The DOI matches its Crossref record; 274 of the 274 references it cites were found in a registry or an index.
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents
Open accessAbstract
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that contribute to tumor progression and therapy resistance. However, the underlying processes are still unclear. Elucidation of the key hallmarks and resistance mechanisms of CSCs may help improve patient outcomes and reduce relapse by altering therapeutic regimens. Here, we reviewed the identification of CSCs, the intrinsic and extrinsic mechanisms of therapy resistance in CSCs, the signaling pathways of CSCs that mediate treatment failure, and potential CSC-targeting agents in various tumors from the clinical perspective. Targeting the mechanisms and pathways described here might contribute to further drug discovery and therapy.
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3 retracted
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Protein neddylation and its role in health and diseases
Zhang, S., Yu, Q., Li, Z., Zhao, Y., & Sun, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01800-9 · Cited by 171
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Metadata
- Authors
- Zhou, H.-M., Zhang, J.-G., Zhang, X., & Li, Q.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2021-02-15
- Volume
- 6
- Issue
- 1
- Pages
- 62-62
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3131854624
- Cited by
- 472
- References
- 274
- FWCI
- 25.27
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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