The PI3K/AKT/mTOR interactive pathway

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

Molecular mechanisms of epithelial–mesenchymal transition

Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216 · see citing works

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115 · see citing works

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · see citing works

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448 · see citing works

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E. J., Frisch, S. M., & Reed, J. C. (1998) · Science · doi:10.1126/science.282.5392.1318 · Cited by 3,118 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

Alessi, D., James, S., Downes, C., Holmes, A. B., Gaffney, P., Reese, C., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 3,047 · see citing works

Targeting the phosphoinositide 3-kinase pathway in cancer

Liu, P., Cheng, H.-L. M., Roberts, T. M., & Zhao, J. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2926 · Cited by 2,722 · see citing works

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

O'Reilly, K. E., Rojo, F., She, Q.-B., Solit, D., Mills, G. B., Smith, D., Lane, H., Hofmann, F., Hicklin, D. J., Ludwig, D. L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2925 · Cited by 2,561 · see citing works

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Engelman, J. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2664 · Cited by 2,445 · see citing works

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

Özeş, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., & Donner, D. B. (1999) · Nature · doi:10.1038/43466 · Cited by 2,175 · see citing works

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,006 · see citing works

Phosphatidylinositol-3-OH kinase direct target of Ras

Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954 · see citing works

Signaling mechanisms of the epithelial-mesenchymal transition

Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721 · see citing works

PI3K and cancer: lessons, challenges and opportunities

Fruman, D. A., & Rommel, C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4204 · Cited by 1,716 · see citing works

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Medema, R. H., Kops, G. J. P. L., Bos, J. L., & Burgering, B. M. T. (2000) · Nature · doi:10.1038/35008115 · Cited by 1,439 · see citing works

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Carracedo, A., Ma, L., Teruya-Feldstein, J., Rojo, F., Salmena, L., Alimonti, A., Egia, A., Sasaki, A. T., Thomas, G., Kozma, S. C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34739 · Cited by 1,381 · see citing works

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Carpten, J. D., Faber, A. L., Horn, C. L., Donoho, G. P., Briggs, S., Robbins, C. M., Hostetter, G. H., Boguslawski, S. J., Moses, T. Y., Savage, S., et al. (2007) · Nature · doi:10.1038/nature05933 · Cited by 1,291 · see citing works

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F. P., & Hawkins, P. T. (1997) · Science · doi:10.1126/science.277.5325.567 · Cited by 1,202 · see citing works

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,135 · see citing works

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

Sun, S., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993) · Science · doi:10.1126/science.8096091 · Cited by 1,108 · see citing works

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

Zimmermann, S., & Moelling, K. (1999) · Science · doi:10.1126/science.286.5445.1741 · Cited by 1,088 · see citing works

Direct control of the Forkhead transcription factor AFX by protein kinase B

Kops, G. J. P. L., de Ruiter, N. D., de Vries-Smits, A. M. M., Powell, D. R., Bos, J. L., & Burgering, B. M. T. (1999) · Nature · doi:10.1038/19328 · Cited by 1,085 · see citing works

Essential role for nuclear PTEN in maintaining chromosomal integrity

Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., & Yin, Y. (2007) · Cell · doi:10.1016/j.cell.2006.11.042 · Cited by 979 · see citing works

Modulation of Akt kinase activity by binding to Hsp90

Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967 · see citing works

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

Chandarlapaty, S., Sawai, A., Scaltriti, M., Rodrik-Outmezguine, V., Grbovic-Huezo, O., Serra, V., Majumder, P. K., Baselga, J., & Rosen, N. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.10.031 · Cited by 967 · see citing works

Life at the Leading Edge

Ridley, A. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.010 · Cited by 960 · see citing works

CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

Du, K., & Montminy, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32377 · Cited by 952 · see citing works

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Liang, J., Zubovitz, J., Petrocelli, T., Kotchetkov, R., Connor, M. K., Han, K. C.-Z., Lee, J.-H., Ciarallo, S., Catzavelos, C., Beniston, R., et al. (2002) · Nature Medicine · doi:10.1038/nm761 · Cited by 947 · see citing works

Cancer Cell Metabolism: One Hallmark, Many Faces

Cantor, J. R., & Sabatini, D. M. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0345 · Cited by 945 · see citing works

Regulation of PTEN Transcription by p53

Stambolic, V., MacPherson, D. P., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S., & Mak, T. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00323-9 · Cited by 913 · see citing works

PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

Gao, T., Furnari, F., & Newton, A. C. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.008 · Cited by 906 · see citing works

TRB3: A <i>tribbles</i> Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

Du, K., Herzig, S., Kulkarni, R. N., & Montminy, M. (2003) · Science · doi:10.1126/science.1079817 · Cited by 842 · see citing works

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

Shin, I., Yakes, F. M., Rojo, F., Shin, N.-Y., Bakin, A. V., Baselga, J. M., & Arteaga, C. L. (2002) · Nature Medicine · doi:10.1038/nm759 · Cited by 790 · see citing works

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

Rena, G., Guo, S., Cichy, S. C., Unterman, T., & Cohen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17179 · Cited by 787 · see citing works

Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy

Weinstein, I. B., & Joe, A. K. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0558 · Cited by 708 · see citing works

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Jia, S., Liu, Z., Zhang, S., Liu, P., Zhang, L., Lee, S., Zhang, J., Signoretti, S., Loda, M. F., Roberts, T. M., et al. (2008) · Nature · doi:10.1038/nature07091 · Cited by 691 · see citing works

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

Mendes‐Pereira, A. M., Martin, S. A., Brough, R., McCarthy, A., Taylor, J. R., Kim, J., Waldman, T. A., Lord, C. J., & Ashworth, A. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900041 · Cited by 630 · see citing works

Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., & Gotoh, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109745200 · Cited by 617 · see citing works

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

Yano, S., Tokumitsu, H., & Soderling, T. R. (1998) · Nature · doi:10.1038/25147 · Cited by 617 · see citing works

Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

Gupta, S., Ramjaun, A. R., Haiko, P., Wang, Y., Warne, P. H., Nicke, B., Nye, E. L., Stamp, G., Alitalo, K. K., & Downward, J. (2007) · Cell · doi:10.1016/j.cell.2007.03.051 · Cited by 589 · see citing works

Tumor adaptation and resistance to RAF inhibitors

Lito, P., Rosen, N., & Solit, D. B. (2013) · Nature Medicine · doi:10.1038/nm.3392 · Cited by 585 · see citing works

Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

Jiang, B., & Liu, L.-Z. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)02002-8 · Cited by 580 · see citing works

Akt‐mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

Bai, D., Ueno, L., & Vogt, P. K. (2009) · International Journal of Cancer · doi:10.1002/ijc.24748 · Cited by 529 · see citing works

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

Huang, H., Regan, K. M., Wang, F., Wang, D., Smith, D. I., van Deursen, J. M. A., & Tindall, D. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406789102 · Cited by 519 · see citing works

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

Freeman, D. J., Li, A. G., Wei, G., Li, H.-H., Kertesz, N. L., Lesche, R., Whale, A. D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R. D., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00021-7 · Cited by 512 · see citing works

Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase

Persad, S., Attwell, S., Gray, V., Mawji, N. M., Deng, J. T., Leung, D., Yan, J., Sanghera, J. S., Walsh, M. P., & Dedhar, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102940200 · Cited by 497 · see citing works

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

Feng, J., Park, J., Cron, P. D., Heß, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406731200 · Cited by 488 · see citing works

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

Kang, S. S., Kwon, T., Kwon, D. Y., & Do, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13085 · Cited by 480 · see citing works

Interactome3D: adding structural details to protein networks

Mosca, R., Céol, A., & Aloy, P. (2013) · Nature Methods · doi:10.1038/nmeth.2289 · Cited by 479 · see citing works

Mechanisms of Motility in Metastasizing Cells

Yilmaz, M., & Christofori, G. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0139 · Cited by 474 · see citing works

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

Wee, S., Jagani, Z., Xiang, K. X., Loo, A., Dorsch, M., Yao, Y.-M., Sellers, W. R., Lengauer, C., & Stegmeier, F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4765 · Cited by 455 · see citing works

AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival

Li, Y., Dowbenko, D. J., & Lasky, L. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109062200 · Cited by 442 · see citing works

Oncogene addiction: setting the stage for molecularly targeted cancer therapyPreprint

Sharma, S. V., & Settleman, J. E. (2007) · Genes & Development · doi:10.1101/gad.1609907 · Cited by 442 · see citing works

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

Rodrik-Outmezguine, V. S., Chandarlapaty, S., Pagano, N. C., Poulikakos, P. I., Scaltriti, M., Moskatel, E., Baselga, J., Guichard, S., & Rosen, N. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0085 · Cited by 442 · see citing works

The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

Shimizu, T., Tolcher, A. W., Papadopoulos, K. P., Beeram, M., Rasco, D. W., Smith, L. S., Gunn, S., Smetzer, L., Mays, T. A., Kaiser, B., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2381 · Cited by 431 · see citing works

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

Bassi, C., Ho, J., Srikumar, T., Dowling, R. J. O., Gorrini, C., Miller, S. J., Mak, T. W., Neel, B. G., Raught, B., & Stambolic, V. (2013) · Science · doi:10.1126/science.1236188 · Cited by 403 · see citing works

Regulation of Raf-Akt Cross-talk

Moelling, K., Schad, K., Bosse, M., Zimmermann, S., & Schweneker, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111974200 · Cited by 389 · see citing works

Identification of a tumour suppressor network opposing nuclear Akt function

Trotman, L. C., Alimonti, A., Scaglioni, P. P., Koutcher, J. A., Cordon‐Cardo, C., & Pandolfi, P. P. (2006) · Nature · doi:10.1038/nature04809 · Cited by 388 · see citing works

PTEN: a new guardian of the genome

Yin, Y., & Shen, W. H. (2008) · Oncogene · doi:10.1038/onc.2008.241 · Cited by 386 · see citing works

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

Bozulic, L., Sürücü, B., Hynx, D., & Hemmings, B. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.024 · Cited by 386 · see citing works

MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors

Turke, A. B., Song, Y., Costa, C., Cook, R., Arteaga, C. L., Asara, J. M., & Engelman, J. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3747 · Cited by 368 · see citing works

Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells

Rössig, L., Jadidi, A., Urbich, C., Badorff, C., Zeiher, A. M., & Dimmeler, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5644-5657.2001 · Cited by 368 · see citing works

Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

Rane, M. J., Pan, Y., Singh, S. P., Powell, D. W., Wu, R., Cummins, T. D., Chen, Q., McLeish, K. R., & Klein, J. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303417200 · Cited by 367 · see citing works

Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

Chakraborty, A., Koldobskiy, M. A., Bello, N. T., Maxwell, M. J., Potter, J. J., Juluri, K. R., Maag, D., Kim, S., Huang, A. S., Dailey, M. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.032 · Cited by 365 · see citing works

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Liu, P., Begley, M., Michowski, W., Inuzuka, H., Ginzberg, M. B., Gao, D., Tsou, P., Gan, W., Papa, A., Kim, B. M., et al. (2014) · Nature · doi:10.1038/nature13079 · Cited by 364 · see citing works

Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization

Fujita, N., Sato, S., Katayama, K., & Tsuruo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203668200 · Cited by 360 · see citing works

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

Saal, L. H., Gruvberger-Saal, S. K., Persson, C., Lövgren, K., Jumppanen, M., Staaf, J., Jönsson, G. B., Pires, M. M., Maurer, M., Holm, K., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.39 · Cited by 357 · see citing works

The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ

Guillermet‐Guibert, J., Björklöf, K., Salpekar, A., Gonella, C., Ramadani, F., Bilancio, A., Meek, S. E., Smith, A. J. H., Okkenhaug, K., & Vanhaesebroeck, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707761105 · Cited by 345 · see citing works

Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt

Guan, K., Figueroa‐Romero, C., Brtva, T. R., Zhu, T., Taylor, J., Barber, T. D., & Vojtek, A. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004371200 · Cited by 281 · see citing works

Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity

Huang, W., & Chen, C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6592-6602.2005 · Cited by 276 · see citing works

Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM

Tunçbağ, N., Gürsoy, A., Nussinov, R., & Keskin, Ö. (2011) · Nature Protocols · doi:10.1038/nprot.2011.367 · Cited by 264 · see citing works

Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1

Cahill, C. M., & Rogers, J. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707692200 · Cited by 254 · see citing works

Oncogene addiction as a foundational rationale for targeted anti‐cancer therapy: promises and perils

Torti, D., & Trusolino, L. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100176 · Cited by 248 · see citing works

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei, M. H., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. L., & Khanna, K. K. (2000) · PubMed · Cited by 247 · see citing works

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

Kawase, T., Ohki, R., Shibata, T., Tsutsumi, S., Kamimura, N., Inazawa, J., Ohta, T., Ichikawa, H., Aburatani, H., Tashiro, F., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.002 · Cited by 239 · see citing works

Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer

Chandarlapaty, S. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0018 · Cited by 235 · see citing works

Evidence That Ser87 of BimEL Is Phosphorylated by Akt and Regulates BimEL Apoptotic Function

Qi, X.-J., Wildey, G. M., & Howe, P. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505546200 · Cited by 234 · see citing works

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Ou, Y.-H., Torres, M. J., Ram, R. R., Formstecher, É., Roland, C. L., Cheng, T., Brekken, R. A., Wurz, R. P., Tasker, A. S., Polverino, T., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.019 · Cited by 229 · see citing works

Genome-wide transcriptome profiling of homologous recombination DNA repair

Peng, G., Lin, C. C.-J., Mo, W., Dai, H., Park, Y., Kim, S. M., Peng, Y., Mo, Q., Siwko, S. K., Hu, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4361 · Cited by 223 · see citing works

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

Estève, P., Chang, Y., Samaranayake, M., Upadhyay, A. K., Horton, J. R., Feehery, G. R., Cheng, X., & Pradhan, S. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1939 · Cited by 220 · see citing works

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

Kennedy, A. L., Morton, J. P., Manoharan, I., Nelson, D. M., Jamieson, N. B., Pawlikowski, J. S., McBryan, T., Doyle, B., McKay, C., Oien, K. A., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.020 · Cited by 213 · see citing works

InterPreTS: protein Interaction Prediction through Tertiary Structure

Aloy, P., & Russell, R. B. (2002) · Bioinformatics · doi:10.1093/bioinformatics/19.1.161 · Cited by 202 · see citing works

A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt

Murga, C., Fukuhara, S., & Gutkind, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12069 · Cited by 199 · see citing works

Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS–ERK Signaling

Will, M., Qin, A. C. R., Toy, W., Yao, Z., Rodrik-Outmezguine, V. S., Schneider, C., Huang, X., Monian, P., Jiang, X., de Stanchina, E., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0611 · Cited by 195 · see citing works

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

Xu, B., O’Donnell‐Luria, A., Kim, S., & Kastan, M. B. (2002) · PubMed · Cited by 189 · see citing works

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA

Kim, J.-S., Lee, C. S., Bonifant, C. L., Ressom, H. W., & Waldman, T. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00537-06 · Cited by 159 · see citing works

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C. R., Hsueh, C., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003264 · Cited by 149 · see citing works

INstruct: a database of high-quality 3D structurally resolved protein interactome networks

Meyer, M. J., Das, J., Wang, X., & Yu, H. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt181 · Cited by 144 · see citing works

Hsp27 Regulates Akt Activation and Polymorphonuclear Leukocyte Apoptosis by Scaffolding MK2 to Akt Signal Complex

Wu, R., Kausar, H., Johnson, P. R., Montoya-Durango, D. E., Merchant, M. L., & Rane, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611316200 · Cited by 143 · see citing works

Struct2Net: a web service to predict protein-protein interactions using a structure-based approach

Singh, R., Park, D., Xu, J., Hosur, R., & Berger, B. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq481 · Cited by 136 · see citing works

Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer

Johnson, G. L., Stuhlmiller, T. J., Angus, S. P., Zawistowski, J. S., & Graves, L. M. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1081 · Cited by 129 · see citing works

Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response

Fan, C.-D., Lum, M. A., Xu, C., Black, J. D., & Wang, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.416339 · Cited by 123 · see citing works

PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.

Su, J. D., Mayo, L. D., Donner, D. B., & Durden, D. L. (2003) · PubMed · Cited by 122 · see citing works

PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells.

Zhou, M., Gu, L., Findley, H. W., Jiang, R., & Woods, W. G. (2003) · PubMed · Cited by 120 · see citing works

Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells

Altiok, S., Batt, D. B., Altıok, N., Papautsky, A., Downward, J., Roberts, T. M., & Avraham, H. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32274 · Cited by 120 · see citing works

PTEN Interacts with Histone H1 and Controls Chromatin Condensation

Chen, Z., Zhu, M., Yang, J., Liang, H., He, J., He, S., Wang, P., Kang, X., McNutt, M. A., Yin, Y., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.008 · Cited by 117 · see citing works

Architectures and Functional Coverage of Protein–Protein Interfaces

Tunçbağ, N., Gürsoy, A., Güney, E., Nussinov, R., & Keskin, Ö. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.04.071 · Cited by 110 · see citing works

Nuclear import of hTERT requires a bipartite nuclear localization signal mediated by Akt phosphorylation

Chung, J., Khadka, P., & Chung, I. K. (2012) · Journal of Cell Science · doi:10.1242/jcs.099267 · Cited by 98 · see citing works

Vulnerabilities of PTEN – TP53 -Deficient Prostate Cancers to Compound PARP–PI3K Inhibition

González‐Billalabeitia, E., Seitzer, N., Song, S. J., Song, M. S., Patnaik, A., Liu, X., Epping, M. T., Papa, A., Hobbs, R. M., Chen, M., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0230 · Cited by 92 · see citing works

The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer

Acuner, S. E., Gürsoy, A., Nussinov, R., & Keskin, Ö. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003470 · Cited by 80 · see citing works

Towards inferring time dimensionality in protein–protein interaction networks by integrating structures: the p53 example

Tunçbağ, N., Kar, G., Gürsoy, A., Keskin, Ö., & Nussinov, R. (2009) · Molecular BioSystems · doi:10.1039/b905661k · Cited by 78 · see citing works

The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor

Won, J., Yang, H. W., Shin, S., Lee, J., Heo, W. D., & Cho, K. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs021 · Cited by 72 · see citing works

Casein Kinase 2–Interacting Protein-1, a Novel Akt Pleckstrin Homology Domain-Interacting Protein, Down-regulates PI3K/Akt Signaling and Suppresses Tumor Growth In vivo

Tokuda, E., Fujita, N., Oh‐hara, T., Sato, S., Kurata, A., Katayama, R., Itoh, T., Takenawa, T., Miyazono, K., & Tsuruo, T. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1050 · Cited by 66 · see citing works

Constructing structural networks of signaling pathways on the proteome scale

Kuzu, G., Keskin, Ö., Gürsoy, A., & Nussinov, R. (2012) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2012.04.004 · Cited by 64 · see citing works

Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status

Buontempo, F., Erşahin, T., Missiroli, S., Şentürk, Ş., Etro, D., Öztürk, M., Capitani, S., Çetin-Atalay, R., & Neri, L. M. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9486-3 · Cited by 55 · see citing works

Human Proteome-scale Structural Modeling of E2–E3 Interactions Exploiting Interface Motifs

Kar, G., Keskin, Ö., Nussinov, R., & Gürsoy, A. (2011) · Journal of Proteome Research · doi:10.1021/pr2009143 · Cited by 54 · see citing works

A novel site of AKT‐mediated phosphorylation in the human MDM2 onco‐protein

Milne, D., Kampanis, P., Nicol, S. M., Dias, S. S., Campbell, D. G., Fuller-Pace, F. V., & Meek, D. W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.081 · Cited by 46 · see citing works

AKT regulates BRCA1 stability in response to hormone signaling

Nelson, A., Lyons, T. R., Young, C. D., Hansen, K. C., Anderson, S. M., & Holt, J. T. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.019 · Cited by 46 · see citing works

Regulation of Intracellular Localization and Transcriptional Activity of FOXO4 by Protein Kinase B through Phosphorylation at the Motif Sites Conserved among the FOXO Family

Matsuzaki, H., Ichino, A., Hayashi, T., Yamamoto, T., & Kikkawa, U. (2005) · The Journal of Biochemistry · doi:10.1093/jb/mvi146 · Cited by 44 · see citing works

Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair

Minami, A., Nakanishi, A., Ogura, Y., Kitagishi, Y., & Matsuda, S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00318 · Cited by 42 · see citing works

Integrating Structure to Protein-Protein Interaction Networks That Drive Metastasis to Brain and Lung in Breast Cancer

Engin, H. B., Güney, E., Keskin, Ö., Oliva, B., & Gürsoy, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081035 · Cited by 39 · see citing works

Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer

Couto, S. S., Cao, M., Duarte, P. C. X., Banach-Petrosky, W. A., Wang, S., Romanienko, P. J., Wu, H., Cardiff, R. D., Abate-Shen, C. T., & Cunha, G. R. (2009) · Differentiation · doi:10.1016/j.diff.2008.09.010 · Cited by 38 · see citing works

Genetic mutual relationship between PTEN and p53 in gastric cancer

Oki, E., Tokunaga, E., Nakamura, T., Ueda, N., Futatsugi, M., Mashino, K., Yamamoto, M., Watanabe, M., Ikebe, M., Kakeji, Y., et al. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.12.006 · Cited by 33 · see citing works

AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion

Hong, S., Jeong, J. H., Chan, A. M.-L., & Park, J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.008 · Cited by 21 · see citing works

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Liu, R., Chen, Y., Liu, G., Li, C., Song, Y., Cao, Z., Li, W., Hu, J., Lu, C., & Liu, Y. (2020) · Cell Death &amp; Disease · doi:10.1038/s41419-020-02998-6 · Cited by 923 · see citing works

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

Haney, M. S., Pálovics, R., Munson, C. N., Long, C., Johansson, P. K., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J. C. M., et al. (2024) · Nature · doi:10.1038/s41586-024-07185-7 · Cited by 536 · see citing works

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., Cai, J., Rose, P., Mao, J., & Zhu, Y. Z. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01331-9 · Cited by 520 · see citing works

Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models

He, Y., Li, Z. A., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 400 · see citing works

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

Zaplatić, E., Bule, M. H., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.055 · Cited by 298 · see citing works

Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling pathway

Li, L., Jiang, W., Yu, B., Liang, H., Mao, S., Hu, X., Feng, Y., Xu, J., & Chu, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115653 · Cited by 285 · see citing works

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Xue, C., Li, G., Lü, J., & Li, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00788-w · Cited by 264 · see citing works

Neutrophil diversity and function in health and disease

Zhang, F., Xia, Y., Su, J., Quan, F., Zhou, H., Li, Q., Feng, Q., Lin, C., Wang, D., & Jiang, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02049-y · Cited by 283 · see citing works

Targeting autophagy-related protein kinases for potential therapeutic purpose

Xiang, H., Zhang, J., Lin, C., Zhang, L., Liu, B., & Ouyang, L. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.003 · Cited by 251 · see citing works

Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review

Ramasubbu, K., & Rajeswari, V. D. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04587-x · Cited by 249 · see citing works

IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma

Xu, J., Lin, H., Wu, G., Zhu, M., & Li, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.760971 · Cited by 228 · see citing works

Liver Regeneration after Hepatectomy and Partial Liver Transplantation

Yagi, S., Hirata, M., Miyachi, Y., & Uemoto, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218414 · Cited by 192 · see citing works

LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway

Zhang, H., Pan, Y., Cheung, M., Cao, M. P.-J., Yu, C., Chen, L., Zhan, L., He, Z., & Sun, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1320-z · Cited by 176 · see citing works

Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

Jin, J., Xie, Y., Zhang, J.-S., Wang, J., Dai, S.-J., He, W., Li, S.-Y., Ashby, C. R., Chen, Z., & He, Q. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100929 · Cited by 171 · see citing works

Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications

Zhang, L., Meng, X. L., Zhu, X., Yang, D., Chen, R., Jiang, Y., & Xu, T. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1021-3 · Cited by 170 · see citing works

Mechanism of cyclosporine A nephrotoxicity: Oxidative stress, autophagy, and signalings

Wu, Q., Wang, X., Nepovimová, E., Wang, Y., Yang, H., & Kuča, K. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.06.054 · Cited by 168 · see citing works

Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo

Jia, P., Sun, T., Junaid, M., Yang, L., Ma, Y., Cui, Z., Wei, D., Shi, H., & Pei, D. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.01.072 · Cited by 167 · see citing works

Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways

Wang, R., Song, F., Li, S., Wu, B., Gu, Y., & Yuan, Y. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s194787 · Cited by 160 · see citing works

Macrophage-based nanotherapeutic strategies in ulcerative colitis

Zhang, J., Zhao, Y., Hou, T., Zeng, H., Kalambhe, D., Wang, B., Shen, X., & Huang, Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.047 · Cited by 160 · see citing works

Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review

Liu, S., Jia, Y., Meng, S., Luo, Y., Yang, Q., & Pan, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119205 · Cited by 165 · see citing works

The potential role of leptin in tumor invasion and metastasis

Ray, A., & Cleary, M. P. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.11.002 · Cited by 155 · see citing works

Therapeutic Targeting of NF-κB in Acute Lung Injury: A Double-Edged Sword

Millar, M. W., Fazal, F., & Rahman, A. (2022) · Cells · doi:10.3390/cells11203317 · Cited by 155 · see citing works

Role of MAPK/MNK1 signaling in virus replication

Kumar, R., Khandelwal, N., Thachamvally, R., Tripathi, B. N., Barua, S., Kashyap, S. K., Maherchandani, S., & Kumar, N. (2018) · Virus Research · doi:10.1016/j.virusres.2018.05.028 · Cited by 153 · see citing works

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Mohseni, A. H., Casolaro, V., Bermúdez‐Humarán, L. G., Keyvani, H., & Taghinezhad‐S, S. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1886844 · Cited by 142 · see citing works

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

Sun, H., Luo, G., Chen, D., & Xiang, Z. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00247 · Cited by 142 · see citing works

Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Kciuk, M., Alam, M., Ali, N., Rashid, S., Głowacka, P., Rajamanikandan, S., Çeli̇k, İ., Yahya, E. B., Dubey, A., Zerroug, E., et al. (2023) · Molecules · doi:10.3390/molecules28135246 · Cited by 148 · see citing works

Targeting the PI3K/AKT/mTOR pathway in biliary tract cancers: A review of current evidences and future perspectives

Corti, F., Nichetti, F., Raimondi, A., Niger, M., Prinzi, N., Torchio, M., Tamborini, E., Perrone, F., Pruneri, G., Bartolomeo, M. D., et al. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.11.001 · Cited by 129 · see citing works

Hybrid membrane camouflaged copper sulfide nanoparticles for photothermal-chemotherapy of hepatocellular carcinoma

Ji, B., Cai, H., Yang, Y., Peng, F., Song, M., Sun, K., Yan, F., & Liu, Y. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.04.046 · Cited by 117 · see citing works

CD25 : A potential tumor therapeutic target

Peng, Y., Tao, Y., Zhang, Y., Wang, J., Yang, J., & Wang, Y. (2022) · International Journal of Cancer · doi:10.1002/ijc.34281 · Cited by 114 · see citing works

Titanium particles in peri-implantitis: distribution, pathogenesis and prospects

Chen, L., Tong, Z., Luo, H., Qu, Y., Gu, X., & Si, M. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00256-x · Cited by 115 · see citing works

Idebenone: When an antioxidant is not an antioxidant

Gueven, N., Ravishankar, P., Eri, R. D., & Rybalka, E. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101812 · Cited by 100 · see citing works

Lineage Commitment, Signaling Pathways, and the Cytoskeleton Systems in Mesenchymal Stem Cells

Saidova, A. A., & Vorobjev, I. A. (2019) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0250 · Cited by 99 · see citing works

The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art

Lu, G., Wang, X., Cheng, M., Wang, S., & Ma, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115132 · Cited by 101 · see citing works

Acquired resistance mechanisms to osimertinib: The constant battle

Zalaquett, Z., Hachem, M. C. R., Kassis, Y., Hachem, S., Eid, R., Kourié, H. R., & Planchard, D. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102557 · Cited by 97 · see citing works

PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

Bădoiu, S. C., Greabu, M., Miricescu, D., Stănescu-Spînu, I.-I., Ilinca, R., Bălan, D. G., Balcangiu‐Stroescu, A.-E., Mihai, D. A., Văcăroiu, I. A., Ștefani, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098391 · Cited by 99 · see citing works

MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

Chawra, H. S., Agarwal, M., Mishra, A., Chandel, S. S., Singh, R. P., Dubey, G., Kukreti, N., & Singh, M. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155091 · Cited by 91 · see citing works

Drosophila insulin‐like peptides: from expression to functions – a review

Semaniuk, U. V., Piskovatska, V., Strilbytska, O. M., Strutynska, T. R., Burdyliuk, N., Vaiserman, A. M., Bubalo, V., Storey, K. B., & Lushchak, O. V. (2020) · Entomologia Experimentalis et Applicata · doi:10.1111/eea.12981 · Cited by 86 · see citing works

SNAIL1: Linking Tumor Metastasis to Immune Evasion

Tang, X., Sui, X., Weng, L., & Liu, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.724200 · Cited by 80 · see citing works

Phytochemical insights into flavonoids in cancer: Mechanisms, therapeutic potential, and the case of quercetin

Silva-Pinto, P. A., de Pontes, J. T. C., Aguilar‐Morón, B., Canales, C. S. C., Pavan, F. R., & Roque‐Borda, C. A. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42682 · Cited by 80 · see citing works

From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression

Thapa, R., Afzal, O., Afzal, M., Gupta, G., Bhat, A. A., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Saleem, S., Arora, P., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154959 · Cited by 78 · see citing works

Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

Gureev, A. P., Popov, V. N., & Starkov, A. A. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113285 · Cited by 73 · see citing works

Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production

Khan, M. Z., Khan, A. A., Xiao, J., Ma, Y., Ma, J., Gao, J., & Cao, Z. (2020) · Animals · doi:10.3390/ani10112107 · Cited by 71 · see citing works

Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis

Wang, H., Ge, X., Qu, H., Wang, N., Zhou, J., Xu, W., Xie, J., Zhou, Y., Shi, L., Qin, Z., et al. (2020) · Cancer Management and Research · doi:10.2147/cmar.s244481 · Cited by 70 · see citing works

Combining Gemcitabine-Loaded Macrophage-like Nanoparticles and Erlotinib for Pancreatic Cancer Therapy

Cai, H., Wang, R., Guo, X., Song, M., Yan, F., Ji, B., & Liu, Y. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c01225 · Cited by 70 · see citing works

Targeting PI3K/AKT/mTOR signaling to overcome drug resistance in cancer

Tufail, M., Wan, W., Jiang, C., & Li, N. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111055 · Cited by 68 · see citing works

From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis

Liu, Z., Ting, Y., Li, M., Li, Y., Tan, Y., & Long, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1415274 · Cited by 74 · see citing works

Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation

Lu, S., Sun, X., Zhou, Z., Tang, H., Xiao, R., Lv, Q., Wang, B., Qu, J., Yu, J., Sun, F., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1235575 · Cited by 66 · see citing works

Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway

Zhou, X., Zhou, R., Li, Q., Jie, X., Hong, J., Zong, Y., Dong, X., Zhang, S., Li, Z., & Wu, G. (2019) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000709 · Cited by 65 · see citing works

Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway

Lu, C., Li, Y., Hu, S., Cai, Y., Yang, Z., & Peng, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.062 · Cited by 65 · see citing works

Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN

Deng, W., Han, W., Fan, T., Wang, X., Cheng, Z., Wan, B., & Chen, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.127 · Cited by 64 · see citing works

Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction

Post, K. L., Belmadani, M., Ganguly, P., Meili, F., Dingwall, R., McDiarmid, T. A., Meyers, W. M., Herrington, C., Young, B. P., Callaghan, D. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15943-0 · Cited by 58 · see citing works

Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects

Zhao, H., Song, G., Zhu, H., Qian, H., Pan, X., Song, X., Xie, Y., & Liu, C. (2023) · Nutrients · doi:10.3390/nu15204441 · Cited by 64 · see citing works

Conditional reprogramming: next generation cell culture

Wu, X., Wang, S., Li, M., Li, J., Shen, J., Zhao, Y., Pang, J., Wen, Q., Chen, M., Wei, B., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.01.011 · Cited by 60 · see citing works

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models

Politz, O., Siegel, F., Bärfacker, L., Bömer, U., Hägebarth, A., Scott, W. J., Michels, M., Ince, S. J., Neuhaus, R., Meyer, K., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30457 · Cited by 61 · see citing works

Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast‐like synoviocytes

Wang, J., & Zhao, Q. (2019) · Phytotherapy Research · doi:10.1002/ptr.6364 · Cited by 61 · see citing works

Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management

Moon, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052911 · Cited by 60 · see citing works

Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition

Pan, X., Shan, H., Bai, J., Gao, T., Chen, B., Shen, Z., Zhou, H., Lu, H., Sheng, L., & Zhou, X. (2022) · Communications Biology · doi:10.1038/s42003-022-03592-6 · Cited by 59 · see citing works

Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma

Rossi, E., Schinzari, G., Maiorano, B., Pagliara, M., Stefani, A. D., Bria, E., Peris, K., Blasi, M., & Tortora, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215447 · Cited by 47 · see citing works

Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs

Liu, X., Yang, H., & Liu, Z. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109301 · Cited by 57 · see citing works

Transcriptome sequencing to detect the potential role of long non-coding RNAs in bovine mammary gland during the dry and lactation period

Yang, B., Jiao, B., Ge, W., Zhang, X., Wang, S., Zhao, H., & Wang, X. (2018) · BMC Genomics · doi:10.1186/s12864-018-4974-5 · Cited by 55 · see citing works

MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells

Moghbeli, M. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00882-1 · Cited by 57 · see citing works

To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway

Zhong, J., Ding, S., Zhang, X., Di, W., Wang, X., Zhang, H., Chen, Y., Zhang, Y., & Hu, Y. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2802037 · Cited by 54 · see citing works

Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer

Xia, Y., Pei, T., Zhao, J., Wang, Z., Shen, Y., Yang, Y., & Liang, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01832-8 · Cited by 57 · see citing works

“Double-Edged Sword” Effect of Reactive Oxygen Species (ROS) in Tumor Development and Carcinogenesis

Zhao, W., Zhuang, P., Chen, Y., Wu, Y. L., Zhong, M., & Lun, Y. (2023) · Physiological Research · doi:10.33549/physiolres.935007 · Cited by 56 · see citing works

Molecular insights into hormone regulation via signaling pathways in Sertoli cells: With discussion on infertility and testicular tumor

Ni, F.-D., Hao, S.-L., & Yang, W.-X. (2020) · Gene · doi:10.1016/j.gene.2020.144812 · Cited by 51 · see citing works

The Configuration of GRB2 in Protein Interaction and Signal Transduction

Wang, D., Liu, G., Meng, Y., Chen, H., Ye, Z., & Ji, J. (2024) · Biomolecules · doi:10.3390/biom14030259 · Cited by 52 · see citing works

The evolving (epi)genetic landscape of pancreatic neuroendocrine tumours

Pipinikas, C., Berner, A., Sposito, T., & Thirlwell, C. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0175 · Cited by 52 · see citing works

Preparation of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides and Their Experimental and Computational Biological Studies

Kciuk, M., Mujwar, S., Szymanowska, A., Marciniak, B., Bukowski, K., Mojzych, M., & Kontek, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115892 · Cited by 51 · see citing works

Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)

Olekšák, P., Nepovimová, E., Chrienová, Ž., Musílek, K., Patočka, J., & Kuča, K. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114498 · Cited by 52 · see citing works

HER2-Positive Gastric Cancer and Antibody Treatment: State of the Art and Future Developments

Scheck, M. K., Hofheinz, R., & Lorenzen, S. (2024) · Cancers · doi:10.3390/cancers16071336 · Cited by 54 · see citing works

Autophagy modulation in bladder cancer development and treatment (Review)

Li, F., Guo, H., Yang, Y., Feng, M., Liu, B., Ren, X. S., & Zhou, H. (2019) · Oncology Reports · doi:10.3892/or.2019.7286 · Cited by 51 · see citing works

The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)

Kumar, R., Huang, J., Ng, Y. S., Chen, C.-Y., & Wang, H. (2021) · Reviews in Aquaculture · doi:10.1111/raq.12643 · Cited by 50 · see citing works

miR-200a-3p modulates gene expression in comorbid pain and depression: Molecular implication for central sensitization

Satyanarayanan, S. K., Shih, Y.-H., Wen, Y., Palani, M., Lin, Y., Su, H., Gałecki, P., & Su, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.190 · Cited by 50 · see citing works

Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes

Singh, S. P., Bhaskar, R., Ghosh, S., Yarlagadda, B., Singh, D. K. K., Verma, P., Sengupta, S., Mladenov, M. I., Hadzi‐Petrushev, N., Stojchevski, R., et al. (2025) · Cancers · doi:10.3390/cancers17071082 · Cited by 55 · see citing works

Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer

Lu, J., Zang, H., Zheng, H., Zhan, Y., Yang, Y., Zhang, Y., Liu, S., Feng, J., Wen, Q., Long, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227768 · Cited by 48 · see citing works

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

Chi, Y., Jiang, H., Yin, Y., Zhou, X., Shao, Y., Li, Y., & Rao, J. (2025) · MedComm · doi:10.1002/mco2.70256 · Cited by 49 · see citing works

Synergistic targeted inhibition of MEK and dual PI 3K/ mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma

Wei, B., Michael, H. T., Halsey, C., Peer, C. J., Adhikari, A. S., Dwyer, J. E., Hoover, S. B., Meskini, R. E., Kozlov, S. V., Ohler, Z. W., et al. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12512 · Cited by 47 · see citing works

Changes in Oviductal Cells and Small Extracellular Vesicles miRNAs in Pregnant Cows

Mazzarella, R., Bastos, N. M., Bridi, A., del Collado, M., Andrade, G. M., Pinzón, J. E., Prado, C. M., Silva, L. A., Meirelles, F. V., Pugliesi, G., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.639752 · Cited by 46 · see citing works

Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

Mayor, E. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1161814 · Cited by 45 · see citing works

Energy metabolism in skin cancers: A therapeutic perspective

Hosseini, M., Kasraian, Z., & Rezvani, H. R. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.01.013 · Cited by 45 · see citing works

Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes

Wilson, R. B., Solaß, W., Archid, R., Weinreich, F., Königsrainer, A., & Reymond, M. A. (2019) · Pleura and Peritoneum · doi:10.1515/pp-2019-0003 · Cited by 48 · see citing works

New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect

Zhu, M., Ding, Q., Lin, Z., Fu, R., Zhang, F., Li, Z., Zhang, M., & Zhu, Y. Z. (2023) · Biomolecules · doi:10.3390/biom13050766 · Cited by 47 · see citing works

Bacillus licheniformis ameliorates Aflatoxin B1-induced testicular damage by improving the gut-metabolism-testis axis

Zhang, F., Ma, H., Dong, P.-Y., Yan, Y. C., Chen, Y., Yang, G.-M., Shen, W., & Zhang, X. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133836 · Cited by 44 · see citing works

Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis

Deng, T., Xu, J., Wang, Q., Wang, X., Jiao, Y., Cao, X., Geng, Q., Zhang, M., Zhao, L., & Xiao, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1369337 · Cited by 49 · see citing works

MicroRNAs Modulate Drug Resistance-Related Mechanisms in Hepatocellular Carcinoma

Liang, Y., Liang, Q., Qiao, L., & Xiao, F. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00920 · Cited by 43 · see citing works

Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status

Durmaz, İ., Güven, E. B., Erşahin, T., Öztürk, M., Çalış, İ., & Çetin-Atalay, R. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.11.012 · Cited by 41 · see citing works

Pva-miR-252 participates in ammonia nitrogen-induced oxidative stress by modulating autophagy in Penaeus vannamei

Wang, F., Huang, L., Liao, M., Dong, W., Liu, C., Zhuang, X., Liu, Y., Yin, X., Liang, Q., & Wang, W. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112774 · Cited by 41 · see citing works

Prediction of HER2 expression in breast cancer by combining PET/CT radiomic analysis and machine learning

Chen, Y., Wang, Z., Yin, G., Sui, C., Liu, Z., Li, X., & Chen, W. (2021) · Annals of Nuclear Medicine · doi:10.1007/s12149-021-01688-3 · Cited by 41 · see citing works

Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome

Yavuz, B. R., Arici, M. K., Demirel, H. C., Tsai, C., Jang, H., Nussinov, R., & Tunçbağ, N. (2023) · npj Genomic Medicine · doi:10.1038/s41525-023-00377-6 · Cited by 40 · see citing works

Targeting the PI3K/AKT/mTOR pathway in lung cancer: mechanisms and therapeutic targeting

Qiang, M., Chen, Z., Liu, H., Dong, J., Gong, K., Zhang, X., Huo, P., Zhu, J., Shao, Y., Ma, J., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1516583 · Cited by 40 · see citing works

Differential Characterization of Temozolomide-Resistant Human Glioma Cells

Lai, S., Huang, B., Liu, Y.-S., Lin, H., Chen, C.-C., Tsai, C., Lu, D., & Lin, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010127 · Cited by 40 · see citing works

Therapeutic approach of Cancer stem cells (CSCs) in gastric adenocarcinoma; DNA methyltransferases enzymes in cancer targeted therapy

Norollahi, S. E., Mansour‐Ghanaei, F., Joukar, F., Ghadarjani, S., Mojtahedi, K., Nejad, K. G., Hemmati, H., Gharibpoor, F., Khaksar, R., & Samadani, A. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108958 · Cited by 41 · see citing works

Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer

Jeong, S. H., Kim, H. H., Ha, S. E., Park, M. Y., Bhosale, P. B., Abusaliya, A., Park, K., Heo, J., Kim, H. W., & Kim, G. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810965 · Cited by 39 · see citing works

Integrin-α5 promoted the progression of oral squamous cell carcinoma and modulated PI3K/AKT signaling pathway

Fan, Q., Tian, H., Wang, Y., & Liu, X.-B. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.03.007 · Cited by 38 · see citing works

Activation of the PI3K-AKT Pathway by Old World Alphaviruses

Huizen, E. V., & McInerney, G. M. (2020) · Cells · doi:10.3390/cells9040970 · Cited by 38 · see citing works

Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway

He, X., Guo, X., Ma, Z., Li, Y., Kang, J., Zhang, G., Gao, Y., Liu, M., Chen, H., & Kang, X. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135793 · Cited by 38 · see citing works

FOXP1 inhibits high glucose-induced ECM accumulation and oxidative stress in mesangial cells

Xiang, H., Xue, W., Wu, X., Zheng, J., Ding, C., Li, Y., & Dou, M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108818 · Cited by 37 · see citing works

Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways

Moens, U. L., & Macdonald, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163914 · Cited by 36 · see citing works

Insulin facilitates corneal wound healing in the diabetic environment through the RTK-PI3K/Akt/mTOR axis in vitro

Peterson, C., & Chandler, H. L. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111611 · Cited by 36 · see citing works

Role of PI3K/AKT/mTOR in Cancer Signaling

Owusu‐Brackett, N., Shariati, M., & Meric‐Bernstam, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-95228-4_20 · Cited by 24 · see citing works

PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics

Chopra, S. S., & Cantley, L. (2016) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-34211-5_1 · Cited by 1 · see citing works

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Yu, L., Wei, J., & Liu, P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.019 · Cited by 785 · see citing works

Targeting PI3K/Akt/mTOR Signaling in Cancer

Porta, C., Paglino, C., & Mosca, A. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00064 · Cited by 1,494 · see citing works

PA: Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 2008

LoPiccolo, J., Blumenthal, G. M., Bernstein, W. B., & Dennis, P. A. (2013)