Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer’s Disease, and Other Dementias
Open accessAbstract
Background and Objectives: Alzheimer’s disease (AD) is the most common form of dementia, with the risk of developing it attributed to non-modifiable and modifiable factors. Currently, there is no cure for AD. A plant-based diet may protect against cognitive decline, due to the effects of plant-based nutrients such as vitamins, antioxidants, and fiber. The aim of the review is to summarize current literature on plant-based nutrients and their impact on cognition. Materials and Methods: A search was conducted on PubMed for clinical and murine studies, using combinations of the following words: “Alzheimer’s disease”, “dementia”, “cognition”, “plant-based diet”, “mild cognitive impairment”, “vitamin B”, “vitamin C”, “vitamin E, “beta carotene”, “antioxidants”, “fiber”, “vitamin K”, “Mediterranean diet”, “vitamin D”, and “mushrooms”. Results and Conclusions: A diet rich in vitamin B and antioxidants can benefit the cognitive functions of individuals as shown in randomized clinical trials. Vitamin K is associated with improved cognition, although large randomized controlled trials need to be done. Fiber has been shown to prevent cognitive decline in animal studies. Vitamin D may contribute to cognitive health via anti-inflammatory processes. Several medical organizations have recommended a plant-based diet for optimizing cognitive health and potentially helping to prevent dementia.
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Alkaloids, flavonoids, and phenolic acids are among the essential secondary metabolites of plants that play a significant role in preventing neurodegeneration in Alzheimer's disease.
“Alkaloids, flavonoids, and phenolic acids are among the essential secondary metabolites of plants that play a significant role in preventing neurodegeneration in AD [17,58,59].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [59]
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1 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430 · cited 1× · see citing works
“Finally, the WHO guidelines recommend a Mediterranean diet to reduce the risk of cognitive decline or dementia, as is might help and does not harm, but conclude that vitamins B and E, polyunsaturated fatty acid, and multicomplex supplementation should not be recommended [203].”
MethodRetractedAyala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,557 · see citing works
Free radicals, antioxidants and functional foods: impact on human health
Lobo, V, Patil, A., Phatak, A., & Chandra, N. (2010) · Pharmacognosy Reviews · doi:10.4103/0973-7847.70902 · Cited by 5,435 · see citing works
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
Breijyeh, Z., & Karaman, R. (2020) · Molecules · doi:10.3390/molecules25245789 · Cited by 2,789 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 1× · see citing works
“There is emerging showing that the gut microbiota influences levels of anxiety, depression, and autistic behavior [170,171].”
BackgroundThe role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425 · see citing works
The cholinergic hypothesis of Alzheimer’s disease: A review of progress
Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.137 · Cited by 2,198 · cited 1× · see citing works
“shown that acetylcholinesterase inhibiting drugs treat cognitive symptoms of Alzheimer’s disease [123].”
BackgroundKurutas, E. B. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0186-5 · Cited by 2,152 · see citing works
Lipid peroxidation in cell death
Gaschler, M. M., & Stockwell, B. R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.086 · Cited by 1,852 · see citing works
Dietary fiber and prebiotics and the gastrointestinal microbiota
Holscher, H. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1290756 · Cited by 1,808 · see citing works
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,773 · see citing works
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works
Dietary fibre in foods: A review
Dhingra, D., Michael, M., Rajput, H., & Patil, R. T. (2012) · Journal of Food Science and Technology · doi:10.1007/s13197-011-0365-5 · Cited by 1,456 · see citing works
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325 · see citing works
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261 · see citing works
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
Tan, B. L., Norhaizan, M. E., Liew, W.-P.-P., & Rahman, H. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01162 · Cited by 1,182 · see citing works
Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080 · see citing works
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
Kennedy, D. (2016) · Nutrients · doi:10.3390/nu8020068 · Cited by 1,055 · see citing works
Role of oxidative stress in Alzheimer’s disease
HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works
Bacterial infection causes stress-induced memory dysfunction in mice
Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909 · cited 1× · see citing works
“Studies on germ-free mice have shown how the composition of gut bacteria impacts the expression of neurotransmitters in both the central and enteric nervous system, stress and anxiety, and memory [173,174].”
BackgroundInnate immunity in Alzheimer's disease
Heneka, M. T., Golenbock, D. T., & Latz, E. (2015) · Nature Immunology · doi:10.1038/ni.3102 · Cited by 902 · see citing works
Oxidative stress in Alzheimer’s disease
Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., & Perry, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00040-5 · Cited by 895 · see citing works
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works
Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., & Refsum, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012244 · Cited by 813 · cited 2× · see citing works
“A 2010 randomized controlled trial found that vitamin B6, B12, and folic acid supplementation decreased the rate of brain atrophy, a characteristic finding in individuals with MCI who later develop Alzheimer’s disease [45].”
BackgroundRelationship Between Diet and Mental Health in Children and Adolescents: A Systematic Review
O’Neil, A., Quirk, S. E., Housden, S., Brennan, S. L., Williams, L. J., Pasco, J. A., Berk, M., & Jacka, F. N. (2014) · American Journal of Public Health · doi:10.2105/ajph.2014.302110 · Cited by 734 · see citing works
Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., West, B. L., & Green, K. N. (2016) · Brain · doi:10.1093/brain/aww016 · Cited by 695 · see citing works
Rajmohan, R., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160612 · Cited by 695 · see citing works
Metabolic effects of dietary fiber consumption and prevention of diabetes
Weickert, M. O., & Pfeiffer, A. F. H. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.3.439 · Cited by 683 · see citing works
Intake of flavonoids and risk of dementia
Commenges, D., Scotet, V., Renaud, S., Jacqmin‐Gadda, H., Barberger‐Gateau, P., & Dartigues, J. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614613771 · Cited by 647 · see citing works
Localized scleroderma-response to 1,25-dihydroxyvitamin D3
Humbert, P. G., DUPOND, J. L., ROCHEFORT, A., VASSELET, R., LUCAS, A., Laurent, R., & Agache, P. G. (1990) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1990.tb02127.x · Cited by 633 · see citing works
Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., et al. (2014) · JAMA · doi:10.1001/jama.2013.282834 · Cited by 628 · see citing works
The Role of Vitamin E in Human Health and Some Diseases
Rizvi, S., Raza, S. T., Ahmed, F., Ahmad, A., Abbas, S., & Mahdi, F. (2014) · Sultan Qaboos University Medical Journal · doi:10.18295/2075-0528.1566 · Cited by 624 · see citing works
Leaky Gut As a Danger Signal for Autoimmune Diseases
Mu, Q., Kirby, J. L., Reilly, C. M., & Luo, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00598 · Cited by 618 · see citing works
Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis
Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017) · Clinics and Practice · doi:10.4081/cp.2017.987 · Cited by 608 · see citing works
Enhanced recognition memory following vagus nerve stimulation in human subjects
Clark, K., Naritoku, D., Smith, D. C., Browning, R., & Jensen, R. A. (1999) · Nature Neuroscience · doi:10.1038/4600 · Cited by 575 · see citing works
Halliwell, B. B. (1996) · Free Radical Research · doi:10.3109/10715769609145656 · Cited by 574 · see citing works
Vitamin D and the risk of dementia and Alzheimer disease
Littlejohns, T. J., Henley, W., Lang, I., Annweiler, C., Beauchet, O., Chaves, P. H. M., Fried, L. F., Kestenbaum, B. R., Kuller, L. H., Langa, K. M., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000755 · Cited by 573 · see citing works
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100339 · Cited by 562 · cited 1× · see citing works
“In addition to increased inflammation, which may be toxic long-term, AD has been associated with mitochondrial dysfunction, with changes in mitochondrial processing resulting in increased oxidative stress [19].”
BackgroundVitamin d3 and brain development
Eyles, D. W., Brown, J., Mackay‐Sim, A., McGrath, J. J., & Feron, F. P. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00040-x · Cited by 552 · see citing works
Homocysteine, B Vitamins, and Cognitive Impairment
Smith, A. D., & Refsum, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050947 · Cited by 526 · see citing works
Vitamin B <sub>12</sub> Sources and Bioavailability
Watanabe, F. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-67 · Cited by 519 · see citing works
Microbial production of vitamin B12: a review and future perspectives
Fang, H., Kang, J., & Zhang, D. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0631-y · Cited by 466 · see citing works
de Jager, C. A., Oulhaj, A., Jacoby, R. J., Refsum, H., & Smith, A. D. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2758 · Cited by 461 · see citing works
Polyunsaturated Fatty Acids, Antioxidants, and Cognitive Function in Very Old Men
Kalmijn, S., Feskens, E. J. M., Launer, L. J., & Kromhout, D. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009029 · Cited by 453 · see citing works
The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
Minter, M. R., Taylor, J. M., & Crack, P. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13411 · Cited by 451 · see citing works
The Role of Tau in Alzheimer's Disease and Related Disorders
Medeiros, R., Baglietto‐Vargas, D., & LaFerla, F. M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00177.x · Cited by 448 · see citing works
Interaction of Ascorbate and α‐Tocopherol
Niki, E. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23761.x · Cited by 443 · see citing works
Antioxidant Vitamin Intake and Risk of Alzheimer Disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.203 · Cited by 414 · see citing works
Galasko, D. R., Peskind, E., Clark, C. M., Quinn, J. F., Ringman, J. M., Jicha, G. A., Cotman, C., Cottrell, B., Montine, T. J., Thomas, R. G., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.85 · Cited by 377 · see citing works
Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., Eldridge, A. L., Schwartz, S. J., & White, W. S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.396 · Cited by 376 · see citing works
The effects of plant-based diets on the body and the brain: a systematic review
Medawar, E., Hühn, S., Villringer, A., & Witte, A. V. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0552-0 · Cited by 355 · see citing works
Bischoff-Ferrari, H. A., Vellas, B., Rizzoli, R., Kressig, R. W., da Silva, J. A. P., Blauth, M., Felson, D. T., McCloskey, E. V., Watzl, B., Hofbauer, L. C., et al. (2020) · JAMA · doi:10.1001/jama.2020.16909 · Cited by 353 · see citing works
Tucker, K. L., Qiao, N., Scott, T. M., Rosenberg, I. H., & Spiro, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.627 · Cited by 351 · see citing works
Tucker, K. L., Qiao, N., Scott, T., Rosenberg, I., & Spiro, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.627 · Cited by 351 · see citing works
Dietary intake and cognitive function in a group of elderly people
Ortega, R., Requejo, A. M., Andrés, P., López-Sobaler, A. M., Quintas, M. E., Redondo, M. R., Navia, B., & Rivas, T. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.803 · Cited by 350 · see citing works
A Review of Mushrooms as a Potential Source of Dietary Vitamin D
Cardwell, G., Bornman, J. F., James, A. P., & Black, L. J. (2018) · Nutrients · doi:10.3390/nu10101498 · Cited by 348 · see citing works
Oxidative stress in Alzheimer's disease
Chauhan, V. P. S., & Chauhan, A. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.004 · Cited by 341 · see citing works
β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease
Gouras, G. K., Olsson, T. T., & Hansson, O. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0313-y · Cited by 331 · see citing works
Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice
Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A., & Johnson, R. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01832 · Cited by 330 · see citing works
Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease
Barbara, G., Stanghellini, V., Brandi, G., Cremon, C., Nardo, G. D., De Giorgio, R., & Corinaldesi, R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00230.x · Cited by 325 · see citing works
The role of menaquinones (vitamin K 2 ) in human health
Beulens, J. W. J., Booth, S. L., van den Heuvel, E. G. H. M., Stoecklin, E., Baka, A., & Vermeer, C. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001013 · Cited by 319 · see citing works
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview
Castro, R., Rivera, I. A., Blom, H. J., Jakobs, C., & de Almeida, I. T. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0106-5 · Cited by 311 · see citing works
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial
Lin, J., Cook, N. R., Albert, C., Zaharris, E., Gaziano, J. M., Van Denburgh, M., Buring, J. E., & Manson, J. E. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn438 · Cited by 309 · see citing works
Current and future treatments in Alzheimer’s disease
Atri, A. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1678581 · Cited by 309 · see citing works
The Impact of Inflammation on Cognitive Function in Older Adults
Sartori, A. C., Vance, D. E., Slater, L. Z., & Crowe, M. G. (2012) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e3182527690 · Cited by 307 · see citing works
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works
Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works
Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Matsunaga, S., Kishi, T., & Iwata, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123289 · Cited by 284 · see citing works
Health benefits and practical aspects of high-fiber diets
Anderson, J., Smith, B. M., & Gustafson, N. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.1242s · Cited by 282 · see citing works
Dietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials
Myhrstad, M. C. W., Tunsjø, H. S., Charnock, C., & Telle‐Hansen, V. H. (2020) · Nutrients · doi:10.3390/nu12030859 · Cited by 280 · see citing works
Patnala, R., Arumugam, T. V., Gupta, N., & Dheen, S. T. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0149-z · Cited by 278 · see citing works
Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease
Schneider, L. S. S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.69 · Cited by 276 · see citing works
Protein oxidation and cellular homeostasis: Emphasis on metabolism
Cecarini, V., Gee, J., Fioretti, E., Amici, M., Angeletti, M., Eleuteri, A. M., & Keller, J. N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.039 · Cited by 274 · see citing works
Giraldo, E., Lloret, A., Fuchsberger, T., & Viña, J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.03.002 · Cited by 268 · cited 1× · see citing works
“Furthermore, tocopherol and tocotrienols have been shown to have an inhibitory effect on enzymes that contribute to neuroinflammation in Alzheimer’s disease [120].”
BackgroundHarms, L. R., Burne, T. H. J., Eyles, D. W., & McGrath, J. J. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.05.009 · Cited by 265 · see citing works
β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice
Shi, H., Yu, Y., Lin, D., Zheng, P., Zhang, P., Hu, M., Wang, Q., Pan, W., Yang, X., Hu, T., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00920-y · Cited by 264 · see citing works
A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease
Johra, F. T., Bepari, A. K., Bristy, A. T., & Reza, H. M. (2020) · Antioxidants · doi:10.3390/antiox9111046 · Cited by 264 · see citing works
Vitamin B 12 sources and microbial interaction
Watanabe, F., & Bito, T. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217746612 · Cited by 263 · see citing works
Nurk, E., Refsum, H., Drevon, C. A., Tell, G. S., Nygaard, H. A., Engedal, K., & Smith, A. D. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.095182 · Cited by 261 · see citing works
Vitamin D in foods and as supplements
Lamberg-Allardt, C. J. E. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.017 · Cited by 259 · see citing works
Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update
Cenini, G., & Voos, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00902 · Cited by 257 · see citing works
Tau Proteins and Tauopathies in Alzheimer’s Disease
Chong, F. P., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0574-1 · Cited by 248 · see citing works
Shi, H., Ge, X., Ma, X., Zheng, M., Cui, X., Pan, W. X., Zheng, P., Yang, X., Zhang, P., Hu, M., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01172-0 · Cited by 248 · see citing works
Vitamin C, Aging and Alzheimer’s Disease
Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A. (2017) · Nutrients · doi:10.3390/nu9070670 · Cited by 243 · cited 1× · see citing works
“The neuroprotective effects of vitamin C are also due to its mitigation of neuroinflammation and suppression of beta-amyloid proteins [112].”
BackgroundPlant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline
Rajaram, S., Jones, J., & Lee, G. J. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz081 · Cited by 235 · see citing works
Lloret, A., Badía, M.-C., Mora, N. J., Pallardó, F. V., Alonso, M.-D., & Viña, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1033 · Cited by 222 · see citing works
Passamonti, L., Tsvetanov, K. A., Jones, P. S., Bevan-Jones, W. R., Arnold, R., Borchert, R. J., Mak, E., Su, L., O'Brien, J. T., & Rowe, J. B. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-18.2019 · Cited by 220 · see citing works
The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?
Smith, A. D. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s119 · Cited by 216 · see citing works
The Function of Vitamin D Receptor in Vitamin D Action
Kato, S. (2000) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022662 · Cited by 216 · see citing works
Diet, cognition, and alzheimer’s disease: food for thought
Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., & Martínez-Lage, P. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0561-3 · Cited by 214 · see citing works
Vitamin K: food composition and dietary intakes
Booth, S. L. (2012) · Food & Nutrition Research · doi:10.3402/fnr.v56i0.5505 · Cited by 211 · see citing works
Homocysteine and Cognitive Decline in Healthy Elderly
McCaddon, A., Hudson, P. R., Davies, G. K., Hughes, A., Williams, J. H. H., & Wilkinson, C. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051275 · Cited by 206 · see citing works
Hu, C., Yu, D., Sun, X., Zhang, M., Wang, L., & Qin, H. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217000473 · Cited by 201 · see citing works
Dalile, B., Vervliet, B., Bergonzelli, G., Verbeke, K., & Van Oudenhove, L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0732-x · Cited by 201 · see citing works
Song, Y., Fleet, J. C., & Shigeaki, K. A. T. O. (2003) · Journal of Nutrition · doi:10.1093/jn/133.2.374 · Cited by 200 · see citing works
Vitamin K and the Nervous System: An Overview of its Actions
Ferland, G. (2012) · Advances in Nutrition · doi:10.3945/an.111.001784 · Cited by 195 · see citing works
Neurofibrillary Tangles and Alzheimer’s Disease
Brion, J. (1998) · European Neurology · doi:10.1159/000007969 · Cited by 194 · see citing works
Haskell, M. J. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034850 · Cited by 194 · see citing works
Grodstein, F. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.20.2184 · Cited by 188 · see citing works
The Role of Vitamin D in Brain Health: A Mini Literature Review
Anjum, I., Jaffery, S. S., Fayyaz, M., et al. (2018) · Cureus · doi:10.7759/cureus.2960 · Cited by 179 · see citing works
Lykkesfeldt, J., Michels, A. J., & Frei, B. B. (2014) · Advances in Nutrition · doi:10.3945/an.113.005157 · Cited by 173 · see citing works
Epidemiología de la enfermedad de Alzheimer y otras demencias
Garre Olmo, J. (2018) · Revista de Neurología · doi:10.33588/rn.6611.2017519 · Cited by 166 · see citing works
Cohen, J. F. W., Gorski, M. T., Gruber, S. A., Kurdziel, L. B. F., & Rimm, E. B. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002877 · Cited by 155 · see citing works
Shishtar, E., Rogers, G. T., Blumberg, J. B., Au, R., & Jacques, P. F. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa079 · Cited by 153 · see citing works
Li, H., Sun, J., Wang, F., Ding, G., Chen, W., Fang, R., Yao, Y., Pang, M., Lu, Z.-Q., & Liu, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.031 · Cited by 152 · see citing works
β‐Carotene with vitamins E and C offers synergistic cell protection against NOx
Böhm, F., Edge, R., McGarvey, D. J., & Truscott, T. G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01173-9 · Cited by 150 · see citing works
A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice
Jørgensen, B. P., Hansen, J. T., Krych, Ł., Larsen, C. S., Klein, A. B., Nielsen, D. S., Josefsen, K. E., Hansen, A. K., & Sørensen, D. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103398 · Cited by 150 · see citing works
CASS, W. A., SMITH, M. P., & PETERS, L. E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1369.023 · Cited by 149 · see citing works
Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging
Tracy, R. P. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802497 · Cited by 148 · see citing works
Wang, Z., Zhu, W. P., Xing, Y., Jia, J., & Tang, Y. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab057 · Cited by 147 · see citing works
Schweiggert, R. M., Kopec, R. E., Villalobos-Gutierrez, M. G., Högel, J., Quesada, S., Esquivel, P., Schwartz, S. J., & Carle, R. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002596 · Cited by 145 · see citing works
Photobiology of vitamin D in mushrooms and its bioavailability in humans
Keegan, R.-J. H., Lu, Z., Bogusz, J., et al. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23321 · Cited by 145 · see citing works
B-vitamins, homocysteine metabolism and CVD
Strain, J., Dowey, L. R. C., Ward, M., Pentieva, K. D., & McNulty, H. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004390 · Cited by 145 · see citing works
Mohajeri, M. H., Troesch, B., & Weber, P. (2015) · Nutrition · doi:10.1016/j.nut.2014.06.016 · Cited by 141 · see citing works
The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus
O’Leary, O. F., Ogbonnaya, E. S., Felice, D., Levone, B. R., C. Conroy, L., Fitzgerald, P., Bravo, J. A., Forsythe, P., Bienenstock, J., Dinan, T. G., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.12.004 · Cited by 139 · see citing works
Hira, S., Saleem, U., Anwar, F., Sohail, M. F., Raza, Z., & Ahmad, B. (2019) · Biomolecules · doi:10.3390/biom9090441 · Cited by 131 · see citing works
Mustacich, D. J., Bruno, R. S., & Traber, M. G. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(07)76001-6 · Cited by 130 · see citing works
Öhrvik, V., & Witthöft, C. M. (2011) · Nutrients · doi:10.3390/nu3040475 · Cited by 129 · see citing works
Price, B. R., Wilcock, D. M., & Weekman, E. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00350 · Cited by 128 · see citing works
Kook, S.-Y., Lee, K.-M., Kim, Y., Cha, M.-Y., Kang, S., Baik, S., Lee, H., Park, R., & Mook‐Jung, I. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.26 · Cited by 127 · see citing works
Sakakeeny, L., Roubenoff, R., Obin, M. S., Fontes, J. D., Benjamin, E. J., Bujanover, Y., Jacques, P. F., & Selhub, J. (2012) · Journal of Nutrition · doi:10.3945/jn.111.153056 · Cited by 124 · see citing works
Reed, C. C., Belger, M. A., Dell’Agnello, G., Wimo, A. B., Argimón, J. M., Bruno, G., Dodel, R. C., Haro, J. M., Jones, R. W., & Vellas, B. J. (2014) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000358234 · Cited by 123 · see citing works
Pharmacological Treatment of Alzheimer Disease
Massoud, F., & Léger, G. C. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105601003 · Cited by 122 · see citing works
Eyles, D. W., Liu, P.-Y., Josh, P. F., & Cui, X. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.042 · Cited by 122 · see citing works
Folates in Fruits and Vegetables: Contents, Processing, and Stability
Delchier, N., Herbig, A.-L., Rychlik, M., et al. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12193 · Cited by 118 · see citing works
Dietary Fiber Is Positively Associated with Cognitive Control among Prepubertal Children ,
Khan, N. A., Raine, L. B., Drollette, E. S., Scudder, M. R., Kramer, A. F., & Hillman, C. H. (2014) · Journal of Nutrition · doi:10.3945/jn.114.198457 · Cited by 117 · see citing works
An, Y., Feng, L., Zhang, X., Wang, Y., Wang, Y., Tao, L., Qin, Z., & Xiao, R. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0741-y · Cited by 117 · see citing works
Russell, C. L., Semerdjieva, S., Empson, R. M., Austen, B., Beesley, P. W., & Alifragis, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043201 · Cited by 115 · see citing works
Ford, A. H., & Almeida, O. P. (2019) · Drugs & Aging · doi:10.1007/s40266-019-00649-w · Cited by 113 · see citing works
DIETARY FACTORS AND COGNITIVE DECLINE
Smith, P. J., & Blumenthal, J. A. (2015) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2015.71 · Cited by 110 · see citing works
Pérez, M., Burgos‐Alonso, N., Torrecilla, M., Marco‐Contelles, J., & Bruzos-Cidón, C. (2021) · Biomedicines · doi:10.3390/biomedicines9111689 · Cited by 110 · see citing works
Folate bioavailability: implications for establishing dietary recommendations and optimizing status
Caudill, M. A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28674e · Cited by 109 · see citing works
Carotenoids as a Source of Antioxidants in the Diet
Xavier, A. A. O., & Pérez‐Gálvez, A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_14 · Cited by 108 · see citing works
Parisi, G., Zilli, M., Miani, M. P., Carrara, M., Bottona, E., Verdianelli, G., Battaglia, G., Desideri, S., Faedo, A., Marzolino, C., et al. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1016419906546 · Cited by 106 · see citing works
Giem, P., Beeson, W. L., & Fraser, G. E. (1993) · Neuroepidemiology · doi:10.1159/000110296 · Cited by 106 · see citing works
Low Vitamin K Intakes in Community-Dwelling Elders at an Early Stage of Alzheimer's Disease
Presse, N., Shatenstein, B., Kergoat, M., & Ferland, G. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.09.013 · Cited by 104 · see citing works
Antioxidant status in vegetarians versus omnivores
Elorinne, A., & Mykkänen, H. M. (2000) · Nutrition · doi:10.1016/s0899-9007(99)00267-1 · Cited by 104 · see citing works
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
Ávila‐Escalante, M. L., Gamas, F. C., Cervantes‐Rodríguez, M., Méndez‐Iturbide, D., & Aranda-González, I. I. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13191 · Cited by 101 · see citing works
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
Berding, K., Carbia, C., & Cryan, J. F. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221995785 · Cited by 100 · see citing works
Ho, R. C. M., Cheung, M. W. L., Fu, E., Win, H. H., Zaw, M. H., Ng, A., & Mak, A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f17eed · Cited by 99 · see citing works
Protein S Confers Neuronal Protection During Ischemic/Hypoxic Injury in Mice
Liu, D., Guo, H., Griffin, J. H., Fernández, J. A., & Zloković, B. V. (2003) · Circulation · doi:10.1161/01.cir.0000058460.34453.5a · Cited by 96 · see citing works
The Relationships Between Vitamin K and Cognition: A Review of Current Evidence
Alisi, L., Cao, R., Angelis, C. D., Cafolla, A., Caramia, F., Cartocci, G., Librando, A., & Fiorelli, M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00239 · Cited by 96 · see citing works
Elias, M. F., Robbins, M. A., Budge, M. M., Elias, P. K., Brennan, S. L., Johnston, C., Nagy, Z., & Bates, C. J. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221380.92521.51 · Cited by 94 · cited 1× · see citing works
“Vitamin B6 is an important co-factor in the breakdown of homocysteine [61].”
BackgroundAstrocytes protect neurons from neurotoxic injury by serum glutamate
Ye, Z., & Sontheimer, H. W. (1998) · Glia · doi:10.1002/(sici)1098-1136(199803)22:3 · Cited by 94 · see citing works
Funakoshi, H., Yonemasu, T., Nakano, T., Matumoto, K., & Nakamura, T. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10211 · Cited by 92 · see citing works
Rota, C., Rimbach, G. H., Minihane, A. M., Stoecklin, E., & Barella, L. (2005) · Nutritional Neuroscience · doi:10.1080/10284150400027123 · Cited by 92 · see citing works
Gas6 rescues cortical neurons from amyloid β protein-induced apoptosis
Yagami, T. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00333-7 · Cited by 92 · see citing works
Role of Vitamins in Neurodegenerative Diseases: A Review
Kumar, R. R., Singh, L., Thakur, A., Singh, S., & Kumar, B. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666211119122150 · Cited by 88 · see citing works
Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk
Agarwal, P., Holland, T. M., Wang, Y., Bennett, D. A., & Morris, M. C. (2019) · Nutrients · doi:10.3390/nu11123060 · Cited by 86 · see citing works
Expression and Regulation of the Vitamin D Receptor in the Zebrafish, Danio rerio
Craig, T. A., Sommer, S. L., Sussman, C. R., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080403 · Cited by 84 · see citing works
C.W.*, T., Paul, A. A., Bates, C. J., Bolton-Smith, C., Prentice, A., & Shearer, M. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn2002583 · Cited by 80 · see citing works
Mueller, R. L., Combs, B., Alhadidy, M. M., Brady, S. T., Morfini, G. A., & Kanaan, N. M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.647054 · Cited by 78 · see citing works
Qin, B., Xun, P., Jacobs, D. R., Zhu, N., Daviglus, M. L., Reis, J. P., Steffen, L. M., Van Horn, L., Sidney, S., & He, K. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.157834 · Cited by 77 · see citing works
Thane, C. W., Paul, A. A., Bates, C. J., Bolton-Smith, C., Prentice, A., & Shearer, M. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002583 · Cited by 76 · see citing works
Prokopidis, K., Giannos, P., Ispoglou, T., Witard, O. C., & Isanejad, M. (2022) · The American Journal of Medicine · doi:10.1016/j.amjmed.2022.03.022 · Cited by 75 · see citing works
Vitamin K‐Dependent Actions of Gas6
Bellido‐Martín, L., & de Frutos, P. G. (2008) · Vitamins and hormones · doi:10.1016/s0083-6729(07)00009-x · Cited by 73 · see citing works
The Physicians Committee for Responsible Medicine
Sobanski, S. (2017) · Digital Commons @ Connecticut College (Connecticut College) · Cited by 73 · see citing works
Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review
Janoutová, J., Šerý, O., Hosák, L., & Janout, V. (2015) · Central European Journal of Public Health · doi:10.21101/cejph.a4414 · Cited by 72 · see citing works
Sil, S., Ghosh, T., Gupta, P., Ghosh, R., Kabir, S. N., & Roy, A. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0817-5 · Cited by 68 · see citing works
Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We?
Chiurchiù, V., Tiberi, M., Matteocci, A., Fazio, F., Siffeti, H., Saracini, S., Mercuri, N. B., & Sancesario, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116235 · Cited by 68 · see citing works
Brain Ischemia as a Prelude to Alzheimer's Disease
Pluta, R. M., Januszewski, S., & Czuczwar, S. J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.636653 · Cited by 67 · see citing works
Vitamins in Alzheimer’s Disease—Review of the Latest Reports
Mielech, A., Puścion‐Jakubik, A., Markiewicz‐Żukowska, R., & Socha, K. (2020) · Nutrients · doi:10.3390/nu12113458 · Cited by 65 · see citing works
Karnauskas, A. J., van Leeuwen, J. P. T. M., van den Bemd, G. J. C. M., et al. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041120 · Cited by 64 · see citing works
Arnim, C. A. F. V., the ActiFE Ulm study group, Herbolsheimer, F., Nikolaus, T., Peter, R., Biesalski, H. K., Ludolph, A. C., Riepe, M. W., & Nagel, G. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120634 · Cited by 62 · see citing works
Berrill, J. W., Gallacher, J., Hood, K., Green, J. T., Matthews, S. B., Campbell, A. K., & Smith, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12219 · Cited by 62 · see citing works
Fatahi, S., Matin, S. S., Sohouli, M. H., Găman, M., Raee, P., Olang, B., Kathirgamathamby, V., Santos, H. O., Guimarães, N. S., & Shidfar, F. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102621 · Cited by 61 · see citing works
Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61 · see citing works
Brouwer-Brolsma, E. M., Dhonukshe-Rutten, R. A. M., van Wijngaarden, J. P., van der Zwaluw, N. L., van der Velde, N., & de Groot, C. P. G. M. (2015) · Nutrients · doi:10.3390/nu7095364 · Cited by 60 · see citing works
Bélarbi, K., Schindowski, K., Burnouf, S., Caillierez, R., Grosjean, M., Demeyer, D., Hamdane, M., Sergeant, N., Blum, D. L., & Buée, L. (2009) · Current Alzheimer Research · doi:10.2174/156720509787602843 · Cited by 57 · see citing works
Saputra, W. D., Aoyama, N., Komai, M., & Shirakawa, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092317 · Cited by 56 · see citing works
Li, J., Yang, Y., Qin, S., Lv, S., Jin, T., Li, K., Han, Z., & Li, Y. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01568-5 · Cited by 56 · see citing works
Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment
Popescu, A., & German, M. (2021) · Nutrients · doi:10.3390/nu13072206 · Cited by 55 · see citing works
Lifelong Low-Phylloquinone Intake Is Associated with Cognitive Impairments in Old Rats
Carri, I., Blanger, E., Portoukalian, J., et al. (2011) · Journal of Nutrition · doi:10.3945/jn.110.137638 · Cited by 54 · see citing works
The role of mitochondrial dysfunction in Alzheimer's disease: A potential pathway to treatment
Reiss, A. B., Ahmed, S., Dayaramani, C., Glass, A. D., Gomolin, I. H., Pinkhasov, A., Stecker, M. M., Wısnıewskı, T., & Leon, J. D. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111828 · Cited by 54 · see citing works
Self-citationMika, A., Gaffney, M., Roller, R., Hills, A., Bouchet, C. A., Hulen, K. A., Thompson, R. S., Chichlowski, M., Berg, B. M., & Fleshner, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.052 · Cited by 51 · see citing works
[Epidemiology of Alzheimer's disease: latest trends].
Dumurgier, J., & Sabia, S. (2020) · PubMed · Cited by 51 · see citing works
Why have we Failed to Cure Alzheimer's Disease?
Korczyn, A. D. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110359 · Cited by 50 · see citing works
Vitamin K status and inflammation are associated with cognition in older Irish adults
Kiely, A.-M., Ferland, G., Ouliass, B., O’Toole, P. W., Purtill, H., & O’Connor, E. M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1536411 · Cited by 48 · see citing works
Effect of vitamin E and vitamin C combination on experimental influenza virus infection
Tantcheva, L., Stoeva, E., Galabov, A. S., et al. (2003) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2003.25.4.769673 · Cited by 47 · see citing works
Zandi, P. P. (2004) · Archives of Neurology · doi:10.1001/archneur.61.1.82 · Cited by 47 · see citing works
Gehlich, K. H., Beller, J., Lange‐Asschenfeldt, B., Köcher, W., Meinke, M. C., & Lademann, J. M. (2018) · Public Health Nutrition · doi:10.1017/s1368980018002525 · Cited by 40 · see citing works
Plasma Aβ, homocysteine, and cognition
Viswanathan, A., Raj, S., Greenberg, S. M., Stampfer, M. J., Campbell, S., Hyman, B. T., & Irizarry, M. C. (2009) · Neurology · doi:10.1212/01.wnl.0000339486.63862.db · Cited by 36 · see citing works
Katsuyama, H., IDEGUCHI, S., Fukunaga, M., Saijoh, K., & Sunami, S. (2002) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.48.207 · Cited by 35 · see citing works
INTESTINAL ABSOPPTION OF VITAMIN B6
Tsuji, T., Yamada, R., & Nose, Y. (1973) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.19.401 · Cited by 32 · see citing works
Puścion‐Jakubik, A., Mielech, A., Abramiuk, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.738549 · Cited by 30 · see citing works
Risk Factors and Screening Methods for Detecting Dementia: A Narrative Review
Stephan, B. C. M., & Brayne, C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141413 · Cited by 27 · see citing works
Alzheimer Disease Clinical Trials Targeting Amyloid
Reiss, A. B., Montufar, N., DeLeon, J. R., Pinkhasov, A., Gomolin, I. H., Glass, A. D., Arain, H. A., & Stecker, M. M. (2021) · The Neurologist · doi:10.1097/nrl.0000000000000320 · Cited by 27 · see citing works
Self-citationAlzheimer's Disease: Many Failed Trials, So Where Do We Go from Here?
Reiss, A. B., Glass, A. D., Wısnıewskı, T., Wolozin, B. L., Gomolin, I. H., Pinkhasov, A., Leon, J. D., & Stecker, M. M. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2020-001297 · Cited by 26 · see citing works
Self-citationRöhl, C., Armbrust, E., Herbst, E., Jess, A., Gülden, M., Maser, E., Rimbach, G. H., & Boesch, C. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9108-z · Cited by 24 · see citing works
Intra- and intercellular trafficking in sphingolipid metabolism in myelination
Wattenberg, B. W. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.11.002 · Cited by 21 · see citing works
Koike, T., Kuzuya, M., Kanda, S., Okada, K., Izawa, S., Enoki, H., & Iguchi, A. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.08.006 · Cited by 20 · see citing works
Vegetarian Dietary Patterns and Cognitive Function among Older Adults: The Adventist Health Study-2
Gatto, N. M., Garcia-Cano, J., Irani, C., Jaceldo‐Siegl, K., Liu, T., Chen, Z., Paul, J. L., Fraser, G. E., Wang, C., & Lee, G. J. (2021) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2021.1965939 · Cited by 19 · see citing works
Vitamin D in mild cognitive impairment and Alzheimer's disease. A study in older Greek adults.
Mavraki, E., Ioannidis, P., Tripsianis, G. A., et al. (2020) · PubMed · Cited by 16 · see citing works
THE IMPACT OF A PLANT-BASED DIETARY PATTERN ON DEMENTIA RISK: A PROSPECTIVE COHORT STUDY.
Lin, M., Chiu, T. H. T., Chang, C.-E., et al. (2019) · Innovation in Aging · doi:10.1093/geroni/igz038.2691 · Cited by 8 · see citing works
Ferland, G., Muhire, G., Racine, M.-C., et al. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa057_020 · Cited by 1 · see citing works
Berding, K., Long-Smith, C., Carbia, C., Bastiaanssen, T., van de Wouw, M., Wiley, N., Strain, C., Fouhy, F., Stanton, C., Cryan, J., et al. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05665-y
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Research works printed but not linked: 6
- [1]Garre-Olmo J. Epidemiology of Alzheimer’s disease and other dementias Rev. Neurol. 2018 66 377 386 Available online: https://europepmc.org/article/med/29790571 (accessed on 4 April 2022) 29790571
- [55]Khan K.M. Jialal I. Folic Acid Deficiency Available online: https://europepmc.org/article/nbk/nbk535377 (accessed on 11 June 2022)
- [58]Brown M.J. Ameer M.A. Beier K. Vitamin B6 Deficiency StatPearls StatPearls Publishing Treasure Island, FL, USA 2021 Available online: https://www.ncbi.nlm.nih.gov/pubmed/29261855 (accessed on 12 May 2022) 29261855
- [60]Panel on Dietary Antioxidants and Related Compounds, Subcommittee on Upper Reference Levels of Nutrients, Subcommittee on Interpretation and Uses of DRIs, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids National Academies Press Washington, DC, USA 2000 Available online: https://play.google.com/store/books/details?id=xlb6zAEACAAJ (accessed on 12 May 2022)
- [143]Sizar O. Khare S. Goyal A. Givler A. Vitamin D Deficiency StatPearls StatPearls Publishing Treasure Island, FL, USA 2022 Available online: https://www.ncbi.nlm.nih.gov/pubmed/30335299 (accessed on 10 May 2022)
- [148]Cole G.T. Basic Biology of Fungi Medical Microbiology Baron S. University of Texas Medical Branch at Galveston Galveston, TX, USA 2011 Available online: https://www.ncbi.nlm.nih.gov/pubmed/21413296 (accessed on 20 June 2022) 21413296
Cited by
Sorted by citations
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
- Authors
- Ding, H., Reiss, A. B., Pinkhasov, A., & Kasselman, L. J.
- Affiliations
- NYU Grossman Long Island School of Medicine (US)
- Corresponding author
- Kasselman, Lora J.
- Venue
- Medicina
- Publisher
- MDPI AG
- Published
- 2022-07-30
- Volume
- 58
- Issue
- 8
- Pages
- 1025
- ISSN
- 1010-660X (ISSN-L)
- 1648-9144
- PMC
- PMC9414574
- OpenAlex
- W4289175904
- Cited by
- 32
- References
- 197
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicina (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- NYU Lang (cc-by)
- Funders
- The Alzheimer’s Foundation of America (AWD00004772)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, dementia, plant-based diet, cognitive function, antioxidants, B vitamins, vitamin E, vitamin C, vitamin K, dietary fiber, vitamin D, Mediterranean diet, mushrooms, mild cognitive impairment, cognitive decline, anti-inflammatory activity
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Cognition, Vitamin E, Vitamins, Mice, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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