History and progress of hypotheses and clinical trials for Alzheimer’s disease

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

IDH1 and IDH2 Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Understanding and controlling amyloid aggregation with chirality

Foley, A. R., & Raskatov, J. A. (2021) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2021.01.003 · Cited by 27

Medicare and the Shocking US Food and Drug Administration Approval of Aducanumab

Crosson, F. J., Covinsky, K. E., & Redberg, R. F. (2021) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2021.4610 · Cited by 27

Multipharmacophore strategy in medicinal chemistry for the design of drugs for the treatment of Alzheimer’s and some other neurodegenerative diseases

Бачурин, С. О., Aksinenko, A. Y., Махаева, Г. Ф., & Shevtsova, E. F. (2023) · Russian Chemical Bulletin · doi:10.1007/s11172-023-3718-0 · Cited by 28

Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization

Madhav, H., Abdel‐Rahman, S. A., Hashmi, M. A., Rahman, M. A., Rehan, M., Pal, K., Nayeem, S. M., Gabr, M. T., & Hoda, N. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115354 · Cited by 27

Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease

Ren, Z., Yang, H., Zhu, C., Fan, D., & Deng, J. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0007 · Cited by 27

Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach

Xu, M., Zhou, M., Li, S., Zhen, X., & Yang, S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24805 · Cited by 27

Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms

Khan, S., Bano, N., Ahamad, S., John, U., Dar, N. J., & Bhat, S. A. (2024) · Aging and Disease · doi:10.14336/ad.2024.0125-1 · Cited by 27

Identification of Butyrylcholinesterase and Monoamine Oxidase B Targeted Ligands and their Putative Application in Alzheimer’s Treatment: A Computational Strategy

Jabir, N. R., Rehman, M. T., Tabrez, S. S. M., Alserihi, R. F., Alajmi, M. F., Khan, M. S., Husain, F. M., & Ahmed, A. B. A. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210226123240 · Cited by 27

Unraveling the Speciation of β-Amyloid Peptides during the Aggregation Process by Taylor Dispersion Analysis

Deleanu, M., Hernandez, J., Cipelletti, L., Biron, J., Rossi, E., Taverna, M., Cottet, H., & Chamieh, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00527 · Cited by 26

Clinically oriented Alzheimer's biosensors: expanding the horizons towards point-of-care diagnostics and beyond

Murti, B. T., Putri, A. D., Huang, Y., Wei, S.-M., Peng, C., & Yang, P. (2021) · RSC Advances · doi:10.1039/d1ra01553b · Cited by 28

The elusive role of herpesviruses in Alzheimer’s disease: current evidence and future directions

Piotrowski, S. L., Tucker, A., & Jacobson, S. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0011 · Cited by 24

In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model

Kumar, N., Jangid, K., Kumar, V., Yadav, R. P., Mishra, J., Upadhayay, S., Kumar, V., Devi, B., Kumar, V., Dwivedi, A. R., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00007 · Cited by 25

Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice

Degiorgis, L., Karatas, M., Sourty, M., Faivre, É., Lamy, J., Noblet, V., Bienert, T., Reisert, M., von Elverfeldt, D., Buée, L., et al. (2020) · Brain · doi:10.1093/brain/awaa312 · Cited by 27

Extracellular vesicles drive tau spreading in Alzheimer's disease

Ruan, Z. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.317975 · Cited by 25

A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimer’s Disease

Mitra, S., Gera, R., Linderoth, B., Lind, G., Wahlberg, L. U., Almqvist, P. M., Behbahani, H., & Eriksdotter, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-74046-7_11 · Cited by 27

(‐)‐cis‐Carveol, a Natural Compound, Improves β‐Amyloid‐Peptide 1‐42‐Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Hriţcu, L., Boiangiu, R. Ş., de Morais, M. C., & de Sousa, D. P. (2020) · BioMed Research International · doi:10.1155/2020/8082560 · Cited by 25

Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer’s disease: A 1 H-[ 13 C]-NMR study

Soni, N. D., Ramesh, A., Roy, D., & Patel, A. B. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x21996176 · Cited by 24

Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?

Prasanna, P., Rathee, S., Rahul, V., Mandal, D., Goud, M. S. C., Yadav, P., Hawthorne, S. J., Sharma, A., Gupta, P. K., Ojha, S. K., et al. (2021) · Life · doi:10.3390/life11101022 · Cited by 25

Mesenchymal Stem Cells Modulate SIRT1/MiR-134/GSK3β Signaling Pathway in a Rat Model of Alzheimer's Disease

Abo-Zaid, O. A., Sallam, M. W., & Ahmed, E. S. A. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.26 · Cited by 24

Correlation Between Brain Structure Atrophy and Plasma Amyloid-β and Phosphorylated Tau in Patients With Alzheimer’s Disease and Amnestic Mild Cognitive Impairment Explored by Surface-Based Morphometry

Li, K., Qu, H., Ma, M., Xia, C., Cai, M., Han, F., Zhang, Q., Gu, X., & Ma, Q. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.816043 · Cited by 24

A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021

Trejo-Castro, A. I., Carrión-Álvarez, D., Martínez‐Torteya, A., & Rangel‐Escareño, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.804177 · Cited by 24

Cytotoxicity, uptake and accumulation of selenium nanoparticles and other selenium species in neuroblastoma cell lines related to Alzheimer's disease by using cytotoxicity assays, TEM and single cell-ICP-MS

Vicente-Zurdo, D., Gómez-Gómez, B., Romero, I., Rosales‐Conrado, N., León‐González, M. E., & Madrid, Y. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.340949 · Cited by 24

Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration

Espay, A. J., Herrup, K., & Daly, T. P. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85538-9.00008-0 · Cited by 27

ALZHEIMER’S DISEASE AND ITS RELATIONSHIP WITH THE MICROBIOTA-GUT-BRAIN AXIS

Faulin, T. D. E. S., & Estadella, D. (2023) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202301000-17 · Cited by 25

Emerging Evidence for the Use of Antidiabetic Drugs, Glucagon-like Peptide 1 Receptor Agonists, for the Treatment of Alzheimer’s Disease

Colin, I. M., Szczepanski, L. W., Gérard, A.-C., & Elosegi, J. A. (2023) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2023.19.1.16 · Cited by 25

Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice

Jing, S., Wang, X., Zhang, Z., Cao, D., Huang, K., Wang, Y., Liu, Z., Su, S., & Wang, Q. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01250-2 · Cited by 24

Ginsenoside Rh4 Alleviates Amyloid β Plaque and Tau Hyperphosphorylation by Regulating Neuroinflammation and the Glycogen Synthase Kinase 3β Signaling Pathway

Ren, Z., Yang, H., Zhu, C., Deng, J., & Fan, D. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02550 · Cited by 23

Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of Alzheimer's disease

Shankar, G., Kumar, P., Rai, S., Ghosh, A., Varma, T., Wani, M. A., Kumar, S., Mandloi, U., Singh, G. K., Garg, P., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117066 · Cited by 23

Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

Qin, T., Prins, S., Groeneveld, G. J., van Westen, G. J. P., de Vries, H. E., Wong, Y. C., Bischoff, L. J. M., & de Lange, E. C. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093158 · Cited by 24

Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease

Ohashi, Y. (2021) · Autophagy · doi:10.1080/15548627.2021.1872240 · Cited by 24

Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

Karabicici, M., Azbazdar, Y., İşcan, E., & Özhan, G. (2021) · Membranes · doi:10.3390/membranes11110844 · Cited by 23

Unraveling Aβ-Mediated Multi-Pathway Calcium Dynamics in Astrocytes: Implications for Alzheimer’s Disease Treatment From Simulations

Liu, L., Gao, H., Zaikin, A. A., & Chen, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.767892 · Cited by 23

Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells

Yao, X., Zhang, J., Lu, Y.-F., Deng, Y., Zhao, R., & Xiao, S. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00591 · Cited by 23

Association between Galectin Levels and Neurodegenerative Diseases: Systematic Review and Meta-Analysis

Ramos-Martínez, E. G., Ramos-Martínez, I. E., Sánchez‐Betancourt, J. I., Ramos-Martínez, J. C., Peña‐Corona, S. I., Valencia‐Ortega, J., Saucedo, R., Almeida-Aguirre, E. K. P., & Cerbón, M. A. (2022) · Biomolecules · doi:10.3390/biom12081062 · Cited by 23

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

Zota, I., Chanoumidou, K., Gravanis, A., & Charalampopoulos, I. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1422130 · Cited by 25

Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

Cutuli, D., Landolfo, E., Decandia, D., Nobili, A., Viscomi, M. T., Barbera, L. L., Sacchetti, S., Bartolo, P. D., Curci, A., D’Amelio, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051741 · Cited by 25

Novel N‐benzylpiperidine derivatives of 5‐arylisoxazole‐3‐carboxamides as anti‐Alzheimer's agents

Saeedi, M., Felegari, P., Iraji, A., Hariri, R., Rastegari, A., Mirfazli, S. S., Edraki, N., Firuzi, O., Mahdavi, M. R., & Akbarzadeh, T. (2020) · Archiv der Pharmazie · doi:10.1002/ardp.202000258 · Cited by 22

The Beneficial Role of Natural Endocrine Disruptors: Phytoestrogens in Alzheimer’s Disease

Domańska, A., Orzechowski, A., Litwiniuk, A., Kalisz, M., Bik, W., & Baranowska-Bik, A. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3961445 · Cited by 24

Site-specific mitochondrial dysfunction in neurodegeneration

Vodičková, A., Koren, S. A., & Wojtovich, A. P. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.02.004 · Cited by 22

Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4

Hou, X., Zhang, X., Zou, H., Guan, M., Fu, C., Wang, W., Zhang, Z.-R., Geng, Y., & Chen, Y. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.024 · Cited by 23

Amyloid-β in Alzheimer’s Disease: A Study of Citation Practices of the Amyloid Cascade Hypothesis Between 1992 and 2019

Daly, T. P., Houot, M., Barberousse, A., Agid, Y., & Epelbaum, S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191321 · Cited by 22

Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials

Zarini-Gakiye, E., Amini, J., Sanadgol, N., Vaezi, G., & Kazem, P. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200422090135 · Cited by 22

The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathology: A role for the neuroimmune system and epigenetics

Coleman, L. G., Crews, F. T., & Vetreno, R. P. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.08.001 · Cited by 26

A Peptide‐Polyphenol Coated Polypyrrole Nanoparticle for Synergetic Attenuation of Aggregation and Cytotoxicity of Amyloid‐β Fibrils

Zhang, Z., Lv, M., Liu, Y., Qin, J., Fan, Z., & Du, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401208 · Cited by 21

Transferrin decorated-nanostructured lipid carriers (NLCs) are a promising delivery system for rapamycin in Alzheimer's disease: An in vivo study

Khonsari, F., Heydari, M., Sharifzadeh, M. S., Valizadeh, H., Dinarvand, R., & Atyabi, F. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212827 · Cited by 21

Extraction, purification, structural characteristics and biological properties of the polysaccharides from Armillaria mellea (Vahl) P. Kumm.: A review

Chen, X., Liu, Y., Ren, L., Dai, X., Zhao, J., Gao, C., Zhang, S., Dong, J., Zhao, Z., Li, Y., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.129175 · Cited by 21

New 1,2,4-oxadiazole derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease: design, synthesis, and biological evaluation

Ayoup, M. S., Ghanem, M., Abdel‐Hamid, H., Abu-Serie, M. M., Masoud, A. A., Ghareeb, D. A., Hawsawi, M. B., Sonousi, A. S. M., & Kassab, A. E. (2024) · BMC Chemistry · doi:10.1186/s13065-024-01235-x · Cited by 21

The Advancements of Marine Natural Products in the Treatment of Alzheimer’s Disease: A Study Based on Cell and Animal Experiments

Jia, C., Chai, J., Zhang, S., Sun, Y., He, L., Sang, Z., Chen, D., & Zheng, X. (2025) · Marine Drugs · doi:10.3390/md23030091 · Cited by 21

Chromeno[3,4-b]xanthones as First-in-Class AChE and Aβ Aggregation Dual-Inhibitors

Malafaia, D., de Oliveira, A. L. N., Fernandes, P. A., Ramos, M. J., Albuquerque, H. M. T., & Silva, A. M. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084145 · Cited by 21

Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer’s Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping

Westi, E. W., Molhemi, S., Hansen, C. T., Skoven, C. S., Knopper, R. W., Ahmad, D., Rindshøj, M. B., Ameen, A. O., Hansen, B., Kohlmeier, K. A., et al. (2024) · Biomolecules · doi:10.3390/biom14101294 · Cited by 21

Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway

Wu, Y., Wei, M., Wang, M., Guo, M., Yu, H., Chen, Y., Xu, T., & Zhou, Y. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156612 · Cited by 20

Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia

Lin, J., Shao, X., Shi, T., Wang, H., Zhang, P., Zhou, Y., Liu, N., He, Y., Fang, D., Shi, Y., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01075-5 · Cited by 20

Saturation Transfer MRI for Detection of Metabolic and Microstructural Impairments Underlying Neurodegeneration in Alzheimer’s Disease

Orzyłowska, A., & Oakden, W. (2021) · Brain Sciences · doi:10.3390/brainsci12010053 · Cited by 20

Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer’s Disease, Parkinson’s Disease, or Frontotemporal Dementia: Implications for Patient Survival

Sabbir, M. G., Speth, R. C., & Albensi, B. C. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220766 · Cited by 20

Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds

Qiu, W., Liu, H., Liu, Y., Lü, X., Wang, L., Hu, Y., Feng, F., Li, Q., & Sun, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21947 · Cited by 20

Synthesis, in silico and in vitro studies of hydrazide‐hydrazone imine derivatives as potential cholinesterase inhibitors

Güngör, S. A. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14274 · Cited by 20

Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer’s disease

He, J., & Tam, K. Y. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.103914 · Cited by 20

Navigating the Maze of Alzheimer’s disease by exploring BACE1: Discovery, current scenario, and future prospects

Iram, F., Shahid, M., Ansari, J., Ashraf, G. M., Hassan, M. I., & Islam, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102342 · Cited by 20

Broadening Horizons: Exploring the Cathepsin Family as Therapeutic Targets for Alzheimer's Disease

Liu, X., Liu, X., Wu, Y., Li, S., Ren, K., Cheng, M., Huang, B., Yang, Y., & Liu, P. (2024) · Aging and Disease · doi:10.14336/ad.2024.0456 · Cited by 20

Design, synthesis, and biological evaluation of novel indanone-based hybrids as multifunctional cholinesterase inhibitors for Alzheimer's disease

Shahrivar‐Gargari, M., Hamzeh‐Mivehroud, M., Hemmati, S., Mojarrad, J. S., Notash, B., Küçükkılınç, T. T., Ayazgök, B., & Dastmalchi, S. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.129787 · Cited by 20

Design and Synthesis of Novel Tacrine–Indole Hybrids As Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Hamuľaková, S., Kudlicková, Z., Janovec, L., Mezencev, R., Deckner, Z. J., Chernoff, Y. O., Janočková, J., Ihnatova, V., Bzonek, P., Novakova, N., et al. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2020-0184 · Cited by 19

The Immune System as a Therapeutic Target for Alzheimer’s Disease

Zieneldien, T., Kim, J., Sawmiller, D. R., & Cao, C. (2022) · Life · doi:10.3390/life12091440 · Cited by 19

ROS-responsive nanomodulators downregulate IFITM3 expression and eliminate ROS for Alzheimer’s disease combination treatment

Xu, H., & Liu, Y. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.139 · Cited by 20

Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research

Ulaganathan, S., & Pitchaimani, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121918 · Cited by 23

Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches

Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 20

Rodent Models of Alzheimer’s Disease: Past Misconceptions and Future Prospects

Collins, H. M., & Greenfield, S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116222 · Cited by 21

Deciphering Alzheimer’s disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis

Khoury, R., & Grossberg, G. T. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1790530 · Cited by 19

From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects

Pont, C., Ginex, T., Griñán‐Ferré, C., Scheiner, M., Mattellone, A., Martínez, N., Arce, E. M., Soriano-Fernández, Y., Naldi, M., Simone, A. D., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113779 · Cited by 20

Advances in Cholinesterase Inhibitor Research—An Overview of Preclinical Studies of Selected Organoruthenium(II) Complexes

Žužek, M. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169049 · Cited by 18

Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

Tylek, K., & Basta‐Kaim, A. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10236-z · Cited by 19

A combination of multiple autoantibodies is associated with the risk of Alzheimer’s disease and cognitive impairment

Shim, S.-M., Koh, Y. H., Kim, J., & Jeon, J. (2022) · Scientific Reports · doi:10.1038/s41598-021-04556-2 · Cited by 18

Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function

Son, Y., Park, H.-J., Jeong, Y. J., Choi, H., Kim, N., & Lee, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371379 · Cited by 19

The Role of Clearance in Neurodegenerative Diseases

Brennan, G. S., Thompson, T., Oliveri, H., Rognes, M. E., & Goriely, A. (2023) · SIAM Journal on Applied Mathematics · doi:10.1137/22m1487801 · Cited by 20

Diastolic dysfunction in Alzheimer’s disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction

Aishwarya, R., Abdullah, C. S., Remex, N. S., Bhuiyan, M. A. N., Lu, X., Dhanesha, N., Stokes, K. Y., Orr, A. W., Kevil, C. G., & Bhuiyan, M. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-67638-x · Cited by 18

Mesenchymal stem cell therapy for Alzheimer’s disease: A novel therapeutic approach for neurodegenerative diseases

Bhatt, A., Bhardwaj, H., & Srivastava, P. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.019 · Cited by 19

Thiophene‐Based Dual Modulators of Aβ and Tau Aggregation

Ramesh, M., Acharya, A., Murugan, N. A., Ila, H., & Govindaraju, T. (2021) · ChemBioChem · doi:10.1002/cbic.202100383 · Cited by 18

Amyloid β-Induced Inflammarafts in Alzheimer’s Disease

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In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease

Mandal, P. K., Roy, R. G., Samkaria, A., Maroon, J. C., & Arora, Y. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03538-8 · Cited by 17

A Review of African Medicinal Plants and Functional Foods for the Management of Alzheimer's Disease-related Phenotypes, Treatment of HSV-1 Infection and/or Improvement of Gut Microbiota

Tettevi, E. J., Maina, M. B., Simpong, D. L., Osei-Atweneboana, M. Y., & Ocloo, A. (2022) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x221114657 · Cited by 19

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice

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Mitochondria-Related Candidate Genes and Diagnostic Model to Predict Late-Onset Alzheimer’s Disease and Mild Cognitive Impairment

Yan, R., Wang, W., Yang, W., Huang, M., & Xu, W. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230314 · Cited by 17

Evaluation of berberine nanoparticles as a strategy to modulate acetylcholinesterase activity

Leimann, F. V., de Souza, L. B., de Oliveira, B. P. M., Rossi, B. F., da Silva, P. S., Shiraishi, C. S. H., Kaplum, V., Abreu, R. M. V., Pereira, C., Barros, L., et al. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113295 · Cited by 17

Involvement of mitochondria in Alzheimer’s disease pathogenesis and their potential as targets for phytotherapeutics

Maruthiyodan, S., Mumbrekar, K. D., & Guruprasad, K. P. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101868 · Cited by 18

A review of the advances, insights, and prospects of gene therapy for Alzheimer’s disease: A novel target for therapeutic medicine

Ataei, B., Hokmabadi, M., Asadi, S., Asadifard, E., Zarch, S. M. A., Najafi, S., & Bagheri‐Mohammadi, S. (2024) · Gene · doi:10.1016/j.gene.2024.148368 · Cited by 18

Alzheimer’s disease rewires gene coexpression networks coupling different brain regions

Mitra, S., Kailash, B. P., Srivatsan, C. R., Saikumar, N. V., Philip, P., & Narayanan, M. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00376-y · Cited by 19

Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia

Lee, J. Y., Marian, O. C., & Don, A. S. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08644-4 · Cited by 18

History in perspective: How Alzheimer's Disease came to be where it is?

Ahmed, T. F., Ahmed, A., & Imtiaz, F. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147342 · Cited by 21

Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors

Şenol, F. S., Eren, G., Orhan, İ. E., Şener, B., Özgen, U., Aldaba, R., & Çalış, İ. (2021) · Molecules · doi:10.3390/molecules26072024 · Cited by 17

Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgenic Mice

Gao, D., Chen, C., Huang, R., Yang, C., Miao, B.-B., Li, L., & Zhang, L. (2021) · Current Medical Science · doi:10.1007/s11596-021-2344-z · Cited by 17

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

Szałaj, N., Godyń, J., Jończyk, J., Pasieka, A., Panek, D., Wichur, T., Więckowski, K., Zaręba, P., Bajda, M., Pišlar, A. H., et al. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1835882 · Cited by 17

Recent insights into viral infections as a trigger and accelerator in alzheimer's disease

Vlieger, L. D., Vandenbroucke, R. E., & Hoecke, L. V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103340 · Cited by 16

Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice

Guo, P., Zeng, M., Cao, B., Liu, M., Zhang, Y., Jia, J., Zhang, Q., Zhang, B., Wang, R., Xiong, W., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105214 · Cited by 16

An Ethical Argument for Ending Human Trials of Amyloid-Lowering Therapies in Alzheimer’s Disease

Daly, T. P., Herrup, K., & Espay, A. J. (2022) · AJOB Neuroscience · doi:10.1080/21507740.2022.2129858 · Cited by 16

Oncolytic Vaccinia Virus Carrying Aphrocallistes vastus Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells

Zheng, X., Xu, W., Ying, Q., Ni, J., Jia, X., Zhou, Y., Ye, T., Li, G., & Chen, K. (2022) · Marine Drugs · doi:10.3390/md20110667 · Cited by 16

Failure, Success, and Future Direction of Alzheimer Drugs Targeting Amyloid‐β Cascade: Pros and Cons of Chemical and Biological Modalities

Kim, J., Jeon, H., Kim, H. Y., & Kim, Y. S. (2023) · ChemBioChem · doi:10.1002/cbic.202300328 · Cited by 17

Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Li, S., Wei, Y., Liang, Z., Guo, L., Hao, X., & Zhang, Y. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250150 · Cited by 16

Current Insights of Nanocarrier-Mediated Gene Therapeutics to Treat Potential Impairment of Amyloid Beta Protein and Tau Protein in Alzheimer’s Disease

Jain, U., Johari, S., & Srivastava, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03671-7 · Cited by 16

Smart treatment strategies for alleviating tauopathy and neuroinflammation to improve clinical outcome in Alzheimer's disease

Tatiparti, K., Sau, S., Rauf, M. A., & Iyer, A. K. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.09.025 · Cited by 16

Alzheimer’s Disease: Hypotheses and therapies

Chen, N. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19968

Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses

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Recent Clinical Developments in Alzheimer's Disease

(2016) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681082318116050005

Clinical Trials in Alzheimer’s Disease: A Hurdle in the Path of Remedy

Oxford, A. E., Stewart, E. S., & Rohn, T. T. (2020) · International Journal of Alzheimer s Disease · doi:10.1155/2020/5380346 · Cited by 111

Alzheimer’s disease hypothesis and related therapies

Du, X., Wang, X., & Geng, M. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0107-y · Cited by 623