The mechanism of Warburg effect-induced chemoresistance in cancer

Liu, Chang; Jin, Ying; Fan, Zhimin

doi:10.3389/fonc.2021.698023

Cited by 177Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

The mechanism of Warburg effect-induced chemoresistance in cancer

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Liu, Chang, Jin, Ying, Fan, Zhimin·2021·Frontiers in Oncology

DOI 10.3389/fonc.2021.698023PMC PMC8446599

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Abstract

Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic. To determine more possibilities for cancer therapy, recent studies have begun to explore changes in the metabolism, especially glycolysis. The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically, even under normoxia, which contributes to chemoresistance. However, the association between glycolysis and chemoresistance and molecular mechanisms of glycolysis-induced chemoresistance remains unclear. This review describes the mechanism of glycolysis-induced chemoresistance from the aspects of glycolysis process, signaling pathways, tumor microenvironment, and their interactions. The understanding of how glycolysis induces chemoresistance may provide new molecular targets and concepts for cancer therapy.

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Inhibition of energy and one-carbon metabolism in tumor cells usually sensitizes them to common therapeutics and radiotherapy.
“In turn, the inhibition of the energy and one-carbon metabolism in tumor cells usually sensitizes them to common therapeutics and radiotherapy [81].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [81]

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20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21 · see citing works

Authors: Liu, C., Jin, Y., & Fan, Z.
Affiliations: First Hospital of Jilin University (CN)
Corresponding author: Fan, Zhimin
ORCID: Liu, Chang
Jin, Ying
Fan, Zhimin
Venue: Frontiers in Oncology
Publisher: Frontiers Media SA
Published: 2021-09-03
Volume: 11
Pages: 698023-698023
ISSN: 2234-943X (ISSN-L)
DOI: 10.3389/fonc.2021.698023
PMC: PMC8446599
OpenAlex: W3197891831
Cited by: 177
References: 244
Citations by year: 2026: 14 · 2025: 36 · 2024: 40 · 2023: 53 · 2022: 33 · 2021: 1
FWCI: 3.83
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Oncology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Foundation for Innovative Research Groups of the National Natural Science Foundation of China (No.82003173)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: Warburg effect, chemoresistance, cancer glycolysis, aerobic glycolysis, tumor microenvironment, signaling pathways, cancer metabolism, therapeutic target

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The mechanism of Warburg effect-induced chemoresistance in cancer

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