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Cited by 300

The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.

Overview of lethal human coronaviruses

Open access
Chen, Bin, Tian, Er-Kang, He, Bin, Tian, Lejin, Han, Ruiying, Wang, Shuangwen, Xiang, Qianrong, Zhang, Shu, El Arnaout, Toufic, Cheng, Wei·2020·Signal Transduction and Targeted Therapy

Abstract

Coronavirus infections of multiple origins have spread to date worldwide, causing severe respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2. Among them, SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012, respectively. SARS-CoV-2 (COVID-19) is the most recently discovered. It has created a severe worldwide outbreak beginning in late 2019, leading to date to over 4 million cases globally. Viruses are genetically simple, yet highly diverse. However, the recent outbreaks of SARS-CoV and MERS-CoV, and the ongoing outbreak of SARS-CoV-2, indicate that there remains a long way to go to identify and develop specific therapeutic treatments. Only after gaining a better understanding of their pathogenic mechanisms can we minimize viral pandemics. This paper mainly focuses on SARS-CoV, MERS-CoV, and SARS-CoV-2. Here, recent studies are summarized and reviewed, with a focus on virus–host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment.

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Crossref · 10.1038/s41392-020-0190-2

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Metadata

Authors
Chen, B., Tian, E.-K., He, B., Tian, L., Han, R., Wang, S., Xiang, Q., Zhang, S., El Arnaout, T., & Cheng, W.
Venue
Signal Transduction and Targeted Therapy
Published
2020-06-10
Volume
5
Issue
1
Pages
89-89
ISSN
2059-3635 (ISSN-L)
OpenAlex
W3034883465
Cited by
300
References
159
FWCI
7.09
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Overview of lethal human coronaviruses. https://app.cochat.ai/papers/10.1038/s41392-020-0190-2
The paper
Chen, B., Tian, E.-K., He, B., Tian, L., Han, R., Wang, S., Xiang, Q., Zhang, S., El Arnaout, T., & Cheng, W. (2020). Overview of lethal human coronaviruses. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-020-0190-2

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.