The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The roles of exosomal miRNAs and lncRNAs in lung diseases
Open accessAbstract
An increasing number of studies have reported that exosomes released from various cells can serve as mediators of information exchange between different cells. With further exploration of exosome content, a more accurate molecular mechanism involved in the process of cell-to-cell communication has been revealed; specifically, microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are shuttled by exosomes. In addition, exosomal miRNAs and lncRNAs may play vital roles in the pathogenesis of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), lung cancer, and asthma. Consequently, exosomal miRNAs and lncRNAs show promise as diagnostic biomarkers and therapeutic targets in several lung diseases. This review will summarize recent knowledge about the roles of exosomal miRNAs and lncRNAs in lung diseases, which has shed light on the discovery of novel diagnostic methods and treatments for these disorders. Because there is almost no published literature about exosomal lncRNAs in COPD, asthma, interstitial lung disease, or tuberculosis, we summarize the roles of exosomal lncRNAs only in lung cancer in the second section. This may inspire some new ideas for researchers who are interested in whether lncRNAs shuttled by exosomes may play roles in other lung diseases.
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Extracellular vesicles: Exosomes, microvesicles, and friends
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Biogenesis and secretion of exosomes
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Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy
Kourembanas, S. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071641 · Cited by 761
Extracellular vesicles round off communication in the nervous system
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Asthma: Definitions and Pathophysiology
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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
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Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT
Zhang, X., Sai, B., Wang, F., Wang, L., Wang, Y., Zheng, L., Li, G., Tang, J., & Xiang, J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0959-5 · Cited by 560
Cited by
A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles
Couch, Y., Buzàs, E. I., Di Vizio, D., Gho, Y. S., Harrison, P., Hill, A. F., Lötvall, J., Raposo, G., Stahl, P. D., Théry, C., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12144 · Cited by 566
Liu, Y., Xia, Y., Smollar, J., Mao, W., & Wan, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188539 · Cited by 23
Metadata
- Authors
- Li, Y., Yin, Z., Fan, J., Zhang, S., & Yang, W.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2019-11-13
- Volume
- 4
- Issue
- 1
- Pages
- 47-47
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W2984418064
- Cited by
- 190
- References
- 12
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, Y., Yin, Z., Fan, J., Zhang, S., & Yang, W. (2019). The roles of exosomal miRNAs and lncRNAs in lung diseases. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-019-0080-7
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