Cited by 392Stress Responses and CortisolChild Abuse and TraumaPosttraumatic Stress Disorder Research

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Early-life adversity and cortisol response to social stress: a meta-analysis

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Bunea, Ioana Maria, Szentágotai-Tătar, Aurora, Miu, Andrei C.·2017·Translational Psychiatry

DOI 10.1038/s41398-017-0032-3PMC PMC5802499

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Abstract

Early-life adversity has been associated with a life-long increased risk for psychopathology and chronic health problems. These long-term negative effects have been explained through stress sensitization, which may involve dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis through either increased or decreased reactivity. The present meta-analysis assessed for the first time the effect of early-life adversity on cortisol response to social stress. Thirty data sets were included in the meta-analysis, in which early-life adversity and salivary cortisol response to social stress were assessed in 4292 individuals of different ages. Results indicated a moderate effect size (g = -0.39) in overall cortisol levels across studies. Separate analyses of cortisol at different stages of response showed large effect sizes at peak and recovery, and a moderate effect at baseline. Heterogeneity was large in this sample of studies and several moderators were identified. The effect size was larger in studies that focused on maltreatment compared to those that included other adversities, and in adults compared to children and adolescents. Percent of women in each sample and methodological quality were positive predictors of the effect size. Publication bias may be present, but the analysis was hampered by the high heterogeneity. Therefore, these results support the association between early-life adversity and blunted cortisol response to social stress, and they suggest that the long-term negative effects of early-life adversity may reach maximum levels in adults.

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Fig. 1 Flow diagram describing the process of study selectionCC BY · PubMed Central

Fig. 2 Forest plot showing the individual and pooled effect sizes of early-life adversity and cortisol response to social stressCC BY · PubMed Central

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Authors: Bunea, I. M., Szentágotai-Tătar, A., & Miu, A. C.
Affiliations: Babeș-Bolyai University (RO)
Corresponding author: Miu, Andrei C.
ORCID: Miu, Andrei C.
Venue: Translational Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2017-12-11
Volume: 7
Issue: 12
Pages: 1274-1274
ISSN: 2158-3188 (ISSN-L)
DOI: 10.1038/s41398-017-0032-3
PMC: PMC5802499
OpenAlex: W2771364118
Cited by: 392
References: 62
Citations by year: 2026: 42 · 2025: 42 · 2024: 52 · 2023: 53 · 2022: 52 · 2021: 63 · 2020: 43 · 2019: 28 · 2018: 16
FWCI: 2.10
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Translational Psychiatry (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (PN-III-P4-ID, PN-III-P4-ID-PCE-2016, PN-III-P4-ID-PCE-2016-0840)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: childhood adversity, cortisol response, social stress, HPA axis dysregulation, stress sensitization, child abuse, blunted cortisol response, salivary cortisol, psychopathology, chronic disease
MeSH terms: Adolescent, Adult, Child, Humans, Hydrocortisone, Life Change Events, Middle Aged, Saliva, Stress, Psychological, Young Adult

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Early-life adversity and cortisol response to social stress: a meta-analysis

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