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Cited by 447

The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.

Inflammation in atherosclerosis: pathophysiology and mechanisms

Open access
Ajoolabady, Amir, Pratico, Domenico, Lin, Ling, Mantzoros, Christos S., Bahijri, Suhad, Tuomilehto, Jaakko, Ren, Jun·2024·Cell Death & Disease
DOI 10.1038/s41419-024-07166-8
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Abstract

Atherosclerosis imposes a heavy burden on cardiovascular health due to its indispensable role in the pathogenesis of cardiovascular disease (CVD) such as coronary artery disease and heart failure. Ample clinical and experimental evidence has corroborated the vital role of inflammation in the pathophysiology of atherosclerosis. Hence, the demand for preclinical research into atherosclerotic inflammation is on the horizon. Indeed, the acquisition of an in-depth knowledge of the molecular and cellular mechanisms of inflammation in atherosclerosis should allow us to identify novel therapeutic targets with translational merits. In this review, we aimed to critically discuss and speculate on the recently identified molecular and cellular mechanisms of inflammation in atherosclerosis. Moreover, we delineated various signaling cascades and proinflammatory responses in macrophages and other leukocytes that promote plaque inflammation and atherosclerosis. In the end, we highlighted potential therapeutic targets, the pros and cons of current interventions, as well as anti-inflammatory and atheroprotective mechanisms.

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Metadata

Authors
Ajoolabady, A., Pratico, D., Lin, L., Mantzoros, C. S., Bahijri, S., Tuomilehto, J., & Ren, J.
Venue
Cell Death & Disease
Publisher
Springer Science and Business Media LLC
Published
2024-11-11
Volume
15
Issue
11
Pages
817-817
ISSN
2041-4889 (ISSN-L)
DOI
10.1038/s41419-024-07166-8
OpenAlex
W4404242781
Cited by
447
References
176
FWCI
61.29
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Inflammation in atherosclerosis: pathophysiology and mechanisms. https://app.cochat.ai/papers/10.1038/s41419-024-07166-8
The paper
Ajoolabady, A., Pratico, D., Lin, L., Mantzoros, C. S., Bahijri, S., Tuomilehto, J., & Ren, J. (2024). Inflammation in atherosclerosis: pathophysiology and mechanisms. Cell Death & Disease. https://doi.org/10.1038/s41419-024-07166-8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.