Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis
Abstract
A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis. Recently, we and several other groups have independently identified several molecules containing a coiled-coil domain and a fibrinogen-like domain, both of which are structurally conserved in angiopoietins. Because these molecules do not bind to the angiopoietin-specific receptor,TIE2, they have been named angiopoietin-related proteins (ARPs) or angiopoietin-like proteins (Angptls). ARPs/Angptls, which are all currently orphan ligands, also have potent activity for regulating angiogenesis as proangiogenic or antiangiogenic factors, suggesting that their receptors may be expressed on endothelial cells. In addition, ARPs/Angptls show pleiotropic effects not only on vascular cells but also on cells of other lineages, such as skin and chondrocyte cells. More recent studies have proposed that ARPs/Angptls are involved in various pathologies, such as tumor angiogenesis and metabolic diseases. To summarize the current findings relating to these proteins, we focus in this review on the functions of ARPs/Angptls as new angiogenic modulating factors in the vascular system and discuss the pleiotropic functions of ARPs/Angptls in nonvascular cell lineages.
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The XENO clusters within the xenograft tissue may be hypoxic because of a lack of vasculature and the wound healing process from the xenograft technique.
“suggesting that the XENO clusters within the xenograft tissue may be hypoxic because of a lack of vasculature and the wound healing process from the xenograft technique.”
From Single-cell transcriptomics of human-skin-equivalent organoids (2023) · cites this paper as [55]
THBS and ANGPTL signaling are known to promote angiogenesis.
“both are known to promote angiogenesis,54,55”
From Single-cell transcriptomics of human-skin-equivalent organoids (2023) · cites this paper as [55]
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- Authors
- Oike, Y., Yasunaga, K., & Suda, T.
- Affiliations
- Keio University (JP)
- Corresponding author
- Suda, Toshio
- Venue
- International Journal of Hematology
- Published
- 2004-07-01
- Volume
- 80
- Issue
- 1
- Pages
- 21-28
- ISSN
- 0925-5710 (ISSN-L)
- OpenAlex
- W2018906703
- Cited by
- 160
- References
- 53
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 7 · 2021: 13 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 14 · 2013: 10 · 2012: 7
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Hematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiopoietin-like proteins, angiogenesis, Tie2 receptor, coiled-coil domain, fibrinogen-like domain, endothelial cells, tumor angiogenesis, metabolic disorders, pleiotropic functions, chondrocytes, skin cells
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 2, Angiopoietin-Like Protein 1, Animals, Blood Proteins, Humans, Neovascularization, Physiologic, Intercellular Signaling Peptides and Proteins, Angiopoietins
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