History and progress of hypotheses and clinical trials for Alzheimer’s disease

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

IDH1 and IDH2 Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer’s Disease

Wong, L. R., Wong, P., & Ho, P. C. (2020) · Biomedicines · doi:10.3390/biomedicines8120589 · Cited by 16

Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease

Zhang, M., Wu, Q., Zhao, R., Yao, X., Du, X., Liu, Q., Lv, G., & Xiao, S. (2021) · Food & Function · doi:10.1039/d1fo01306h · Cited by 16

A Proposal to Make Biomedical Research into Alzheimer’s Disease More Democratic Following an International Survey with Researchers

Daly, T. P., Houot, M., Barberousse, A., Petit, A., & Epelbaum, S. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210030 · Cited by 16

Deconstructing Alzheimer’s Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

Vignon, A., Salvador-Prince, L., Lehmann, S., Perrier, V., & Torrent, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168769 · Cited by 17

Cryptotanshinone Attenuates Amyloid-β42-induced Tau Phosphorylation by Regulating PI3K/Akt/GSK3β Pathway in HT22 Cells

Lyu, D., & Jia, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02850-2 · Cited by 16

Fluorogenic toolbox for visualizing protein aggregation: From designing principles to biological application

Liu, L., Huang, Y., Zhou, Y., Zhao, Y., Qi, J., Zhang, X., & Shen, B. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116764 · Cited by 16

A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson’s disease

Wang, R., Pang, S., Li, J., Li, C.-L., Liu, J.-M., Wang, Y., Chen, M., & Li, Y. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04520-1 · Cited by 16

Neutrophils and NETosis in Alzheimer’s disease: Unraveling pathogenic mechanisms and novel therapeutic targets

Chavoshinezhad, S., Beirami, E., & Izadpanah, E. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118568 · Cited by 15

Neuroprotective and Antioxidant Role of Oxotremorine-M, a Non-selective Muscarinic Acetylcholine Receptors Agonist, in a Cellular Model of Alzheimer Disease

Nuzzo, D., Frinchi, M., Giardina, C., Scordino, M., Zuccarini, M., Simone, C. D., Carlo, M. D., Belluardo, N., Mudò, G., & Liberto, V. D. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01274-9 · Cited by 15

An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer’s disease

Jeyaraman, M., Rajendran, R. L., Muthu, S., Jeyaraman, N., Sharma, S., Jha, S. K., Muthukanagaraj, P., Hong, C. M., da Fonseca, L. F., Lana, J. F., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17808 · Cited by 15

American Ginseng for the Treatment of Alzheimer’s Disease: A Review

Shan, M., Bai, Y., Fang, X., Lan, X., Zhang, Y., Cao, Y., Zhu, D., & Luo, H. (2023) · Molecules · doi:10.3390/molecules28155716 · Cited by 15

Protective effects of Embelin in Benzo[α]pyrene induced cognitive and memory impairment in experimental model of mice

Goal, A., Raj, K., Singh, S., & Arora, R. (2024) · Current Research in Neurobiology · doi:10.1016/j.crneur.2023.100122 · Cited by 16

Hybridization‐based design of novel anticholinesterase indanone–carbamates for Alzheimer's disease: Synthesis, biological evaluation, and docking studies

Shahrivar‐Gargari, M., Hamzeh‐Mivehroud, M., Hemmati, S., Mojarrad, J. S., Küçükkılınç, T. T., Ayazgök, B., & Dastmalchi, S. (2021) · Archiv der Pharmazie · doi:10.1002/ardp.202000453 · Cited by 15

Public opinion regarding U.S. Food and Drug Administration approval of aducanumab and potential policy responses: A nationally representative survey

DiStefano, M. J., Alexander, G. C., Polsky, D. E., & Anderson, G. F. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17692 · Cited by 15

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Rogdakis, T., Charou, D., Latorrata, A., Papadimitriou, E., Tsengenes, A., Athanasiou, C., Papadopoulou, M. A., Chalikiopoulou, C., Κάτσιλα, Θ., Ramos, I., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10030614 · Cited by 15

Model scenarios for cell cycle re-entry in Alzheimer's disease

Pandey, N., & Vinod, P. K. U. (2022) · iScience · doi:10.1016/j.isci.2022.104543 · Cited by 15

Roles of hybrid donepezil scaffolds as potent human acetylcholinesterase inhibitors using in silico interaction analysis, drug-likeness, and pharmacokinetics prediction

Honorio, P., Hannongbua, S., & Saparpakorn, P. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110227 · Cited by 14

Dynamic distribution of gut microbiota during Alzheimer's disease progression in a mice model

Zhu, J., Liu, S., Zhang, H., Zhao, W., Ding, J., Dai, R., Xu, K., He, C., Liu, J., Yang, L., et al. (2023) · Apmis · doi:10.1111/apm.13339 · Cited by 14

A new approach for the treatment of Alzheimer’s disease: insulin-quantum dots

Çamlık, G., Bilakaya, B., Özsoy, Y., & Değim, İ. T. (2023) · Journal of Microencapsulation · doi:10.1080/02652048.2023.2282968 · Cited by 14

Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism

Kotah, J. M., Kater, M. S. J., Brosens, N., Lesuis, S. L., Tandari, R., Blok, T. M., Marchetto, L., Yusaf, E., Koopmans, F., Smit, A. B., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13569 · Cited by 15

Gene therapy: an alternative to treat Alzheimer’s disease

Doshi, V., Joshi, G., Sharma, S., & Choudhary, D. K. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02873-z · Cited by 14

Targeting misfolding and aggregation of the amyloid-β peptide and mutant p53 protein using multifunctional molecules

Grcic, L., Leech, G., Kwan, K., & Storr, T. (2024) · Chemical Communications · doi:10.1039/d3cc05834d · Cited by 14

Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists

Chvojková, M., Kolář, D., Kovacova, K., Cejkova, L., Misiachna, A., Hakenova, K., Górecki, L., Hořák, M., Korábečný, J., Soukup, O., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116821 · Cited by 14

A Lipid-Raft Theory of Alzheimer's Disease

Rappoport, A. (2024) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052024-115455 · Cited by 15

In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy

Khedraoui, M., Guerguer, F. Z., Karim, E. M., Errougui, A., & Chtita, S. (2025) · Current Pharmaceutical Analysis · doi:10.1016/j.cpan.2025.03.005 · Cited by 14

Modeling Alzheimer’s Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling

Timofeeva, A. M., Aulova, K. S., & Nevinsky, G. A. (2025) · Brain Sciences · doi:10.3390/brainsci15050486 · Cited by 17

Cell-specific copper dyshomeostasis mechanism in Alzheimer’s disease

Okafor, M., Faller, P., & Vitale, N. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00504-6 · Cited by 16

Unifying Vascular Injury and Neurodegeneration: A Mechanistic Continuum in Cerebral Small Vessel Disease and Dementia

Jin, C., & Bhaskar, S. M. M. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70246 · Cited by 14

Therapeutic Ultrasound as a Treatment Modality for Physiological and Pathological Ageing Including Alzheimer’s Disease

Götz, J., Richter-Stretton, G. L., & Cruz, E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071002 · Cited by 15

Engineering extracellular vesicles for Alzheimer's disease: An emerging cell‐free approach for earlier diagnosis and treatment

Lazar, S. V., Mor, S., Wang, D., Goldbloom‐Helzner, L., Clark, K. C., Hao, D., Farmer, D. L., & Wang, A. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1541 · Cited by 14

Taylor Dispersion Analysis and Atomic Force Microscopy Provide a Quantitative Insight into the Aggregation Kinetics of Aβ (1–40)/Aβ (1–42) Amyloid Peptide Mixtures

Deleanu, M., Deschaume, O., Cipelletti, L., Hernandez, J., Bartic, C., Cottet, H., & Chamieh, J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00784 · Cited by 14

Digging into the intrinsic capacity concept: Can it be applied to Alzheimer’s disease?

López‐Ortiz, S., Caruso, G., Emanuele, E., Menéndez, H., Peñín‐Grandes, S., Guerrera, C. S., Caraci, F., Nisticò, R., Lucía, A., Santos‐Lozano, A., et al. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102574 · Cited by 14

Fluorescence microscopic platforms imaging mitochondrial abnormalities in neurodegenerative diseases

Wang, Y., Wang, P., & Li, C. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114841 · Cited by 13

A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases

Singh, A. N., Maheshwari, S., Yadav, J. P., Varshney, A. P., Singh, S. K., & Prajapati, B. G. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249289120240321065936 · Cited by 13

Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies

Rathee, S., Sen, D., Pandey, V., & Jain, S. (2024) · Current Drug Targets · doi:10.2174/0113894501320096240627071400 · Cited by 16

Biofluid biomarkers for Alzheimer’s disease: past, present, and future

An, C., Cai, H., Ren, Z., Fu, X., Quan, S., & Jia, L. (2024) · Medical Review · doi:10.1515/mr-2023-0071 · Cited by 14

β-Sitosterol ameliorates the cognitive deficits and neuropathological hallmarks in an Alzheimer’s disease model

Sajad, M., Ali, R., Kumar, R., Khan, N. J., Wahab, S., Alshehri, S. A., & Thakur, S. C. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.106072 · Cited by 13

Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge

Darabi, S., Gorgich, E. A. C., Moradi, F., & Rustamzadeh, A. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.01.004 · Cited by 13

Conformation-specific perturbation of membrane dynamics by structurally distinct oligomers of Alzheimer's amyloid-β peptide

Madhu, P., Das, D., & Mukhopadhyay, S. (2021) · Physical Chemistry Chemical Physics · doi:10.1039/d0cp06456d · Cited by 15

Probable Reasons for Neuron Copper Deficiency in the Brain of Patients with Alzheimer’s Disease: The Complex Role of Amyloid

Bagheri, S., Saboury, A. A., Haertlé, T., Rongioletti, M. C. A., & Saso, L. (2022) · Inorganics · doi:10.3390/inorganics10010006 · Cited by 14

The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches

Panda, S. P., Dhurandhar, Y., & Agrawal, M. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.07.002 · Cited by 13

Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease

Kapoor, B., Gulati, M., Rani, P., Kochhar, R. S., Atanasov, A. G., Gupta, R., Sharma, D., & Kapoor, D. N. (2022) · BioFactors · doi:10.1002/biof.1910 · Cited by 13

Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease

Silva, J. R., Patricio, F., Patricio-Martínez, A., Santos‐López, G., Cedillo, L., Tizabi, Y., & Limón, I. D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.867825 · Cited by 14

Nature's Toolbox for Alzheimer's Disease: A Review on the Potential of Natural Products as Alzheimer's Disease Drugs

Yusof, N. I. S. M., & Fauzi, F. M. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105738 · Cited by 13

Research Hotspots and Frontiers of Alzheimer’s Disease and Gut Microbiota: A Knowledge Mapping and Text Mining Analysis

Zhang, Y., Jia, Z., Wang, J., & Liang, H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04168-7 · Cited by 12

A superior near infrared fluorescent probe for revealing the relationship between peroxynitrite and Alzheimer's disease

Zhou, Z., Fang, C., Shen, Y., Zhang, X., Li, H., & Zhang, Y. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135971 · Cited by 12

Potential therapeutic natural compounds for the treatment of Alzheimer's disease

Huang, Q., Wu, W., Wen, Y., Lu, S., & Zhao, C. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155822 · Cited by 12

A philosophy of science approach to the amyloid hypothesis of Alzheimer's disease

Daly, T. P. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16500 · Cited by 14

Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases

Liang, J., Zhu, Y., Liu, S., Kuang, B., Tian, Z., Zhang, L., Yang, S., Lin, M., Chen, N., Liu, X., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8322 · Cited by 13

Omega-3 EPA Supplementation Shapes the Gut Microbiota Composition and Reduces Major Histocompatibility Complex Class II in Aged Wild-Type and APP/PS1 Alzheimer’s Mice: A Pilot Experimental Study

Altendorfer, B., Benedetti, A., Mrowetz, H., Bernegger, S., Bretl, A., Preishuber‐Pflügl, J., de Sousa, D. M. B., Ladek, A., Koller, A., Faouder, P. L., et al. (2025) · Nutrients · doi:10.3390/nu17071108 · Cited by 12

Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment

Mezeiová, E., Hrabinová, M., Hepnarová, V., Jun, D., Janočková, J., Múčková, Ľ., Prchal, L., Krištofíková, Z., Kucera, T., Górecki, L., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128100 · Cited by 12

Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer's disease

Liu, Y., Han, C., Dai, R., & Li, B. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105662 · Cited by 12

Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice

Díaz‐Amarilla, P., Arredondo, F., Dapueto, R., Boix, V., Carvalho, D. B., Santi, M. D., Vasilskis, E., Mesquita-Ribeiro, R., Dajas‐Bailador, F., Abin‐Carriquiry, J. A., et al. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105403 · Cited by 12

Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

Nguyen, T. H., Wang, S., & Nguyen, V. B. (2023) · Pharmaceuticals · doi:10.3390/ph16040580 · Cited by 12

Design, synthesis, metal chelation potential and biological evaluation of pyridine chalcones as multi-target-directed ligands against Alzheimer's disease

Dixit, G., & Prabhu, A. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.136498 · Cited by 12

Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer’s disease

Das, B., Baidya, A. T. K., Chakrabarti, S., Chouhan, D., Thakur, B., Darreh‐Shori, T., Chen, G., Tiwari, V. K., & Kumar, R. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107373 · Cited by 12

8-Hydroxyquinoline-based anti-Alzheimer multimodal agents

Knez, D., Sosič, I., Mitrović, A., Pišlar, A. H., Kos, J., & Gobec, S. (2020) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-020-02651-0 · Cited by 12

New benzamide derivatives and their nicotinamide/cinnamamide analogs as cholinesterase inhibitors

Koca, M., & Bilginer, S. (2021) · Molecular Diversity · doi:10.1007/s11030-021-10249-9 · Cited by 12

Survey of New, Small-Molecule Isatin-Based Oxindole Hybrids as Multi-Targeted Drugs for the Treatment of Alzheimer’s Disease

Marques, C. S., López, Ó., Leitzbach, L., Fernández‐Bolaños, J. G., Stark, H., & Burke, A. J. (2022) · Synthesis · doi:10.1055/s-0041-1737343 · Cited by 12

AD Hypotheses and Suggested Clinical Trials

Mandal, P. K., Samkaria, A., & Maroon, J. C. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00627 · Cited by 12

Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer’s model

Hanafy, A. S., Lamprecht, A., & Dietrich, D. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00492-7 · Cited by 11

Metalloproteins and metalloproteomics in health and disease

Ibrahim, I. H. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.12.013 · Cited by 12

Chiral thioureas containing naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, cholinesterase inhibition activity and molecular docking studies

Karaküçük‐İyidoğan, A., Sıcak, Y., Uysal, D. B., Taşkın‐Tok, T., Öztürk, M., & Oruç‐Emre, E. E. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.139333 · Cited by 11

Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease

Hayden, M. R., & Tyagi, N. (2024) · Pharmaceuticals · doi:10.3390/ph17121741 · Cited by 11

Multi-targeted benzylpiperidine–isatin hybrids: Design, synthesis, biological and in silico evaluation as monoamine oxidases and acetylcholinesterase inhibitors for neurodegenerative disease therapies

Negi, N., Ayyannan, S. R., & Tripathi, R. K. P. (2025) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-025-00588-2 · Cited by 11

Bioactive peptides as multipotent molecules bespoke and designed for Alzheimer's disease

Mesias, A., Borges, S., Pintado, M., & Baptista-Silva, S. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102515 · Cited by 11

Molecular PET Imaging in Alzheimer’s Disease

Thientunyakit, T., Shiratori, S., Ishii, K., & Gelovani, J. G. (2022) · Journal of Medical and Biological Engineering · doi:10.1007/s40846-022-00717-4 · Cited by 12

Amylin and Secretases in the Pathology and Treatment of Alzheimer’s Disease

Singh, S. P., Yang, F., Sivils, A., Cegielski, V., & Chu, X. (2022) · Biomolecules · doi:10.3390/biom12070996 · Cited by 11

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Fan, Y., Wang, Z., & He, D. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220817140737 · Cited by 11

Repurposing of phyto-ligand molecules from the honey bee products for Alzheimer’s disease as novel inhibitors of BACE-1: small molecule bioinformatics strategies as amyloid-based therapy

Nisa, N., Rasmita, B., Arati, C., Uditraj, C., Siddhartha, R., Dinata, R., Bhanushree, B., Bidanchi, R. M., Manikandan, B., Saeed, A.-L., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-25943-4 · Cited by 11

Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma ameliorate scopolamine-induced cognitive impairment by regulating the cholinergic and synaptic associated proteins

Xie, Y., Liu, L., Zheng, J., Shi, K., Ai, W., Zhang, X., Wang, P., Lan, Z., & Chen, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116400 · Cited by 11

Exploring Promising Biomarkers for Alzheimer’s Disease through the Computational Analysis of Peripheral Blood Single-Cell RNA Sequencing Data

Krokidis, M. G., Vrahatis, A. G., Lazaros, K., & Vlamos, P. (2023) · Applied Sciences · doi:10.3390/app13095553 · Cited by 11

Analysis of the potential and mechanism of Ginkgo biloba in the treatment of Alzheimer's disease based on network pharmacology

Huang, X., Li, T., Zhou, L., Liu, T., Xiong, L., & Yu, C. (2021) · Ibrain · doi:10.1002/j.2769-2795.2021.tb00060.x · Cited by 11

Phyllodulcin improves hippocampal long-term potentiation in 5XFAD mice

Cho, E., Jeon, S. J., Jeon, J., Yi, J. H., Kwon, H., Kwon, H.-J., Kwon, K. J., Moon, M., Shin, C. Y., & Kim, D. H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114511 · Cited by 10

Decoding the Role of Neurotrophins in Glycogen Synthase Kinase 3-Beta Regulation in Alzheimer’s Disease

Rahmatkar, S. N., & Singh, D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04776-x · Cited by 10

Design, synthesis, and biological evaluation of caffeic acid-based novel multifunctional molecules for the management of Alzheimer's disease

kumar, S., V, & Modi, G. P. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117831 · Cited by 10

Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research

Singhaarachchi, P. H., Antal, P., Calon, F., Culmsee, C., Delpech, J.-C., Feldotto, M., Geertsema, J., Hoeksema, E. E., Kőrösi, A., Layé, S., et al. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102821 · Cited by 13

Review of anti-amyloid-beta (Aβ) monoclonal antibodies for the treatment of Alzheimer’s disease

Francis, E., Paylor, S., Van, C., Mathews, B., Sobhanian, M. J., Mansour, D. Z., Hennawi, G., & Brandt, N. (2025) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2025.2556122 · Cited by 10

Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer’s Disease

Shen, Y., Wang, X., Liu, X., Wang, G., Hou, X., & Zhou, X. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01648-9 · Cited by 12

Impact of Gut Microbiome Lactobacillus spp. in Brain Function and its Medicament towards Alzheimer’s Disease Pathogenesis

John, S. K., Chandrapragasam, V., & Dey, P. (2021) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.15.3.02 · Cited by 10

Molecular Insights into the Inhibitory Effect of GV971 Components Derived from Marine Acidic Oligosaccharides against the Conformational Transition of Aβ42 Monomers

Jiang, L., Sun, Q., Li, L., Lu, F., & Liu, F. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00555 · Cited by 10

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Tyler, S. E. B., & Tyler, L. D. K. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00354-z · Cited by 10

Cerebral Folate Metabolism in Post-Mortem Alzheimer’s Disease Tissues: A Small Cohort Study

Naz, N., Naqvi, S. F., Hohn, N., Whelan, K., Littler, P., Roncaroli, F., Robinson, A., & Miyan, J. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010660 · Cited by 10

Artificial intelligence in precision medicine

Siddiqui, S. S., Loganathan, S., Elangovan, V. R., & Ali, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89925-3.00020-4 · Cited by 10

Malate dehydrogenase as a multi-purpose target for drug discovery

Fermaintt, C. S., & Wacker, S. (2024) · Essays in Biochemistry · doi:10.1042/ebc20230081 · Cited by 10

Neuroprotective and anti-neuroinflammatory effects of ethanolic extract from leaves and stems of Aster glehni

Lim, M. K., Lee, S., Kim, J. Y., Jeong, J., Han, E. H., Lee, S. H., Ryu, J. H., & Lee, J. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104400 · Cited by 10

From childhood maltreatment to adult inflammation: Evidence for the mediational status of social anxiety and low positive affect

Carlton, C. N., Garcia, K. M., Sullivan‐Toole, H., Stanton, K. J., McDonnell, C. G., & Richey, J. A. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100366 · Cited by 13

Recent Progress in the Drug Development for the Treatment of Alzheimer’s Disease Especially on Inhibition of Amyloid-peptide Aggregation

Liu, Y., Cong, L., Han, C., Li, B., & Dai, R. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666201127104539 · Cited by 10

Regulation of phase I and phase II neurosteroid enzymes in the hippocampus of an Alzheimer’s disease rat model: A focus on sulphotransferases and UDP-glucuronosyltransferases

Chik, M. W., Hazalin, N. A. M. N., & Singh, G. K. S. (2022) · Steroids · doi:10.1016/j.steroids.2022.109035 · Cited by 10

Unravelling Binding of Human Serum Albumin with Galantamine: Spectroscopic, Calorimetric, and Computational Approaches

Ashraf, G. M., Gupta, D. D., Alam, M. Z., Baeesa, S. S., Alghamdi, B. S. A., Anwar, F., Alqurashi, T. M. A., Abdulmonem, W. A., Alyousef, M., Alhumaydhi, F. A., et al. (2022) · ACS Omega · doi:10.1021/acsomega.2c04004 · Cited by 10

Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis

Piec, P.-A., Pons, V., & Rivest, S. (2021) · Cells · doi:10.3390/cells10082164 · Cited by 10

Biofluid biomarkers for Alzheimer’s disease

Wang, S., Xie, S., Zheng, Q., Zhang, Z., Wang, T., & Zhang, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1380237 · Cited by 9

Mushroom-derived bioactive components with definite structures in alleviating the pathogenesis of Alzheimer’s disease

Jiang, X., Song, Y., Lv, C., Li, Y., Feng, X., Zhang, H., Chen, Y., & Wang, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1373660 · Cited by 9

Development of coumarin-inspired bifunctional hybrids as a new class of anti-Alzheimer's agents with potent in vivo efficacy

Singh, A., Sharma, A., Singh, K., Kaur, K., Mohana, P., Prajapati, J., Kaur, U., Goswami, D., Arora, S., Chadha, R., et al. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00782d · Cited by 9

Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and Optimization

Xing, S., Kang, X., Wang, R., Wang, C., Wang, Y., Bao, X., & Zhao, J. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.5c00038 · Cited by 9

Evaluating computational and experimental approaches in early-stage Alzheimer’s drug discovery: a systematic review

Azmal, M., Paul, J. K., Shohan, M. N. H., Haque, A. N. M. S. N. B., Mrinmoy, M., Talukder, O. F., & Ghosh, A. (2025) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-025-00610-7 · Cited by 9

Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers

Chatzipieris, F. P., Mavromoustakou, K., Matsoukas, J., & Mavromoustakos, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188819 · Cited by 10

A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models

Jarné‐Ferrer, J., Griñán‐Ferré, C., Bellver‐Sanchís, A., Vázquez, S., Muñoz‐Torrero, D., & Pallàs, M. (2022) · Pharmaceuticals · doi:10.3390/ph15080908 · Cited by 9

Atg9A-mediated mitophagy is required for decidual differentiation of endometrial stromal cells

Li, J., Zhang, S., Zhang, Y., Dai, Y., Zhang, Y., Yang, A., Hong, F., & Pan, Y. (2022) · Reproductive Biology · doi:10.1016/j.repbio.2022.100707 · Cited by 9

From Association to Intervention: The Alzheimer’s Disease-Associated Processes and Targets (ADAPT) Ontology

Daly, T. P., Henry, V., & Bourdenx, M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221004 · Cited by 11

Alzheimer’s Disease: Hypotheses and therapies

Chen, N. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19968

Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses

(2024) · aging and disease · doi:10.14336/ad.2023.0608 · Cited by 183

Recent Clinical Developments in Alzheimer's Disease

(2016) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681082318116050005

Clinical Trials in Alzheimer’s Disease: A Hurdle in the Path of Remedy

Oxford, A. E., Stewart, E. S., & Rohn, T. T. (2020) · International Journal of Alzheimer s Disease · doi:10.1155/2020/5380346 · Cited by 111

Alzheimer’s disease hypothesis and related therapies

Du, X., Wang, X., & Geng, M. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0107-y · Cited by 623