NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer
Abstract
Non-muscle myosin IIA (NMIIA) protein plays an important role in cell cytokinesis and cell migration. The role and underlying regulatory mechanisms of NMIIA in pancreatic cancer (PC) remain elusive. We found that NMIIA is highly expressed in PC tissues and contributes to PC poor progression by using open microarray datasets from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and PC tissue arrays. NMIIA regulates β-catenin mediated EMT to promote the proliferation, migration, invasion, and sphere formation of PC cells in vitro and in vivo. NMIIA controls the β-catenin transcriptional activity by interacting with β-catenin. Moreover, MEK/ERK signaling is critical in MLC2 (Ser19) phosphorylation, which can mediate NMIIA activity and regulate Wnt/β-catenin signaling. These findings highlight the significance of NMIIA in tumor regression and implicate NMIIA as a promising candidate for PC treatment.
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The Wnt/β-catenin pathway is among the key regulators of PDAC metastasis.
“Among the key regulators of PDAC metastasis is the Wnt/β‐catenin pathway.”
From Pyrvinium Pamoate Alone and With Gemcitabine Exhibits Anti‐Pancreatic Cancer Activity in <scp>2D</scp> and <scp>3D</scp> Cell Culture Models (2024) · cites this paper as [42]
Upon activation, the Wnt/β-catenin pathway leads to translocation of β-catenin into the nucleus where it facilitates transcription of genes that induce EMT, invasion and migration to distant sites.
“Upon activation, this pathway leads to the translocation of β‐catenin into the nucleus where it facilitates the transcription of genes that induce EMT, invasion and migration to distant sites [41, 42]”
From Pyrvinium Pamoate Alone and With Gemcitabine Exhibits Anti‐Pancreatic Cancer Activity in <scp>2D</scp> and <scp>3D</scp> Cell Culture Models (2024) · cites this paper as [42]
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Self-citation
- Authors
- Zhou, P., Li, Y., Li, B., Zhang, M., Liu, Y., Yao, Y., & Li, D.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Second Military Medical University (CN)
- Nanjing Medical University (CN)
- Corresponding author
- Liu, Yuanhua
- Li, Dong
- Venue
- Oncogene
- Published
- 2019-04-09
- Volume
- 38
- Issue
- 27
- Pages
- 5500-5515
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2939437655
- Cited by
- 108
- References
- 63
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 13 · 2023: 14 · 2022: 34 · 2021: 19 · 2020: 16 · 2019: 4
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Innovation Program for Ph.D. students in Shanghai Jiaotong University School of Medicine
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- non-muscle myosin IIA, pancreatic cancer, Wnt/β-catenin signaling, epithelial-mesenchymal transition, tumor growth, metastasis, MEK/ERK signaling, myosin light chain 2 phosphorylation, cell proliferation, cell migration and invasion, tumor sphere formation
- MeSH terms
- Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Pancreatic Neoplasms, Myosin Heavy Chains, Cell Proliferation, beta Catenin, Epithelial-Mesenchymal Transition, Wnt Signaling Pathway
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