The DOI matches its Crossref record; 89 of the 90 references it cites were found in a registry or an index.
Imprinting of the immune system by the microbiota early in life
Open accessAbstract
The ontogeny and maturation of the immune system is modulated by the microbiota. During fetal life, the mother's microbiota produces compounds that are transferred to the fetus and offspring, and enhance the generation of innate immune cells. After birth, the colonizing microbiota induces the development of intestinal lymphoid tissues and maturation of myeloid and lymphoid cells, and imprints the immune system with a reactivity level that persists long after weaning into adulthood. When the cross-talk between host and microbiota is perturbed early in life, a pathological imprinting may develop that is characterized by excessive immune reactivity in adulthood, which translates into increased susceptibility to inflammatory pathologies. In this review, we discuss the recent data that demonstrate the existence of a time window of opportunity early in life during which mice and human have to be exposed to microbiota in order to develop a balanced immune system. We also discuss the factors involved in imprinting, such as the microbiota, immune cells and stromal cells, as well as the nature of imprinting.
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“In the cross-talk between mucosal immunity and gut microbes, there are defined periods of plasticity, such as during weaning and neonatal periods when host lymphocytes and gut bacteria expand and colonize the intestinal mucosa. 80”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [80]
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Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Porcari, S., Benech, N., Valles-Colomer, M., Segata, N., Gasbarrini, A., Cammarota, G., Sokol, H., & Ianiro, G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.020 · Cited by 331
Metadata
- Authors
- Al Nabhani, Z., & Eberl, G.
- Affiliations
- Inserm (FR)
- Corresponding author
- Eberl, Gérard
- ORCID
- Eberl, Gérard
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 13
- Issue
- 2
- Pages
- 183-189
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W3001781379
- Cited by
- 301
- References
- 90
- Citations by year
- 2026: 41 · 2025: 45 · 2024: 39 · 2023: 51 · 2022: 45 · 2021: 66 · 2020: 14
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kenneth Rainin Foundation
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- gut microbiota, early life, innate immune cells, intestinal lymphoid tissue, myeloid cell maturation, immunoreactivity, stromal cells, immune ontogeny
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Adult, Animals, Female, Homeostasis, Humans, Immune System, Inflammation, Lymphocytes, Pregnancy, Mice
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