The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder
Open accessAbstract
Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energetics, or in the circulating cell-free mtDNA (ccf-mtDNA) levels, which may reflect a fraction of the mitochondrial genome released during cellular stress. Few studies have examined ccf-mtDNA in MDD, and no studies have tested its relationship with intracellular mtDNA-cn or with antidepressant treatment response. Here, mtDNA levels were quantified in parallel from: (i) PBMCs and (ii) cell-free plasma of 50 unmedicated MDD subjects and 55 controls, in parallel with PBMC telomere length (TL) and antioxidant enzyme glutathione peroxidase (GpX) activity. MtDNA measures were repeated in 19 MDD subjects after 8 weeks of open-label SSRI treatment. In analyses adjusted for age, sex, BMI, and smoking, MDD subjects had significantly elevated levels of ccf-mtDNA (F = 20.6, p = 0.00002). PBMC mtDNA-cn did not differ between groups (p > 0.4). In preliminary analyses, we found that changes in ccf-mtDNA with SSRI treatment differed between SSRI responders and non-responders (F = 6.47, p = 0.02), with the non-responders showing an increase in ccf-mtDNA and responders not changing. Baseline ccf-mtDNA was positively correlated with GpX (r = 0.32, p = 0.001), and PBMC mtDNA correlated positively with PBMC TL (r = 0.38, p = 0.0001). These data suggest that plasma ccf-mtDNA and PBMC mtDNA-cn reflect different cellular processes and that the former may be more reflective of certain aspects of MDD pathophysiology and of the response to SSRI antidepressants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Assessing the presence of extracellular mitochondria or their fragments by measuring ccf-mtDNA levels could allow on-flight direct estimation of cellular stress to take preventive measures of cumulative damage196,199–206.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [206]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Jahr, S., Hentze, H., Englisch, S., Hardt, D., Fackelmayer, F. O., Hesch, R. D., & Knippers, R. (2001) · PubMed · Cited by 2,169
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · cited 2×
“Mitochondrial integrity and bioenergetics are also related to nuclear DNA senescence, due to a direct link between telomere shortening, repression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and diminished mitochondrial biogenesis in certain tissues [28].”
BackgroundLubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3586 · Cited by 1,280
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275 · cited 1×
“Beyond energy production, mitochondria generate other signaling molecules that influence cellular and physiological functions, [8, 9] including cellular senescence [10] and production of free radicals [11].”
BackgroundNumber matters: control of mammalian mitochondrial DNA copy number
Montier, L., Deng, J., & Bai, Y. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60099-5 · Cited by 532
Impaired mitochondrial function in psychiatric disorders
Manji, H. K., Kato, T., Prospero, N. A. D., Ness, S. L., Beal, M. F., Krams, M., & Chen, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3229 · Cited by 493
Cited by
Sorted by citations
Molecular pathways of major depressive disorder converge on the synapse
Fries, G. R., Saldana, V. A., Finnstein, J., & Rein, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01806-1 · Cited by 504
Todkar, K., Chikhi, L., Desjardins, V., El-Mortada, F., Pépin, G., & Germain, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21984-w · Cited by 382
Han, L. K. M., Dinga, R., Hahn, T., Ching, C. R. K., Eyler, L. T., Aftanas, L. I., Aghajani, M., Aleman, A., Baune, B. T., Berger, K., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0754-0 · Cited by 351
Mitochondria: It is all about energy
Casanova, A., Wevers, A., Ledesma, S. N., & Pruimboom, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1114231 · Cited by 350
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
Liu, Z., Sun, Y., Qi, Z., Cao, L., & Ding, S. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00805-7 · Cited by 236
Role of Platelet Mitochondria: Life in a Nucleus-Free Zone
Melchinger, H., Jain, K., Tyagi, T., & Hwa, J. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00153 · Cited by 208
Trumpff, C., Michelson, J., Lagranha, C. J., Taleon, V., Karan, K. R., Sturm, G., Lindqvist, D., Fernström, J., Moser, D., Kaufman, B. A., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.04.002 · Cited by 190
Self-citationBlood mitochondrial DNA copy number: What are we counting?
Picard, M. A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.010 · Cited by 183
Self-citationCell-free DNA release under psychosocial and physical stress conditions
Hummel, E. M., Hessas, E.-M., Müller, S., Beiter, T., Fisch, M. R., Eibl, A., Wolf, O. T., Giebel, B., Platen, P., Kumsta, R., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0264-x · Cited by 177
Bae, J. H., Jo, S. I., Kim, S. J., Lee, J. M., Jeong, J. H., Kang, J. S., Cho, N., Kim, S. S., Lee, E. Y., & Moon, J. (2019) · Cells · doi:10.3390/cells8040328 · Cited by 167
Stress and Psychiatric Disorders: The Role of Mitochondria
Daniels, T. E., Olsen, E. M., & Tyrka, A. R. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-082719-104030 · Cited by 157
The energetic cost of allostasis and allostatic load
Bobba‐Alves, N., Juster, R., & Picard, M. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105951 · Cited by 167
Self-citationAcute psychological stress increases serum circulating cell-free mitochondrial DNA
Trumpff, C., Marsland, A. L., Basualto-Alarcón, C., Martin, J. L., Carroll, J. E., Sturm, G., Vincent, A. E., Mosharov, E. V., Gu, Z., Kaufman, B. A., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.026 · Cited by 147
Self-citationForms of extracellular mitochondria and their impact in health
Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138
Major depression and the biological hallmarks of aging
Lorenzo, E. C., Kuchel, G. A., Kuo, C., Moffitt, T. E., & Diniz, B. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101805 · Cited by 132
Mitochondrial Extracellular Vesicles – Origins and Roles
Amari, L., & Germain, M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.767219 · Cited by 123
Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.004 · Cited by 104
“MDD is among the most frequently studied disorders in this context, possibly as a consequence of its relatively well-documented associations with dysregulated physical health (Penninx et al., 2013).”
InfluentialSelf-citationThe social nature of mitochondria: Implications for human health
Picard, M. A., & Sandi, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.017 · Cited by 107
Self-citationValenti, D., Vacca, R. A., Moro, L., & Atlante, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158312 · Cited by 100
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92
Circulating cell-free mitochondrial DNA levels in Parkinson’s disease are influenced by treatment
Lowes, H., Pyle, A., Santibanez‐Koref, M., & Hudson, G. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00362-y · Cited by 92
Moya, G. E., Rivera, P. D., & Dittenhafer‐Reed, K. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137030 · Cited by 90
Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?
Crigna, A. T., Samec, M., Koklesová, L., Líšková, A., Giordano, F. A., Kubatka, P., & Golubnitschaja, O. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00226-x · Cited by 80
Aging: All roads lead to mitochondria
Son, J. M., & Lee, C. D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.02.006 · Cited by 86
New Perspectives on the Importance of Cell-Free DNA Biology
Bronkhorst, A. J., Ungerer, V., Oberhofer, A., Gabriel, S., Polatoglou, E., Randeu, H., Uhlig, C., Pfister, H., Mayer, Z., & Holdenrieder, S. (2022) · Diagnostics · doi:10.3390/diagnostics12092147 · Cited by 78
Zhang, G., Wei, H., Zhao, A., Xu, Y., Zhang, X., Gan, J., Guo, M., Wang, J., Zhang, F., Jiang, Y., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03363-0 · Cited by 81
Mitophagy in depression: Pathophysiology and treatment targets
Tripathi, A., Scaini, G., Barichello, T., Quevedo, J., & Pillai, A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.08.016 · Cited by 71
Peripheral biomarkers of mitochondrial dysfunction in adolescents with bipolar disorder
Jeong, H., Dimick, M. K., Sultan, A. A., Duong, A., Park, S. S., Sabbagh, D. E. S. E., Goldstein, B. I., & Andreazza, A. C. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.009 · Cited by 70
The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment
Caruso, G., Benatti, C., Blom, J. M. C., Caraci, F., & Tascedda, F. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00995 · Cited by 65
Mitochondrial psychobiology: foundations and applications
Picard, M. A., Trumpff, C., & Burelle, Y. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.04.015 · Cited by 66
Self-citationBezdan, D., Grigorev, K., Meydan, C., Pelissier Vatter, F. A., Cioffi, M., Rao, V., MacKay, M., Nakahira, K., Burnham, P., Afshinnekoo, E., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101844 · Cited by 59
Allen, J., Caruncho, H. J., & Kalynchuk, L. E. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.11.010 · Cited by 62
Neuronal Mitochondrial Dysfunction and Bioenergetic Failure in Inflammation-Associated Depression
Casaril, A. M., Dantzer, R., & Orth, C. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.725547 · Cited by 62
Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation
Wiersma, M., van Marion, D. M. S., Bouman, E. J., Li, J., Zhang, D., Ramos, K. S., Lanters, E. A. H., de Groot, N. M. S., & Brundel, B. J. J. M. (2020) · Cells · doi:10.3390/cells9051159 · Cited by 57
Breaking the vicious cycle: The interplay between loneliness, metabolic illness, and mental health
Ahmed, M., Cerda, I. H., & Maloof, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1134865 · Cited by 64
Kim, Y., Moon, H., Kim, S.-Y., Lee, Y.-H., Jeong, D.-W., Kim, K., Moon, J. Y., Lee, Y., Cho, A., Lee, S. H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41964-x · Cited by 52
Ampo, E., Mendes‐Silva, A. P., Gonçalves, V. F., Bartley, J. M., Kuchel, G. A., & Diniz, B. S. (2021) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2021.07.012 · Cited by 54
Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder
Jembrek, M. J., Oršolić, N., Karlović, D., & Peitl, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086888 · Cited by 58
Ridout, K. K., Parade, S. H., Kao, H., Magnan, S., Seifer, R., Porton, B., Price, L. H., & Tyrka, A. R. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.015 · Cited by 54
Mitochondria and early-life adversity
Zitkovsky, E. K., Daniels, T. E., & Tyrka, A. R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.01.005 · Cited by 53
Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression
Ahmadimanesh, M., Abbaszadegan, M. R., Rad, D. M., Moallem, S. A., Mohammadpour, A. H., Ghahremani, M. H., Hosseini, F. F., Behdani, F., Manteghi, A. A., Jowsey, P. A., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119874461 · Cited by 47
Investigation of mitochondrial DNA copy number in patients with major depressive disorder
Chung, J. K., Lee, S. Y., Park, M., Joo, E.-J., & Kim, S. A. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112616 · Cited by 48
Accelerated aging in serious mental disorders
Bersani, F. S., Mellon, S. H., Reus, V. I., & Wolkowitz, O. M. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000525 · Cited by 47
Self-citationPro‐inflammatory role of cell‐free mitochondrial DNA in cardiovascular diseases
Nie, S., Lu, J., Wang, L., & Gao, M. (2020) · IUBMB Life · doi:10.1002/iub.2339 · Cited by 50
Rappeneau, V., Wilmes, L., & Touma, C. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103555 · Cited by 47
Increased levels of circulating cell-free mtDNA in plasma of late life depression subjects
Gonçalves, V. F., Mendes‐Silva, A. P., Koyama, E., Vieira, É. L. M., Kennedy, J. L., & Diniz, B. S. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.015 · Cited by 46
Nidadavolu, L. S., Feger, D. M., Chen, D., Wu, Y., Grodstein, F., Gross, A. L., Bennett, D. A., Walston, J. D., Oh, E. S., & Abadir, P. M. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00342-y · Cited by 52
Tripathi, A., Bartosh, A., Whitehead, C., & Pillai, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02189-7 · Cited by 47
The Role of Mitochondria in Immune-Cell-Mediated Tissue Regeneration and Ageing
Su, Y., Wang, P., & Weng, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052668 · Cited by 45
Plasma circulating cell-free mitochondrial DNA in depressive disorders
Fernström, J., Ohlsson, L., Asp, M., Lavant, E., Holck, A., Grudet, C., Westrin, Å., & Lindqvist, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259591 · Cited by 47
Self-citationFighting Parkinson’s disease: The return of the mitochondria
Zambrano, K., Barba, D., Castillo, K., Noboa, L. E., Argueta-Zamora, D., Robayo, P., Arizaga, E., Caicedo, A., & Gavilanes, A. W. D. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.02.003 · Cited by 44
Targeting PDK2 rescues stress-induced impaired brain energy metabolism
Wang, C., Cui, C., Xu, P., Zhu, L., Xue, H., Chen, B., & Jiang, P. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02098-9 · Cited by 46
Circulating Cell-Free DNA Levels in Psychiatric Diseases: A Systematic Review and Meta-Analysis
Melamud, M. M., Buneva, V. N., & Ermakov, E. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043402 · Cited by 38
Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder
Czarny, P. L., Wigner, P., Strycharz, J., Świderska, E., Synowiec, E., Szatkowska, M., Śliwińska, A., Talarowska, M. E., Szemraj, J., Su, K., et al. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1588993 · Cited by 38
Han, S., Chen, Y., Zheng, R., Li, S., Jiang, Y. B., Wang, C., Fang, K., Yang, Z., Liu, L., Zhou, B., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25460 · Cited by 39
Humphreys, K. L., Sisk, L. M., Manczak, E. M., Lin, J., & Gotlib, I. H. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.09.031 · Cited by 37
Self-citationMitochondrial dynamics and psychiatric disorders: The missing link
Papageorgiou, M. P., & Filiou, M. D. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105837 · Cited by 39
Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood
Karan, K. R., Trumpff, C., McGill, M. A., Thomas, J. E., Sturm, G., Lauriola, V., Sloan, R. P., Rohleder, N., Kaufman, B. A., Marsland, A. L., et al. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100080 · Cited by 35
Self-citationCirculating nucleic acids in the plasma and serum as potential biomarkers in neurological disorders
Bruno, D. D. C. F., Donatti, A., Martin, M., de Almeida, V. S., Geraldis, J. C., de Oliveira, F. S., Dogini, D. B., & Lopes‐Cendes, Í. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20209881 · Cited by 39
Cushen, S. C., Ricci, C. A., Bradshaw, J. L., Silzer, T., Blessing, A., Sun, J., Zhou, Z., Scroggins, S. M., Santillan, M. K., Santillan, D. A., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.021726 · Cited by 35
Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome Signatures
Morrison, K. E., Stenson, A. F., Marx-Rattner, R., Carter, S. E., Michopoulos, V., Gillespie, C. F., Powers, A. D., Huang, W., Kane, M. A., Jovanović, T., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.08.003 · Cited by 35
Ware, S. A., Desai, N., Lopez, M. A., Leach, D., Zhang, Y., Giordano, L., Nouraie, M. S., Picard, M. A., & Kaufman, B. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015237 · Cited by 31
Self-citationBlood-based mitochondrial respiratory chain function in major depression
Fernström, J., Mellon, S. H., McGill, M. A., Picard, M. A., Reus, V. I., Hough, C. M., Lin, J., Epel, E. S., Wolkowitz, O. M., & Lindqvist, D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01723-x · Cited by 39
Self-citationOhlsson, L., Hall, A., Lindahl, H., Danielsson, R., Gustafsson, A., Lavant, E., & Ljunggren, L. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04330-8 · Cited by 31
Self-citationBehnke, A., Gumpp, A. M., Rojas, R., Sänger, T., Lutz‐Bonengel, S., Moser, D., Schelling, G., Krumbholz, A., & Kolassa, I. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2070666 · Cited by 32
Czarny, P. L., Białek, K. I., Ziółkowska, S., Strycharz, J., & Śliwiński, T. (2019) · Mutagenesis · doi:10.1093/mutage/gez035 · Cited by 32
Long-term treated HIV infection is associated with platelet mitochondrial dysfunction
van der Heijden, W. A., de Wijer, L. V., Jaeger, M., Grintjes, K. J. T., Netea, M. G., Urbanus, R. T., van Crevel, R., van den Heuvel, L. P., Brink, M., Rodenburg, R. J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85775-5 · Cited by 28
Relationship between circulating mitochondrial DNA and microRNA in patients with major depression
Ogata, H., Higasa, K., Kageyama, Y., Tahara, H., Shimamoto, A., Takekita, Y., Koshikawa, Y., Nonen, S., Kato, T., Kinoshita, T., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.073 · Cited by 30
Michelson, J., Rausser, S., Peng, A., Yu, T., Sturm, G., Trumpff, C., Kaufman, B. A., Rai, A. J., & Picard, M. A. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.05.001 · Cited by 26
Self-citationPeripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
Ye, J., Duan, C., Han, J., Chen, J., Sun, N., Li, Y., Yuan, T., & Peng, D. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01878 · Cited by 30
Circulating Mitochondrial DNA and Inter-Organelle Contact Sites in Aging and Associated Conditions
Picca, A., Guerra, F., Calvani, R., Romanò, R., Coelho‐Júnior, H. J., Damiano, F. P., Bucci, C., & Marzetti, E. (2022) · Cells · doi:10.3390/cells11040675 · Cited by 27
Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., Bergman-Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0668-2 · Cited by 25
Self-citationGoossens, J., Morrens, M., & Coppens, V. (2021) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-021-00516-8 · Cited by 27
Dynamic behavior of cell-free mitochondrial DNA in human saliva
Trumpff, C., Rausser, S., Haahr, R., Karan, K. R., Gouspillou, G., Puterman, E. M., Kirschbaum, C., & Picard, M. A. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105852 · Cited by 26
Self-citationPark, S. S., Jeong, H., & Andreazza, A. C. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1938214 · Cited by 27
Liu, L., Cheng, S., Qi, X., Meng, P., Yang, X., Pan, C., Chen, Y., Zhang, H., Zhang, Z., Zhang, J., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02518-y · Cited by 25
Al‐Kafaji, G., Jahrami, H., Alwehaidah, M. S., Alshammari, Y. H., & Husni, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1196035 · Cited by 23
Ceylan, D., Karaçiçek, B., Tufekci, K., Aksahin, I. C., Şenol, Ş. H., & Genç, Ş. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1304660 · Cited by 24
Tymofiyeva, O., Henje, E., Ho, T. C., Connolly, C. G., Lindqvist, D., Wolkowitz, O. M., Lin, J., LeWinn, K. Z., Sacchet, M. D., Han, L. K. M., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.024 · Cited by 24
Self-citationWankhar, W., Syiem, D., Pakyntein, C. L., Thabah, D., & Sunn, S. E. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112780 · Cited by 22
Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations
Sun, D., Wei, Y., Zheng, H.-X., Jin, L., & Wang, J. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00128 · Cited by 21
Whole blood mitochondrial copy number in clinical populations with mood disorders: A meta-analysis
Calarco, C. A., Keppetipola, S. M., Kumar, G., Shipper, A. G., & Lobo, M. K. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115662 · Cited by 21
Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell
PARASKEVAIDIS, I. A., Kourek, C., Farmakis, D. T., & Tsougos, E. (2024) · Biomolecules · doi:10.3390/biom14121534 · Cited by 22
Suárez-Méndez, S., la Cruz, D. D. G.-D., Tovilla‐Zárate, C. A., Mendoza, A. D. G., Ramón-Torres, R. A., González‐Castro, T. B., & Juárez‐Rojop, I. E. (2020) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2020.04.004 · Cited by 21
Post-mortem ventricular cerebrospinal fluid cell-free-mtDNA in neurodegenerative disease
Lowes, H., Kurzawa-Akanbi, M., Pyle, A., & Hudson, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-72190-5 · Cited by 21
Kang, J. I., Park, C. I., Lin, J., Kim, S. T., Kim, H. W., & Kim, S. J. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.200238 · Cited by 21
Self-citationNabi, S. U., Rehman, M. U., Arafah, A. M., Taifa, S., Khan, I. S., Khan, A., Rashid, S., Jan, F., Wani, H. A., & Ahmad, S. F. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221121095618 · Cited by 22
The war against Alzheimer, the mitochondrion strikes back!
Zambrano, K., Barba, D., Castillo, K., Robayo, P., Argueta-Zamora, D., Sanon, S., Arizaga, E., Caicedo, A., & Gavilanes, A. W. D. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.03.003 · Cited by 20
Mendes‐Silva, A. P., Nikolova, Y. S., Rajji, T. K., Kennedy, J. L., Diniz, B. S., Gonçalves, V. F., & Vieira, É. L. M. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.06.092 · Cited by 19
Li, B., Kalinowski, P., Kim, B., Pauls, A. D., & Poburko, D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107995 · Cited by 19
Oppong, R., Terracciano, A., Picard, M. A., Qian, Y., Butler, T. J., Tanaka, T., Moore, A. Z., Simonsick, E. M., Opsahl-Ong, K., Coletta, C. E., et al. (2022) · eLife · doi:10.7554/elife.77806 · Cited by 19
Self-citationGumpp, A. M., Behnke, A., Bach, A. M., Piller, S., Boeck, C., Rojas, R., & Kolassa, I. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.12.009 · Cited by 17
Mitochondrial DNA in atherosclerosis: Mechanisms, biomarker potential, and therapeutic perspectives
Zhang, R., Jiang, Y., Zhang, G., Zeng, W., Suo, Y., Zhang, F., & Jiang, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114449 · Cited by 16
Morales, J. J., Korucu, B., Pike, M., Lipworth, L. P., Stewart, T. G., Headley, S., Germain, M., Begue, G., Roshanravan, B., Tuttle, K. R., et al. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00270.2021 · Cited by 16
Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis
Li, W., Zhu, L., Chen, Y., Zhuo, Y., Wan, S., & Guo, R. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05358-8 · Cited by 16
Blalock, Z., Wu, G. W. Y., Lindqvist, D., Trumpff, C., Flory, J. D., Lin, J., Reus, V. I., Rampersaud, R., Hammamieh, R., Gautam, A., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-023-02721-x · Cited by 18
Self-citationTrumpff, C., Marsland, A. L., Sloan, R. P., Kaufman, B. A., & Picard, M. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.001 · Cited by 16
Self-citationWhole blood mitochondrial DNA copy number in depression and response to electroconvulsive therapy
Ryan, K. M., Doody, E., & McLoughlin, D. M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110656 · Cited by 15
Cell-free DNA release following psychosocial and physical stress in women and men
Limberg, A., Berg, F., Köper, E., Lindgraf, C., Gevers, C., Kumsta, R., Hummel, E. M., & Moser, D. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03242-5 · Cited by 15
Plasma circulating cell-free mitochondrial DNA in social anxiety disorder
Lindqvist, D., Furmark, T., Lavebratt, C., Ohlsson, L., & Månsson, K. N. T. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.106001 · Cited by 16
Self-citation
Metadata
- Authors
- Lindqvist, D., Wolkowitz, O. M., Picard, M., Ohlsson, L., Bersani, F. S., Fernström, J., Westrin, Å., Hough, C. M., Lin, J., Reus, V. I., Epel, E. S., & Mellon, S. H.
- Affiliations
- University of California, San Francisco (US)
- Columbia University Irving Medical Center (US)
- Malmö University (SE)
- Lund University (SE)
- University of California, Los Angeles (US)
- Corresponding author
- Lindqvist, Daniel
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2018-01-30
- Volume
- 43
- Issue
- 7
- Pages
- 1557-1564
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5983469
- OpenAlex
- W2789855059
- Cited by
- 188
- References
- 56
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 26 · 2023: 27 · 2022: 23 · 2021: 27 · 2020: 26 · 2019: 20 · 2018: 5
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuropsychopharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Lund University Publications (Lund University) (submittedVersion)
- Malmö University Publications (Malmö University) (submittedVersion)
- Funders
- Vetenskapsrådet (2015-00387)
- Svenska Läkaresällskapet
- University of California, San Francisco
- National Institute of Mental Health (MH083784, R01MH083784)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, circulating cell-free mitochondrial DNA, mitochondrial DNA copy number, peripheral blood mononuclear cells, telomere length, glutathione peroxidase, oxidative stress, antidepressant non-responders, mitochondrial dysfunction
- MeSH terms
- Cell-Free Nucleic Acids, Adult, Major Depressive Disorder, Depressive Disorder, Major, DNA, Mitochondrial, Female, Glutathione Peroxidase, Humans, Leukocytes, Mononuclear, Male, Case-Control Studies, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Young Adult, DNA Copy Number Variations, Telomere Homeostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
