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Cited by 65Treatment of Major DepressionMitochondrial Function and PathologyStress Responses and Cortisol

The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment

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Caruso, Giuseppe, Benatti, Cristina, Blom, Joan M.C., Caraci, Filippo, Tascedda, Fabio·2019·Frontiers in Pharmacology
DOI 10.3389/fphar.2019.00995PMC PMC6746908
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  • Changes in mitochondrial DNA and cell membrane permeability were found in both depression patients and animal models of depression.

    “Changes in mitochondrial DNA and cell membrane permeability were found in both depression patients and animal models of depression [32, 33].”

    From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [33]

    The “Mitochondria and Depressive Disorders” section (page unavailable) reports elevated circulating cell-free mitochondrial DNA in patients with major depression and dissipated mitochondrial membrane potential in a mouse model. It does not report changes in mitochondrial DNA in the animal model or changes in cell membrane permeability in either group; membrane potential is a different measure. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Caruso, G., Benatti, C., Blom, J. M. C., Caraci, F., & Tascedda, F.
Affiliations
  • I.R.C.C.S. Oasi Maria SS (IT)
  • University of Modena and Reggio Emilia (IT)
  • University of Catania (IT)
Corresponding author
Tascedda, Fabio
ORCID
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2019-09-10
Volume
10
Pages
995-995
ISSN
1663-9812 (ISSN-L)
DOI
10.3389/fphar.2019.00995
PMC
PMC6746908
OpenAlex
W2966182111
Cited by
65
References
5
Citations by year
2026: 7 · 2025: 14 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 5 · 2019: 1
FWCI
3.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, mitochondrial dysfunction, brain energy metabolism, allostasis, antidepressant efficacy, antidepressant resistance, neuroplasticity, stress-related disorders, neuroinflammation, neuroendocrine-immune interaction, neuroimmune interactions

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