Cited by 201Gut microbiota and healthStress Responses and CortisolGastrointestinal motility and disorders

The DOI matches its Crossref record; 85 of the 87 references it cites were found in a registry or an index.

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

Open access

Dalile, Boushra, Vervliet, Bram, Bergonzelli, Gabriela, Verbeke, Kristin, Van Oudenhove, Lukas·2020·Neuropsychopharmacology

DOI 10.1038/s41386-020-0732-xPMC PMC7784980

Open this paper in CoChat — free account Open PDF

Abstract

Short-chain fatty acids (SCFAs) are products of microbial fermentation of dietary fiber in the colon and may mediate microbiota-gut-brain communication. However, their role in modulating psychobiological processes that underlie the development of stress- and anxiety-related disorders is not mechanistically studied in humans. In this triple-blind, randomized, placebo-controlled intervention trial, we examine in a parallel group design the effects of 1-week colonic SCFA-mixture delivery in doses equivalent to fermentation of 10 g or 20 g of arabinoxylan oligosaccharides on responses to psychosocial stress and fear tasks in 66 healthy men. We demonstrate that low and high doses of SCFAs significantly attenuate the cortisol response to psychosocial stress compared to placebo. Both doses of SCFAs increase serum SCFA levels and this increase in circulating SCFAs co-varies significantly with the attenuation of the cortisol response to psychosocial stress. Colonic SCFA delivery does not modulate fecal SCFA concentrations, serum brain-derived neurotrophic factor, cortisol awakening response, fear learning and extinction, or subjective mood ratings. These results demonstrate that colon-delivered SCFAs modulate hypothalamic-pituitary-adrenal axis reactivity to psychosocial stress, thereby supporting their hypothesized role in microbiota-gut-brain communication.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41386-020-0732-x

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research
Dickerson, S. S., & Kemeny, M. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.3.355 · Cited by 5,881
The short‐form version of the Depression Anxiety Stress Scales (DASS‐21): Construct validity and normative data in a large non‐clinical sample
Henry, J. D., & Crawford, J. R. (2005) · British Journal of Clinical Psychology · doi:10.1348/014466505x29657 · Cited by 5,801
Emotion regulation: affective, cognitive, and social consequences.
Gross, J. J. (2002) · Psychophysiology · doi:10.1017/s0048577201393198 · Cited by 4,890
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Self-citation
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119

Show all 87 references

Research works printed but not linked: 1

Boets E. Production of short chain fatty acids in the human colon and their impact on health. Doctoral thesis, KU Leuven, 2016.

Sorted by citations

The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 788
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415
Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis
Schneider, E., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01108-6 · Cited by 317
Microbiota medicine: towards clinical revolution
Gebrayel, P., Nicco, C., Khodor, S. A., Biliński, J., Caselli, E., Comelli, E. M., Egert, M., Giaroni, C., Karpiński, T. M. M., Łoniewski, I., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03296-9 · Cited by 307
Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 229
Gut microbiota‐derived short‐chain fatty acids and depression: deep insight into biological mechanisms and potential applications
Cheng, J., Hu, H., Ju, Y., Liu, J., Wang, M., Liu, B., & Zhang, Y. (2024) · General Psychiatry · doi:10.1136/gpsych-2023-101374 · Cited by 234
The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
Leigh, S., Uhlig, F., Wilmes, L., Sánchez-Díaz, P., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Hyland, N. P., Cryan, J. F., & Clarke, G. A. (2023) · The Journal of Physiology · doi:10.1113/jp281951 · Cited by 201
Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan
Snigdha, S., Ha, K., Tsai, P., Dinan, T. G., Bartos, J. D., & Shahid, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107978 · Cited by 173
Impact of Microbial Metabolites on Microbiota–Gut–Brain Axis in Inflammatory Bowel Disease
Banfi, D., Moro, E., Bosi, A., Bistoletti, M., Cerantola, S., Crema, F., Maggi, F., Giron, M. C., Giaroni, C., & Baj, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041623 · Cited by 160
Implications of Gut Microbiota in Neurodegenerative Diseases
Zhang, H., Chen, Y., Wang, Z., Xie, G., Liu, M., Yuan, B., Chai, H., Wang, W., & Cheng, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.785644 · Cited by 161
The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: a systematic review
Barrio, C., Arias-Sánchez, S., & Martín-Monzón, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105640 · Cited by 143
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome
Hillestad, E. M. R., van der Meeren, A., Nagaraja, B. H., Bjørsvik, B. R., Haleem, N., Benítez‐Páez, A., Sanz, Y., Hausken, T., Lied, G. A., Lundervold, A., et al. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i4.412 · Cited by 154
The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
Bear, T., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040723 · Cited by 136
Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway
Cao, Q., Shen, M., Li, R., Liu, Y., Zeng, Z., Zhou, J., Niu, D., Zhang, Q., Wang, R., Yao, J., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03454-y · Cited by 138
Food additives containing nanoparticles induce gastrotoxicity, hepatotoxicity and alterations in animal behavior: The unknown role of oxidative stress
Medina‐Reyes, E. I., Rodríguez‐Ibarra, C., Déciga‐Alcaraz, A., Díaz‐Urbina, D., Chirino, Y. I., & Pedraza‐Chaverrí, J. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111814 · Cited by 116
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
Berding, K., Carbia, C., & Cryan, J. F. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221995785 · Cited by 100
Regulation of CD4+ and CD8+ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology
Schiweck, C., Thanarajah, S. E., Aichholzer, M., Matura, S., Reif, A., Vrieze, E., Weigert, A., & Visekruna, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158272 · Cited by 80
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy
Kalkan, H., Pagano, E., Paris, D., Panza, E., Cuozzo, M., Moriello, C., Piscitelli, F., Abolghasemi, A., Gazzerro, E., Silvestri, C., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216225 · Cited by 80
The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives
Ragavan, M. L., & Hemalatha, S. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-023-01414-x · Cited by 86
Effects of a high-prebiotic diet versus probiotic supplements versus synbiotics on adult mental health: The “Gut Feelings” randomised controlled trial
Freijy, T. M., Cribb, L., Oliver, G., Metri, N., Opie, R., Jacka, F. N., Hawrelak, J. A., Rucklidge, J. J., Ng, C. H., & Sarris, J. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1097278 · Cited by 86
Microbially-derived short-chain fatty acids impact astrocyte gene expression in a sex-specific manner
Spichak, S., Donoso, F., Moloney, G. M., Gunnigle, E., Brown, J. R.-M., Codagnone, M. G., Dinan, T. G., & Cryan, J. F. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100318 · Cited by 74
A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants
Rosin, S., Xia, K., Azcarate-Peril, M. A., Carlson, A. L., Propper, C. B., Thompson, A. L., Grewen, K., & Knickmeyer, R. C. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105046 · Cited by 74
Dietary fibre and the gut–brain axis: microbiota-dependent and independent mechanisms of action
Torre, D. L., Verbeke, K., & Dalile, B. (2021) · Gut Microbiome · doi:10.1017/gmb.2021.3 · Cited by 74
Self-citation
Increased efficacy of combining prebiotic and postbiotic in mouse models relevant to autism and depression
Leo, A., Caro, C. D., Mainardi, P., Tallarico, M., Nesci, V., Marascio, N., Striano, P., Russo, E., Constanti, A., Sarro, G. D., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108782 · Cited by 72
Microbiota-targeted interventions for mental health
Berding, K., & Cryan, J. F. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000758 · Cited by 69
Bifidobacterium longum subsp. longum Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial
Boehme, M., Rémond-Derbez, N., Lerond, C., Lavalle, L., Keddani, S., Steinmann, M., Rytz, A., Dalile, B., Verbeke, K., Oudenhove, L. V., et al. (2023) · Nutrients · doi:10.3390/nu15143122 · Cited by 74
Self-citation
SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats
Palepu, M. S. K., Gajula, S. N. R., Malleshwari, K., Sonti, R., & Dandekar, M. P. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00727 · Cited by 65
Role of Short Chain Fatty Acids in Epilepsy and Potential Benefits of Probiotics and Prebiotics: Targeting “Health” of Epileptic Patients
Kim, S., Park, S., Choi, T. G., & Kim, S. S. (2022) · Nutrients · doi:10.3390/nu14142982 · Cited by 62
Gastrointestinal symptoms, gut microbiome, probiotics and prebiotics in anorexia nervosa: A review of mechanistic rationale and clinical evidence
Dhopatkar, N., Keeler, J. L., Mutwalli, H., Whelan, K., Treasure, J. L., & Himmerich, H. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105959 · Cited by 62
Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
Medawar, E., Beyer, F., Thieleking, R., Haange, S., Rolle-Kampczyk, U. E., Reinicke, M., Chakaroun, R., von Bergen�, M., Stümvoll, M., Villringer, A., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-330365 · Cited by 59
Effects of gut microbiota on neurodegenerative diseases
Khatoon, S., Kalam, N., Rashid, S., & Bano, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1145241 · Cited by 55
Neuropsychiatric Ramifications of COVID‐19: Short‐Chain Fatty Acid Deficiency and Disturbance of Microbiota‐Gut‐Brain Axis Signaling
Sajdel, E. M. (2021) · BioMed Research International · doi:10.1155/2021/7880448 · Cited by 49
Early life adversity predicts brain-gut alterations associated with increased stress and mood
Coley, E. J. L., Mayer, E. A., Osadchiy, V., Chen, Z., Subramanyam, V., Zhang, Y., Hsiao, E. Y., Gao, K., Bhatt, R. R., Dong, T. S., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100348 · Cited by 51
Inulin-type fructans and 2’fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial
Jackson, P. P. J., Wijeyesekera, A., Williams, C. M., Theis, S., Harsselaar, J. V., & Rastall, R. A. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.08.016 · Cited by 50
Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases
Głowacka, P., Oszajca, K., Pudlarz, A. M., Szemraj, J., & Witusik‐Perkowska, M. (2024) · Nutrients · doi:10.3390/nu16142244 · Cited by 52
Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review
Petakh, P., Duve, K. V., Oksenych, V., Behzadi, P., & Kamyshnyi, O. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1394953 · Cited by 50
Oral short-chain fatty acids administration regulates innate anxiety in adult microbiome-depleted mice
Wu, J.-T., Sun, C.-L., Lai, T.-T., Liou, C.-W., Lin, Y.-Y., Xue, J.-Y., Wang, H.-W., Chai, L. M. X., Lee, Y.-J., Chen, S., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109140 · Cited by 42
Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy
Slykerman, R. F., Davies, N., Vlčková, K., O’Riordan, K. J., Bassett, S. A., Dekker, J., Schellekens, H., Hyland, N. P., Clarke, G. A., & Patterson, E. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70079 · Cited by 47
Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects
Bashir, B., Gulati, M., Vishwas, S., Gupta, G., Dhanasekaran, M., Paudel, K. R., Chellappan, D. K., Anand, K., Negi, P., Singh, P. K., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102689 · Cited by 45
Colonic butyrate administration modulates fear memory but not the acute stress response in men: A randomized, triple-blind, placebo-controlled trial
Dalile, B., Fuchs, A., Torre, D. L., Vervliet, B., Oudenhove, L. V., & Verbeke, K. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110939 · Cited by 37
Self-citation
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health
Marco, M. L., Cunningham, M., Bischoff, S. C., Clarke, G. A., Delzenne, N. M., Lewis, J., Meisel, M., Merenstein, D. J., O’Toole, P. W., Staudacher, H. M., et al. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-026-01176-x · Cited by 50
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition
Wang, X., Sun, Z., Yang, T., Lin, F. H., Ye, S., Yan, J., Li, T., & Chen, J. (2023) · mSystems · doi:10.1128/msystems.00415-23 · Cited by 48
Effect of prebiotics, probiotics, and synbiotics on gastrointestinal outcomes in healthy adults and active adults at rest and in response to exercise—A systematic literature review
Rauch, C., Mika, A. S., McCubbin, A. J., Huschtscha, Z., & Costa, R. J. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1003620 · Cited by 36
Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer’s Disease, and Other Dementias
Ding, H., Reiss, A. B., Pinkhasov, A., & Kasselman, L. J. (2022) · Medicina · doi:10.3390/medicina58081025 · Cited by 32
Fibre & fermented foods: differential effects on the microbiota-gut-brain axis
Schneider, E., Balasubramanian, R., Ferri, A., Cotter, P. D., Clarke, G. A., & Cryan, J. F. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124004907 · Cited by 37
Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches
Williams, L. M., & Cao, S. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108605 · Cited by 33
Gut‐Brain Axis Impact on Canine Anxiety Disorders: New Challenges for Behavioral Veterinary Medicine
Sacoor, C., Marugg, J. D., Lima, N. R., Empadinhas, N., & Montezinho, L. (2024) · Veterinary Medicine International · doi:10.1155/2024/2856759 · Cited by 33
Associations between short-chain fatty acid levels and mood disorder symptoms: a systematic review
Bruun, C. F., Hansen, T. H., Vinberg, M., Kessing, L. V., & Coello, K. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2277970 · Cited by 33
Alcohol Use Disorder and the Gut–Brain Axis: A Narrative Review of the Role of Gut Microbiota and Implications for Treatment
Shukla, S., & Hsu, C. L. (2025) · Microorganisms · doi:10.3390/microorganisms13010067 · Cited by 31
Biological, environmental, and psychological stress and the human gut microbiome in healthy adults
Delgadillo, D. R., Borelli, J. L., Mayer, E. A., Labus, J. S., Cross, M. P., & Pressman, S. D. (2025) · Scientific Reports · doi:10.1038/s41598-024-77473-9 · Cited by 31
Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice
Ma, T., Li, Y., Yang, N., Wang, H., Shi, X., Liu, Y., Jin, H., Kwok, L., Sun, Z., & Zhang, H. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102093 · Cited by 31
Butyrate-Producing Bacteria as a Keystone Species of the Gut Microbiome: A Systemic Review of Dietary Impact on Gut–Brain and Host Health
Snodgrass, J. D., & Velayudhan, B. T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031289 · Cited by 34
Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder
Amadieu, C., Leclercq, S., Coste, V., Thijssen, V., Neyrinck, A. M., Bindels, L. B., Cani, P. D., Piessevaux, H. H., Stärkel, P., de Timary, P., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.03.029 · Cited by 28
Prebiotics for depression: how does the gut microbiota play a role?
Yang, Y., Bi, Z., Zhang, S., Si, L., Liu, X., & Li, F. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1206468 · Cited by 31
Resilience by design: How nature, nurture, environment, and microbiome mitigate stress and allostatic load
Chbeir, S., & Carrión, V. (2023) · World Journal of Psychiatry · doi:10.5498/wjp.v13.i5.144 · Cited by 25
When the mind says one thing, but the HPA axis says another: Lack of coherence between subjective and neuroendocrine stress response trajectories in healthy men
Dalile, B., Torre, D. L., Verbeke, K., Oudenhove, L. V., & Vervliet, B. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105692 · Cited by 26
Self-citation
Sodium propionate oral supplementation ameliorates depressive-like behavior through gut microbiome and histone 3 epigenetic regulation
Behrens, L. M. P., Gasparotto, J., Rampelotto, P. H., Escalona, M. A. R., da Silva, L. D. S., Kessler, F. G. C., Barbosa, C. P., Campos, M. S., Dorn, M., Gelain, D. P., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109660 · Cited by 27
The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease
Nassir, C. M. N. C. M., Ramli, M. D. C., Ghazali, M. M., Jaffer, U., Hamid, H. A., Mehat, M. Z., & Hein, Z. M. (2024) · Life · doi:10.3390/life15010003 · Cited by 31
Dietary Fats and Cognitive Status in Italian Middle-Old Adults
Currenti, W., Godos, J., Alanazi, A. M., Lanza, G., Ferri, R., Caraci, F., Grosso, G., Galvano, F., & Castellano, S. (2023) · Nutrients · doi:10.3390/nu15061429 · Cited by 24
Wrapping Things Up: Recent Developments in Understanding the Role of the Microbiome in Regulating Myelination
Lynch, C. M. K., Nagpal, J. K., Clarke, G. A., & Cryan, J. F. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100468 · Cited by 25
Effect of fermented foods on some neurological diseases, microbiota, behaviors: mini review
Eroğlu, F. E., & Şanlıer, N. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2053060 · Cited by 25
Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach
Cao, Y., Aquino-Martínez, R., Hutchison, E. R., Allayee, H., Lusis, A. J., & Rey, F. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101557 · Cited by 26
Potentially probiotic or postbiotic pre-converted nitrite from celery produced by an axenic culture system with probiotic lacticaseibacilli strain
Oliveira, W. A., Rodrigues, A. R. P., de Oliveira, F. A., de Oliveira, V. S., Laureano‐Melo, R., Stutz, E. T. G., Lemos, W. J. F., de Paula, B. P., Esmerino, E. A., Corich, V., et al. (2020) · Meat Science · doi:10.1016/j.meatsci.2020.108408 · Cited by 22
Targeting Cognitive Resilience through Prebiotics: A Focused Perspective
Dalile, B., Boyle, N. B., Ruiz, F. T., Chakrabarti, A., Respondek, F., Dodd, G. F., Kadosh, K. C., Hepsomali, P., Brummer, R. J., McArthur, S., et al. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100343 · Cited by 21
Self-citation
Gut Microbiota in Psychiatric and Neurological Disorders: Current Insights and Therapeutic Implications
Dziedziak, M., Mytych, A., Szyller, H. P., Lasocka, M., Augustynowicz, G., Szydziak, J., Hrapkowicz, A., Dyda, M., Braksator, J., & Pytrus, T. (2025) · Biomedicines · doi:10.3390/biomedicines13092104 · Cited by 26
Reproducibility, Temporal Variability, and Concordance of Serum and Fecal Bile Acids and Short Chain Fatty Acids in a Population-Based Study
Farhat, Z., Sampson, J. N., Hildesheim, A., Safaeian, M., Porras, C., Cortés, B., Herrero, R., Romero, B., Vogtmann, E., Sinha, R. R., et al. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0361 · Cited by 22
Associations Between the Gut Microbiota and Internalizing Behaviors in Preschool Children
van de Wouw, M., Wang, Y., Workentine, M. L., Vaghef‐Mehrabany, E., Dewey, D., Reimer, R. A., Tomfohr‐Madsen, L. M., & Giesbrecht, G. F. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001026 · Cited by 23
Prebiotics Beyond the Gut: Omics Insights, Artificial Intelligence, and Clinical Trials in Organ-Specific Applications
Al-Adham, I. S. I., Agha, A. S. A. A., Al‐Akayleh, F., Al-Remawi, M. M., Jaber, N., Al-Manasur, M. A., & Collier, P. J. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10465-x · Cited by 19
Acute stress-induced alterations in short-chain fatty acids: Implications for the intestinal and blood brain barriers
Rosell‐Cardona, C., Leigh, S., Knox, E. G., Tirelli, E., Lyte, J. M., Goodson, M. S., Kelley‐Loughnane, N., Aburto, M. R., Cryan, J. F., & Clarke, G. A. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100992 · Cited by 20
Circulating short chain fatty acids are associated with depression severity and predict remission from major depressive disorder
Schiweck, C., Dalile, B., Balliet, A., Aichholzer, M., Reinken, H., Erhardt, F., Freiling, J., Bouzouina, A., Uckermark, C., Reif, A., et al. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101070 · Cited by 22
Self-citation
Extruded Wheat Bran Consumption Increases Serum Short-Chain Fatty Acids but Does Not Modulate Psychobiological Functions in Healthy Men: A Randomized, Placebo-Controlled Trial
Dalile, B., Torre, D. L., Kalc, P., Zoppas, F., Roye, C., Loret, C., Lamothe, L. M., Bergonzelli, G. E., Courtin, C. M., Vervliet, B., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.896154 · Cited by 18
Self-citation
A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines
Hong, M., Lan, T., Li, Q., Li, B., Yuan, Y., Xu, F., & Wang, W. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2233146 · Cited by 19
The role of short-chain fatty acids (SCFAs) in regulating stress responses, eating behavior, and nutritional state in anorexia nervosa: protocol for a randomized controlled trial
Quagebeur, R., Dalile, B., Raes, J., Oudenhove, L. V., Verbeke, K., & Vrieze, E. (2023) · Journal of Eating Disorders · doi:10.1186/s40337-023-00917-6 · Cited by 23
Self-citation
Aging Gut-Brain Interactions: Pro-Inflammatory Gut Bacteria Are Elevated in Fecal Samples from Individuals Living with Alzheimer’s Dementia
Donaldson, A. I. C., Fyfe, C., Martin, J. C., SMITH, E., Horgan, G. W., Myint, P. K., Johnstone, A. M., & Scott, K. P. (2025) · Geriatrics · doi:10.3390/geriatrics10020037 · Cited by 22
Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota and affective symptoms in metabolic syndrome: a pilot open-label randomised controlled trial
Hall, C. V., Hepsomali, P., Dalile, B., Scapozza, L., & Gurry, T. (2024) · British Journal Of Nutrition · doi:10.1017/s0007114524002186 · Cited by 20
Self-citation
The Gut Microbiome in Anxiety Disorders
Butler, M., Kittel‐Schneider, S., Wagner‐Skacel, J., Mörkl, S., & Clarke, G. A. (2025) · Current Psychiatry Reports · doi:10.1007/s11920-025-01604-w · Cited by 21
The microbiome-gut-brain axis in nutritional neuroscience
Schellekens, H., Ribeiro, G., Cuesta‐Marti, C., & Cryan, J. F. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2128007 · Cited by 17
Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women?
Marano, G., Traversi, G., Pola, R., Gasbarrini, A., Gaetani, E., & Mazza, M. (2025) · Life · doi:10.3390/life15020277 · Cited by 27
Health benefits of medicinal plant natural products via microbiota-mediated different gut axes
Li, X., Liu, Y., Liu, N., Wu, H., Cong, K., Duan, L., Chen, T., & Zhang, J. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107730 · Cited by 17
Infant gut microbiota and SCFAs mediate the association between early-life human milk microbiota and neurodevelopment
Wu, S., Jia, W., Li, J., Luo, Y., Chen, F., Yang, T., Jiang, X., He, F., & Cheng, R. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00790-y · Cited by 18
Social Isolation and Breast Cancer
Hilakivi-Clarke, L. A., & Andrade, F. D. O. (2023) · Endocrinology · doi:10.1210/endocr/bqad126 · Cited by 22
Bacteria - derived short chain fatty acids restore sympathoadrenal responsiveness to hypoglycemia after antibiotic-induced gut microbiota depletion
LaGamma, E. F., Hu, F., Cruz, F. P., Bouchev, P., & Nankova, B. B. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100376 · Cited by 16
Microbiota links to neural dynamics supporting threat processing
Hall, C. V., Harrison, B. J., Iyer, K. K., Savage, H. S., Zakrzewski, M., Simms, L. A., Radford‐Smith, G. L., Moran, R., & Cocchi, L. (2021) · Human Brain Mapping · doi:10.1002/hbm.25682 · Cited by 14
Identification of carbohydrate gene clusters obtained from in vitro fermentations as predictive biomarkers of prebiotic responses
Kok, C. R., Rose, D. J., Cui, J., Whisenhunt, L. A., & Hutkins, R. L. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03344-y · Cited by 19
Associations of air PM2.5 level with gut microbiota in Chinese Han preschoolers and effect modification by oxytocin receptor gene polymorphism
Sun, Y., Deng, G., Fan, J., Feng, F., Ge, Q., Song, Y., & Kang, X. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114123 · Cited by 15
Microbiota-Gut-Brain Axis and Antidepressant Treatment
Lachmansingh, D. A., Lavelle, A., Cryan, J. F., & Clarke, G. A. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_449 · Cited by 17
Microbiome and Brain Development: A Tale of Two Systems
Cryan, J. F. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000544950 · Cited by 15
Study of the Effect of Dietary Agavin Supplementation in Blood Parameters and Antioxidant Enzymes of Juvenile Nile Tilapia (Oreochromis niloticus) under Stress Conditions
Flores-Méndez, L. C., Lizárraga-Velázquez, C. E., Sánchez-Gutiérrez, E. Y., Arrizón, J., Leyva‐López, N., & Hernández, C. (2022) · Fishes · doi:10.3390/fishes7060340 · Cited by 15
Colonic Lactulose Fermentation Has No Impact on Glucagon-like Peptide-1 and Peptide-YY Secretion in Healthy Young Men
Christiansen, C. B., Veedfald, S., Hartmann, B., Gauguin, A. M., Møller, S., Möritz, T., Madsbad, S., & Holst, J. J. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab666 · Cited by 15
Nutraceutical eicosapentaenoic acid in treatment-resistant depression: The psychoneuroimmunity and clinical implications
Chang, J. P., Iqbal, A. Z., Do, Q. L., Yaseen, M., Wu, S., Malau, I. A., Zailani, H., & Su, K. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107857 · Cited by 13
Paeoniflorin ameliorates depressive behaviours by modulating microbiota–gut–brain axis functions
Zhang, S., Pan, D., Chen, S., Tang, D., Yang, H., Song, D., Yuan, B., Huang, J. H., Jiang, M. C., Wang, F., et al. (2025) · General Psychiatry · doi:10.1136/gpsych-2024-101979 · Cited by 14
Advancements in sensors for rapid detection of short-chain fatty acids (SCFAs): Applications and limitations in gut health and the microbiota-gut-brain axis
Wasiewska, L. A., Uhlig, F., Barry, F., Teixeira, S. R., Clarke, G. A., & Schellekens, H. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.118118 · Cited by 14
Vasovagal reactions following venepuncture result in aberrant stress-induced cortisol levels
Dalile, B., Verbeke, K., & Oudenhove, L. V. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105220 · Cited by 13
Self-citation
The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain
Leyrolle, Q., Prado-Perez, L., & Layé, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1155533 · Cited by 13
Acute stress enhances synaptic plasticity in male mice via a microbiota-dependent mechanism
Rosell‐Cardona, C., Collins, M., O’Riordan, K. J., Goodson, M. S., Kelley‐Loughnane, N., Cryan, J. F., & Clarke, G. A. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110434 · Cited by 12
Disorders in the gut and liver are involved in depression contagion between isosexual post-stroke depression mice and the healthy cohabitors
Wang, H., Wang, B., Pan, M.-B., Jiang, S.-T., Wang, Y.-C., Zhu, Y., Zhang, Q., & Dong, Y. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114246 · Cited by 15
Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS
Császár-Nagy, N., Bob, P., & Bókkon, I. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240507095700 · Cited by 13
Characterization of luminal contents from the fasted human proximal colon
Steigert, S., Brouwers, J., Verbeke, K., Vanuytsel, T., & Augustijns, P. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106821 · Cited by 12
Self-citation

Authors: Dalile, B., Vervliet, B., Bergonzelli, G., Verbeke, K., & Van Oudenhove, L.
Affiliations: KU Leuven (BE)
Nestlé (Switzerland) (CH)
ORCID: Dalile, Boushra
Vervliet, Bram
Bergonzelli, Gabriela
Verbeke, Kristin
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2020-06-10
Volume: 45
Issue: 13
Pages: 2257-2266
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/s41386-020-0732-x
PMC: PMC7784980
OpenAlex: W3033823110
Cited by: 201
References: 87
Citations by year: 2026: 36 · 2025: 46 · 2024: 38 · 2023: 27 · 2022: 28 · 2021: 21 · 2020: 5
FWCI: 6.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Lirias (KU Leuven) (submittedVersion, other-oa)
Funders: Fondation Nestlé
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: short-chain fatty acids, arabinoxylan oligosaccharides, psychosocial stress, cortisol response, hypothalamic-pituitary-adrenal axis, dietary fiber fermentation, fear extinction, brain-derived neurotrophic factor, cortisol awakening response, anxiety
MeSH terms: Gastrointestinal Microbiome, Colon, Fatty Acids, Volatile, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks