The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
Open accessAbstract
Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to promote cancer progression by helping cancer cells survive stress or, instead, when mutated or abnormal, to induce carcinogenesis by influencing cell signaling or promoting intracellular toxicity. For this reason, the study of autophagy in cancer is the main focus of many researchers and several clinical trials are already ongoing to manipulate autophagy and by this way determine the outcome of disease therapy. Since the establishment of the cancer stem cell (CSC) theory and the discovery of CSCs in individual cancer types, autophagy and mitophagy have been proposed as key mechanisms in their homeostasis, dismissal or spread, even though we still miss a comprehensive view of how and by which regulatory molecules these two processes drive cell fate. In this review, we will dive into the deep water of autophagy, mitophagy, and CSCs and offer novel viewpoints on possible therapeutic strategies, based on the modulation of these degradative systems.
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Cited by
Autophagy in major human diseases
Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585
Self-citationMechanisms of temozolomide resistance in glioblastoma - a comprehensive review
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Roles of Autophagy in Oxidative Stress
Yun, H. R., Jo, Y. H., Kim, J., Shin, Y., Kim, S. S., & Choi, T. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093289 · Cited by 396
The Role of the Extracellular Matrix in Cancer Stemness
Nallanthighal, S., Heiserman, J. P., & Cheon, D.-J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00086 · Cited by 344
Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance
Wang, X., Lee, J., & Xie, C. (2022) · Cancers · doi:10.3390/cancers14020381 · Cited by 53
Metadata
- Authors
- Nazio, F., Bordi, M., Cianfanelli, V., Locatelli, F., & Cecconi, F.
- Venue
- Cell Death & Differentiation
- Published
- 2019-02-06
- Volume
- 26
- Issue
- 4
- Pages
- 690-702
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2914661118
- Cited by
- 388
- References
- 152
- FWCI
- 37.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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