COVID-19: immunopathology and its implications for therapy

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545 · see citing works

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

Qin, C., Zhou, L., Hu, Z., Zhang, S., Yang, S., Tao, Y., Xie, C., Ma, K., Shang, K., Wang, W., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa248 · Cited by 4,775 · see citing works

Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019

Zhao, J., Yuan, Q., Wang, H., Liu, W., Liao, X., Su, Y., Wang, X., Yuan, J., Li, T., Li, J., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa344 · Cited by 2,607 · see citing works

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

Shen, C., Wang, Z., Zhao, F., Yang, Y., Li, J., Yuan, J., Wang, F., Li, D., Yang, M., Xing, L., et al. (2020) · JAMA · doi:10.1001/jama.2020.4783 · Cited by 2,278 · see citing works

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Zheng, M., Gao, Y., Wang, G., Song, G., Liu, S., Sun, D., Xu, Y., & Tian, Z. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0402-2 · Cited by 1,768 · see citing works

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Li, R., Yunlong, H., Jicheng, H., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104761 · Cited by 660 · see citing works

Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19

Zhang, B., Zhou, X., Zhu, C., Song, Y., Feng, F., Qiu, Y., Feng, J., Jia, Q., Song, Q., Zhu, B., et al. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00157 · Cited by 532 · see citing works

Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

Shi, Y., Tan, M., Chen, X., Liu, Y., Huang, J., Ou, J., & 邓西龙 (2020) · Immunology · doi:10.1111/imm.13223 · Cited by 376 · see citing works

Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19Preprint

Zhang, B., Zhou, X., Zhu, C., et al. (2020) · medRxiv · doi:10.1101/2020.03.12.20035048 · Cited by 168 · see citing works

Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, ChinaPreprint

Shi, Y., Tan, M., Chen, X., et al. (2020) · medRxiv · doi:10.1101/2020.03.12.20034736 · Cited by 91 · see citing works

Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patientsPreprint

Chen, X., Ling, J., Mo, P., Zhang, Y., Jiang, Q., Ma, Z., Cao, Q., Hu, W., Zou, S., Chen, L., et al. (2020) · medRxiv · doi:10.1101/2020.03.03.20030437 · Cited by 75 · see citing works

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.015 · Cited by 3,595 · see citing works

Immunology of COVID-19: Current State of the Science

Vabret, N., Britton, G. J., Gruber, C., Hegde, S., Kim, J., Kuksin, M., Levantovsky, R., Malle, L., Moreira, A., Park, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.002 · Cited by 1,623 · see citing works

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

Zhu, F.-C., Li, Y.-H., Guan, X.-H., Hou, L.-H., Wang, W.-J., Li, J.-X., Wu, S.-P., Wang, B.-S., Wang, Z., Wang, L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31208-3 · Cited by 1,382 · see citing works

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

Cao, Y., Su, B., Guo, X., Sun, W., Deng, Y., Bao, L., Zhu, Q., Zhang, X., Zheng, Y., Geng, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.025 · Cited by 1,188 · see citing works

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Tang, Y., Liu, J., Zhang, D., Xu, Z., Ji, J., & Wen, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01708 · Cited by 1,094 · see citing works

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Ren, X., Wen, W., Fan, X., Hou, W., Su, B., Cai, P., Li, J., Liu, Y., Tang, F., Zhang, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.053 · Cited by 865 · see citing works

COVID-19 and the human innate immune system

Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714 · see citing works

Immune response, inflammation, and the clinical spectrum of COVID-19

García, L. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01441 · Cited by 739 · see citing works

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Huang, A. T., Garcia-Carreras, B., Hitchings, M. D. T., Yang, B., Katzelnick, L. C., Rattigan, S. M., Borgert, B. A., Moreno, C. A., Solomon, B. D., Trimmer-Smith, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18450-4 · Cited by 1,026 · see citing works

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Carvelli, J., Demaria, O., Vély, F., Batista, L., Chouaki Benmansour, N., Fares, J., Carpentier, S., Thibult, M.-L., Morel, A., Remark, R., et al. (2020) · Nature · doi:10.1038/s41586-020-2600-6 · Cited by 526 · see citing works

Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature

da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00650-3 · Cited by 475 · see citing works

Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic

Ding, X., Clifton, D., Ji, N., Lovell, N. H., Bonato, P., Chen, W., Yu, X., Xue, Z., Xiang, T., Long, X., et al. (2021) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2020.2992838 · Cited by 281 · see citing works

The Rise of Wearable Devices during the COVID-19 Pandemic: A Systematic Review

Channa, A., Popescu, N., Skibinska, J., & Burget, R. (2021) · Sensors · doi:10.3390/s21175787 · Cited by 209 · see citing works

COVID-19 in Africa: Dampening the storm?

Mbow, M., Lell, B., Jochems, S. P., Cisse, B., Mboup, S., Dewals, B. G., Jaye, A., Dieye, A., & Yazdanbakhsh, M. (2020) · Science · doi:10.1126/science.abd3902 · Cited by 180 · see citing works

Herpes zoster following inactivated COVID-19 vaccine: a coexistence or coincidence?

Bostan, E., & Yalici‐Armagan, B. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14035 · Cited by 148 · see citing works

B-cell depleting therapies may affect susceptibility to acute respiratory illness among patients with Multiple Sclerosis during the early COVID-19 epidemic in Iran

Safavi, F., Nourbakhsh, B., & Azimi, A. R. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102195 · Cited by 140 · see citing works

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

Gangaev, A., Ketelaars, S. L. C., Isaeva, O. I., Patiwael, S., Dopler, A., Hoefakker, K., De Biasi, S., Gibellini, L., Mussini, C., Guaraldi, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22811-y · Cited by 111 · see citing works

Clinical practice guidance for hepatology and liver transplant providers during the COVID-19 pandemic: APASL expert panel consensus recommendations

APASL Covid-19 Task Force, Lau, G., & Sharma, M. (2020) · Hepatology International · doi:10.1007/s12072-020-10054-w · Cited by 88 · see citing works

Mesenchymal stem cell immunomodulation: in pursuit of controlling COVID-19 related cytokine storm

Song, N., Wakimoto, H., Rossignoli, F., Bhere, D., Ciccocioppo, R., Chen, K.-S., Khalsa, J. K., Mastrolia, I., Samarelli, A. V., Dominici, M., et al. (2021) · Stem Cells · doi:10.1002/stem.3354 · Cited by 62 · see citing works

Inflammatory profiles and clinical features of coronavirus 2019 survivors 3 months after discharge in Wuhan, China.

Zhou, M., Yin, Z., Xu, J., Wang, S., Liao, T., Wang, K., Li, Y., Yang, F., Wang, Z., Yang, G., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab181 · Cited by 39 · see citing works

A Randomized, Single-blind, Group sequential, Active-controlled Study to evaluate the clinical efficacy and safety of α-Lipoic acid for critically ill patients with coronavirus disease 2019(COVID-19)

Zhong, M., Sun, A., Xiao, T., Yao, G., Sang, L., Zheng, X., Zhang, J., Jin, X., Xu, L., Yang, W., et al. (2020) · doi:10.1101/2020.04.15.20066266 · Cited by 53 · see citing works

Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients

Pietrobon, A. J., Andrejew, R., Custódio, R. W. A., Oliveira, L. D. M., Scholl, J. N., Teixeira, F. M. E., de Brito, C. A., Glaser, T., Kazmierski, J., Goffinet, C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1012027 · Cited by 23 · see citing works

CellDrift: inferring perturbation responses in temporally sampled single-cell data

Jin, K., Schnell, D., Li, G., Salomonis, N., Prasath, V. B. S., Szczesniak, R., & Aronow, B. J. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac324 · Cited by 11 · see citing works

Cytokine and cytokine storm after SARS-CoV-2 infection

Wang, Y. (2020) · Cited by 1 · see citing works

Cytokine storm and stem cell activation in unveiling potential targets for diagnosis and therapy

Miranda, D., & Sanchez, D. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89972-7.00006-4

Cytokine and cytokine storm

Wang, Y. (2020) · Tianjin yiyao · Cited by 4 · see citing works

Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Tang, X., Ji, T.-T., Dong, J.-R., Feng, H., Chen, F.-Q., Chen, X., Zhao, H., Chen, D., & Ma, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313009 · Cited by 102 · see citing works

Cytokine storm: When the immune system goes into overdrive

Kale, P. P., Mani, A., Gurha, S., et al. (2023) · Journal of Cellular Biotechnology · doi:10.3233/jcb-230091