Cited by 312Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsTreatment of Major Depression

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

Open access

Dafsari, Forugh S., Jessen, Frank·2020·Translational Psychiatry

DOI 10.1038/s41398-020-0839-1PMC PMC7239844

Open this paper in CoChat — free account Open PDF

Abstract

It is broadly acknowledged that the onset of dementia in Alzheimer’s disease (AD) may be modifiable by the management of risk factors. While several recent guidelines and multidomain intervention trials on prevention of cognitive decline address lifestyle factors and risk diseases, such as hypertension and diabetes, a special reference to the established risk factor of depression or depressive symptoms is systematically lacking. In this article we review epidemiological studies and biological mechanisms linking depression with AD and cognitive decline. We also emphasize the effects of antidepressive treatment on AD pathology including the molecular effects of antidepressants on neurogenesis, amyloid burden, tau pathology, and inflammation. We advocate moving depression and depressive symptoms into the focus of prevention of cognitive decline and dementia. We constitute that early treatment of depressive symptoms may impact on the disease course of AD and affect the risk of developing dementia and we propose the need for clinical trials.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41398-020-0839-1

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 The relationship between depression and cognitive decline throughout the development and clinical course of Alzheimer‘s disease (AD). Depression can occur in three different stages in relation to the process of neurodegeneration in AD. Depression can be a predisposing risk factor occuring before the onset of AD pathology. It might also be an early sign of neurodegenerative changes or a prodromal symptom with or without cognitive deficits. Finally, it may occur at the more advanced dementia stage of AD. In every stage depression is an important accelerating factor contributing to the clinical progression and conversion from a preclinical state to MCI and to dementia.CC BY · PubMed Central

Fig. 2 Impact of HPA axis dysregulation in depression on AD pathology. HPA axis: hypothalamic-pituitary-adrenal axis, GR: glucocorticoid receptor, APP: amyloid precursor protein, BDNF: brain-derived neurotrophic factor, AD: Alzheimer’s disease.CC BY · PubMed Central

Fig. 3 Impact of inflammation in depression on AD pathology. APP: amyloid precursor protein, BDNF: Brain-derived neurotrophic factor, AD: Alzheimer’s disease.CC BY · PubMed Central

Fig. 4 Impact of neurotransmitter imbalance in depression on AD pathology. 5-HT: 5-Hydroxytryptamine, DA: Dopamin, BDNF: Brain-derived neurotrophic factor, AD: Alzheimer’s disease.CC BY · PubMed Central

Fig. 5 Impact of depression-related mechanisms on AD pathology. AD: Alzheimer’s disease, HPA: Hypothalamic-pituitary-adrenal axis.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375

Show all 121 references

Sorted by citations

Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs
Monteiro, A. R., Barbosa, D. J., Remião, F., & Silva, R. V. D. S. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115522 · Cited by 375
The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology
Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324
Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment
Juszczyk, G., Mikulska, J., Kasperek, K., Pietrzak, D., Mrozek, W., & Herbet, M. (2021) · Antioxidants · doi:10.3390/antiox10091439 · Cited by 247
Ergothioneine, recent developments
Cheah, I. K.-M., & Halliwell, B. B. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101868 · Cited by 203
Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective
Mielke, M. M., Aggarwal, N. T., Vila‐Castelar, C., Agarwal, P., Arenaza‐Urquijo, E. M., Brett, B., Brugulat‐Serrat, A., DuBose, L. E., Eikelboom, W. S., Flatt, J., et al. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12662 · Cited by 198
Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160
Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers
Bang, D., Lim, S., Lee, S., & Kim, S. (2023) · Nature Communications · doi:10.1038/s41467-023-39301-y · Cited by 132
Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation
Castro, B. D., Bernstein, A. M., Coppola, G., Sofroniew, M. V., & Khakh, B. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109508 · Cited by 121
Inter-relationship between cognitive performance and depressive symptoms and their association with quality of life in older adults: A network analysis based on the 2017–2018 wave of Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Bai, W., Zhang, J., Smith, R. D., Cheung, T. C. C., Su, Z., Ng, C. H., Zhang, Q., & Xiang, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.159 · Cited by 116
Untitled work
(2022) · doi:10.1016/j.biopsych.2022.08.026 · Cited by 113
Depression and Dementia in Older Adults: A Neuropsychological Review
Tetsuka, S. (2021) · Aging and Disease · doi:10.14336/ad.2021.0526 · Cited by 120
Modifiable Risk Factors in Alzheimer Disease and Related Dementias: A Review
Litke, R. R., Garcharna, L. C., Jiwani, S., & Neugroschl, J. A. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2021.05.006 · Cited by 118
Stress-Induced Depression and Alzheimer’s Disease: Focus on Astrocytes
Dolotov, O. V., Inozemtseva, L. S., Myasoedov, N. F., & Grivennikov, I. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094999 · Cited by 104
Alzheimer’s Disease and Inflammaging
Kosyreva, A., Sentyabreva, A., Tsvetkov, I., & Makarova, O. (2022) · Brain Sciences · doi:10.3390/brainsci12091237 · Cited by 98
A novel hybrid model in the diagnosis and classification of Alzheimer's disease using EEG signals: Deep ensemble learning (DEL) approach
Nour, M., Şentürk, Ü., & Polat, K. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.105751 · Cited by 93
A Highly Selective In Vitro JNK3 Inhibitor, FMU200, Restores Mitochondrial Membrane Potential and Reduces Oxidative Stress and Apoptosis in SH-SY5Y Cells
Rehfeldt, S. C. H., Laufer, S., & Goettert, M. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073701 · Cited by 86
Predictors of depression among middle-aged and older men and women in Europe: A machine learning approach
Handing, E. P., Strobl, C., Jiao, Y., Feliciano, L., & Aichele, S. (2022) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2022.100391 · Cited by 81
Genetic Evidence Supporting a Causal Role of Depression in Alzheimer’s Disease
Harerimana, N. V., Liu, Y., Gerasimov, E. S., Duong, D. M., Beach, T. G., Reiman, E. M., Schneider, J. A., Boyle, P. A., Lori, A., Bennett, D. A., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.025 · Cited by 76
Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges
Wu, C., Yang, L., Feng, S., Zhu, L., Yang, L., Liu, T. C., & Duan, R. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00216-8 · Cited by 71
Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies
Chang, J., Jiang, T., Shan, X., Zhang, M., Li, Y. Y., Qi, X., Bian, Y., & Zhao, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110931 · Cited by 72
Gut microbiome predicts cognitive function and depressive symptoms in late life
Kolobaric, A., Andreescu, C., Jašarević, E., Hong, C. H., Roh, H., Cheong, J. Y., Kim, Y., Shin, T. S., Kang, C. S., Kwon, C. O., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02551-3 · Cited by 63
Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer’s disease
Reddy, A. P., Yin, X., Sawant, N. A., & Reddy, P. H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab054 · Cited by 54
Urban-rural disparities in the prevalence and trends of depressive symptoms among Chinese elderly and their associated factors
Wu, Y., Su, B., Chen, C., Zhao, Y., Zhong, P., & Zheng, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.117 · Cited by 57
Neuropsychiatric Symptoms in Mild Cognitive Impairment and Dementia Due to AD: Relation With Disease Stage and Cognitive Deficits
Wiels, W. A., Wittens, M. M. J., Zeeuws, D., Baeken, C., & Engelborghs, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.707580 · Cited by 52
Toward manipulating serotonin signaling via the microbiota–gut–brain axis
Everett, B. A., Tran, P., & Prindle, A. B. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102826 · Cited by 52
Novel Concepts for Conformal Load-Bearing Antenna Structure
Callus, P. J. (2008) · Cited by 52
Risk of incident dementia varies with different onset and courses of depression
Lee, A. T. C., Fung, A. W. T., Richards, M., Chan, W. C., Chiu, H. F. K., Lee, R. S. Y., & LAM, L. C. W. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.195 · Cited by 57
c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases
Rehfeldt, S. C. H., Majolo, F., Goettert, M. I., & Laufer, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249677 · Cited by 47
Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease
Caruso, G., Grasso, M., Fidilio, A., Torrisi, S. A., Musso, N., Geraci, F., Tropea, M. R., Privitera, A., Tascedda, F., Puzzo, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.809541 · Cited by 53
Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model
Chen, C., Lu, J., Peng, W., Mak, S., Yang, Y., Zhu, Z., Wang, S., Hou, J., Zhou, X. J., Xin, W., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106003 · Cited by 51
The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer’s disease
Fronza, M. G., Alves, D. A. C., Praticò, D., & Savegnago, L. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102033 · Cited by 47
Effectiveness of Dance-Based Interventions on Depression for Persons With MCI and Dementia: A Systematic Review and Meta-Analysis
Wang, Y., Liu, M., Tan, Y., Dong, Z., Wu, J., Cui, H., Shen, D., & Chi, I. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.709208 · Cited by 43
Antidepressants in Alzheimer’s Disease: A Focus on the Role of Mirtazapine
Correia, A. S., & Vale, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090930 · Cited by 42
The physician's Alzheimer's disease management guide: Early detection and diagnosis of cognitive impairment, Alzheimer's disease and related dementia
Reiss, A. B., Raphael, D. D. L., Chin, N. A., & Sinha, V. (2022) · AIMS Public Health · doi:10.3934/publichealth.2022047 · Cited by 40
Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation
Du, L., Fan, X., Yang, Y., Wu, S., & Liu, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03926-x · Cited by 41
Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling
Cong, Y.-F., Liu, F.-W., Xu, L., Song, S., Shen, X.-R., Liu, D., Hou, X.-Q., & Zhang, H. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad042 · Cited by 40
Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study
Gonzales, M. M., Samra, J. K., O’Donnell, A., Mackin, R. S., Salinas, J., Jacob, M. E., Satizábal, C. L., Aparicio, H. J., Thibault, E. G., Sanchez, J. S., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210232 · Cited by 39
Effectiveness of vortioxetine in patients with major depressive disorder and early-stage dementia: The MEMORY study
Christensen, M. C., Schmidt, S. N., & Grande, I. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.06.024 · Cited by 38
Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis
Twait, E. L., Wu, J.-H., Kamarioti, M., Basten, M., van der Flier, W. M., Gerritsen, L., & Geerlings, M. I. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02739-9 · Cited by 41
Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer’s disease
Shu, S., Xu, S., Ye, L., Liu, Y., Cao, X., Jia, J., Bian, H.-J., Liu, Y., Zhu, X., & Xu, Y. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01435-w · Cited by 39
Later life depression as risk factor for developing dementia: epidemiological evidence, predictive models, preventive strategies and future trends
Piras, F., Banaj, N., Porcari, D. E., Piras, F., & Spalletta, G. (2021) · Minerva Medica · doi:10.23736/s0026-4806.21.07571-6 · Cited by 35
Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity
Gillotin, S., Sahni, V., Lepko, T., Hanspal, M. A., Swartz, J., Alexopoulou, Z., & Marshall, F. H. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101447 · Cited by 34
Perspectives on the complex links between depression and dementia
Hakim, A. M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.821866 · Cited by 34
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model
Yang, L., Wu, C., Tucker, L. D., Dong, Y., Li, Y., Xu, P., & Zhang, Q. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201616 · Cited by 34
Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission
Maia, W. M. N., de Andrade, F. D. C. P., Filgueiras, L. A., Mendes, A. N., Assunção, A. F. C., Rodrigues, N. D. S., Marques, R. B., Filho, A. L. M. M., de Sousa, D. P., & Lopes, L. D. S. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06620 · Cited by 32
Stress vulnerability shapes disruption of motor cortical neuroplasticity
Gellner, A., Sitter, A., Rackiewicz, M., Sylvester, M., Philipsen, A., Zimmer, A., & Stein, V. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01855-8 · Cited by 34
Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial
Dafsari, F. S., Bewernick, B., Böhringer, S., Domschke, K., Elsaesser, M., Löbner, M., Luppa, M., Preis, L., Püsken, J., Schmitt, S., et al. (2023) · Psychotherapy and Psychosomatics · doi:10.1159/000529445 · Cited by 30
Self-citation
Association of long-term air pollution and ambient noise with cognitive decline in the Heinz Nixdorf Recall study
Ogurtsova, K., Soppa, V., Weimar, C., Jöckel, K., Jokisch, M., & Hoffmann, B. H. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121898 · Cited by 30
Divorce and physical health: A three-level meta-analysis
Pellón-Elexpuru, I., van Dijk, R., van der Valk, I. E., Martínez‐Pampliega, A., Molleda, A., & Cormenzana, S. (2024) · Social Science & Medicine · doi:10.1016/j.socscimed.2024.117005 · Cited by 48
The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia
Phyo, A. Z. Z., on behalf of the ASPREE Investigator Group, González‐Chica, D. A., Stocks, N., Storey, E., Woods, R. L., Murray, A. M., Orchard, S. G., Shah, R. C., Gašević, D., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201349 · Cited by 30
The associations between whole grain and refined grain intakes and serum C-reactive protein
Taskinen, R. E., Hantunen, S., Tuomainen, T., & Virtanen, J. K. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00996-1 · Cited by 30
Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
Lima‐Filho, R. A. S., Fortuna, J. T. S., Cozachenco, D., Isaac, A. R., Silva, N. M. L. E., Saldanha, A., Santos, L. E., Ferreira, S. T., Lourenco, M. V., & Felice, F. G. D. (2023) · eNeuro · doi:10.1523/eneuro.0256-22.2023 · Cited by 31
Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares
Smith, G. S., Workman, C. I., Protas, H. D., Su, Y., Savonenko, A. V., Kuwabara, H., Gould, N. F., Kraut, M. A., Joo, J. H., Nandi, A., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01539-9 · Cited by 32
Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population
Yao, Q., Jiang, K., Lin, F., Zhu, T., Khan, N. H., & Jiang, E. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s400527 · Cited by 31
Disease severity and mortality in Alzheimer's disease: an analysis using the U.S. National Alzheimer’s Coordinating Center Uniform Data Set
Crowell, V., Reyes, A., Zhou, S. Q., Vassilaki, M. E., Gsteiger, S., & Gustavsson, A. (2023) · BMC Neurology · doi:10.1186/s12883-023-03353-w · Cited by 31
Distinguishing features of depression in dementia from primary psychiatric disease
Fisher, D. W., Dunn, J. T., & Dong, H. (2024) · Discover Mental Health · doi:10.1007/s44192-023-00057-y · Cited by 34
The impact of immersive virtual reality meditation for depression and anxiety among inpatients with major depressive and generalized anxiety disorders
Lee, J., Kim, J., & Ory, M. G. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1471269 · Cited by 29
Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
Rostamzadeh, A., Kahlert, A., Kalthegener, F., & Jessen, F. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00956-8 · Cited by 26
Self-citation
Neurological and mental health consequences of COVID-19: potential implications for well-being and labour force
Meier, I. B., Teixeira, C. V. L., Tarnanas, I., Mirza, F., & Rajendran, L. (2021) · Brain Communications · doi:10.1093/braincomms/fcab012 · Cited by 26
Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study
Preez, A. D., Lefèvre‐Arbogast, S., González‐Domínguez, R., Houghton, V., de Lucia, C., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust‐Lima, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01644-1 · Cited by 27
Once-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice
Pignataro, P., Dicarlo, M., Suriano, C., Sanesi, L., Zerlotin, R., Storlino, G., Oranger, A., Zecca, C., Dell’Abate, M. T., Mori, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076715 · Cited by 29
Dementia Prevention in Clinical Practice
Niotis, K., Akiyoshi, K., Carlton, C., & Isaacson, R. (2022) · Seminars in Neurology · doi:10.1055/s-0042-1759580 · Cited by 26
Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Liu, J.-J., Long, Y.-F., Xu, P., Guo, H.-D., & Cui, G.-H. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01264-z · Cited by 26
Molecular bases of comorbidities: present and future perspectives
Sánchez-Valle, J., & Valencia, A. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.06.003 · Cited by 25
Bidirectional crosstalk between microglia and serotonin signaling in neuroinflammation and CNS disorders
Zheng, Y., & Xu, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1646740 · Cited by 25
Molecular imaging of beta-amyloid deposition in late-life depression
Smith, G. S., Kuwabara, H., Nandi, A., Gould, N. F., Nassery, N., Savonenko, A. V., Joo, J. H., Kraut, M. A., Brašić, J. R., Holt, D. P., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.002 · Cited by 27
Ensemble feature selection with data-driven thresholding for Alzheimer's disease biomarker discovery
Spooner, A., Mohammadi, G., Sachdev, P. S., Brodaty, H., Sowmya, A., & Initiative, A. D. N. (2023) · BMC Bioinformatics · doi:10.1186/s12859-022-05132-9 · Cited by 32
CALHM2 V136G polymorphism reduces astrocytic ATP release and is associated with depressive symptoms and Alzheimer's disease risk
Liao, Y., Wang, Y., Tao, Q.-Q., Yang, C., Wang, J.-L., Cheng, J.-B., Ma, J., Wu, Z.-Y., Pan, R., & Yuan, Z.-Q. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13366 · Cited by 19
Association between antidepressants and dementia risk in older adults with depression: a systematic review and meta-analysis
Wang, G. H.-M., Li, P., Wang, Y., Guo, J., Wilson, D. L., & Lo-Ciganic, W.-H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196342 · Cited by 23
Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Bajaj, S., & Mahesh, R. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09170-1 · Cited by 25
Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer’s disease
Tag, S. H., Kim, B., Bae, J., Chang, K., & Im, H. (2022) · Molecular Brain · doi:10.1186/s13041-022-00933-8 · Cited by 22
Intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an Alzheimer's disease model
Farhangian, M., Azarafrouz, F., Chavoshinezhad, S., & Dargahi, L. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136968 · Cited by 22
Associations between psychological therapy outcomes for depression and incidence of dementia
John, A., Saunders, R., Desai, R., Bell, G., Fearn, C., Buckman, J. E. J., Brown, B., Nurock, S., Michael, S., Ware, P., et al. (2022) · Psychological Medicine · doi:10.1017/s0033291722002537 · Cited by 28
Alzheimer’s disease risk reduction in clinical practice: a priority in the emerging field of preventive neurology
Niotis, K., Saperia, C., Saif, N., Carlton, C., & Isaacson, R. (2024) · Nature Mental Health · doi:10.1038/s44220-023-00191-0 · Cited by 20
Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
Haniff, Z. R., Bocharova, M., Mantingh, T., Rucker, J., Velayudhan, L., Taylor, D. M., Young, A. H., Aarsland, D., Vernon, A. C., & Thuret, S. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108641 · Cited by 21
Effects of three-duration Tai-Chi exercises on depression and sleep quality in older women
Chang, S., Cheng, L., & Liu, H. (2024) · European Geriatric Medicine · doi:10.1007/s41999-024-00981-4 · Cited by 26
Exploring the L-shaped relationship between Atherogenic Index of Plasma and depression: Results from NHANES 2005–2018
Zhang, H., Zhang, G., & Fu, J. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.073 · Cited by 21
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders
Wen, J., Skampardoni, I., Tian, Y., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G. B., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01412-w · Cited by 21
The trajectories of depressive symptoms and subsequent incident dementia, coronary heart diseases, stroke and all-cause mortality
Wu, T., Li, C., Zhu, Y., Ma, Y., Hua, R., Zhong, B., & Xie, W. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.001 · Cited by 18
Sleep duration, sleep efficiency, and amyloid β among cognitively healthy later-life adults: a systematic review and meta-analysis
Moon, C., Schneider, A. C., Cho, Y.-E., Zhang, M., Dang, H., & Vu, K. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05010-4 · Cited by 22
Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies
Gao, X., Li, Y., Sun, Z., Xu, H., Ma, G., Deng, Q., Zhang, C. X., & Li, R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02313-0 · Cited by 18
Alzheimer’s disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling
Cutuli, D., Giacovazzo, G., Decandia, D., & Coccurello, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1010169 · Cited by 19
Does resveratrol improve cognition in humans? A scientometric study to an in‐depth review
Tu, W., Song, M., & Fan, X. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14276 · Cited by 18
Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults
Munro, C. E., Farrell, M. E., Hanseeuw, B. J., Rentz, D. M., Buckley, R. F., Properzi, M. J., Yuan, Z., Vannini, P., Amariglio, R. E., Quiroz, Y. T., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.27248 · Cited by 22
The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study
Bocharova, M., Borza, T., Watne, L. O., Engedal, K., O'Brien, J. T., Selbæk, G., Idland, A., Hodsoll, J. P., Young, A. H., & Aarsland, D. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02908-2 · Cited by 19
Impact of Integrated Care Pathways Within the Framework of Collaborative Care on Older Adults With Anxiety, Depression, or Mild Cognitive Impairment
Dham, P., McAiney, C. A., Saperson, K., Wang, W., Malik, N., Parascandalo, F., Zhao, H., Lourenço, L., Oliver, D., Kates, N., et al. (2022) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2022.01.010 · Cited by 17
From Mild Cognitive Impairment to Dementia: The Impact of Comorbid Conditions on Disease Conversion
Menegon, F., Marchi, F. D., Aprile, D., Zanelli, I., Decaroli, G., Comi, C., & Tondo, G. (2024) · Biomedicines · doi:10.3390/biomedicines12081675 · Cited by 18
Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading
Liu, X., Wang, H., Tian, X., Luo, Y., Ma, M., Zheng, Z., Wang, Y., Shi, F., Wang, Q., Xu, Z. F., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03488-2 · Cited by 17
Glucocorticoids, synaptic plasticity and Alzheimer’s disease
Klyubin, I., Ondrejcak, T., Hu, N.-W., & Rowan, M. J. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100365 · Cited by 16
Pinus halepensis Essential Oil Ameliorates Aβ1-42-Induced Brain Injury by Diminishing Anxiety, Oxidative Stress, and Neuroinflammation in Rats
Postu, P. A., Mihăşan, M., Gorgan, L., Sadiki, F. Z., Idrissi, M. E., & Hriţcu, L. (2022) · Biomedicines · doi:10.3390/biomedicines10092300 · Cited by 16
Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders
Gao, X., Sun, Z., Ma, G., Li, Y., Liu, M., Zhang, G., Xu, H., Gao, Y., Zhou, J., Deng, Q., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.682691 · Cited by 16
Structural variants linked to Alzheimer’s disease and other common age-related clinical and neuropathologic traits
Vialle, R. A., Lopes, K. D. P., Li, Y., Ng, B., Schneider, J. A., Buchman, A. S., Wang, Y., Farfel, J. M., Barnes, L. L., Wingo, A. P., et al. (2025) · Genome Medicine · doi:10.1186/s13073-025-01444-6 · Cited by 19
Inhibition Of Tau Protein Aggregation By a Chaperone-like β-Boswellic Acid Conjugated To Gold Nanoparticles
Gharb, M., Nouralishahi, A., Riazi, A., & Riazi, G. H. (2022) · ACS Omega · doi:10.1021/acsomega.2c03616 · Cited by 15
Adolescent neurodevelopment and psychopathology: The interplay between adversity exposure and genetic risk for accelerated brain ageing
Petrican, R., & Fornito, A. (2023) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2023.101229 · Cited by 16
Predicting Dementia Risk Factors Based on Feature Selection and Neural Networks
Javeed, A., Dallora, A. L., Berglund, J. S., Ali, A., Anderberg, P., & Ali, L. (2023) · Computers, materials & continua/Computers, materials & continua (Print) · doi:10.32604/cmc.2023.033783 · Cited by 15
Exploring the Relationship of Leisure Travel with Loneliness, Depression, and Cognitive Function in Older Adults
Cole, S. T., Hua, C., Peng, S., & Wang, W. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21040498 · Cited by 17
Therapeutic implications of hypothalamic-pituitaryadrenal-axis modulation in Alzheimer’s disease: A narrative review of pharmacological and lifestyle interventions
Watermeyer, T., Robb, C. E., Gregory, S., & Udeh‐Momoh, C. T. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100877 · Cited by 15
Effectiveness of vortioxetine in patients with major depressive disorder and comorbid Alzheimer’s disease in routine clinical practice: An analysis of a post-marketing surveillance study in South Korea
Cumbo, E., Adair, M., Åström, D. O., & Christensen, M. C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1037816 · Cited by 14
Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer’s Disease Based on Major Depressive Disorder Risk Variants
Upadhya, S., Liu, H., Luo, S., Lutz, M. W., & Chiba‐Falek, O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.827447 · Cited by 15
Chronic stress, gut microbiota, and immunity: interconnections and implications for health
Jia, H., Guo, X., Wei, Y., Can, C., He, N., Zhang, H., Yang, X., Wu, H., Liu, W., & Ma, D. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05376-y · Cited by 14

Authors: Dafsari, F. S., & Jessen, F.
Affiliations: University of Cologne (DE)
Corresponding author: Dafsari, Forugh S.
ORCID: Dafsari, Forugh S.
Jessen, Frank
Venue: Translational Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2020-05-20
Volume: 10
Issue: 1
Pages: 160-160
ISSN: 2158-3188 (ISSN-L)
DOI: 10.1038/s41398-020-0839-1
PMC: PMC7239844
OpenAlex: W3028374504
Cited by: 312
References: 121
Citations by year: 2026: 38 · 2025: 65 · 2024: 68 · 2023: 56 · 2022: 44 · 2021: 33 · 2020: 6
FWCI: 5.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Translational Psychiatry (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
DZNE Pub (publishedVersion, other-oa)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: depression, Alzheimer's disease, dementia prevention, cognitive decline, depressive symptoms, antidepressants, neurogenesis, amyloid burden, tau pathology, neuroinflammation, risk factors, early treatment
MeSH terms: Alzheimer Disease, Depression, Humans, Life Style, Risk Factors, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks