Cited by 212Sperm and Testicular FunctionMicroRNA in disease regulationEpigenetics and DNA Methylation

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Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress

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Dickson, David A., Paulus, Jessica K., Mensah, Virginia, Lem, Janis, Saavedra-Rodriguez, Lorena, Gentry, Adrienne, Pagidas, Kelly, Feig, Larry A.·2018·Translational Psychiatry

DOI 10.1038/s41398-018-0146-2PMC PMC5966454

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Abstract

Exposure of male mice to early life stress alters the levels of specific sperm miRNAs that promote stress-associated behaviors in their offspring. To begin to evaluate whether similar phenomena occur in men, we searched for sperm miRNA changes that occur in both mice and men exposed to early life stressors that have long-lasting effects. For men, we used the Adverse Childhood Experience (ACE) questionnaire. It reveals the degree of abusive and/or dysfunctional family experiences when young, which increases risks of developing future psychological and physical disorders. For male mice, we used adolescent chronic social instability (CSI) stress, which not only enhances sociability defects for >1 year, but also anxiety and defective sociability in female offspring for multiple generations through the male lineage. Here we found a statistically significant inverse correlation between levels of multiple miRNAs of the miR-449/34 family and ACE scores of Caucasian males. Remarkably, we found members of the same sperm miRNA family are also reduced in mice exposed to CSI stress. Thus, future studies should be designed to directly test whether reduced levels of these miRNAs could be used as unbiased indicators of current and/or early life exposure to severe stress. Moreover, after mating stressed male mice, these sperm miRNA reductions persist in both early embryos through at least the morula stage and in sperm of males derived from them, suggesting these miRNA changes contribute to transmission of stress phenotypes across generations. Since offspring of men exposed to early life trauma have elevated risks for psychological disorders, these findings raise the possibility that a portion of this risk may be derived from epigenetic regulation of these sperm miRNAs.

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Exercise
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Physical Disability
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Additional file 2 of Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential
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Additional file 1 of Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction
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Additional file 5 of Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential
Salas‐Huetos, A., Ribas‐Maynou, J., Mateo‐Otero, Y., Tamargo, C., Llavanera, M., & Yeste, M. (2024) · Figshare · doi:10.6084/m9.figshare.26618620
Additional file 1 of Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential
Salas‐Huetos, A., Ribas‐Maynou, J., Mateo‐Otero, Y., Tamargo, C., Llavanera, M., & Yeste, M. (2024) · Figshare · doi:10.6084/m9.figshare.26618608
Additional file 4 of Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential
Salas‐Huetos, A., Ribas‐Maynou, J., Mateo‐Otero, Y., Tamargo, C., Llavanera, M., & Yeste, M. (2024) · Figshare · doi:10.6084/m9.figshare.26618617
Additional file 2 of Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction
Ma, Z., Li, J., Fu, L., Fu, R., Tang, N., Quan, Y., Xin, Z., Ding, Z., & Liu, Y. (2024) · Figshare · doi:10.6084/m9.figshare.24628169
Additional file 6 of Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential
Salas‐Huetos, A., Ribas‐Maynou, J., Mateo‐Otero, Y., Tamargo, C., Llavanera, M., & Yeste, M. (2024) · Figshare · doi:10.6084/m9.figshare.26618623
Additional file 3 of Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential
Salas‐Huetos, A., Ribas‐Maynou, J., Mateo‐Otero, Y., Tamargo, C., Llavanera, M., & Yeste, M. (2024) · Figshare · doi:10.6084/m9.figshare.26618614
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Authors: Dickson, D. A., Paulus, J. K., Mensah, V., Lem, J., Saavedra-Rodriguez, L., Gentry, A., Pagidas, K., & Feig, L. A.
Affiliations: Tufts University (US)
Brown University (US)
Tufts Medical Center (US)
University of Louisville (US)
Corresponding author: Feig, Larry A.
ORCID: Dickson, David A.
Paulus, Jessica K.
Gentry, Adrienne
Pagidas, Kelly
Feig, Larry A.
Venue: Translational Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2018-05-23
Volume: 8
Issue: 1
Pages: 101-101
ISSN: 2158-3188 (ISSN-L)
DOI: 10.1038/s41398-018-0146-2
PMC: PMC5966454
OpenAlex: W2803802792
Cited by: 208
References: 41
Citations by year: 2026: 11 · 2025: 20 · 2024: 16 · 2023: 61 · 2022: 16 · 2021: 25 · 2020: 27 · 2019: 28 · 2018: 4
FWCI: 22.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Translational Psychiatry (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Institutes of Health
Center for Neuroscience Research (P30 NS047243)
National Institute of Mental Health (R01MH107536)
National Institute of Neurological Disorders and Stroke (P30NS047243)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: sperm microRNA, miR-449, miR-34, early life stress, adverse childhood experiences, epigenetic regulation, sociability, anxiety, male fertility, embryonic development, stress biomarkers
MeSH terms: Adult Survivors of Child Adverse Events, Adult, Animals, Humans, Male, Spermatozoa, Stress, Psychological, MicroRNAs, White People, Mice

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Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress

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