Ras protein abundance correlates with Ras isoform mutation patterns in cancer

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The Frequency of Ras Mutations in Cancer

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RAS isoforms and mutations in cancer at a glance

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A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

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Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

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Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding

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CAIcal: A combined set of tools to assess codon usage adaptation

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K-ras is an essential gene in the mouse with partial functional overlap with N-rasPreprint

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis

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Targeted Degradation of Oncogenic KRAS ^G12C by VHL-Recruiting PROTACs

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Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

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A model for RAS mutation patterns in cancers: finding the sweet spot

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Translation is a non-uniform process

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K-Ras is essential for the development of the mouse embryo

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Isotope dilution strategies for absolute quantitative proteomics

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Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development

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K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

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Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy

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Mutant proteins as cancer-specific biomarkers

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Rare Codons Regulate KRas Oncogenesis

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Protein Standard Absolute Quantification (PSAQ) for improved investigation of staphylococcal food poisoning outbreaks

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Replacement of K‐Ras with H‐Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice

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Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

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While K-ras Is Essential for MouseDevelopment, Expression of the K-ras 4A Splice VariantIsDispensable

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Ras isoform abundance and signalling in human cancer cell lines

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Rare codons capacitate Kras-driven de novo tumorigenesis

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A rare codon-based translational program of cell proliferation

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Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras- Driven Hematopoietic Transformation

Xu, J., Haigis, K. M., Firestone, A. J., McNerney, M. E., Li, Q., Davis, E., Chen, S.-C., Nakitandwe, J., Downing, J. R., Jacks, T., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0096 · Cited by 68 · see citing works

Quantification of spatiotemporal patterns of Ras isoform expression during development

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Absolute Quantification of Endogenous Ras Isoform Abundance

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Mutation bias within oncogene families is related to proliferation-specific codon usage

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Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes

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Oncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer Cells

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Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice

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Signaling levels mold the RAS mutation tropism of urethane

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Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo

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Absolute Quantitation of GTPase Protein Abundance

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Protein conformational ensembles in function: roles and mechanisms

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MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer

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Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution

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Gastric intestinal metaplasia: progress and remaining challenges

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Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

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D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities

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Emerging landscape of KRAS inhibitors in cancer treatment

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Pioneer in Molecular Biology: Conformational Ensembles in Molecular Recognition, Allostery, and Cell Function

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Recapitulating the potential contribution of protein S-palmitoylation in cancer

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Ultrasensitive and High‐Resolution Protein Spatially Decoding Framework for Tumor Extracellular Vesicles

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Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib

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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle

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Differential functions of the KRAS splice variants

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RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

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Design, synthesis, and antitumor activity evaluation of BF3-o, m, p-phenylenediamine bridged with pyrimidine-indole BF3 adduction derivatives

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The ubiquitin code of RAS proteins: Decoding its role in cancer progression

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Experimental variables determine the outcome of RAS-RAS interactions

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Development of Receptor Desolvation Scoring and Covalent Sampling in DOCK 6: Methods Evaluated on a RAS Test Set

Tan, Y. S., Chakrabarti, M., Stein, R. M., Prentis, L. E., Rizzo, R. C., Kurtzman, T., Fischer, M. M., & Balius, T. E. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01623 · Cited by 6 · see citing works

Wild-type RAS signaling is an essential therapeutic target in RAS -mutated cancers

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The impact of RAS on cell differentiation in health and disease

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Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus

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MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Lange, T. E., Naji, A. K., van der Hoeven, R., Liang, H., Zhou, Y., Hammond, G. R. V., Hancock, J. F., & Cho, K. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202403126 · Cited by 5 · see citing works

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass

Simanshu, D. K., & McCormick, F. P. (2026) · Biochemical Journal · doi:10.1042/bcj20250142 · Cited by 4 · see citing works

Ras/Raf dimerization model for activation of Raf kinase

de Barros, M., Labrie, G., & Mattos, C. (2025) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2025.103150 · Cited by 4 · see citing works

RAS GTPases and Interleaflet Coupling in the Plasma MembranePreprint

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In Silico Identification of Selective KRAS G12D Inhibitor via Machine Learning‐Based Molecular Docking Combined with Molecular Dynamics Simulation

Nadee, P., Prompat, N., Yamabhai, M., Sangkhathat, S., Benjakul, S., Tipmanee, V., & Saetang, J. (2024) · Advanced Theory and Simulations · doi:10.1002/adts.202400489 · Cited by 3 · see citing works

LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression

Shah, K. K., Anastasakou, E., Sejour, L., Wang, Y., Wert-Lamas, L., Rauchet, C., Studer, S., Goller, S. G., Distel, R. J., Marasco, W. A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115608 · Cited by 3 · see citing works

Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans

Lyu, H., & Chamberlin, H. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050577 · Cited by 3 · see citing works

KRAS inhibitors in drug resistance and potential for combination therapy

Rathod, L. S., Sakle, N. S., & Mokale, S. N. (2024) · Tumori Journal · doi:10.1177/03008916241289206 · Cited by 2 · see citing works

Rac1 selectively binds a specific lamellipodin isoform via a noncanonical helical interface

Gao, T., Zhang, P., Kurimchak, A. M., Duncan, J. S., & Wu, J. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111023 · Cited by 2 · see citing works

Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling

Zhang, R., Huetzen, M. A., Binici, A., Martín‐Gago, P., Gasper, R., Rudashevskaya, E. L., Liu, J., Nagaraju, C., Reckzeh, E. S., Stuedle, A. S. T., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02082 · Cited by 2 · see citing works

KRAS is required for plexiform neurofibroma formation and represents a targetable vulnerability in established tumors

Hu, L., Ahmari, N., Schaeper, A., Pundavela, J., Kim, M., Dombi, E., Wu, J., Brunmair, J., Petronczki, Ö. Y., & Ratner, N. (2026) · Science Advances · doi:10.1126/sciadv.aeg3475 · Cited by 2 · see citing works

Computational screening of phytochemicals targeting mutant KRAS in colorectal cancer

Arooj, M., Mateen, R. M., Javed, M., Ali, M., Fareed, M. I., Parveen, R., Bahadur, A., Iqbal, S., Mahmood, S., Knani, S., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-14229-z · Cited by 2 · see citing works

Baseline expression of c-Myc defines the tissue specificity of oncogenic K-RasPreprint

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Multifunctional antimicrobial properties of Rosmarinus officinalis L.: in silico bioactivity prediction, molecular docking, and in vitro evaluation

Almowallad, S. J., Alanazi, S. S., Obidan, A., Alsulami, S. O., Younis, F. A., & Alwabsi, H. A. (2025) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-025-00541-9 · Cited by 1 · see citing works

Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation

Ivanišević, T., Ma, Y., Boxel, E. V., Magits, W., Lechat, B., Koçberber, Z., Willnow, P., Fendt, S., Velde, G. V., Sewduth, R. N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67109-5 · Cited by 2 · see citing works

Lnc-ing the Hallmarks of Cancer: The Interplay between lncRNAs and the p53 Family Members across the Hallmarks of Cancer

Deshpande, A. A., Lockhart, J. H., Napoli, M., & Flores, E. R. (2026) · Molecular and Cellular Biology · doi:10.1080/10985549.2026.2662223 · Cited by 1 · see citing works

Repurposing melatonin for its potential roles in gastrointestinal cancers: highlighting the molecular mechanisms

Yousefipour, K., Rohani, S. S. R., Hosseini, S. M. M., Kafilzadeh, K., Alavi, N. S., & Firouzabadi, N. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04351-x · Cited by 1 · see citing works

Magnesium as a conformational gatekeeper of KRAS : Structural dynamics and therapeutic implications

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ADCs for colorectal carcinoma: decoding clinical evidence for molecular design innovation

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An updated patent review of antitumor macrocyclic kinase inhibitors (2019 present)

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The tumor suppressor p53 mutational status controls epithelial 3D cell growth under mechanical compressionPreprint

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HPV-18-Immortalised Cells Require the Downregulation of the SncmtRNA-2/Hsa-miR-620 Axis During Cell Transformation

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Rare Codons Regulate KRas Oncogenesis

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Absolute Quantification of Endogenous Ras Isoform Abundance

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