The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Tumor Necrosis Factor-α Signaling in Macrophages
Open accessAbstract
Tumor necrosis factor-α (TNFα) was cloned over 2 decades ago and its identification in part led to the discovery of a super family of tumor necrosis factors (TNFs) and their receptors. TNFα signals through two transmembrane receptors, TNFR1 and TNFR2, and regulates a number of critical cell functions including cell proliferation, survival, differentiation, and apoptosis. Macrophages are the major producers of TNFα and interestingly are also highly responsive to TNFα. Aberrant TNFα production and TNF receptor signaling have been associated with the pathogenesis of several diseases, including rheumatoid arthritis, Crohn's disease, atherosclerosis, psoriasis, sepsis, diabetes, and obesity. TNFα has been shown to play a pivotal role in orchestrating the cytokine cascade in many inflammatory diseases and because of this role as a "master-regulator" of inflammatory cytokine production, it has been proposed as a therapeutic target for a number of diseases. Indeed anti-TNFα drugs are now licensed for treating certain inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. In this review we discuss the discovery of TNFα and its actions especially in regulating macrophage biology. Given its importance in several human diseases, we also briefly discuss the role of anti-TNFα therapeutics in the treatment of inflammatory diseases.
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Cited by
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Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
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Metadata
- Authors
- Parameswaran, N., & Patial, S.
- Venue
- Critical Reviews™ in Eukaryotic Gene Expression
- Publisher
- Begell House
- Published
- 2010
- Volume
- 20
- Issue
- 2
- Pages
- 87-103
- ISSN
- 1045-4403 (ISSN-L)
- OpenAlex
- W1997834526
- Cited by
- 1,437
- References
- 12
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- green
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