The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
COVID-19: immunopathogenesis and Immunotherapeutics
Open accessAbstract
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and severe multiple organ dysfunction. Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19.
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Self-citationA pneumonia outbreak associated with a new coronavirus of probable bat origin
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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Self-citationPathological findings of COVID-19 associated with acute respiratory distress syndrome
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Cited by
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COVID-19 vaccines: The status and perspectives in delivery points of view
Chung, J. Y., Thone, M. N., & Kwon, Y. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.011 · Cited by 375
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 281
A time-resolved proteomic and prognostic map of COVID-19
Demichev, V., Tober-Lau, P., Lemke, O., Nazarenko, T., Thibeault, C., Whitwell, H., Röhl, A., Freiwald, A., Szyrwiel, L., Ludwig, D., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.05.005 · Cited by 200
Self-citationLafon, E., Diem, G., Witting, C., Zaderer, V., Bellmann-Weiler, R. M., Reindl, M., Bauer, A., Griesmacher, A., Fux, V., Hoermann, G., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.684014 · Cited by 46
Metadata
- Authors
- Yang, L., Liu, S., Liu, J., Zhang, Z., Wan, X., Huang, B., Chen, Y., & Zhang, Y.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2020-07-25
- Volume
- 5
- Issue
- 1
- Pages
- 128-128
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3044898763
- Cited by
- 912
- References
- 79
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- gold
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