The DOI matches its Crossref record; 265 of the 265 references it cites were found in a registry or an index.
COVID-19 vaccine development: milestones, lessons and prospects
Open accessAbstract
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern (VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 vaccines mainly include inactivated, live attenuated, viral vector, protein subunit, RNA, DNA, and virus-like particle (VLP) vaccines. Viral vector vaccines, protein subunit vaccines, and mRNA vaccines may induce additional cellular or humoral immune regulations, including Th cell responses and germinal center responses, and form relevant memory cells, greatly improving their efficiency. However, some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis, raising concerns about the safety of these COVID-19 vaccines. Here, we systemically assess the safety and efficacy of COVID-19 vaccines, including the possible complications and different effects on pregnant women, the elderly, people with immune diseases and acquired immunodeficiency syndrome (AIDS), transplant recipients, and cancer patients. Based on the current analysis, governments and relevant agencies are recommended to continue to advance the vaccine immunization process. Simultaneously, special attention should be paid to the health status of the vaccines, timely treatment of complications, vaccine development, and ensuring the lives and health of patients. In addition, available measures such as mix-and-match vaccination, developing new vaccines like nanoparticle vaccines, and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered.
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Citations
Cites
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
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“In a clinical trial of the COVID-19 mRNA-1273 vaccine, three of 15,210 subjects developed facial paralysis.(114,118) Wan et al.”
BackgroundMethodInfluentialEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035389 · Cited by 10,119
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“Antitumor treatments, including radiotherapy and chemotherapy, may lead to systemic hypoimmunity.(203) Several studies have indicated that vaccination can protect about 50–60% of cancer patients from the SARS-CoV-2 infection; thus, they should receive COVID-19 vaccines as soon as possible and complete at least two dos…”
BackgroundAn mRNA Vaccine against SARS-CoV-2 — Preliminary Report
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“Similar to the viral vector vaccines, mRNA vaccines, especially mRNA-1273, also induced Th1 biased CD4 T-cell responses in clinical trials.(28,113) Moderna performed a Phase I clinical trial of mRNA-1273 (NCT04283461).”
BackgroundEffectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
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“Compared with other variants at that time, the Alpha variant had a stronger transmission ability, with a higher reproduction number.(128) Interestingly, the variant lineage contained three subgroups initially, but the variant with Del69/70 in the S protein eventually occupied the mainstream, and 96.”
BackgroundEstimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England
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Cited by
Toyama, K., Eto, T., Takazawa, K., Shimizu, S., Nakayama, T., Furihata, K., Sogawa, Y., Kumazaki, M., Jonai, N., Matsunaga, S., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.07.012 · Cited by 18
Li, X., Yin, Y., Cui, Q., Huang, W., Zou, Q., & Shen, T. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28279 · Cited by 4
Metadata
- Authors
- Li, M., Wang, H., Tian, L., Pang, Z., Yang, Q., Huang, T., Fan, J., Song, L., Tong, Y., & Fan, H.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2022-05-03
- Volume
- 7
- Issue
- 1
- Pages
- 146-146
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4225293614
- Cited by
- 434
- References
- 265
- FWCI
- 44.91
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, M., Wang, H., Tian, L., Pang, Z., Yang, Q., Huang, T., Fan, J., Song, L., Tong, Y., & Fan, H. (2022). COVID-19 vaccine development: milestones, lessons and prospects. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-022-00996-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
