CoChat
Sign Up
Cited by 14Fatty Acid Research and HealthCholesterol and Lipid MetabolismLipid metabolism and biosynthesis

Fatty acid regio-specificity of triacylglycerol molecules may affect plasma lipid responses to dietary fats—a randomised controlled cross-over trial

Open access
Stonehouse, Welma, Benassi-Evans, Bianca, James-Martin, Genevieve, Abeywardena, Mahinda·2020·European Journal of Clinical Nutrition
DOI 10.1038/s41430-019-0452-7PMC PMC7007409
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND/OBJECTIVES: Hypercholesterolaemic effects of saturated fatty acids (SFA) may be influenced not only by the chain length, but also by their specific location within the triacylglycerol (TAG) molecule. We examined the hypothesis that dietary fats rich in SFA, but containing mostly unsaturated fatty acids in the sn-2 position with most SFA in sn-1 and -3 (palm olein [PO] and cocoa butter [CB]) will have similar serum lipid outcomes to unsaturated olive oil (OO). SUBJECTS/METHODS: ) completed a 4-week randomised 3 × 3 crossover feeding intervention, preceded by 2-week run-in and separated by 2-week washout periods. Background diet contained 35 percentage of total energy (%E) fat, 18%E protein, 48%E carbohydrates, differing in test fats only (palm olein (PO), CB, OO; 20%E). Total cholesterol (TC)/high density lipoprotein cholesterol (HDL-C) ratio and related variables; TC, HDL-C, low density lipoprotein cholesterol (LDL-C), TAG, apoA1, ApoB, ApoA1 (apolipoprotein A1)/ApoB (apolipoprotein B), lipoprotein (a) (Lp(a)), NEFA, LDL sub-fractions, were assessed pre- and post-intervention. Data were analysed using mixed effects longitudinal models with a P-value < 0.05 considered significant. RESULTS: Changes in plasma fatty acids (P < 0.05) confirmed compliance; C18:1 increased with OO compared to PO and CB; C16:0 decreased with OO and C18:0 increased following CB. No differences were seen for TC/HDL-C (mean [95%CI] change for PO, 0.08[0.00, 0.15] mmol/L; CB, 0.06 [-0.05, 0.16] mmol/L; and OO, -0.01 [-0.15, 0.13] mmol/L; P = 0.53] or any other parameter including LDL sub-fractions. OO decreased IDL-A compared to PO (-2.2 [-4.31, -0.21] mg/dL, P = 0.03). CONCLUSION: In healthy young participants, plasma lipid responses to PO and CB, enriched in SFA but having primarily unsaturated fatty acid in the sn-2 position of TAG, did not differ from OO.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41430-019-0452-7

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Stonehouse, W., Benassi-Evans, B., James-Martin, G., & Abeywardena, M.
Affiliations
Commonwealth Scientific and Industrial Research Organisation (AU)
Corresponding author
Stonehouse, Welma
ORCID
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2019-06-21
Volume
74
Issue
2
Pages
268-277
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/s41430-019-0452-7
PMC
PMC7007409
OpenAlex
W2951476211
Cited by
14
References
45
Citations by year
2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2
FWCI
1.71
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
Malaysian Palm Oil Board
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
saturated fatty acids, dietary fat, palm olein, cocoa butter, olive oil, plasma lipids, TC/HDL-C ratio, apolipoprotein A-I, apolipoprotein B, lipoprotein(a), free fatty acids, hypercholesterolemia, dietary adherence, fatty acid composition
MeSH terms
Adult, Dietary Fats, Fatty Acids, Humans, Cholesterol, HDL, Triglycerides, Cross-Over Studies, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review