PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Multidrug resistance in cancer: role of ATP–dependent transporters

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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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Mechanisms of Multidrug Resistance in Cancer Chemotherapy

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The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin

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Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

Ediriweera, M. K., Tennekoon, K. H., & Samarakoon, S. R. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.012 · Cited by 752 · see citing works

The PI3K/AKT/mTOR interactive pathway

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Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

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Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies

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Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

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Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

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The BCL-2 arbiters of apoptosis and their growing role as cancer targets

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The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

Mabuchi, S., Kuroda, H., Takahashi, R., & Sasano, T. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.02.003 · Cited by 412 · see citing works

PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex

Liu, P., Gan, W., Chin, Y. R., Ogura, K., Guo, J., Zhang, J., Wang, B., Blenis, J., Cantley, L. C., Toker, A., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0460 · Cited by 385 · see citing works

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

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Fas death receptor signalling: roles of Bid and XIAP

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XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells.

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Insights into new mechanisms and models of cancer stem cell multidrug resistance

Garcia‐Mayea, Y., Mir, C., Masson, F., Paciucci, R., & LLeonart, M. E. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.022 · Cited by 326 · see citing works

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

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Targeting AKT for cancer therapy

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Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

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The rheostat in the membrane: BCL-2 family proteins and apoptosis

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PI3K Inhibitors in Breast Cancer Therapy

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Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

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EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

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p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells.

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Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance

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Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC

Heavey, S., O'Byrne, K. J., & Gately, K. A. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.08.006 · Cited by 177 · see citing works

Constitutive activation of phosphatidyl‐inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR

Dutton, A., Reynolds, G. M., Dawson, W. O., Young, L. S., & Murray, P. G. (2005) · The Journal of Pathology · doi:10.1002/path.1725 · Cited by 177 · see citing works

Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway

Cheng, J. Q., Jiang, X., Fraser, M. E., Li, M., Dan, H. C., Sun, M., & Tsang, B. K. (2002) · Drug Resistance Updates · doi:10.1016/s1368-7646(02)00003-1 · Cited by 148 · see citing works

XIAP inhibits autophagy via XIAP‐Mdm2‐p53 signalling

Huang, X., Wu, Z., Mei, Y., & Wu, M. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.133 · Cited by 135 · see citing works

Knockdown of lncRNA‑HOTAIR downregulates the drug‑resistance of breast cancer cells to doxorubicin via the PI3K/AKT/mTOR signaling pathway

Li, Z., Qian, J., Li, J., et al. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7629 · Cited by 124 · see citing works

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

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The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1

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The phosphoinositide 3-kinase pathway and therapy resistance in cancer

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The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling

Wu, D., Zhang, T., Liu, Y., Deng, S., Han, R., Liu, T., Li, J., & Xu, Y. X. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1591-4 · Cited by 110 · see citing works

MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

Tripathi, S. C., Fahrmann, J. F., Çeliktaş, M., Aguilar, M., Marini, K. D., Jolly, M. K., Katayama, H., Wang, H., Murage, E. N., Dennison, J. B., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2874 · Cited by 103 · see citing works

Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

Rahmani, F., Ziaeemehr, A., Shahidsales, S., Gharib, M., Khazaei, M., Ferns, G. A., Ryzhikov, M., Avan, A., & Hassanian, S. M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29333 · Cited by 103 · see citing works

Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin

Zhou, Q., Yan, B., Hu, X., Li, X., Zhang, J., & Fang, J. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0191 · Cited by 98 · see citing works

Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer

Xu, S., Yang, Z., Jin, P., Yang, X., Li, X., Xiao, W., Wang, Y., Long, S., Zhang, T., Chen, G., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0927 · Cited by 97 · see citing works

Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway

Meng, Y., Lin, Z., Ge, N., Zhang, D.-L., Huang, J., & Kong, F. (2015) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x15500834 · Cited by 93 · see citing works

Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells

Hu, Y., Guo, R., Wei, J., Zhou, Y., Ji, W., Liu, J., Zhi, X., & Zhang, J. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.363 · Cited by 92 · see citing works

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem–like Cells

House, C. D., Jordan, E., Hernandez, L. F., Ozaki, M. K., James, J. M., Kim, M., Kruhlak, M. J., Batchelor, E., Elloumi, F., Cam, M. C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0366 · Cited by 91 · see citing works

20(s)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/Akt and XIAP pathways

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Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

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SHBG expression is correlated with PI3K/AKT pathway activity in a cellular model of human insulin resistance

Feng, C., Jin, Z., Chi, X., Zhang, B., Wang, X., Sun, L., Fan, J., Sun, Q., & Zhang, X. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1411474 · Cited by 84 · see citing works

Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas

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Chemoresistance in Cancer Cells: Exosomes As Potential Regulators of Therapeutic Tumor Heterogeneity

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Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450

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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma

Balaji, S., Ahmed, M., Lorence, E., Yan, F., Nomie, K. J., & Wang, M. L. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0621-5 · Cited by 77 · see citing works

Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway

Rubinstein, M. M. Z., Hyman, D. M., Caird, I., Won, H. H., Soldan, K., Seier, K., Iasonos, A. E., Tew, W. P., O'Cearbhaill, R. E., Grisham, R. N., et al. (2019) · Cancer · doi:10.1002/cncr.32677 · Cited by 74 · see citing works

Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells

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Ferulic acid reverses P-glycoprotein-mediated multidrug resistance via inhibition of PI3K/Akt/NF-κB signaling pathway

Muthusamy, G., Gunaseelan, S., & Prasad, N. R. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.022 · Cited by 72 · see citing works

Lessons from gain‐ and loss‐of‐function models of pro‐survival Bcl2 family proteins: implications for targeted therapy

Sochalska, M., Tuzlak, S., Egle, A., & Villunger, A. (2015) · FEBS Journal · doi:10.1111/febs.13188 · Cited by 68 · see citing works

Suppression of ABCG2 inhibits cancer cell proliferation

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mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism

Lampada, A., O’Prey, J., Szabadkai, G., Ryan, K. M., Hochhauser, D., & Salomoni, P. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.41 · Cited by 66 · see citing works

Down‐regulated lncRNA SLC25A5‐AS1 facilitates cell growth and inhibits apoptosis via miR‐19a‐3p/PTEN/PI3K/AKT signalling pathway in gastric cancer

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Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine

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Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway

Sui, H. X., Pan, S.-F., Feng, Y., Jin, B.-H., Liu, X., Zhou, L., Hou, F., Wang, W., Fu, X., Han, Z., et al. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-279 · Cited by 65 · see citing works

Cellular and molecular biology of cancer stem cells in melanoma: Possible therapeutic implications

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Targeting CD133 reverses drug-resistance via the AKT/NF-κB/MDR1 pathway in colorectal cancer

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ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates

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The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia

Chen, Y., Wang, T.-T., Du, J., Li, Y.-C., Wang, X., Zhou, Y., Yu, X., Fan, W., Zhu, Q., Tong, X.-M., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490142 · Cited by 61 · see citing works

AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

Choi, E.-J., Kim, E., Kim, J. H., Yoon, K., Kim, S.-G., Lee, J., & Cho, J. Y. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.07.001 · Cited by 59 · see citing works

The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma

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Long Non-Coding RNA XLOC_006753 Promotes the Development of Multidrug Resistance in Gastric Cancer Cells Through the PI3K/AKT/mTOR Signaling Pathway

Zeng, L., Liao, Q., Zou, Z., Wen, Y., Wang, J., Liu, C., He, Q., Weng, N., Zeng, J., Tang, H., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495499 · Cited by 57 · see citing works

Phosphatidylinositol 3‐kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities

Millis, S. Z., Jardim, D. L. F., Albacker, L. A., Ross, J. S., Miller, V. A., Ali, S. M., & Kurzrock, R. (2018) · Cancer · doi:10.1002/cncr.31921 · Cited by 56 · see citing works

The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia

Deng, L., Jiang, L., Lin, X., et al. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.121 · Cited by 55 · see citing works

Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells

Goan, Y., Wu, W.-T., Liu, C.-I., et al. (2019) · Molecules · doi:10.3390/molecules24162881 · Cited by 54 · see citing works

Dihydroartemisinin suppresses glycolysis of LNCaP cells by inhibiting PI3K/AKT pathway and downregulating HIF-1α expression

Zhu, W., Li, Y., Zhao, D., Li, H.-L., Zhang, W. J., Xu, J., Hou, J., Feng, X., & Wang, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116730 · Cited by 54 · see citing works

Adenosine A2A receptor inactivation alleviates early-onset cognitive dysfunction after traumatic brain injury involving an inhibition of tau hyperphosphorylation

Zhao, Z., Zhao, Y., Ning, Y.-L., Yang, N., Peng, Y., Li, P., Chen, X.-Y., Liu, D., Wang, H., Chen, X., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.98 · Cited by 52 · see citing works

MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma

Wu, S. J., Chen, J., Wu, B., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0639-5 · Cited by 52 · see citing works

Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions

Kahana, S., Finniss, S., Cazacu, S., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.03.017 · Cited by 51 · see citing works

Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells

García-Regalado, A., Vargas, M. A., García-Carrancá, A. M., Aréchaga-Ocampo, E., & la Rosa, C. H. G.-D. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-44 · Cited by 51 · see citing works

Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

Yao, J., Wei, X., & Lü, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.141 · Cited by 51 · see citing works

Therapeutic Suppression of mTOR (Mammalian Target of Rapamycin) Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats

Kumar, V., Evans, L. C., Kurth, T. M., Yang, C., Wollner, C., Nasci, V. L., Zheleznova, N. N., Bukowy, J. D., Dayton, A., & Cowley, A. W. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.12378 · Cited by 50 · see citing works

Anti-tumor activity of the X-linked inhibitor of apoptosis (XIAP) inhibitor embelin in gastric cancer cells

Wang, D., Sun, Y., Ye, F., Li, W., Kharbuja, P., Gao, L., Zhang, D. Y., & Suo, J. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1853-x · Cited by 49 · see citing works

Transgelin 2 Promotes Paclitaxel Resistance, Migration, and Invasion of Breast Cancer by Directly Interacting with PTEN and Activating PI3K/Akt/GSK-3β Pathway

Liu, L., Meng, T., Zheng, X., Liu, Y., Hao, R., Yan, Y., Chen, S., You, H., Xing, J., & Dong, Y. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0261 · Cited by 49 · see citing works

5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells

Ranjbar, S., Khonkarn, R., Moréno, A., Baubichon-Cortay, H., Miri, R., Khoshneviszadeh, M., Saso, L., Edraki, N., Falson, P., & Firuzi, O. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.10.025 · Cited by 48 · see citing works

RACK1 induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression

Liu, B., Wang, C., Chen, P., Cheng, B., & Cheng, Y. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s152818 · Cited by 47 · see citing works

Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells

Li, Y., Guo, Y., Zhuang, F., Bergan, R. C., Li, B., Qin, Y., Zhao, L., Zhang, Z., & Shi, M. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1578387 · Cited by 46 · see citing works

Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria

Roundhill, E. A., & Burchill, S. A. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.40 · Cited by 45 · see citing works

Countering TRAIL Resistance in Melanoma

Eberle, J. (2019) · Cancers · doi:10.3390/cancers11050656 · Cited by 45 · see citing works

Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency

Hasanovic, A., & Mus‐Veteau, I. (2018) · Cells · doi:10.3390/cells7080107 · Cited by 44 · see citing works

NOR1 Suppresses Cancer Stem‐Like Cells Properties of Tumor Cells via the Inhibition of the AKT‐GSK‐3β‐Wnt/β‐catenin‐ALDH1A1 Signal Circuit

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