The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies
Open accessAbstract
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies (including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA.
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1 retracted
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RetractedThe Pathogenesis of Rheumatoid Arthritis
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Tumor Necrosis Factor-α Signaling in Macrophages
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Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial
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Zhou, F., Mei, J., Han, X., Li, H., Yang, S., Wang, M., Chu, L., Qiao, H., & Tang, T. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.015 · Cited by 400
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
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Metadata
- Authors
- Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N. J., & Xu, J.
- Venue
- Bone Research
- Published
- 2018-04-27
- Volume
- 6
- Issue
- 1
- Pages
- 15-15
- ISSN
- 2095-4700 (ISSN-L)
- 2095-6231
- OpenAlex
- W2803973097
- Cited by
- 1,767
- References
- 149
- FWCI
- 95.40
- Type
- journal article
- Language
- en
- Open access
- gold
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