The DOI matches its Crossref record; 392 of the 392 references it cites were found in a registry or an index.
Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
Open accessAbstract
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of signal transduction pathways and affect the expression levels of genes in epigenetics, which is called metabolite sensing. Life body regulates metabolism, immunity, and inflammation by metabolite sensing, coordinating the pathophysiology of the host to achieve balance with the external environment. Metabolic reprogramming in cancers cause different phenotypic characteristics of cancer cell from normal cell, including cell proliferation, migration, invasion, angiogenesis, etc. Metabolic disorders in cancer cells further create a microenvironment including many kinds of oncometabolites that are conducive to the growth of cancer, thus forming a vicious circle. At the same time, exogenous metabolites can also affect the biological behavior of tumors. Here, we discuss the metabolite sensing mechanisms of the three major nutrients and their derivatives, as well as their abnormalities in the development of various cancers, and discuss the potential therapeutic targets based on metabolite-sensing signaling pathways to prevent the progression of cancer.
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Cited by
Panwar, V., Singh, A., Bhatt, M., Tonk, R. K., Azizov, S., Raza, A. S., Sengupta, S., Kumar, D., & Garg, M. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01608-z · Cited by 967
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L.-L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 399
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133
Prognostic Implication of Plasma Metabolites in Gastric Cancer
Cao, K., Lyu, Y., Chen, J., He, C., Lyu, X., Zhang, Y., Chen, L., Jiang, Y., Xiang, J., Liu, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612774 · Cited by 16
Self-citation
Metadata
- Authors
- You, M., Xie, Z., Zhang, N., Zhang, Y., Xiao, D., Liu, S., Zhuang, W., Li, L., & Tao, Y.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2023-05-10
- Volume
- 8
- Issue
- 1
- Pages
- 196-196
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4376131851
- Cited by
- 292
- References
- 392
- FWCI
- 29.41
- Type
- journal article
- Language
- en
- Open access
- gold
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