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Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation
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INSIG1 is essential for STING pathway-mediated antiviral immunity and suppresses NLRP3 inflammasome activation and IL-1β production.
“INSIG1 is essential for the stimulator of interferon genes (STING) pathway-mediated antiviral immunity and suppresses the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and IL-1β production31,32.”
From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [32]
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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
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Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
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“For example, we previously reported that PKA kinase induces phosphorylation on Ser 291 and ubiquitination of NLRP3, which hinders activation of the inflammasome [3].”
BackgroundUbiquitin in the immune system
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Cited by
Sorted by citations
Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis
Li, X., Zang, Y., Li, X., Sheng, T., Liu, S., Chen, L., Xu, X., Wang, L., Long, R., Zhang, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73278-8 · Cited by 1
Metadata
- Authors
- Xu, T., Yu, W., Fang, H., Wang, Z., Chi, Z., Guo, X., Jiang, D., Zhang, K., Chen, S., Li, M., Guo, Y., Zhang, J., Yang, D., Yu, Q., Wang, D., & Zhang, X.
- ORCID
- Venue
- Cell Death & Differentiation
- Published
- 2022-02-02
- Volume
- 29
- Issue
- 8
- Pages
- 1582-1595
- ISSN
- 1350-9047
- 1476-5403
- Cited by
- 73
- References
- 10
- Language
- en
- Funders
- National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (81930042, 81730047, 31670926, and 31800759)
- National Key Research and Development Program of China
- National Natural Science Foundation of China (81930042, 81730047, 31670926, and 31800759)
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