Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review

Burns, Grace; Carroll, Georgia; Mathe, Andrea; Horvat, Jay; Foster, Paul; Walker, Marjorie M.; Talley, Nicholas J.; Keely, Simon

doi:10.1038/s41395-018-0377-0

Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review

BACKGROUND: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the ga…