Circadian and state-dependent core body temperature in people with spinal cord injury
Abstract
Study design Prospective cohort study.Objectives To analyze the circadian rhythm and state-dependent modulation of core body temperature (Tcore) in individuals with spinal cord injury (SCI) under controlled environmental conditions.Setting Institute of the Neurological Sciences of Bologna, Italy.Methods We assessed 48-h rectal Tcore and sleep-wake cycle by means of video-polygraphic recording in five cervical SCI (cSCI), seven thoracic SCI (tSCI), and seven healthy controls under controlled environmental conditions.Results cSCI showed higher night-time Tcore values with reduced nocturnal decrease, higher MESOR and earlier acrophase compared with tSCI and controls (p < 0.05 in all comparisons). The mean Tcore values during wake and non-rapid eye movement (NREM) and rapid eye movement (REM) sleep stages were higher in cSCI compared with tSCI and controls (p < 0.05). Tcore variability throughout the 24 h differed significantly between cSCI, tSCI, and controls.Conclusions cSCI had higher Tcore values without physiological night-time fall compared with controls and tSCI, and a disrupted Tcore circadian rhythm. Furthermore, SCI individuals did not display the physiological state-dependent Tcore modulation. The disconnection of the sympathetic nervous system from its central control caused by the SCI could affect thermoregulation including Tcore modulation during sleep. It is also possible that the reduced representation of deep sleep in people with SCI impairs such ability. Further studies are necessary to evaluate whether improvement of sleep could ameliorate thermoregulation and vice versa.
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Core temperature changes are affected by circadian rhythms.
“Core temperature changes are affected by circadian rhythms.”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [136]
Continuous measurement of core body temperature can determine the patient's circadian cycle.
“From continuous measurements of core body temperature, we can determine the circadian cycle of the patient.”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [136]
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The Current State of Optical Sensors in Medical Wearables
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- Authors
- Baschieri, F., Guaraldi, P., Provini, F., Chiogna, M., Barletta, G., Cecere, A., De Scisciolo, G., Cortelli, P., & Calandra-Buonaura, G.
- Affiliations
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- University of Bologna (IT)
- Corresponding author
- Guaraldi, Pietro
- ORCID
- Venue
- Spinal Cord
- Published
- 2020-07-17
- Volume
- 59
- Issue
- 5
- Pages
- 538-546
- ISSN
- 1362-4393 (ISSN-L)
- 1476-5624
- OpenAlex
- W3043520553
- Cited by
- 13
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Spinal Cord (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Keywords
- spinal cord injury, core body temperature, circadian rhythm, sleep-wake cycle, REM sleep, NREM sleep, cervical spinal cord injury, thoracic spinal cord injury, sympathetic nervous system, thermoregulation, acrophase, mesor
- MeSH terms
- Body Temperature, Circadian Rhythm, Humans, Prospective Studies, Sleep, Spinal Cord Injuries
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