Hypoxia-inducible factors: a central link between inflammation and cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works

The blockade of immune checkpoints in cancer immunotherapy

Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838 · see citing works

A genetic model for colorectal tumorigenesis

Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works

Pancreatic Cancer

Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516 · see citing works

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works

Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments

Grauer, O. M., Wesseling, P., & Adema, G. J. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00315.x · Cited by 4,025 · see citing works

Hypoxia-inducible factors in physiology and medicine

Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645 · see citing works

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works

The prognostic landscape of genes and infiltrating immune cells across human cancers

Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,096 · see citing works

Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid

Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046 · see citing works

Pancreatic cancer

Vincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,612 · see citing works

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502 · see citing works

Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Sato, E., Olson, S. H., Ahn, J., Bundy, B. N., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509182102 · Cited by 2,375 · see citing works

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation

Noman, M. Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., Bronte, V., & Chouaib, S. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131916 · Cited by 2,166 · see citing works

Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer

Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051424 · Cited by 2,135 · cited 1× · see citing works

Cancer immunotherapy via dendritic cells

Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,060 · see citing works

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works

Molecular Genetics of Colorectal Cancer

Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805 · see citing works

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Coffelt, S. B., Kersten, K., Doornebal, C. W., Weiden, J., Vrijland, K., Hau, C.-S., Verstegen, N. J. M., Ciampricotti, M., Hawinkels, L. J. A. C., Jonkers, J., et al. (2015) · Nature · doi:10.1038/nature14282 · Cited by 1,703 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · cited 1× · see citing works

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

Semenza, G. L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.01.005 · Cited by 1,514 · see citing works

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., et al. (2011) · Nature · doi:10.1038/nature10169 · Cited by 1,376 · see citing works

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327 · see citing works

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Talks, K. L., Turley, H., Gatter, K. C., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J., & Harris, A. L. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64554-3 · Cited by 1,312 · see citing works

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

Rodriguez, P. C., Quiceno, D. G., Zabaleta, J., Ortiz, B., Zea, A. H., Piazuelo, M. B., Delgado, A., Correa, P., Brayer, J., Sotomayor, E. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0465 · Cited by 1,276 · see citing works

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

Movahedi, K., Laoui, D., Gysemans, C. A., Baeten, M., Stangé, G. M., den Bossche, J. V., Mack, M., PIPELEERS, D. G., Veld, P. I. '., BAETSELIER, P. D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4672 · Cited by 1,229 · see citing works

HIF transcription factors, inflammation, and immunity

Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.008 · Cited by 1,195 · see citing works

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176 · see citing works

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136 · cited 1× · see citing works

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,131 · see citing works

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution

McGranahan, N., & Swanton, C. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.001 · Cited by 1,077 · see citing works

Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer

Lin, E. Y., Li, J.-F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X.-N., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1278 · Cited by 1,074 · see citing works

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Schwitalla, S., Fingerle, A. A., Cammareri, P., Nebelsiek, T., Göktuna, S. İ., Ziegler, P. K., Canli, Ö., Heijmans, J., Huels, D. J., Moreaux, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.12.012 · Cited by 1,057 · see citing works

Macrophages in Tumor Microenvironments and the Progression of Tumors

Hao, N.-B., Lü, M.-H., Fan, Y.-H., Cao, Y.-L., Zhang, Z.-R., & Yang, S.-M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/948098 · Cited by 1,003 · see citing works

Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells

Sato, K., Ozaki, K., Oh, I., Meguro, A., Hatanaka, K., Nagai, T., Muroi, K., & Ozawa, K. (2006) · Blood · doi:10.1182/blood-2006-02-002246 · Cited by 952 · see citing works

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma

Raval, R. R., Lau, K. W., Tran, M. G. B., Sowter, H. M., Mandriota, S. J., Li, J.-L., Pugh, C. W., Maxwell, P. H., Harris, A. L., & Ratcliffe, P. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5675-5686.2005 · Cited by 940 · see citing works

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891 · see citing works

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 854 · see citing works

Regulatory T cells: how do they suppress immune responses?

Sakaguchi, S., Wing, K., Onishi, Y., Martín, P. P., & Yamaguchi, T. (2009) · International Immunology · doi:10.1093/intimm/dxp095 · Cited by 850 · see citing works

Tumor-specific Th17-polarized cells eradicate large established melanoma

Muranski, P. J., Boni, A., Antony, P. A., Cassard, L., Irvine, K. R., Kaiser, A., Paulos, C. M., Palmer, D. C., Touloukian, C. E., Ptak, K., et al. (2008) · Blood · doi:10.1182/blood-2007-11-120998 · Cited by 846 · see citing works

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

Popivanova, B. K., Kitamura, K., Wu, Y., Kondo, T., Kagaya, T., Kaneko, S., Oshima, M., Fujii, C., & Mukaida, N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32453 · Cited by 845 · see citing works

PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

Boire, A. A., Covic, L., Agarwal, A., Jacques, S. L., Sherifi, S., & Kuliopulos, A. (2005) · Cell · doi:10.1016/j.cell.2004.12.018 · Cited by 841 · see citing works

Regulation of the Chemokine Receptor CXCR4 by Hypoxia

Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S. K., Doni, A., Rapisarda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030267 · Cited by 841 · see citing works

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.006 · Cited by 781 · see citing works

Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs

Wiesener, M. S., Jürgensen, J. S., Rosenberger, C., Scholze, C. K., Hörstrup, J. H., Warnecke, C., Mandriota, S. J., Bechmann, I., Frei, U. A., Pugh, C. W., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0445fje · Cited by 741 · see citing works

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasionPreprint

Gocheva, V., Wang, H., Gadea, B. B., Shree, T., Hunter, K. E., Garfall, A. L., Berman, T. A., & Joyce, J. A. (2010) · Genes & Development · doi:10.1101/gad.1874010 · Cited by 739 · see citing works

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Mabjeesh, N. J., Escuin, D., LaVallee, T. M., Pribluda, V. S., Swartz, G. M., Johnson, M. S., Willard, M. T., Zhong, H., Simons, J. W., & Giannakakou, P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00077-1 · Cited by 730 · see citing works

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

Rodrı́guez, P. C., & Ochoa, A. C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00608.x · Cited by 722 · see citing works

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

Mazzoni, A., Bronte, V., Visintin, A., Spitzer, J. H., Apolloni, E., Serafini, P., Zanovello, P., & Segal, D. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.689 · Cited by 692 · see citing works

Tumor antigen-specific T helper cells in cancer immunity and immunotherapy

Knutson, K. L., & Disis, M. L. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-004-0653-2 · Cited by 689 · see citing works

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

Wan, S., Zhao, E., Kryczek, I., Vatan, L., Sadovskaya, A., Ludema, G., Simeone, D. M., Zou, W., & Welling, T. H. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.039 · Cited by 676 · see citing works

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Doedens, A. L., Phan, A. T., Stradner, M. H., Fujimoto, J. K., Nguyen, J. V., Yang, E., Johnson, R. S., & Goldrath, A. W. (2013) · Nature Immunology · doi:10.1038/ni.2714 · Cited by 660 · see citing works

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W., & Johnson, R. S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1439 · Cited by 652 · see citing works

Stromal contribution to the colorectal cancer transcriptome

Isella, C., Terrasi, A., Bellomo, S. E., Petti, C., Galatola, G., Muratore, A., Mellano, A., Senetta, R., Cassenti, A., Sonetto, C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3224 · Cited by 640 · see citing works

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

Riabov, V., Gudima, A., Wang, N., Mickley, A., Orekhov, A. N., & Kzhyshkowska, J. G. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00075 · Cited by 631 · see citing works

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809763105 · Cited by 624 · see citing works

Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasisPreprint

Takeda, N., O'Dea, E. L., Doedens, A. L., Kim, J., Weidemann, A., Stockmann, C., Asagiri, M., Simon, M. C., Hoffmann, A., & Johnson, R. S. (2010) · Genes & Development · doi:10.1101/gad.1881410 · Cited by 621 · see citing works

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

Casazza, A., Laoui, D., Wenes, M., Rizzolio, S., Bassani, N., Mambretti, M., Deschoemaeker, S., Ginderachter, J. V. V., Tamagnone, L., & Mazzone, M. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.11.007 · Cited by 601 · see citing works

Tumor associated macrophages and neutrophils in cancer

Galdiero, M. R., Bonavita, E., Barajon, I., Garlanda, C., Mantovani, A., & Jaillon, S. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.06.003 · Cited by 597 · see citing works

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

Gu, Y.-Z., Moran, S. M., Hogenesch, J. B., Wartman, L. D., & Bradfield, C. A. (1998) · Europe PMC (PubMed Central) · Cited by 577 · see citing works

Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease

Munkholm, P. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.18.s2.2.x · Cited by 570 · see citing works

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560 · see citing works

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

Martínez‐Reyes, I., Diebold, L. P., Kong, H., Schieber, M., Huang, H., Hensley, C. T., Mehta, M., Wang, T., Santos, J. H., Woychik, R. P., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.12.002 · Cited by 512 · see citing works

MET is required for the recruitment of anti-tumoural neutrophils

Finisguerra, V., Conza, G. D., Matteo, M. D., Serneels, J., Costa, S., Thompson, A. A. R., Wauters, E., Walmsley, S. R., Prenen, H., Granot, Z., et al. (2015) · Nature · doi:10.1038/nature14407 · Cited by 494 · see citing works

CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis

Katoh, H., Wang, D., Daikoku, T., Sun, H., Dey, S. K., & DuBois, R. N. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.009 · Cited by 477 · see citing works

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Hellwig‐Bürgel, T., Rutkowski, K., Metzen, E., Fandrey, J., & JELKMANN, W. E. B. (1999) · Blood · doi:10.1182/blood.v94.5.1561.417a06_1561_1567 · Cited by 475 · see citing works

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

Campbell, E. L., Bruyninckx, W. J., Kelly, C. J., Glover, L. E., McNamee, E. N., Bowers, B., Bayless, A. J., Scully, M. M., Saeedi, B. J., Golden‐Mason, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.020 · Cited by 472 · see citing works

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Imtiyaz, H. Z., Williams, E. P., Hickey, M. M., Patel, S. A., Durham, A. C., Yuan, L.-J., Hammond, R., Gimotty, P. A., Keith, B., & Simon, M. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39506 · Cited by 461 · see citing works

Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK

Hagemann, T., Wilson, J. L., Kulbe, H., Li, N. F., Leinster, D. A., Charles, K. A., Klemm, F., Pukrop, T., Binder, C. R., & Balkwill, F. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.1197 · Cited by 433 · see citing works

Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

Kim, E. R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9872 · Cited by 420 · see citing works

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

Bonavita, E., Gentile, S., Rubino, M., Maina, V., Papait, R., Kunderfranco, P., Greco, C. M., Feruglio, F., Molgora, M., Laface, I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.004 · Cited by 417 · see citing works

Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

Jantsch, J., Chakravortty, D., Turza, N., Prechtel, A. T., Buchholz, B., Gerlach, R. G., Volke, M., Gläsner, J., Warnecke, C., Wiesener, M. S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4697 · Cited by 414 · see citing works

Macrophage Responses to Hypoxia

Lewis, C., & Murdoch, C. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62038-x · Cited by 413 · see citing works

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

Wiener, C. M., Booth, G., & Semenza, G. L. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1199 · Cited by 413 · see citing works

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

Laoui, D., Overmeire, E. V., Conza, G. D., Aldeni, C., Keirsse, J., Morias, Y., Movahedi, K., Houbracken, I., Schouppe, E., Elkrim, Y., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1196 · Cited by 410 · see citing works

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · see citing works

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

Chun, E., Lavoie, S., Michaud, M., Gallini, C. A., Kim, J., Soucy, G., Odze, R., Glickman, J. N., & Garrett, W. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.024 · Cited by 402 · cited 1× · see citing works

TNF signaling drives myeloid-derived suppressor cell accumulation

Zhao, X., Rong, L., Zhao, X., Li, X., Liu, X., Deng, J., Wu, H., Xu, X., Erben, U., Wu, P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64115 · Cited by 380 · see citing works

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368 · see citing works

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

Lu, T., Ramakrishnan, R., Altiok, S., Youn, J. I., Cheng, P., Celis, E., Писарев, В. М., Sherman, S., Sporn, M. B., & Gabrilovich, D. I. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45862 · Cited by 365 · see citing works

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

Sceneay, J., Chow, M. T., Chen, A., Halse, H. M., Wong, C. S. F., Andrews, D. M., Sloan, E. K., Parker, B. S., Bowtell, D. D. L., Smyth, M. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3873 · Cited by 365 · see citing works

Structural integration in hypoxia-inducible factors

Wu, D., Potluri, N., Lu, J., Kim, Y., & Rastinejad, F. (2015) · Nature · doi:10.1038/nature14883 · Cited by 346 · see citing works

T helper 17 cells play a critical pathogenic role in lung cancer

Chang, S. H., Mirabolfathinejad, S. G., Katta, H., Cumpian, A. M., Gong, L., Caetano, M. S., Moghaddam, S. J., & Dong, C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319051111 · Cited by 326 · see citing works

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Scheuermann, T. H., Li, Q., Ma, H.-W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1185 · Cited by 315 · see citing works

Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

Scheuermann, T. H., Tomchick, D. R., Machius, M., Guo, Y., Bruick, R. K., & Gardner, K. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808092106 · Cited by 301 · see citing works

A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α

Haddad, J. J., & Land, S. C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02833-2 · Cited by 270 · see citing works

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

Klages, K., Mayer, C. T., Lahl, K., Loddenkemper, C., Teng, M. W. L., Ngiow, S. F., Smyth, M. J., Hamann, A., Huehn, J., & Sparwasser, T. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1736 · Cited by 267 · see citing works

Hypoxia controls CD4+CD25+ regulatory T‐cell homeostasis via hypoxia‐inducible factor‐1α

Ben‐Shoshan, J., Maysel-Auslender, S., Mor, A., Keren, G., & George, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838318 · Cited by 260 · see citing works

Whole-exome Sequencing analyses of Inflammatory Bowel Disease-associated Colorectal Cancers

Robles, A., Traverso, G., Zhang, M., Roberts, N. J., Khan, M. A., Joseph, C. G., Lauwers, G., Selaru, F., Popoli, M., Pittman, M., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.036 · Cited by 252 · see citing works

Natural and Induced T Regulatory Cells in Cancer

Adeegbe, D. O., & Nishikawa, H. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00190 · Cited by 248 · see citing works

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

Tripathi, C., Tewari, B. N., Kanchan, R. K., Baghel, K. S., Nautiyal, N., Shrivastava, R., Kaur, H., Bhatt, M. L. B., & Bhadauria, S. (2014) · Oncotarget · doi:10.18632/oncotarget.2110 · Cited by 223 · see citing works

Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes

Lukashev, D., Klebanov, B., Kojima, H., Grinberg, A., Ohta, A., Berenfeld, L., Wenger, R. H., Ohta, A., & Sitkovsky, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.4962 · Cited by 208 · see citing works

Hif1α deletion reveals pro-neoplastic function of B cells in pancreatic neoplasia

Lee, K., Spata, M., Bayne, L., Buza, E., Durham, A., Allman, D., Vonderheide, R., & Simon, M. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0822 · Cited by 203 · see citing works

Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.

Leek, R., Talks, K., Pezzella, F., Turley, H., Campo, L., Brown, N. S., Bicknell, R., Taylor, M., Gatter, K. C., & Harris, A. L. (2002) · PubMed · Cited by 201 · see citing works

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

Zimmer, M., Ebert, B. L., Neil, C., Brenner, K., Papaioannou, I., Melas, A., Tolliday, N., Lamb, J., Pantopoulos, K., Golub, T., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.004 · Cited by 191 · see citing works

Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression.

Hlatky, L., Tsionou, C., Hahnfeldt, P., & Coleman, C. N. (1994) · PubMed · Cited by 189 · see citing works

Divergent effects of hypoxia on dendritic cell functions

Mancino, A., Schioppa, T., Larghi, P., Pasqualini, F., Nebuloni, M., Chen, I., Sozzani, S., Austyn, J. M., Mantovani, A., & Sica, A. (2008) · Blood · doi:10.1182/blood-2008-02-142091 · Cited by 186 · see citing works

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

Palazón, A., Martínez‐Forero, I., Teijeira, Á., Morales‐Kastresana, A., Alfaro, C., Sanmamed, M. F., Perez‐Gracia, J. L., Peñuelas, I., Hervás‐Stubbs, S., Rouzaut, A., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0314 · Cited by 186 · see citing works

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

Wang, L., Yi, T., Zhang, W., Pardoll, D. M., & Yu, H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0775 · Cited by 186 · see citing works

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

Blaisdell, A., Créquer-Grandhomme, A., Columbus, D., Daikoku, T., Mittal, K., Dey, S. K., & Erlebacher, A. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.11.005 · Cited by 176 · see citing works

“Of Mice and Men”: Arginine Metabolism in Macrophages

Thomas, A. C., & Mattila, J. T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00479 · Cited by 175 · see citing works

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

Xue, X., Ramakrishnan, S. K., Anderson, E. R., Taylor, M. J., Zimmermann, E. M., Spence, J. R., Huang, S., Greenson, J. K., & Shah, Y. M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.010 · Cited by 171 · see citing works

Expression of HIF‐1α by human macrophages: implications for the use of macrophages in hypoxia‐regulated cancer gene therapy

Burke, B., Tang, N., Corke, K. P., Tazzyman, D., Ameri, K., Wells, M. W., & Lewis, C. E. (2001) · The Journal of Pathology · doi:10.1002/path.1029 · Cited by 169 · see citing works

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

Branco-Price, C., Zhang, N., Schnelle, M., Evans, C., Katschinski, D. M., Liao, D., Ellies, L., & Johnson, R. S. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.11.017 · Cited by 168 · see citing works

Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses

Rabinowitz, M. H. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400386j · Cited by 165 · see citing works

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

Eckle, T. D. L. G., Brodsky, K. S., Bonney, M., Packard, T. A., Han, J., Borchers, C. H., Mariani, T. J., Kominsky, D. J., Mittelbronn, M. G. A., & Eltzschig, H. K. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001665 · Cited by 165 · see citing works

Adoptive Transfer of Tumor Reactive B Cells Confers Host T-Cell Immunity and Tumor Regression

Li, Q., Lao, X., Pan, Q., Ning, N., Yet, J., Xu, Y., Li, S., & Chang, A. E. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0207 · Cited by 158 · see citing works

The role of HIF in immunity and inflammation

Cummins, E. P., Keogh, C. E., Crean, D., & Taylor, C. T. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.12.004 · Cited by 153 · see citing works

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Thompson, A. A. R., Elks, P. M., Marriott, H. M., Eamsamarng, S., Higgins, K. R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E. E., et al. (2013) · Blood · doi:10.1182/blood-2013-05-500207 · Cited by 150 · see citing works

Hypoxia-Inducible Factor-2α Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

Xue, X., Taylor, M. J., Anderson, E. R., Hao, C., Qu, A., Greenson, J. K., Zimmermann, E. M., Gonzalez, F. J., & Shah, Y. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3836 · Cited by 146 · see citing works

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

Noman, M. Z., Janji, B., Hu, S., Wu, J. C., Martelli, F., Bronte, V., & Chouaı̈b, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0405 · Cited by 144 · see citing works

Helicobacter pylori in gastric carcinogenesis

Ahn, H. J., & Lee, D. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i12.455 · Cited by 135 · see citing works

Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α

Haddad, J. J., & Harb, H. L. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.009 · Cited by 134 · see citing works

HIF-2α deletion promotes Kras-driven lung tumor development

Mazumdar, J., Hickey, M. M., Pant, D. K., Durham, A. C., Sweet-Cordero, A., Vachani, A., Jacks, T., Chodosh, L. A., Kissil, J. L., Simon, M. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001296107 · Cited by 130 · see citing works

Efficient Treg depletion induces T‐cell infiltration and rejection of large tumors

Li, X., Kostareli, E., Suffner, J., Garbi, N., & Hämmerling, G. J. (2010) · European Journal of Immunology · doi:10.1002/eji.201041093 · Cited by 126 · see citing works

Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

Deng, B., Zhu, J., Wang, Y., Liu, T., Ding, Y., Xiao, W., Lu, G., Bo, P., & Shen, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063777 · Cited by 121 · see citing works

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

Siegert, I., Schödel, J., Nairz, M., Schatz, V., Dettmer, K., Dick, C., Kalucka, J., Franke, K., Ehrenschwender, M., Schley, G., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.005 · Cited by 110 · cited 1× · see citing works

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

Keely, S., Campbell, E. L., Baird, A. W., Hansbro, P. M., Shalwitz, R. A., Kotsakis, A., McNamee, E. N., Eltzschig, H. K., Kominsky, D., & Colgan, S. P. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.29 · Cited by 110 · see citing works

Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis

Shaykhiev, R., & Bals, R. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207096 · Cited by 109 · see citing works

A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level

Erapaneedi, R., Belousov, V. V., Schäfers, M. A., & Kiefer, F. (2015) · The EMBO Journal · doi:10.15252/embj.201592775 · Cited by 108 · see citing works

Hypoxia skews dendritic cells to a T helper type 2‐stimulating phenotype and promotes tumour cell migration by dendritic cell‐derived osteopontin

Yang, M., Ma, C., Liu, S., Sun, J., Shao, Q., Gao, W., Zhang, Y., Li, Z., Xie, Q., Dong, Z., et al. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.02954.x · Cited by 99 · see citing works

Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α–Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow

Kojima, H., Kobayashi, A., Sakurai, D., Kanno, Y., Hase, H., Takahashi, R., Totsuka, Y., Semenza, G. L., Sitkovsky, M. V., & Kobata, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800167 · Cited by 99 · see citing works

Topotecan Blocks Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Expression Induced by Insulin-Like Growth Factor-I in Neuroblastoma Cells

Beppu, K., Nakamura, K., Linehan, W. M., Rapisarda, A., & Thiele, C. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3332 · Cited by 96 · see citing works

Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1α Axis

Pencreach, E., Guérin, É., Nicolet, C., Lelong-Rebel, I. H., Voegeli, A., Oudet, P., Larsen, A. K., Gaub, M., & Guénot, D. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0889 · Cited by 88 · see citing works

B-cell Depletion Using an Anti-CD20 Antibody Augments Antitumor Immune Responses and Immunotherapy in Nonhematopoetic Murine Tumor Models

Kim, S., Fridlender, Z. G., Dunn, R., Kehry, M. R., Kapoor, V., Blouin, A., Kaiser, L. R., & Albelda, S. Μ. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31816d1d6a · Cited by 75 · see citing works

HIF-α/MIF and NF-κB/IL-6 Axes Contribute to the Recruitment of CD11b+Gr-1+ Myeloid Cells in Hypoxic Microenvironment of HNSCC

Zhu, G., Tang, Y., Geng, N., Zheng, M. H., Jiang, J. D., Li, L., Li, K., Lei, Z., Chen, W., Fan, Y., et al. (2014) · Neoplasia · doi:10.1593/neo.132034 · Cited by 73 · see citing works

Loss of Fibroblast HIF-1α Accelerates Tumorigenesis

Kim, J., Evans, C. E., Weidemann, A., Takeda, N., Lee, Y. S., Stockmann, C., Branco‐Price, C., Brandberg, F., Leone, G. W., Ostrowski, M. C., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0534 · Cited by 58 · see citing works

PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis

Criscimanna, A., Duan, L.-J., Rhodes, J., Fendrich, V., Wickline, E., Hartman, D., Monga, S., Lotze, M., Gittes, G., Fong, G., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0566 · Cited by 51 · see citing works

Augmentation of an Antitumor CTL Response In Vivo by Inhibition of Suppressor Macrophage Nitric Oxide

Medot-Pirenne, M., Heilman, M. J., Saxena, M., McDermott, P. E., & Mills, C. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5877 · Cited by 45 · see citing works

Activation of HIF-1α does not increase intestinal tumorigenesis

Xue, X., Ramakrishnan, S. K., & Shah, Y. M. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00112.2014 · Cited by 44 · see citing works

Optimal Population of FoxP3+ T Cells in Tumors Requires an Antigen Priming-Dependent Trafficking Receptor Switch

Wang, C., Lee, J. H., & Kim, C. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030793 · Cited by 30 · see citing works

Hepatitis C-related Hepatocellular Carcinoma: Prevalence Around the World, Factors Interacting, and Role of Genotypes

Mitra, A. (1999) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017995 · Cited by 19 · see citing works

18 F-Fluoromisonidazole PET Reveals Spatial and Temporal Heterogeneity of Hypoxia in Mouse Models of Human Non-Small-Cell Lung Cancer

Cui, Y., Wang, X., & Li, X. (2015) · Future Oncology · doi:10.2217/fon.15.205 · Cited by 6 · see citing works

The 2008 Dolph Adams Award and the State of the Journal of Leukocyte Biology

Oppenheim, J. J., & Rosenberg, H. F. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908999 · Cited by 4 · see citing works

Micro Regional Heterogeneity of 64Cu-ATSM and 18F-FDG Uptake in Canine Soft Tissue Sarcomas: Relation to Cell Proliferation, Hypoxia and Glycolysis

Zornhagen, K. W., Hansen, A. E., Oxboel, J., Clemmensen, A., Ali, H. H. E., Kristensen, A. T., & Kjær, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141379 · Cited by 4 · see citing works

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Jing, X., Yang, F., Shao, C., Wei, K., Xie, M., Shen, H., & Shu, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1089-9 · Cited by 2,054 · see citing works

The hypoxic tumour microenvironment

Petrova, V., Annicchiarico‐Petruzzelli, M., Melino, G., & Amelio, I. (2018) · Oncogenesis · doi:10.1038/s41389-017-0011-9 · Cited by 1,035 · see citing works

The immunology of renal cell carcinoma

Diaz-Montero, C. M., Rini, B. I., & Finke, J. H. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0316-3 · Cited by 439 · see citing works

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis

Kawanishi, S., Ohnishi, S., Ma, N., Hiraku, Y., & Murata, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081808 · Cited by 289 · see citing works

Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

Cytlak, U., Dyer, D. P., Honeychurch, J., Williams, K. J., Travis, M. A., & Illidge, T. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00568-1 · Cited by 262 · see citing works

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Sørensen, B. S., & Horsman, M. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00562 · Cited by 231 · see citing works

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Singhal, R., Mitta, S. R., Das, N. K., Kerk, S. A., Sajjakulnukit, P., Solanki, S., Andren, A., Kumar, R., Olive, K. P., Banerjee, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143691 · Cited by 215 · see citing works

Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

Hsu, Y., Hung, J., Chang, W., Jian, S., Lin, Y.-S., Pan, Y., Wu, C., & Kuo, P. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.016 · Cited by 208 · see citing works

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB

D’Ignazio, L., Batie, M., & Rocha, S. (2017) · Biomedicines · doi:10.3390/biomedicines5020021 · Cited by 206 · see citing works

The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells

Corre, I., Paris, F., & Huot, J. (2017) · Oncotarget · doi:10.18632/oncotarget.18264 · Cited by 195 · see citing works

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

Yu, T., Tang, B., & Sun, X. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.3.489 · Cited by 192 · see citing works

The B-Side of Cancer Immunity: The Underrated Tune

Largeot, A., Pagano, G., Gonder, S., Moussay, E., & Paggetti, J. (2019) · Cells · doi:10.3390/cells8050449 · Cited by 180 · see citing works

Hypoxia and HIF Signaling: One Axis with Divergent Effects

Corrado, C., & Fontana, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165611 · Cited by 182 · see citing works

Tumor Hypoxia as a Barrier in Cancer Therapy: Why Levels Matter

Hompland, T., Fjeldbo, C. S., & Lyng, H. (2021) · Cancers · doi:10.3390/cancers13030499 · Cited by 179 · see citing works

Hypoxia-inducible factors: key regulators of myeloid cells during inflammation

Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170 · see citing works

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice

Triner, D. A., Devenport, S. N., Ramakrishnan, S. K., Ma, X., Frieler, R. A., Greenson, J. K., Inohara, N., Núñez, G., Colacino, J. A., Mortensen, R. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.12.003 · Cited by 168 · see citing works

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Xie, C., Yagai, T., Luo, Y., Liang, X., Chen, T., Wang, Q., Sun, D., Zhao, J., Ramakrishnan, S. K., Sun, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4412 · Cited by 161 · see citing works

HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

Yan, Y., Liu, F., Han, L., Zhao, L., Chen, J., Olopade, O. I., He, M., & Wei, M. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0925-x · Cited by 161 · see citing works

Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

van Staalduinen, J., Baker, D., ten Dijke, P., & van Dam, H. (2018) · Oncogene · doi:10.1038/s41388-018-0378-x · Cited by 158 · see citing works

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Schwartz, A. J., Goyert, J. W., Solanki, S. A., Kerk, S. A., Chen, B., Castillo, C., Hsu, P. P., Do, B. T., Singhal, R., Dame, M. K., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00406-7 · Cited by 133 · see citing works

HIF-2α is indispensable for regulatory T cell function

Hsu, T.-S., Lin, Y.-L., Wang, Y.-A., Mo, S.-T., Chi, P.-Y., Lai, A. C.-Y., Pan, H.-Y., Chang, Y.-J., & Lai, M.-Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18731-y · Cited by 126 · see citing works

HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy

Salman, S., Meyers, D. J., Wicks, E. E., Lee, S. N., Datan, E., Thomas, A. M., Anders, N. M., Hwang, Y., Lyu, Y., Yang, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci156774 · Cited by 111 · see citing works

Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer

Markopoulos, G. S., Roupakia, E., Tokamani, M., Alabasi, G., Sandaltzopoulos, R., Marcu, K. B., & Kolettas, E. (2018) · Biomedicines · doi:10.3390/biomedicines6020040 · Cited by 112 · see citing works

Exosomes increased angiogenesis in papillary thyroid cancer microenvironment

Wu, F., Li, F., Lin, X., Xu, F., Cui, R., Zhong, J., Zhu, T., Shan, S., Liao, X., Yuan, L., et al. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0008 · Cited by 107 · see citing works

MYC as a Multifaceted Regulator of Tumor Microenvironment Leading to Metastasis

Meškytė, E. M., Keskas, S., & Ciribilli, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207710 · Cited by 105 · see citing works

Redox Role of ROS and Inflammation in Pulmonary Diseases

Zuo, L., & Wijegunawardana, D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-68748-9_11 · Cited by 103 · see citing works

Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications

Zhang, Y., Zhang, H., Wang, M., Schmid, T., Xin, Z., Kozhuharova, L., Yu, W.-K., Huang, Y., Cai, F., & Biskup, E. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652266 · Cited by 100 · see citing works

Unboxing the molecular modalities of mutagens in cancer

Kumari, S., Sharma, S., Advani, D., Khosla, A., Kumar, P., & Ambasta, R. K. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16726-w · Cited by 105 · see citing works

JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance

Sabaawy, H. E., Ryan, B. M., Khiabanian, H., & Pine, S. R. (2021) · Carcinogenesis · doi:10.1093/carcin/bgab075 · Cited by 101 · see citing works

Synergizing sunitinib and radiofrequency ablation to treat hepatocellular cancer by triggering the antitumor immune response

Qi, X., Yang, M. J., Ma, L., Sauer, M. A., Avella, D. M., Kaifi, J. T., Bryan, J. N., Cheng, K., Staveley-O’Carroll, K. F., Kimchi, E. T., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001038 · Cited by 96 · see citing works

COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment

Dong, X., Liu, T., Zhi, X., Zou, J., Zhong, J., Li, T., Mo, X.-L., Zhou, W., Guo, W., Liu, X., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2725 · Cited by 95 · see citing works

Hypoxia-mediated cancer stem cell resistance and targeted therapy

Sun, X., Lv, X., Yan, Y., Zhao, Y., Ma, R., He, M., & Wei, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110623 · Cited by 91 · see citing works

Controlled oxygen delivery to power tissue regeneration

Zoneff, E., Wang, Y., Jackson, C., Smith, O., Duchi, S., Onofrillo, C., Farrugia, B., Moulton, S. E., Williams, R., Parish, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48719-x · Cited by 89 · see citing works

Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1α activation

Wang, M., Yan, J., Cao, X., Hua, P., & Li, Z. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113775 · Cited by 83 · see citing works

Reactive Oxygen Species‐Mediated Tumor Microenvironment Transformation: The Mechanism of Radioresistant Gastric Cancer

Gu, H., Huang, T., Shen, Y., Liu, Y., Zhou, F., Jin, Y., Sattar, H., & Wei, Y. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5801209 · Cited by 83 · see citing works

Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio, and C-reactive Protein as New and Simple Prognostic Factors in Patients With Metastatic Renal Cell Cancer Treated With Tyrosine Kinase Inhibitors: A Systemic Review and Meta-analysis

Semeniuk-Wojtaś, A., Lubas, A., Stec, R., Syryło, T., Niemczyk, S., & Szczylik, C. A. (2018) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2018.01.010 · Cited by 81 · see citing works

The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming

Liu, Y., Ren, H., Zhou, Y., Shang, L., Zhang, Y., Yang, F., & Shi, X. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1219-7 · Cited by 81 · see citing works

3D culture technologies of cancer stem cells: promising ex vivo tumor models

Zhang, C., Yang, Z., Dong, D.-L., Jang, T., Knowles, J. C., Kim, H., Jin, G., & Xuan, Y. (2020) · Journal of Tissue Engineering · doi:10.1177/2041731420933407 · Cited by 79 · see citing works

Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation

Liu, S., Zhao, H., Hu, Y., Chang, Y. Z., Mi, Y., Li, X., Tao, D., & Qin, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05111-1 · Cited by 69 · see citing works

IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15‐Dependent BMI1 Stability

Zhang, L., Qiang, J., Yang, X., Wang, D., Rehman, A. U., He, X., Chen, W., Sheng, D., Zhou, L., Jiang, Y., et al. (2019) · Advanced Science · doi:10.1002/advs.201901728 · Cited by 66 · see citing works

Elastin is a key factor of tumor development in colorectal cancer

Li, J., Xu, X., Jiang, Y., Hansbro, N. G., Hansbro, P. M., Xu, J., & Liu, G. (2020) · BMC Cancer · doi:10.1186/s12885-020-6686-x · Cited by 64 · see citing works

Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling

Triner, D. A., Castillo, C., Hakim, J. B., Xue, X., Greenson, J. K., Núñez, G., Chen, G., Colacino, J. A., & Shah, Y. M. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00386-18 · Cited by 62 · see citing works

The ATP-binding cassette transporter ABCF1 is a hepatic oncofetal protein that promotes chemoresistance, EMT and cancer stemness in hepatocellular carcinoma

Fung, S. W., Cheung, P. F., Yip, C. W., Ng, L. W. C., Cheung, T. T., Chong, C. C. N., Lee, C. M., Lai, P. B. S., Chan, A. W. H., Tsao, G. S., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.010 · Cited by 62 · see citing works

Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection

Dey, S., Murmu, N., Mondal, T., Saha, I., Chatterjee, S., Manna, R., Haldar, S., Dash, S. K., Sarkar, T. R., & Giri, B. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113801 · Cited by 58 · see citing works

Insights into the New Cancer Therapy through Redox Homeostasis and Metabolic Shifts

Hyun, D. (2020) · Cancers · doi:10.3390/cancers12071822 · Cited by 57 · see citing works

Target of obstructive sleep apnea syndrome merge lung cancer: based on big data platform

Li, L., Lü, J., Xue, W., Wang, L., Zhai, Y., Fan, Z., Wu, G., Fan, F., Li, J., Zhang, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15372 · Cited by 53 · see citing works

EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC

Zhang, R., Lai, L., He, J., Chen, C., You, D., Duan, W., Dong, X., Zhu, Y., Lin, L., Shen, S., et al. (2019) · Epigenetics · doi:10.1080/15592294.2019.1573066 · Cited by 50 · see citing works

Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis

Carlo, S. E. D., Raffenne, J., Varet, H., Ode, A., Granados, D. C., Stein, M., Legendre, R., Tuckermann, J. P., Bousquet, C., & Peduto, L. (2023) · Nature Immunology · doi:10.1038/s41590-023-01642-7 · Cited by 49 · see citing works

The multifaceted role of YAP in the tumor microenvironment and its therapeutic implications in cancer

Kim, H., & Nam, J. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01551-9 · Cited by 51 · see citing works

Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review

Haibe, Y., Husseini, Z. E., Sayed, R. E., & Shamseddine, A. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176176 · Cited by 45 · see citing works

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ

Toss, M. S., Abidi, A., Lesche, D., Joseph, C., Mahale, S., Saunders, H., Kader, T., Miligy, I. M., Green, A. R., Gorringe, K. L., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0797-7 · Cited by 44 · see citing works

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Song, P., Zhang, J., Tan, X., Huang, Y., Xu, J., Silk, N., Zhang, D., Liu, Q., & Jiang, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.586857 · Cited by 42 · see citing works

The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation

Acuña-Pilarte, K., & Koh, M. Y. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.06.005 · Cited by 41 · see citing works

MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer

Hillestad, T., Hompland, T., Fjeldbo, C. S., Skingen, V. E., Salberg, U. B., Aarnes, E., Nilsen, A., Lund, K. V., Evensen, T. S., Kristensen, G. B., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0950 · Cited by 41 · see citing works

Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress

Tang, Y., Zhang, Z., Chen, Y., Qin, S., Zhou, L., Gao, W., & Shen, Z. (2022) · Antioxidants · doi:10.3390/antiox11071324 · Cited by 41 · see citing works

Therapeutic Modification of Hypoxia

Horsman, M. R., Sørensen, B. S., Busk, M., & Siemann, D. W. (2021) · Clinical Oncology · doi:10.1016/j.clon.2021.08.014 · Cited by 39 · see citing works

Hypoxia differently modulates the release of mitochondrial and nuclear DNA

Otandault, A., Abraham, J.-D., Dache, Z. A. A., Khalyfa, A., Jariel‐Encontre, I., Forné, T., Prévostel, C., Chouaı̈b, S., Gozal, D., & Thierry, A. R. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0716-y · Cited by 38 · see citing works

HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

Meng, X., Zhu, Y., Yang, W., Zhang, J., Jin, W., Tian, R., Yang, Z., & Wang, R. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.11.010 · Cited by 36 · see citing works

Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy

Coleman, M. F., Cozzo, A. J., Pfeil, A. J., Etigunta, S. K., & Hursting, S. D. (2020) · Cancers · doi:10.3390/cancers12040852 · Cited by 37 · see citing works

The prognostic outcome of ‘type 2 diabetes mellitus and breast cancer’ association pivots on hypoxia-hyperglycemia axis

Durrani, I. A., Bhatti, A., & John, P. C. L. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02040-5 · Cited by 36 · see citing works

Metallic Nanoparticles for the Modulation of Tumor Microenvironment; A New Horizon

Shariatzadeh, S., Moghimi, N., Khalafi, F., Shafiee, S., Mehrabi, M., Ilkhani, S., Tosan, F., Nakhaei, P., Alizadeh, A. M., Varma, R. S., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.847433 · Cited by 36 · see citing works

Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells

Gupta, N., Gaikwad, S. R., Kaushik, I., Wright, S. E., Markiewski, M. M., & Srivastava, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105150 · Cited by 35 · see citing works

Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review

Begagić, E., Bečulić, H., Džidić-Krivić, A., Vukas, S. K., Hadžić, S., Mekić–Abazović, A., Šegalo, S., Papić, E., Muchai, E., Pugonja, R., et al. (2024) · Cancers · doi:10.3390/cancers16112089 · Cited by 32 · see citing works

ARNT / HIF ‐1β links high‐risk 1q21 gain and microenvironmental hypoxia to drug resistance and poor prognosis in multiple myeloma

Wu, C., Yang, T., Liu, Y., Yi-cheng, L., Yang, Y., Liu, X., Liu, X., Ye, L., Sun, Y., Wang, X., et al. (2018) · Cancer Medicine · doi:10.1002/cam4.1596 · Cited by 32 · see citing works

HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development

Dzhalilova, D. S., & Makarova, O. V. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921100011 · Cited by 33 · see citing works

Hypoxia-Induced Signaling in Gut and Liver Pathobiology

Solanki, S. A., & Shah, Y. M. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051122-094743 · Cited by 32 · see citing works

Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1)

Raggi, F., & Bosco, M. C. (2020) · Cancers · doi:10.3390/cancers12051337 · Cited by 30 · see citing works

Therapeutic Opportunities of Targeting Histone Deacetylase Isoforms to Eradicate Cancer Stem Cells

Lin, P., Hsieh, H.-Y., Chu, P., & Chen, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071939 · Cited by 30 · see citing works

Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

Kwon, Y., Kim, Y., Jung, H. S., & Jeoung, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010051 · Cited by 29 · see citing works

Hypoxic stress suppresses lung tumor-secreted exosomal miR101 to activate macrophages and induce inflammation

Li, J., Xu, P., Wu, D., Guan, M.-J., Weng, X., Lu, Y., Zeng, Y., & Chen, R. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04030-x · Cited by 28 · see citing works

Hypoxia Shapes Autophagy in LPS-Activated Dendritic Cells

Monaci, S., Aldinucci, C., Rossi, D., Giuntini, G., Filippi, I., Ulivieri, C., Marotta, G., Sozzani, S., Carraro, F., & Naldini, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573646 · Cited by 27 · see citing works

Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer

Taneja, S., Vetter, S. W., & Leclerc, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158153 · Cited by 27 · see citing works

Hypoxia and Its Influence on Radiotherapy Response of HPV-Positive and HPV-Negative Head and Neck Cancer

Wegge, M., Dok, R., & Nuyts, S. (2021) · Cancers · doi:10.3390/cancers13235959 · Cited by 27 · see citing works

Single-cell RNA sequencing of baseline PBMCs predicts ICI efficacy and irAE severity in patients with NSCLC

Kim, G. D., Shin, S.-I., Sun, P., Lee, J. E., Chung, C., Kang, Y. E., Kang, D. H., & Park, J. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-011636 · Cited by 27 · see citing works

Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial–mesenchymal transition of colon cancer

Xiong, Z., Guo, M., Yu, Y., Zhang, F., Ge, M.-K., Chen, G., & Shen, S.-M. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw089 · Cited by 25 · see citing works

Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation

Suwannakul, N., Ma, N., Thanan, R., Pinlaor, S., Ungarreevittaya, P., Midorikawa, K., Hiraku, Y., Oikawa, S., Kawanishi, S., & Murata, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/4867234 · Cited by 25 · see citing works

Identification of Hypoxia Signature to Assess the Tumor Immune Microenvironment and Predict Prognosis in Patients with Ovarian Cancer

Wei, C., Liu, X., Wang, Q., Li, Q., & Xie, M. (2021) · International Journal of Endocrinology · doi:10.1155/2021/4156187 · Cited by 25 · see citing works

Hypoxia upregulates the expression of lncRNA H19 in non-small cell lung cancer cells and induces drug resistance

Li, H., Wang, J., Jin, Y., Lin, J., Gong, L., & Xu, Y. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-1812 · Cited by 24 · see citing works

Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients

Zhao, Z., Zhao, D., Ji, X., Wang, Y., & Wang, B. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00691 · Cited by 24 · see citing works

Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective

Aramini, B., Masciale, V., & Haider, K. H. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i6.406 · Cited by 23 · see citing works

A microfluidic co-culture model for investigating colonocytes–microbiota interactions in colorectal cancer

Penarete-Acosta, D., Stading, R. E., Emerson, L., Horn, M., Chakraborty, S., Han, A., & Jayaraman, A. (2024) · Lab on a Chip · doi:10.1039/d4lc00013g · Cited by 23 · see citing works

Navigating through the PD-1/PDL-1 Landscape: A Systematic Review and Meta-Analysis of Clinical Outcomes in Hepatocellular Carcinoma and Their Influence on Immunotherapy and Tumor Microenvironment

Ailia, M. J., Heo, J., & Yoo, S. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076495 · Cited by 22 · see citing works

Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer

Otálora-Otálora, B. A., López-Kleine, L., & Rojas, A. P. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45010029 · Cited by 20 · see citing works

Gastric Cancer Vascularization and the Contribution of Reactive Oxygen Species

Biagioni, A., Peri, S., Versienti, G., Fiorillo, C., Becatti, M., Magnelli, L., & Papucci, L. (2023) · Biomolecules · doi:10.3390/biom13060886 · Cited by 21 · see citing works

SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes

Ma, X., Das, N. K., Castillo, C., Gourani, A., Perekatt, A. O., Verzi, M. P., & Shah, Y. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005549 · Cited by 21 · see citing works

Critical roles of miR-21 in promotions angiogenesis: friend or foe?

Saadh, M. J., Jasim, N. Y., Ahmed, M. H., Ballal, S., Kumar, A., Atteri, S., Vashishth, R., Rizaev, J. A., Alhili, A., Jawad, M. J., et al. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01600-7 · Cited by 20 · see citing works

An Inflammatory Response Related Gene Signature Associated with Survival Outcome and Gemcitabine Response in Patients with Pancreatic Ductal Adenocarcinoma

Xiao, Z., Jin-yin, L., Yu, Q., Zhou, T., Duan, J., Yang, Z., Liu, C., & Xu, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.778294 · Cited by 20 · see citing works

Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation

Salem, D., Chelvanambi, M., Storkus, W. J., & Fecek, R. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629519 · Cited by 19 · see citing works

Tumor-related stress regulates functional plasticity of MDSCs

Mandula, J. K., & Rodrı́guez, P. C. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104312 · Cited by 18 · see citing works

Bone Marrow Macrophages Induce Inflammation by Efferocytosis of Apoptotic Prostate Cancer Cells via HIF-1α Stabilization

Mendoza‐Reinoso, V., Schnepp, P. M., Baek, D. Y., Rubin, J. R., Schipani, E., Keller, E. T., McCauley, L. K., & Roca, H. (2022) · Cells · doi:10.3390/cells11233712 · Cited by 18 · see citing works

HIF-2α affects proliferation and apoptosis of MG-63 osteosarcoma cells through MAPK signaling

Wang, Y., Wang, X., Su, X., & Liu, T. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6243 · Cited by 18 · see citing works

Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents

Horsman, M. R., Wittenborn, T. R., Nielsen, P. S., & Elming, P. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134778 · Cited by 18 · see citing works

PARP1 and PRC2 double deficiency promotes BRCA‐proficient breast cancer growth by modification of the tumor microenvironment

Yang, A., Choi, E., Park, M. S., Kim, S., Park, M., & Kim, M. (2020) · FEBS Journal · doi:10.1111/febs.15636 · Cited by 18 · see citing works

Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer

Bousquet, P. A., Meltzer, S., Sønstevold, L., Esbensen, Y., Dueland, S., Flatmark, K., Sitter, B., Bathen, T. F., Seierstad, T., Redalen, K. R., et al. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.09.010 · Cited by 18 · see citing works

Orchestration of Gut–Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic Innovation

Liu, A., Huang, M.-T., Xi, Y., Deng, X.-L., & Xu, K.-S. (2025) · Biomedicines · doi:10.3390/biomedicines13061422 · Cited by 16 · see citing works

Hypoxic Regulation of Neutrophils in Cancer

Triner, D. A., & Shah, Y. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174189 · Cited by 18 · see citing works

Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients

Chu, P., Wang, S.-M., Chen, P., Tang, F., & Chiang, E. I. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103153 · Cited by 17 · see citing works

iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation

Zhao, D. H., Zheng, S., Wang, X., Liu, H., Zhao, K., Li, L., & Hu, Y. (2022) · Oncogene · doi:10.1038/s41388-022-02234-9 · Cited by 17 · see citing works

Inflammation and tumor microenvironment.

Niu, T., & Zhou, F. (2023) · PubMed Central · doi:10.11817/j.issn.1672-7347.2023.230231 · Cited by 16 · see citing works

Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes

Hu, J., Meng, F., Hu, X., Huang, L., Liu, H., Liu, Z., & Li, L. (2020) · Leukemia Research · doi:10.1016/j.leukres.2020.106354 · Cited by 16 · see citing works

Hypoxia-inducible factors as key regulators of tumor inflammation

Mamlouk, S., & Wielockx, B. (2013) · International Journal of Cancer · doi:10.1002/ijc.27901 · Cited by 61 · see citing works

Hypoxia as a Modulator of Inflammation and Immune Response in Cancer

Castillo‐Rodríguez, R. A., Trejo‐Solís, C., Cabrera‐Cano, A., Gómez‐Manzo, S., & Dávila‐Borja, V. M. (2022) · Cancers · doi:10.3390/cancers14092291 · Cited by 69 · see citing works

Molecular pathways: hypoxia response in immune cells fighting or promoting cancer

Palazón, A., Aragonés, J., Morales-Kastresana, A., de Landázuri, M. O., & Melero, I. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1591 · Cited by 214 · see citing works

The relation of hypoxia-inducible factor with inflammation and tumor

Zhang, Y. (2007) · Zhongguo yaolixue tongbao

Hypoxia‐inducible factors in regulation of immune responses in tumour microenvironment

Kumar, V., & Gabrilovich, D. I. (2014) · Immunology · doi:10.1111/imm.12380 · Cited by 329 · see citing works