Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

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Neuroinflammation in Alzheimer's disease

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Dementia prevention, intervention, and care

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The global prevalence of dementia: a systematic review and metaanalysis.

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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A Meta-Analysis of Cytokines in Major Depression

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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

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The role of inflammation in depression: from evolutionary imperative to modern treatment target

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A Neurotrophic Model for Stress-Related Mood Disorders

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Association between first-line antidepressant use and risk of dementia in older adults: a retrospective cohort study

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Epigenetic modification related to cognitive changes during a cognitive training intervention in depression

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Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease

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Association between CNS-active drugs and risk of Alzheimer’s and age-related neurodegenerative diseases

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Biomarkers of cognitive and memory decline in psychotropic drug users

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Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease

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Tai chi improves depressive symptoms among community-dwelling older persons by mediating BDNF methylation: A preliminary study

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Modifiable psychosocial risk factors and delayed onset of dementia in older populations: analysis of two prospective US cohorts

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Using artificial intelligence to learn optimal regimen plan for Alzheimer’s disease

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Deciphering the links between psychological stress, depression, and neurocognitive decline in patients with Down syndrome

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Depressive Symptoms Correlate With Tau Accumulation Rates in Amyloid Positive Adults

Talmasov, D., Johnson, A. S., Brown, P. J., Provenzano, F. A., Lao, P. J., Marder, K. S., & Miller, J. M. (2025) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2025.04.207 · Cited by 11

A network analysis study of anxiety, depression and loneliness among middle-aged and elderly people in Xining area

Dong, B., Li, B., Fan, X.-W., Chen, H., Dang, Z.-C., & Li, Z. (2025) · BMC Psychology · doi:10.1186/s40359-025-03248-0 · Cited by 11

Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults

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Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer’s Disease

Acosta‐Baena, N., Gómez, C. M. L., Elorza, M. C. J., Velilla-Jiménez, L. M., Villegas‐Lanau, C. A., Falla, D. S., Arcos‐Burgos, M., & Lopera, F. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221294 · Cited by 11

Old-age mental telehealth services at primary healthcare centers in low- resource areas in Greece: design, iterative development and single-site pilot study findings

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Lifestyle Factors Counteract the Neurodevelopmental Impact of Genetic Risk for Accelerated Brain Aging in Adolescence

Petrican, R., Fornito, A., & Boyland, E. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.023 · Cited by 14

Exercise as a Potential Therapeutic Strategy to Target the Clinical Link Between Depression and Alzheimer’s Disease: A Narrative Review

Freberg, E., & Taglialatela, G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-210632 · Cited by 11

Three dimensions of long‐term care provision in middle‐income countries—A view across Africa, Latin America and Asia

Kraus, M., & Riedel, M. (2022) · International Journal of Social Welfare · doi:10.1111/ijsw.12537 · Cited by 11

Mendelian Randomization Analysis Reveals Causal Factors behind Alzheimer's Disease Risk: Evidence, Opportunities, and Challenges

Feng, X., Zhang, L., Hou, Y., Ma, W., Ma, J., Chang, X., & Yang, L. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.30 · Cited by 10

“Cognitive” Criteria in Older Adults With Slow Gait Speed: Implications for Motoric Cognitive Risk Syndrome

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20‐year depressive symptoms, dementia, and structural neuropathology in older women

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Affective reserve: A new reserve concept we should talk about

Rosa, E. D. (2024) · PLOS mental health. · doi:10.1371/journal.pmen.0000083 · Cited by 10

Mechanistic Approach to Immunity and Immunotherapy of Alzheimer’s Disease: A Review

Islam, M. R., Rabbi, M. A., Hossain, T., Sultana, S., & Uddin, S. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00360 · Cited by 10

Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co‐pathologies, and sex differences

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Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer’s disease and/or major depressive disorder

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The combination of olfactory dysfunction and depression increases the risk of incident dementia in older adults

Kalam, S., Numbers, K. T., Lipnicki, D. M., Lam, B. C. P., Brodaty, H., & Reppermund, S. (2023) · International Psychogeriatrics · doi:10.1017/s1041610223000480 · Cited by 10

Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential

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Neuroimmunological investigations of cerebrospinal fluid in patients with recent onset depression – a study protocol

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Identifying progression subphenotypes of Alzheimer's disease from large-scale electronic health records with machine learning

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Resolving a paradox: antidepressants, neuroinflammation, and neurodegeneration

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Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App NL - F Mouse Model of Alzheimer’s Disease

Portal, B., Södergren, M., Borrell, T. P. I., Giraud, R., Metzendorf, N. G., Hultqvist, G., Nilsson, P., & Lindskog, M. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231461 · Cited by 10

Interactions of Emotion and Memory in the Aging Brain: Neural and Psychological Correlates

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Prescription Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Incidence of Depression Among Older Cancer Survivors With Osteoarthritis: A Machine Learning Analysis

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Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study

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Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults

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A Gut Microbial Metabolite Alleviates Stress-Induced Neurobehavioral Dysfunction in an Alzheimer’s Disease Model

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Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise

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Antidepressants as a potential candidate to reduce microglia activation in neurodegenerative diseases. A systematic review and meta-analysis of preclinical studies

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Neurobiological correlation between phosphorylated tau and mood symptoms in memory clinic patients

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Prevalence of Depressive Symptoms in a Memory Clinic Cohort: A Retrospective Study

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Multimorbid Patterns and Cognitive Performance in the Presence of Informative Dropout Among Community-Dwelling Taiwanese Older Adults

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Emotion expressions and cognitive impairments in the elderly: review of the contactless detection approach

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The relationship between widowhood and depressive symptoms among Chinese older adults: Does living alone make a difference?

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Low levels of soluble neuropilin‐1 were associated with depression in adults with newly diagnosed type 2 diabetes

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The integral role of lifestyle in the prevention and management of hypertension and associated cardiometabolic and cognitive disorders: a review

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The role of frailty in advanced HF and cardiac transplantation

Bart, N., Powell, A., & Macdonald, P. S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1082371 · Cited by 7

Depressive Symptomatology as a Predictor of Cognitive Impairment: Evidence from the Korean Longitudinal Study of Aging (KLOSA), 2006–2020

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Does the Cognitive Change Index Predict Future Cognitive and Clinical Decline? Longitudinal Analysis in a Demographically Diverse Cohort

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Association of Depression and Cognitive Performance in US Older Adults: A Secondary Analysis of Cross-Sectional Data Using NHANES 2013–2014

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ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer’s disease

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Psychological resilience and neurodegenerative risk: A connectomics‐transcriptomics investigation in healthy adolescent and middle‐aged females

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Anti-Amyloid Drugs for Alzheimer’s Disease: Considering the Role of Depression

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Successful aging was negatively associated with depression and anxiety symptoms among adults aged 65 years and older in Ningbo, China

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Alzheimer’s disease with depression: clinical characteristics and potential mechanisms involving orexin and brain atrophy

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Depression as a risk factor for Alzheimer’s disease: A human post-mortem study

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Characterizing the progression from mild cognitive impairment to dementia: a network analysis of longitudinal clinical visits

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Exploring the Complex Relationship Between Antidepressants, Depression and Neurocognitive Disorders

Neațu, M., Ioniță, I., Jugurt, A., Davidescu, E. I., & Popescu, B. O. (2024) · Biomedicines · doi:10.3390/biomedicines12122747 · Cited by 7

Alterations in structural and functional magnetic resonance imaging associated with cognitive function in patients with treatment-naïve first-episode major depressive disorder

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Fluoxetine Protects Retinal Ischemic Damage in Mice

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Morphofunctional Changes in Brain and Peripheral Blood in Adult and Aged Wistar Rats with AlCl3-Induced Neurodegeneration

Sentyabreva, A. V., Miroshnichenko, E. A., Melnikova, E. A., Цветков, И. С., & Kosyreva, A. M. (2023) · Biomedicines · doi:10.3390/biomedicines11092336 · Cited by 7

Physical Activity Intensity and Suspected Dementia in Older Japanese Adults: A Dose-Response Analysis Based on an 8-Year Longitudinal Study

Nagata, K., Tsunoda, K., Fujii, Y., Tsuji, T., & Okura, T. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220104 · Cited by 6

Views of Aging and Subjective Cognition in Middle-Aged and Older Adults: A Systematic Review

Hill, N. L., Do, J., Bratlee‐Whitaker, E., Turner, J. R., Sillner, A. Y., Fishman, C., & Mogle, J. A. (2024) · Gerontology · doi:10.1159/000542507 · Cited by 6

Application of machine learning models for predicting depression among older adults with non-communicable diseases in India

Yadav, K., & Bhutia, D. T. (2025) · Scientific Reports · doi:10.1038/s41598-025-18053-3 · Cited by 10

The flavonoid fisetin reduces multiple physiological risk factors for dementia

Maher, P. A. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105805 · Cited by 5

Effectiveness of Vortioxetine Treatment on Depression and Cognitive Functions in Patients with Alzheimer’s Disease: A 12-Month, Retrospective, Observational Study

García‐Alberca, J. M., de la Guía, P., Gris, E., Mendoza, S., de la Rica, M. L., Barbancho, M. Á., Lara, J. P., & Blanco‐Reina, E. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14090918 · Cited by 5

Use of high cost care among Veterans with comorbid mental illness and Alzheimer’s Disease and related dementias

Shepherd‐Banigan, M. E., Miller, K. E. M., Hastings, S. N., Schleiden, L. J., & Thorpe, J. M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282071 · Cited by 7

Cognitive Sequelae of COVID ‐19: Mechanistic Insights and Therapeutic Approaches

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Potential role of Drug Repositioning Strategy (DRS) for management of tauopathy

Zaki, M. O., Elsherbiny, D. A., Salama, M., & Azab, S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120267 · Cited by 6

Fluctuation of depressive symptoms in cognitively unimpaired participants and the risk of mild cognitive impairment 5 years later: Results of the Heinz Nixdorf Recall study

Jokisch, M., Schramm, S. H., Weimar, C., Moebus, S., Gronewold, J., Dragano, N., & Jöckel, K. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.988621 · Cited by 5

Sex Differences in Longitudinal Trajectories of Cognitive Aging in Zaragoza, Spain

Lobo, E., Lobo, A., Gracia‐García, P., López‐Antón, R., Saz, P., & de la Cámara, C. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.04.012 · Cited by 5

Race and Ethnicity and Comorbidities Among Medicare Beneficiaries With Young-Onset Dementia

Dai, J., Chau, T., Corrada, M. M., Manson, S. M., O’Connell, J., & Jiang, L. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.28001 · Cited by 4

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts

Qi, X., Liu, L., Jin, Y., Pan, C., Hao, J., Wei, W., Cheng, S., Gou, Y., Zhao, B., Wen, Y. F., et al. (2025) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796025100176 · Cited by 5

The potential for synergistic effect of non-invasive brain stimulation and cognitive behavioural therapy for depressive and cognitive outcomes in major depressive disorder: A scoping review

Khanna, A., Shergill, M., Soni, N., Blair, M., & Burhan, A. M. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117011 · Cited by 4

KET-MCI: A Pilot Safety and Tolerability Study of Single Infusion Intravenous Ketamine for Older Adults with Depression and Mild Cognitive Impairment

Fremont, R., Karim, A., Estevez, T. P., McDonough, C., LaBarbiera, A., Feder, A., Naasan, G., Delgado, A. D., Ds, C., & Murrough, J. W. (2026) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2026.02.005 · Cited by 4

Depressive symptoms in the entire spectrum of cognitive ageing in Greece: evidence from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)

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