The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
New aspects of amino acid metabolism in cancer
Open accessAbstract
An abundant supply of amino acids is important for cancers to sustain their proliferative drive. Alongside their direct role as substrates for protein synthesis, they can have roles in energy generation, driving the synthesis of nucleosides and maintenance of cellular redox homoeostasis. As cancer cells exist within a complex and often nutrient-poor microenvironment, they sometimes exist as part of a metabolic community, forming relationships that can be both symbiotic and parasitic. Indeed, this is particularly evident in cancers that are auxotrophic for particular amino acids. This review discusses the stromal/cancer cell relationship, by using examples to illustrate a number of different ways in which cancer cells can rely on and contribute to their microenvironment – both as a stable network and in response to therapy. In addition, it examines situations when amino acid synthesis is driven through metabolic coupling to other reactions, and synthesis is in excess of the cancer cell’s proliferative demand. Finally, it highlights the understudied area of non-proteinogenic amino acids in cancer metabolism and their potential role.
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Cites
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Cited by
Metabolism of Amino Acids in Cancer
Wei, Z., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603837 · Cited by 429
Amino Acid Depletion Therapies: Starving Cancer Cells to Death
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Zhang, Y., Liu, Z., Wang, X., Jian, H., Xiao, H., & Wen, T. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00470-5 · Cited by 47
Metabolic reprogramming: The driving force behind cancer drug resistance
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Metadata
- Authors
- Vettore, L., Westbrook, R. L., & Tennant, D. A.
- Venue
- British Journal of Cancer
- Published
- 2019-12-10
- Volume
- 122
- Issue
- 2
- Pages
- 150-156
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2996642684
- Cited by
- 502
- References
- 79
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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