Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

Dementia prevention, intervention, and care

Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072

The global prevalence of dementia: a systematic review and metaanalysis.

Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

The role of inflammation in depression: from evolutionary imperative to modern treatment target

Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111

Cytokines sing the blues: inflammation and the pathogenesis of depression

Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis

Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343

The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis

SAPOLSKY, R. M., KREY, L. C., & McEWEN, B. S. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-3-284 · Cited by 2,298

World Alzheimer Report 2015 - The Global Impact of Dementia:An analysis of prevalence, incidence, cost and trends

(2015) · HAL · Cited by 2,238

'Vascular Depression' Hypothesis

Alexopoulos, G. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220033006 · Cited by 1,843

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis

Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610

Depression and Risk for Alzheimer Disease: Systematic Review, Meta-analysis, and Metaregression Analysis

Ownby, R. L., Crocco, E., Acevedo, A., John, V., & Loewenstein, D. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.530 · Cited by 1,493

Twenty years of research on cytokine-induced sickness behavior

Dantzer, R., & Kelley, K. W. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.006 · Cited by 1,420

Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies

Diniz, B. S., Butters, M. A., Albert, S. M., Dew, M. A., & Reynolds, C. F. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.112.118307 · Cited by 1,290

Depression and risk of developing dementia

Byers, A. L., & Yaffe, K. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.60 · Cited by 1,265

Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications

Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180

Untreated Depression and Hippocampal Volume Loss

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180

Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

Czéh, B., Michaelis, T., Watanabe, T., Frahm, J., de Biurrun, G., van Kampen, M., Bartolomucci, A., & Fuchs, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427898 · Cited by 1,114

A Meta-Analysis of Cytokines in Alzheimer's Disease

Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

ARUK Consortium, Sims, R., GERAD/PERADES, C., van der Lee, S. J., Naj, A. C., Bellenguez, C., Badarinarayan, N., Jakobsdottir, J., Kunkle, B. W., Boland, A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3916 · Cited by 1,012

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939

Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment

Malberg, J. E., & Duman, R. S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300234 · Cited by 815

Hippocampal Neurogenesis: Regulation by Stress and Antidepressants

Dranovsky, A., & Hen, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.082 · Cited by 663

Depression: a case of neuronal life and death?

Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.033 · Cited by 630

Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease

Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623

Preclinical models: status of basic research in depression

Nestler, E. J., Gould, E., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01405-1 · Cited by 571

How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans

Frodl, T., & O'Keane, V. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.012 · Cited by 555

Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study

Green, R. C., Cupples, L. A., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., Duara, R., Kukull, W. A., Chui, H., Edeki, T., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.5.753 · Cited by 551

Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice

Mainardi, M., Garbo, A. D., Caleo, M., Berardi, N., Sale, A., & Maffei, L. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00001 · Cited by 550

Pathways linking late-life depression to persistent cognitive impairment and dementia

Butters, M. A., Young, J. K., López, O. L., Aizenstein, H. J., Mulsant, B. H., Reynolds, C. F., DeKosky, S. T., & Becker, J. T. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.3/mabutters · Cited by 549

Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis

Ismail, Z., Elbayoumi, H., Fischer, C. E., Hogan, D. B., Millikin, C. P., Schweizer, T., Mortby, M. E., Smith, E. E., Patten, S. B., & Fiest, K. M. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3162 · Cited by 532

Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study

Singh-Manoux, A., Dugravot, A., Fournier, A., Abell, J., Ebmeier, K., Kivimäki, M., & Sabia, S. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0660 · Cited by 529

History of Depression as a Risk Factor for Dementia: An Updated Review

Jorm, A. F. (2001) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.00967.x · Cited by 526

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 474

Midlife vs Late-Life Depressive Symptoms and Risk of Dementia

Yaffe, K. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1481 · Cited by 468

Depressive Symptoms, Vascular Disease, and Mild Cognitive Impairment: Findings From the Cardiovascular Health Study

Barnes, D. E., Alexopoulos, G. S., Lopez, O. L., Williamson, J. D., & Yaffe, K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.273 · Cited by 465

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

Fagan, A. M., Xiong, C., Jasielec, M. S., Bateman, R. J., Goate, A. M., Benzinger, T. L. S., Ghetti, B., Martins, R. N., Masters, C. L., Mayeux, R., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007901 · Cited by 434

Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?

Kessing, L. V. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.031773 · Cited by 406

Treating Depression in Alzheimer Disease: Efficacy and Safety of Sertraline Therapy, and the Benefits of Depression Reduction: The DIADS

Lyketsos, C. G., DelCampo, L., Steinberg, M., Miles, Q., Steele, C. D., Munro, C., Baker, A. S., Sheppard, J.-M. E., Frangakis, C., Brandt, J., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.737 · Cited by 398

Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects

Ma, K., Xiong, N., Shen, Y., Han, C., Liu, L., Zhang, G., Wang, L., Guo, S., Guo, X., Xia, Y. F., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00001 · Cited by 394

Late-life depression, mild cognitive impairment, and dementia

Richard, E., Reitz, C., Honig, L. H., Schupf, N., Tang, M. X., Manly, J. J., Mayeux, R., Devanand, D., & Luchsinger, J. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.603 · Cited by 389

Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment

Dotson, V. M., Beydoun, M. A., & Zonderman, A. B. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e62124 · Cited by 385

10-year trajectories of depressive symptoms and risk of dementia: a population-based study

Mirza, S. S., Wolters, F. J., Swanson, S. A., Koudstaal, P. J., Hofman, A., Tiemeier, H., & Ikram, M. A. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00097-3 · Cited by 385

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

Tynan, R. J., Weidenhofer, J., Hinwood, M., Cairns, M. J., Day, T. A., & Walker, F. R. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.12.011 · Cited by 382

Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107411108 · Cited by 377

Hippocampal volume in geriatric depression

Steffens, D. C., Byrum, C. E., McQuoid, D. R., Greenberg, D. L., Payne, M. E., Blitchington, T. F., MacFall, J. R., & Krishnan, K. R. R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00829-5 · Cited by 375

Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress

Magariños, A. M., Deslandes, A., & McEwen, B. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00163-6 · Cited by 330

The temporal relationship between depressive symptoms and dementia—A community-based prospective study

Chen, P., Ganguli, M., Mulsant, B. H., & DeKosky, S. T. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.261 · Cited by 327

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Lewczuk, P., Riederer, P. F., O’Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramírez, A., Parnetti, L., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1375556 · Cited by 318

Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia

Kaup, A. R., Byers, A. L., Falvey, C., Simonsick, E. M., Satterfield, S., Ayonayon, H. N., Smagula, S. F., Rubin, S. M., & Yaffe, K. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0004 · Cited by 302

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults

Donovan, N. J., Locascio, J. J., Marshall, G. A., Gatchel, J., Hanseeuw, B. J., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Study, F. T. H. A. B. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040442 · Cited by 272

Serotonin and Human Cognitive Performance

Schmitt, J. A. J., Wingen, M., Ramaekers, J. G., Evers, E. A. T., & Riedel, W. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698909 · Cited by 260

Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study

Setiawan, E., Attwells, S., Wilson, A. A., Mizrahi, R., Rusjan, P., Miler, L., Xu, C., Sharma, S. K., Kish, S. J., Houle, S., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30048-8 · Cited by 256

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Sprecher, K. E., Bendlin, B. B., Racine, A. M., Okonkwo, O. C., Christian, B. T., Koscik, R. L., Sager, M. A., Asthana, S., Johnson, S. C., & Benca, R. M. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.004 · Cited by 255

Inflammatory markers and the risk of dementia and Alzheimer's disease: a meta-analysis

Darweesh, S. K. L., Wolters, F. J., Ikram, M. A., de Wolf, F., Bos, D., & Hofman, A. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.014 · Cited by 244

Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults

Sprecher, K. E., Koscik, R. L., Carlsson, C. M., Zetterberg, H., Blennow, K., Okonkwo, O. C., Sager, M. A., Asthana, S., Johnson, S. C., Benca, R. M., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004171 · Cited by 235

Depression, Apolipoprotein E Genotype, and the Incidence of Mild Cognitive Impairment: A Prospective Cohort Study

Geda, Y. E., Knopman, D. S., Mrazek, D. A., Jicha, G. A., Smith, G. E., Negash, S., Boeve, B. F., Ivnik, R. J., Petersen, R. C., Pankratz, V. S., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.3.435 · Cited by 230

Stress and the Aging Hippocampus

McEwen, B. S. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0173 · Cited by 229

An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice

Sheline, Y. I., West, T., Yarasheski, K., Swarm, R., Jasielec, M. S., Fisher, J. R., Ficker, W. D., Yan, P., Xiong, C., Frederiksen, C., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008169 · Cited by 223

Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia

Carvalho, D. Z., Louis, E. K. S., Knopman, D. S., Boeve, B. F., Lowe, V. J., Roberts, R. O., Mielke, M. M., Przybelski, S. A., Machulda, M. M., Petersen, R. C., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0049 · Cited by 216

Depression as a modifiable factor to decrease the risk of dementia

Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., & Flicker, L. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.90 · Cited by 212

Cerebrospinal fluid and plasma free cortisol concentrations in depression

Carroll, B. J., Curtis, G. C., & MENDELS, J. (1976) · Psychological Medicine · doi:10.1017/s0033291700013775 · Cited by 207

Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer’s Dementia in Individuals With Previous Depression

Bartels, C., Wagner, M., Wolfsgruber, S., Ehrenreich, H., Schneider, A., & Initiative, F. T. A. D. N. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040404 · Cited by 202

Cell atrophy and loss in depression: reversal by antidepressant treatment

Banasr, M., Dwyer, J. M., & Duman, R. S. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.09.002 · Cited by 201

A new chapter opens in anti-inflammatory treatments:The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice

Brustolim, D., Ribeiro‐dos‐Santos, R., Kast, R. E., Altschuler, E. L., & Soares, M. B. P. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2005.12.007 · Cited by 195

Late-Life Depression as a Risk Factor for Mild Cognitive Impairment or Alzheimer's Disease in 30 US Alzheimer's Disease Centers

Steenland, K., Karnes, C., Seals, R. M., Carnevale, C. V., Hermida, A. P., & Levey, A. I. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111922 · Cited by 188

Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type

Popp, J., Wolfsgruber, S., Heuser, I., Peters, O., Hüll, M., Schröder, J., Möller, H., Lewczuk, P., Schneider, A., Jahn, H., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.031 · Cited by 180

A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: Do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?

Walker, F. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.10.002 · Cited by 175

Clinical risk factors for Alzheimer's disease

Kokmen, E., Beard, C. M., Chandra, V., OFFORD, K. P., Schoenberg, B. S., & Ballard, D. (1991) · Neurology · doi:10.1212/wnl.41.9.1393 · Cited by 171

Depressive Symptoms and Incidence of Mild Cognitive Impairment and Probable Dementia in Elderly Women: The Women's Health Initiative Memory Study

Goveas, J. S., Espeland, M. A., Woods, N. F., Wassertheil-Smoller, S. W., & Kotchen, J. M. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03233.x · Cited by 154

Long-term cortisol measures predict Alzheimer disease risk

Ennis, G. E., An, Y., Resnick, S. M., Ferrucci, L., O'Brien, R. J., & Moffat, S. D. (2017) · Neurology · doi:10.1212/wnl.0000000000003537 · Cited by 151

Does Fluoxetine Have Any Effect on the Cognition of Patients With Mild Cognitive Impairment?

Mowla, A., Mosavinasab, M., & Pani, A. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31802e0002 · Cited by 143

Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?

Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139

Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults

Gatchel, J. R., Rabin, J. S., Buckley, R. F., Locascio, J. J., Quiroz, Y. T., Yang, H., Vannini, P., Amariglio, R. E., Rentz, D. M., Properzi, M. J., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.8964 · Cited by 137

Inflammation-induced depression: Its pathophysiology and therapeutic implications

Jeon, S. W., & Kim, Y.-K. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.016 · Cited by 134

Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

Gatchel, J. R., Donovan, N. J., Locascio, J. J., Schultz, A. P., Becker, J. A., Chhatwal, J. P., Papp, K. V., Amariglio, R. E., Rentz, D. M., Blacker, D., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170001 · Cited by 129

Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression

Gallagher, D., Kiss, A., Lanctot, K., & Herrmann, N. (2018) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.05.002 · Cited by 122

Longitudinal Association of Dementia and Depression

Snowden, M. B., Atkins, D. C., Steinman, L. E., Bell, J. F., Bryant, L. L., Copeland, C., & Fitzpatrick, A. L. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.09.002 · Cited by 121

The Prevalence of Depression in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Chi, S., Wang, C., Jiang, T., Zhu, X., Yu, J., & Tan, L. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150204124310 · Cited by 120

Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus

Alfonso, J., Pollevick, G. D., Hart, M. G. V. D., Flügge, G., Fuchs, E., & Frasch, A. C. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03178.x · Cited by 117

Cortisol, cytokines, and hippocampal volume interactions in the elderly

Sudheimer, K. D., O'Hara, R. M., Spiegel, D., Powers, B. N., KRAEMER, H. C., Neri, E., Weiner, M. W., Hardan, A. Y., Hallmayer, J. F., & Dhabhar, F. S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00153 · Cited by 115

Antidepressants and dementia

Kessing, L. V., Søndergård, L., Forman, J. L., & Andersen, P. K. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.11.020 · Cited by 113

The association between late-life depression, mild cognitive impairment and dementia: is inflammation the missing link?

Hermida, A. P., McDonald, W. M., Steenland, K., & Levey, A. I. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.127 · Cited by 112

Genetics of Alzheimer disease in the pre- and post-GWAS era

Ertekin‐Taner, N. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt26 · Cited by 112

Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients

Initiative, F. T. A. D. N., Brendel, M., Pogarell, O., Xiong, G., Delker, A., Bartenstein, P., & Rominger, A. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2975-4 · Cited by 94

Methodology and Preliminary Results From the Neurocognitive Outcomes of Depression in the Elderly Study

Steffens, D. C., Welsh-Bohmer, K. A., Burke, J. R., Plassman, B. L., Beyer, J. L., Gersing, K. R., & Potter, G. G. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704269819 · Cited by 90

Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Rozzini, L., Chilovi, B. V., Conti, M. Z., Delrio, I., Borroni, B., Trabucchi, M., & Padovani, A. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111133 · Cited by 86

CSF cortisol in Alzheimer's disease and mild cognitive impairment

Popp, J., Schaper, K., Kölsch, H., Cvetanovska, G., Rommel, F., Klingmüller, D., Dodel, R. C., Wüllner, U., & Jessen, F. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.007 · Cited by 86

Late-Life Depression and the Prodromes of Dementia

Steffens, D. C. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0658 · Cited by 82

No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression

De Winter, F.-L., Emsell, L., Bouckaert, F., Claes, L., Jain, S., Farrar, G., Billiet, T., Evers, S., Van den Stock, J., Sienaert, P., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16030319 · Cited by 80

Venlafaxine exhibits an anti-inflammatory effect in an inflammatory co-culture model

Vollmar, P., Haghikia, A., Dermietzel, R., & Faustmann, P. M. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007729 · Cited by 75

Do continued antidepressants protect against dementia in patients with severe depressive disorder?

Kessing, L. V., Forman, J. L., & Andersen, P. K. (2011) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32834ace0f · Cited by 74

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease

Kajiwara, Y., Franciosi, S., Takahashi, N., Krug, L., Schmeidler, J., Taddei, K., Haroutunian, V. H., Fried, U., Ehrlich, M. E., Martins, R. N., et al. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-1 · Cited by 72

Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease

Aboukhatwa, M. A., Dosanjh, L. E., & Luo, Y. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-10 · Cited by 70

Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice

Minakawa, E. N., Miyazaki, K., Maruo, K., Yagihara, H., Fujita, H., Wada, K., & Nagai, Y. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.05.054 · Cited by 62

Comparison of Sertraline, Venlafaxine and Desipramine Effects on Depression, Cognition and the Daily Living Activities in Alzheimer Patients

Mokhber, N., Abdollahian, E., Soltanifar, A., Samadi, R., Saghebi, A., Haghighi, M., & Azarpazhooh, A. (2014) · Pharmacopsychiatry · doi:10.1055/s-0034-1377041 · Cited by 61

The Role of Fluoxetine in Activating Wnt/β-Catenin Signaling and Repressing β-Amyloid Production in an Alzheimer Mouse Model

Huang, M., Liang, Y., Chen, H., Xu, B., Chai, C., & Xing, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00164 · Cited by 61

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway

Wang, Y., Ren, Q., Gong, W.-G., Wu, D., Tang, X., Li, X.-L., Wu, F., Bai, F., Xu, L., & Zhang, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.7798 · Cited by 60

Trajectories of depressive symptoms and their relationship to the progression of dementia

Barca, M. L., Persson, K., Eldholm, R. S., Benth, J. Š., Kersten, H., Knapskog, A., Saltvedt, I. T., Selbæk, G., & Engedal, K. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.008 · Cited by 58

Differential and Converging Molecular Mechanisms of Antidepressants’ Action in the Hippocampal Dentate Gyrus

Patrício, P., Mateus-Pinheiro, A., Irmler, M., Alves, N. D., Machado-Santos, A. R., Morais, M., Correia, J. S., Korostynski, M., Piechota, M., Stoffel, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.176 · Cited by 57

Depression in dementia sufferers

Ballard, C. G., Bannister, C., & Oyebode, F. (1996) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199606)11:6 · Cited by 55

Subtypes of depression among patients with Alzheimer's disease and other dementias

Castilla‐Puentes, R., & Habeych, M. E. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.1232 · Cited by 55

Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture

Bielecka, A., Paul-Samojedny, M., & Obuchowicz, E. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0535-4 · Cited by 43

Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress

Yang, C., Guo, X.-L., Wang, G. H., Wang, H., Liu, Z. C., Liu, H., Zhu, Z., & Li, Y. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133275 · Cited by 41

Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?

Tan, Z. S., & Seshadri, S. (2010) · Alzheimer's Research & Therapy · doi:10.1186/alzrt29 · Cited by 39

Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

Li, Y., Zhang, Y., Liu, Y., Wang, H., Yuan, L., & Luo, Z.-P. (2004) · PubMed · Cited by 38

Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice

Sun, D., Gao, L., Jin, L., Wu, H., Wang, Q., Zhou, Y. L., Fan, S., Jiang, X., Ke, D., Lei, H. C., et al. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.037 · Cited by 38

The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo

Budas, G. R., Coughlan, C. M., Seckl, J. R., & Breen, K. C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00790-9 · Cited by 37

Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

Zhang, W., Junhong, G., Niu, X., Jie, W., Zhaojun, W., Meina, W., Yang, W., Zhang, J., & Qi, J. (2017) · BioMed Research International · doi:10.1155/2017/1238687 · Cited by 29

Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells

Ren, Q., Wang, Y., Gong, W.-G., Zhou, Q.-D., Xu, L., & Zhang, Z. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0519-4 · Cited by 24

Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity.

Caraci, F., Pappalardo, G., Basile, L., Giuffrida, A., Copani, A., Tosto, R., Sinopoli, A., Giuffrida, M. L., Pirrone, E., Drago, F., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.07.015 · Cited by 23

Pre-treatment with amitriptyline causes epigenetic up-regulation of neuroprotection-associated genes and has anti-apoptotic effects in mouse neuronal cells

Tran, N. Q. V., Nguyen, N. A., Takabe, K., Yamagata, Z., & Miyake, K. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.05.002 · Cited by 23

Impaired adult hippocampal neurogenesis and its partial reversal by chronic treatment of fluoxetine in a mouse model of Angelman syndrome

Godavarthi, S. K., Dey, P. N., Sharma, A., & Jana, N. R. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.103 · Cited by 17

A new voice for global neurology?

Neurology, T. L. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70347-3 · Cited by 8

Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

Monteiro, A. R., Barbosa, D. J., Remião, F., & Silva, R. V. D. S. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115522 · Cited by 375

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324

Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

Juszczyk, G., Mikulska, J., Kasperek, K., Pietrzak, D., Mrozek, W., & Herbet, M. (2021) · Antioxidants · doi:10.3390/antiox10091439 · Cited by 247

Ergothioneine, recent developments

Cheah, I. K.-M., & Halliwell, B. B. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101868 · Cited by 203

Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective

Mielke, M. M., Aggarwal, N. T., Vila‐Castelar, C., Agarwal, P., Arenaza‐Urquijo, E. M., Brett, B., Brugulat‐Serrat, A., DuBose, L. E., Eikelboom, W. S., Flatt, J., et al. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12662 · Cited by 198

Antidepressants to Prevent the Progression of Depressive Dementia to Alzheimer’s Disease: Evaluating the Degree of Knowledge about this Topic

Hussein, W., Alshammari, M. D., Alheibshy, F., Alsadiq, A. A., Almubalea, R. S., Alanazi, F. K., & Almarshdi, M. F. (2025) · Asian Journal of Pharmaceutical Research and Health Care · doi:10.4103/ajprhc.ajprhc_138_25

Depression in Alzheimer's Disease: Epidemiology, Mechanisms, and Management

Chi, S., Yu, J., Tan, M., & Tan, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140324 · Cited by 173

Pharmacological Treatment of Depression in Alzheimer’s Disease: A Challenging Task

Cassano, T., Calcagnini, S., Carbone, A., Bukke, V. N., Orkisz, S., Villani, R., Romano, A., Avolio, C., & Gaetani, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01067 · Cited by 52

Depressive Symptoms in Clinical and Incipient Alzheimer’s Disease

Hsiao, J. J., & Teng, E. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.10 · Cited by 18

What is the association between depression and Alzheimer’s disease?

Tsuno, N., & Homma, A. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.106 · Cited by 115