Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation
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Abstract Background Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. Subjects and methods We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations. Results Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 ± 9.51 and 134.19 ± 7.69 vs. 50.34 ± 4.22 ng/ml, p < 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 ± 4.48 vs. 65.80 ± 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. Nutritional status had no effect on ANGPTL3 and 4 mRNA expression in adipose tissue. Fasting decreased ANGPTL3 and increased ANGPTL4 levels, while VLCD reduced only ANGPTL3. Bariatric surgery and realimentation of AN or SBS patients had no effect on either ANGPTL. Multiple regression analysis identified BMI as an independent predictor of ANGPTL3; and BMI and HbA1c as independent predictors of ANGPTL4, respectively. Conclusions Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and AN.
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Serum ANGPTL4 is increased in obese patients (with or without T2DM), in patients who underwent bariatric surgery, and in fasting patients, while it is reduced in patients with anorexia.
“In addition, an increase in serum ANGPTL4 in obese patients (with or without T2DM) was observed, and the same was observed in patients who underwent bariatric surgery and in fasting patients, while it was reduced in patients with anorexia (Cinkajzlova et al., 2018).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Cinkajzlova et al., 2018
The Abstract (Results) reports higher serum ANGPTL4 in obese subjects with and without T2DM, lower levels in subjects with anorexia nervosa, and an increase during fasting. The Results (Effect of interventions; page unavailable) report elevated ANGPTL4 in the bariatric-surgery group before surgery, but not a sustained increase after surgery: levels fell at months 6 and 12 relative to month 1. Thus the claim is supported for obesity, fasting, and anorexia, but its wording about patients who underwent surgery obscures the timing of the increase. (LLM, conf=0.88)
Experimental — accuracy not yet measuredANGPTL4 is related to insulin sensitivity, lipid metabolism, adipogenesis, and the increase of circulating fatty acids generated mainly by chronic caloric restrictions, fasting, and aerobic physical training.
“The performance of this protein is related to several physiological processes, among them are insulin sensitivity, lipid metabolism, adipogenesis (Cinkajzlova et al., 2018), and the increase of circulating fatty acids, which are generated mainly by chronic caloric restrictions, fasting, and aerobic physical training (Raschke and Eckel, 2013).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Cinkajzlova et al., 2018
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- [37]Nidhina Haridas PA Regulation of angiopoietin-like proteins (ANGPTLs) 3 and 8 by insulin J. Clin. Endocrinol. Metab. 2015 100 E1299 E1307 10.1210/jc.2015-1254 26204133 · DOI
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Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works
“In addition, an increase in serum ANGPTL4 in obese patients (with or without T2DM) was observed, and the same was observed in patients who underwent bariatric surgery and in fasting patients, while it was reduced in patients with anorexia (Cinkajzlova et al., 2018).”
BackgroundResultHepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
- Authors
- Cinkajzlová, A., Mráz, M., Lacinová, Z., Kloučková, J., Kaválková, P., Kratochvílová, H., Trachta, P., Křížová, J., Haluzíková, D., Škrha, J., Papežová, H., & Haluzík, M.
- Affiliations
- Charles University (CZ)
- ORCID
- Venue
- Nutrition & Diabetes
- Published
- 2018-04-25
- Volume
- 8
- Issue
- 1
- Pages
- 21-21
- ISSN
- 2044-4052 (ISSN-L)
- PMC
- PMC5916880
- OpenAlex
- W2806386746
- Cited by
- 73
- References
- 36
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 13 · 2020: 15 · 2019: 10 · 2018: 3
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nutrition and Diabetes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- ANGPTL3, ANGPTL4, obesity, type 2 diabetes, anorexia nervosa, malnutrition, short bowel syndrome, very low calorie diet, bariatric surgery, refeeding, fasting, parenteral nutrition, adipose tissue gene expression, body mass index, HbA1c, glycolipid metabolism
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 4, Angiopoietin-Like Protein 3, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Obesity, Short Bowel Syndrome, Digestive System Surgical Procedures, Weight Loss, Treatment Outcome, Malnutrition, Bariatric Surgery
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