The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
The interaction between ferroptosis and inflammatory signaling pathways
Open accessAbstract
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of inflammatory responses can cause imbalance of the immune system, cell dysfunction and death. Recent studies have pointed out that activation of inflammation, including the activation of multiple inflammation-related signaling pathways, can lead to ferroptosis. Among the related signal transduction pathways, we focused on five classical inflammatory pathways, namely, the JAK-STAT, NF-κB, inflammasome, cGAS-STING and MAPK signaling pathways, and expounded on their roles in ferroptosis. To date, many agents have shown therapeutic effects on ferroptosis-related diseases by modulating the aforementioned pathways in vivo and in vitro. Moreover, the regulatory effects of these pathways on iron metabolism and lipid peroxidation have been described in detail, contributing to further understanding of the pathophysiological process of ferroptosis. Taken together, targeting these pathways related to inflammation will provide appropriate ways to intervene ferroptosis and diseases.
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Cites
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Ferroptosis: mechanisms, biology and role in disease
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Ferroptosis: molecular mechanisms and health implications
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Ferroptosis: past, present and future
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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FSP1 is a glutathione-independent ferroptosis suppressor
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Ferroptosis: Death by Lipid Peroxidation
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Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
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Regulated cell death in myocardial ischemia–reperfusion injury
Xiang, Q., Yi, X., Zhu, X.-H., Wei, X., & Jiang, D.-S. (2024) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2023.10.010 · Cited by 448
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Metadata
- Authors
- Chen, Y., Fang, Z.-M., Yi, X., Wei, X., & Jiang, D.-S.
- Venue
- Cell Death & Disease
- Published
- 2023-03-21
- Volume
- 14
- Issue
- 3
- Pages
- 205-205
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W4328128251
- Cited by
- 567
- References
- 135
- FWCI
- 90.07
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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