J., Wang, E. C. Y., & Al‐Shamkhani, A. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.70 · Cited by 101 · see citing works
TNFSF15 is an ethnic-specific IBD gene
Picornell, Y., Mei, L., Taylor, K. D., Yang, H., Targan, S. R., & Rotter, J. I. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20223 · Cited by 91 · see citing works
Self-citationDrygiannakis, I., Valatas, V., Sfakianaki, O., Bourikas, L. A., Manousou, P., Kambas, K., Ritis, K., Kolios, G. C., & Kouroumalis, E. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2012.04.008 · Cited by 91 · see citing works
Barrett, R. J., Zhang, X., Koon, H. W., Vu, M., Chang, J.-Y., Yeager, N., Nguyen, M. A., Michelsen, K. S., Berel, D., Pothoulakis, C., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.026 · Cited by 90 · see citing works
Self-citationShih, D. Q., Kwan, L. Y., Chavez, V., Cohavy, O., Gonsky, R., Chang, E. Y., Chang, C. C.-C., Elson, C. O., & Targan, S. R. (2009) · European Journal of Immunology · doi:10.1002/eji.200839087 · Cited by 86 · see citing works
Self-citationTL1A Both Promotes and Protects from Renal Inflammation and Injury
Al‐Lamki, R. S., Wang, J., Tolkovsky, A. M., Bradley, J. A., Griffin, J. L., Thiru, S., Wang, E. C. Y., Bolton, E. M., Wang, M., Moore, P. A., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007060706 · Cited by 78 · see citing works
Association Study of 71 European Crohnʼs Disease Susceptibility Loci in a Japanese Population
Hirano, A., Yamazaki, K., Umeno, J., Ashikawa, K., Aoki, M., Matsumoto, T., Nakamura, S., Ninomiya, T., Matsui, T., Hirai, F., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31828075e7 · Cited by 68 · see citing works
Zheng, D., Dong, S., Li, T., Yang, F., Yu, X., Wu, J., Zhong, X., Zhao, Y., Wang, L., Xu, C., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430266 · Cited by 58 · see citing works
Jacobs, J. P., Lin, L., Goudarzi, M., Ruegger, P. M., McGovern, D. P. B., Fornace, A. J., Borneman, J., Xia, L., & Braun, J. G. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1257469 · Cited by 54 · see citing works
Self-citationZheng, L., Zhang, X., Chen, J., Ichikawa, R., Wallace, K. L., Pothoulakis, C., Koon, H. W., Targan, S. R., & Shih, D. Q. (2013) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.3.2013.1.2 · Cited by 45 · see citing works
Self-citationZeng, O., Fang, L., Li, Y., Li, L., Xiao, T., Chu, C., & Yang, J. (2016) · Bioengineered · doi:10.1080/21655979.2016.1197743 · Cited by 25 · see citing works
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Fibroblasts as immune regulators in infection, inflammation and cancer
Davidson, S., Coles, M. C., Thomas, T. R., Kollias, G. A., Ludewig, B., Turley, S. J., Brenner, M. B., & Buckley, C. D. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00540-z · Cited by 612 · see citing works
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D’Alessio, S., Ungaro, F., Noviello, D., Lovisa, S., Peyrin‐Biroulet, L., & Danese, S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00543-0 · Cited by 258 · see citing works
Shao, X., Sun, C., Tang, X., Zhang, X., Han, D., Liang, S., Qu, R., Hui, X., Shan, Y., Hu, L., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04773 · Cited by 249 · see citing works
Fibrosis in IBD: from pathogenesis to therapeutic targets
Rieder, F., Mukherjee, P. K., Massey, W. J., Wang, Y., & Fiocchi, C. (2024) · Gut · doi:10.1136/gutjnl-2023-329963 · Cited by 205 · see citing works
Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
Liu, Y., Liu, Y., He, W., Mu, X., Wu, X., Deng, J., & Nie, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918223 · Cited by 169 · see citing works
Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 149 · see citing works
Wang, Y., Xie, Q., Zhang, Y., Ma, W., Ning, K., Xiang, J., Cui, J., & Xiang, H. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10259-6 · Cited by 144 · see citing works
Valatas, V., Kolios, G. C., & Bamias, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00583 · Cited by 125 · see citing works
Dysbiotic microbiota interactions in Crohn’s disease
Caparrós, E., Wiest, R., Scharl, M. M., Rogler, G., Gutiérrez, A., Yılmaz, B., Wawrzyniak, M., & Francés, R. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1949096 · Cited by 123 · see citing works
Novel mechanisms and clinical trial endpoints in intestinal fibrosis*
Wang, J., Lin, S., Brown, J. M., Wagoner, D. R. V., Fiocchi, C., & Rieder, F. (2021) · Immunological Reviews · doi:10.1111/imr.12974 · Cited by 119 · see citing works
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Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114 · see citing works
Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy
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Flannigan, K. L., Nieves, K., Szczepanski, H. E., Serra, A., Lee, J. W., Alston, L. A., Ramay, H. R., Mani, S., & Hirota, S. A. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.10.014 · Cited by 96 · see citing works
Lin, S., Mao, R., Qian, C., Bettenworth, D., Wang, J., Li, J., Bruining, D. H., Jairath, V., Feagan, B. G., Chen, M., et al. (2021) · Physiological Reviews · doi:10.1152/physrev.00005.2021 · Cited by 83 · see citing works
Zhao, S., Dejanovic, D., Yao, P., Bhilocha, S., Sadler, T., Schirbel, A., West, G., Doyon, G., Lopez, R., Mao, R., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0259-9 · Cited by 59 · see citing works
Mangoni, A. A., & Jarmuzewska, E. A. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13760 · Cited by 59 · see citing works
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Pai, Y.-C., Weng, L.-T., Wei, S., Wu, L., Shih, D. Q., Targan, S. R., Turner, J. R., & Yu, L. C. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa165 · Cited by 51 · see citing works
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Solitano, V., Jairath, V., Ungaro, F., Peyrin‐Biroulet, L., & Danese, S. (2024) · Med · doi:10.1016/j.medj.2024.03.010 · Cited by 35 · see citing works
DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
Shafiei-Jahani, P., Hurrell, B. P., Galle-Treger, L., Helou, D. G., Howard, E. D., Painter, J. D., Lo, R., Lewis, G. M., Soroosh, P., & Akbari, O. (2020) · Nature Communications · doi:10.1038/s41467-020-18601-7 · Cited by 35 · see citing works
Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs
Zhan, S., Li, N., Liu, C., Mao, R., Wu, D., Li, T., Chen, M., Zhuang, X., & Zeng, Z. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.694967 · Cited by 34 · see citing works
Gut Microbiota Metabolites: Unveiling Their Role in Inflammatory Bowel Diseases and Fibrosis
Bernardi, F., D’Amico, F., Bencardino, S., Faggiani, I., Fanizza, J., Zilli, A., Parigi, T. L., Allocca, M., Danese, S., & Furfaro, F. (2024) · Pharmaceuticals · doi:10.3390/ph17030347 · Cited by 37 · see citing works
Inflammation accelerating intestinal fibrosis: from mechanism to clinic
Xin, S., Liu, X., He, C., Gao, H., Wang, B., Hua, R., Gao, L., Shang, H., Sun, F., & Xu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-01932-2 · Cited by 35 · see citing works
Immunological roles of intestinal mesenchymal cells
Thomson, C. A., Nibbs, R. J. B., McCoy, K. D., & Mowat, A. M. (2020) · Immunology · doi:10.1111/imm.13191 · Cited by 32 · see citing works
Haberman, Y., Minar, P., Karns, R. A., Dexheimer, P. J., Ghandikota, S. K., Tegge, S. M., Shapiro, D., Shuler, B., Venkateswaran, S., Braun, T., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa166 · Cited by 32 · see citing works
Mathematical-based microbiome analytics for clinical translation
Narayana, J. K., Aogáin, M. M., Goh, W. W. B., Xia, K., Tsaneva-Atanasova, K. T., & Chotirmall, S. H. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.11.029 · Cited by 30 · see citing works
Yang, J. C., Jacobs, J. P., Hwang, M., Sabui, S., Liang, F., Said, H. M., & Skupsky, J. (2023) · Nutrients · doi:10.3390/nu15020264 · Cited by 30 · see citing works
Self-citationRecent advances in intestinal fibrosis
Lenti, M. V., Santacroce, G., Broglio, G., Rossi, C. M., & Sabatino, A. D. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101251 · Cited by 29 · see citing works
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders
Varricchi, G., Poto, R., Criscuolo, G., Strisciuglio, C., Nair, P., & Marone, G. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.02.018 · Cited by 28 · see citing works
Metabolic modulation during intestinal fibrosis
Bos, S., & Laukens, D. (2020) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12882 · Cited by 28 · see citing works
Friščić, J., Dürholz, K., Chen, X., Engdahl, C., Möller, L., Schett, G. A., Zaiss, M. M., & Hoffmann, M. H. (2021) · Nutrients · doi:10.3390/nu13051643 · Cited by 26 · see citing works
Yang, L., Li, X.-M., Duan, H.-Y., Yang, K., & Ye, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1398652 · Cited by 25 · see citing works
Tumor necrosis factor–like cytokine 1A plays a role in inflammatory bowel disease pathogenesis
Meng, F., Jiang, X., Wang, X., Zheng, Q., Wang, X., Mei, C., Yan, S., He, Y., Xue, J., Zhang, X., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120771120 · Cited by 24 · see citing works
Contribution of the Gut Microbiota to Intestinal Fibrosis in Crohn's Disease
Watanabe, D., & Kamada, N. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.826240 · Cited by 23 · see citing works
Russo, E., Bellando-Randone, S., Carboni, D., Fioretto, B. S., Romano, E., Baldi, S., Aoufy, K. E., Ramazzotti, M., Rosa, I., Lepri, G., et al. (2023) · Rheumatology · doi:10.1093/rheumatology/kead208 · Cited by 22 · see citing works
Stromal Cell Regulation of Intestinal Inflammatory Fibrosis
Yang, W., Yu, T., & Cong, Y. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.007 · Cited by 21 · see citing works
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn’s disease
Li, X.-H., Hu, S., Shen, X.-D., Zhang, R.-N., Liu, C.-G., Xiao, L., Lin, J.-J., Huang, L., He, W.-T., Wang, X., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00129-8 · Cited by 22 · see citing works
Intestinal fibrosis associated with inflammatory bowel disease: Known and unknown
Zhang, Y., Zhuang, H., Chen, K., Zhao, Y., Wang, D., Ran, T., & Zou, D. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003545 · Cited by 21 · see citing works
Zhan, S., Liu, C., Meng, J., Mao, R., Tu, T., Lin, J., Chen, M., Zeng, Z., & Zhuang, X. (2023) · Microorganisms · doi:10.3390/microorganisms11030794 · Cited by 20 · see citing works
TL1A modulates the severity of colitis by promoting Th9 differentiation and IL-9 secretion
Wang, D., Li, H., Duan, Y.-Y., Han, F., Luo, Y., Mengyao, W., Yang, M.-Y., Zhan, R., Song, J. M., Zhang, H., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.06.011 · Cited by 20 · see citing works
Intestinal stricture in Crohn's disease: A 2020 update
Lin, X., Qiu, Y., Zhuang, X. J., Liu, F., Wu, X. M., Chen, M. H., & Mao, R. (2021) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13022 · Cited by 19 · see citing works
DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury
Shimodaira, Y., More, S. K., Hamade, H., Blackwood, A. Y., Abraham, J. P., Thomas, L. S., Miller, J. H., Stamps, D. T., Castanon, S. L., Jacob, N., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.03.008 · Cited by 19 · see citing works
Self-citationTissue Niches Formed by Intestinal Mesenchymal Stromal Cells in Mucosal Homeostasis and Immunity
Pásztói, M., & Ohnmacht, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095181 · Cited by 21 · see citing works
NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota
Zhao, X., Ji, K., Zhang, M., Huang, H., Wang, F., Liu, Y., & Liu, Q. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2145029 · Cited by 18 · see citing works
Ditrich, F., Blümel, S., Biedermann, L., Fournier, N., Rossel, J., Ellinghaus, D., Franke, A., Stange, E. F., Rogler, G., Scharl, M. M., et al. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284820959252 · Cited by 18 · see citing works
TL1A as a Target in Inflammatory Bowel Disease: Exploring Mechanisms and Therapeutic Potential
Tettoni, E., Gabbiadini, R., Buono, A. D., Privitera, G., Vadalà, V., Migliorisi, G., Bertoli, P., Quadarella, A., Bezzio, C., & Armuzzi, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115017 · Cited by 17 · see citing works
Chang, C., Gupta, R., Sedighian, F., Louie, A., Gonzalez, D. H., Le, C., Cho, J. M., Park, S., Castellanos, J. A., Ting, T.-W., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118242 · Cited by 17 · see citing works
Self-citationSoluble ligands as drug targets for treatment of inflammatory bowel disease
Tong, X., Zheng, Y., Li, Y., Xiong, Y., & Chen, D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107859 · Cited by 17 · see citing works
Role of non‐inflammatory factors in intestinal fibrosis
Zhao, J., Ling, F. M., Li, J. R., Chen, Y. D., Huang, L., & Zhu, L. (2020) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12883 · Cited by 17 · see citing works
Chokr, D., Cornu, M., Neut, C., Bortolus, C., Charlet, R., Desreumaux, P., Speca, S., & Sendid, B. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00401-z · Cited by 16 · see citing works
Mechanisms and therapeutic research progress in intestinal fibrosis
Liu, Y., Zhang, T., Pan, K., & He, W. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1368977 · Cited by 15 · see citing works
Ta, A., Ollberding, N. J., Karns, R. A., Haberman, Y., Alazraki, A. L., Hercules, D., Baldassano, R. N., Markowitz, J. F., Heyman, M. B., Kim, S. S. Y., et al. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa339 · Cited by 15 · see citing works
Touny, A. A., Venkataraman, B., Ojha, S. K., Pessia, M., Subramanian, V. S., gowdru, S. N. H., & Subramanya, S. B. (2024) · Nutrients · doi:10.3390/nu16213633 · Cited by 14 · see citing works
Laforêt, F., Antoine, C., Lebrun, S., Gonza, I., Goya‐Jorge, E., Douny, C., Duprez, J.-N., Scippo, M., Taminiau, B., Daube, G., et al. (2023) · Viruses · doi:10.3390/v15030719 · Cited by 14 · see citing works
Fibrostenosing Crohn’s Disease: Pathogenetic Mechanisms and New Therapeutic Horizons
Mignini, I., Blasi, V., Termite, F., Esposto, G., Borriello, R., Laterza, L., Scaldaferri, F., Ainora, M. E., Gasbarrini, A., & Zocco, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126326 · Cited by 12 · see citing works
TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review
Solitano, V., Estevinho, M. M., Ungaro, F., Magro, F., Danese, S., & Jairath, V. (2025) · BioDrugs · doi:10.1007/s40259-025-00706-4 · Cited by 11 · see citing works
Li, Y., Xu, F., Fang, Y., Cui, Y., Zhu, Z., Wu, Y., Tong, Y., Hu, J., Zhu, L., & Shen, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1530797 · Cited by 11 · see citing works
TL1A promotes metastasis and EMT process of colorectal cancer
Niu, W., Liu, Q., Huo, X., Luo, Y., & Zhang, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24392 · Cited by 10 · see citing works
Intestinal Fibrosis in Crohn’s Disease: Pathophysiology, Diagnosis, and New Therapeutic Targets
Fousekis, F. S., Mpakogiannis, K., Mastorogianni, I. N., Lianos, G. D., Christodoulou, D. K., & Katsanos, K. H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124060 · Cited by 10 · see citing works
Honig, G., Larkin, P. B., Heller, C. A., & Hurtado‐Lorenzo, A. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab230 · Cited by 10 · see citing works
Preventing fibrosis in IBD: update on immune pathways and clinical strategies
Wang, J., Yang, B., Chandra, J., Ivanov, A. I., Brown, J. M., & Rieder, F. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2330604 · Cited by 9 · see citing works
Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
Liu, C., Li, R., Nie, J., He, J., Lin, Z., Wu, X., Tan, J., Liu, Z., Zhou, L., Li, X., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70027 · Cited by 8 · see citing works
Tian, L., Tao, S., He, C., Dong, S., Chen, Y., Chen, L., & Jiang, S. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102128 · Cited by 8 · see citing works
Mechanisms of Insulin Signaling as a Potential Therapeutic Method in Intestinal Diseases
Jarmakiewicz-Czaja, S., Sokal-Dembowska, A., Ferenc, K., & Filip, R. (2024) · Cells · doi:10.3390/cells13221879 · Cited by 7 · see citing works
Drygiannakis, I., Kolios, G. C., Filidou, E., Bamias, G., & Valatas, V. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae066 · Cited by 7 · see citing works
Diet in Intestinal Fibrosis: A Double-Edged Sword
Marion‐Letellier, R., Leboutte, M., Amamou, A., Raman, M., Savoye, G., & Ghosh, S. K. (2021) · Nutrients · doi:10.3390/nu13093148 · Cited by 7 · see citing works
Druzhinin, V. G., Baranova, E. D., Matskova, L. V., Сергеевич, Д. П., Volobaev, V. P., Minina, V. I., Викторович, Л. А., & Paradnikova, S. A. (2022) · Life · doi:10.3390/life12060830 · Cited by 7 · see citing works
Fang, L., Peng, H., Tan, Z., Deng, N., & Peng, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s504827 · Cited by 7 · see citing works
The Therapeutic Potential of Targeting TL1A in a Spectrum of Inflammatory Disorders
Kitsou, K., Kokkotis, G., & Bamias, G. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s546272 · Cited by 5 · see citing works
The aryl hydrocarbon receptor: A promising target for intestinal fibrosis therapy
Pan, Y., Deng, Y., Yang, H., & Yu, M. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107909 · Cited by 6 · see citing works
Anti-fibrotic Drugs for Crohn’s Disease: Ready for Prime Time?
ARGOLLO, M. C., Gilardi, D., Roda, G., Fiorino, G., Peyrin‐Biroulet, L., & Danese, S. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190308100844 · Cited by 5 · see citing works
Čaja, F., Stakheev, D., Chernyavskiy, O., Křížan, J., Dvořák, J., Rossmann, P., Štěpánková, R., Makovický, P., Makovický, P., Kozáková, H., et al. (2021) · Journal of Immunotoxicology · doi:10.1080/1547691x.2021.1887412 · Cited by 4 · see citing works
Liu, J., Gong, W., Liu, P., Li, Y., Jiang, H., Wu, X., Zhao, Y., & Ren, J. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2161889 · Cited by 4 · see citing works
TNFSF15 variant predicts disease progression in Chinese patients with Crohn’s disease
Zhang, Q., Wang, W., Xiang, B., Lin, D., Hu, J. X., Zhao, J., Lin, J., Liu, T., Deng, J., Zhang, M., et al. (2023) · Gastroenterology report · doi:10.1093/gastro/goae103 · Cited by 3 · see citing works
628 - Direct Signaling of TL1A-DR3 on Fibroblasts Induces Intestinal Fibrosis In Vivo
Jacob, N., Kumagai, K., Abraham, J. P., Shimodaira, Y., Ye, Y., Luu, J. M., Targan, S. R., Michelsen, K. S., & Shih, D. (2018) · Gastroenterology · doi:10.1016/s0016-5085(18)30865-5 · Cited by 3 · see citing works
Self-citationLiang, R. F.-H., Pugliano, C. L., Hughes, R., Majumder, S., Bello, A. L., Iacucci, M., & Ghosh, S. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag039 · Cited by 2 · see citing works
Current Topics of the Mechanism of Intestinal Fibrosis in Crohn’s Disease
Honzawa, Y., Yamamoto, S., Okabe, M., Seno, H., & Nakase, H. (2021) · Immuno · doi:10.3390/immuno1040040 · Cited by 2 · see citing works
The TL1A inhibitors in IBD: what’s in the pot?
Lusetti, F., Bezzio, C., Bernardi, A. D., Dota, M., Manes, G., & Saibeni, S. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2450795 · Cited by 1 · see citing works
The different meanings of tolerating the gut microbiome
Vidal, V. M., Montes‐Cobos, E., Canto, F. B., & Bozza, M. T. (2026) · mBio · doi:10.1128/mbio.01736-24 · Cited by 1 · see citing works
Sia, J., Lee, B., & Oon, H. H. B. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09152-8 · Cited by 1 · see citing works
Li, W., Huang, W., Wang, J., Tu, Y., Yang, Q., Zhou, Y., Zhang, Z., Zhuang, H., Gu, Y., Zou, D., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.198895 · Cited by 1 · see citing works
TL1A and DR3 in IBD: from mucosal immunopathology to a new era of targeted therapy
Longman, R. (2026) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izag116 · Cited by 1 · see citing works
Lan, C. (2022) · Current Trends in Gastroenterology and Hepatology · doi:10.32474/ctgh.2022.03.000172 · Cited by 1 · see citing works
Paneth cells and intestinal health
Han, Y., Gao, H., Hua, R., Chen, L., Guo, Y., Shang, H.-W., Lu, X., & Xu, J. (2021) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v29.i23.1362
Ye, Y., More, S. K., Hamade, H., Alexeev, E. E., Shimodaira, Y., Blackwood, A. Y., Stamps, D. T., Miller, J. H., Abraham, J. P., Thomas, L. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.02.641061
Self-citationRole of TL1A in perianal fistulising Crohn’s disease: a new therapeutic target?
Parigi, T. L., & Cominelli, F. (2026) · Gut · doi:10.1136/gutjnl-2025-337684
Le récepteur minéralocorticoide : une cible potentielle dans la fibrose intestinale ?
Amamou, A. (2020) · theses.fr (ABES) · doi:10.70675/ec2e0df7z8ae1z4feczaf08z10bcbd86d2f3
Fibrose intestinale, récepteur minéralocorticoide,alimentation.
Leboutte, M. (2023) · theses.fr (ABES) · doi:10.70675/a47cb697z212az4a17za4d6zeaf9d5cbaf24
- Authors
- Jacob, N., Jacobs, J. P., Kumagai, K., Ha, C. W. Y., Kanazawa, Y., Lagishetty, V., Altmayer, K., Hamill, A. M., Von Arx, A., Sartor, R. B., Devkota, S., Braun, J., Michelsen, K. S., Targan, S. R., & Shih, D. Q.
- Affiliations
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Jacob, Noam
- Shih, David Q.
- ORCID
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 11
- Issue
- 5
- Pages
- 1466-1476
- ISSN
- 1933-0219 (ISSN-L)
- PMC
- PMC6162160
- OpenAlex
- W2863875449
- Cited by
- 102
- References
- 51
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 18 · 2023: 10 · 2022: 12 · 2021: 21 · 2020: 12 · 2019: 5 · 2018: 2
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Crohn's and Colitis Foundation
- National Institutes of Health (NIH T32, NIH-R01, DK034987, DK056328, T32DK07180—40, P40OD010995)
- Inflammatory Bowel and Immunobiology Research Institute
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK046763, K08DK093578, P01DK094779, P30DK041301, R01DK056328, L30 DK110927, T32DK007180, P30DK034987)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- TL1A, TNFSF15, intestinal fibrosis, gut microbiota, inflammatory bowel disease, Crohn's disease, fibroblast activation, fibroblast migration, germ-free mice, transgenic mice, collagen deposition
- MeSH terms
- Gastrointestinal Microbiome, Animals, Colitis, Collagen, Crohn Disease, Fibroblasts, Fibrosis, Humans, Ileitis, Inflammation, Intestinal Mucosa, Intestines, Mice, Inbred C57BL, Mice, Transgenic, Inflammatory Bowel Diseases, Mice, Tumor Necrosis Factor Ligand Superfamily Member 15
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