The DOI matches its Crossref record; 305 of the 305 references it cites were found in a registry or an index.
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
Open accessAbstract
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback for global economy and health. SARS-CoV-2 has an exceptionally high level of transmissibility and extremely broad tissue tropism. However, the underlying molecular mechanism responsible for sustaining this degree of virulence remains largely unexplored. In this article, we review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors, such as ACE2, neuropilin-1, AXL, and antibody–FcγR complexes. We further explain how its spike (S) protein undergoes conformational transition from prefusion to postfusion with the help of proteases like furin, TMPRSS2, and cathepsins. We then review the ongoing experimental studies and clinical trials of antibodies, peptides, or small-molecule compounds with anti-SARS-CoV-2 activity, and discuss how these antiviral therapies targeting host–pathogen interaction could potentially suppress viral attachment, reduce the exposure of fusion peptide to curtail membrane fusion and block the formation of six-helix bundle (6-HB) fusion core. Finally, the specter of rapidly emerging SARS-CoV-2 variants deserves a serious review of broad-spectrum drugs or vaccines for long-term prevention and control of COVID-19 in the future.
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2 retracted
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RetractedMehra, M. R., Ruschitzka, F., & Patel, A. N. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31324-6 · Cited by 553
RetractedClinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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A novel coronavirus from patients with pneumonia in China, 2019
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
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Self-citationUltrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
Cappello, V., Marchetti, L., Parlanti, P., Landi, S., Tonazzini, I., Cecchini, M., Piazza, V., & Gemmi, M. (2016) · Scientific Reports · doi:10.1038/s41598-016-0001-8 · Cited by 13,097
Cited by
SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19
Gusev, E., Sarapultsev, A., Solomatina, L., & Chereshnev, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031716 · Cited by 281
Husain, I., Bala, K., Khan, I. A., & Khan, S. I. (2021) · Food Frontiers · doi:10.1002/fft2.110 · Cited by 104
Dong, T. N., Brogden, G., Gerold, G., & Khosla, M. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04484-y · Cited by 39
Metadata
- Authors
- Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2021-06-11
- Volume
- 6
- Issue
- 1
- Pages
- 233-233
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3172207918
- Cited by
- 339
- References
- 305
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F. (2021). Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-021-00653-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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