Cerebrovascular and cardiovascular diseases caused by drugs of abuse

Akasaki, Yuichi; Ohishi, Mitsuru

doi:10.1038/s41440-019-0367-7

Cited by 30Substance Abuse Treatment and OutcomesTakotsubo Cardiomyopathy and Associated PhenomenaBlood Pressure and Hypertension Studies

Cerebrovascular and cardiovascular diseases caused by drugs of abuse

Akasaki, Yuichi, Ohishi, Mitsuru·2020·Hypertension Research

DOI 10.1038/s41440-019-0367-7

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Abstract

Drugs such as stimulants, sedatives, sleeping pills, and narcotics are associated with drug abuse and are therefore regulated by law. Physical dependence on these drugs is sometimes difficult to control despite an awareness of the problems they cause in daily life and the harm they can cause to the body. Drug dependence is a social problem worldwide, and the physical implications are serious. Many of these drugs cause cerebrovascular and cardiovascular diseases, which often require emergency medical treatment. Differential diagnosis is essential because of the likelihood of life-threatening events, especially among young people who exhibit cerebrovascular and cardiovascular diseases without any of the typical risk factors. Drugs of abuse, especially stimulants, induce a hyperadrenergic state that evokes vasoconstriction and tachycardia, as well as subsequent ischemic and hemorrhagic stroke, acute coronary syndrome, arrhythmias, and aortic dissection. Chronic drug abuse can also cause cardiac hypertrophy and left ventricular dysfunction. As a treatment for these conditions, sedative drugs can be effective but the use of vasodilators may also be required. There are concerns that the use of both alpha- and beta-adrenergic receptor blockers may cause tachycardia and increased blood pressure. Therefore, careful differential diagnosis and selection of therapeutic agents is required.

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Insights into US life expectancy stagnation from birth cohort mortality dynamics
Abrams, L., Bramajo, O., van Raalte, A., Myrskylä, M., & Mehta, N. K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2519356123 · Cited by 6 · see citing works

Authors: Akasaki, Y., & Ohishi, M.
Affiliations: Kagoshima University (JP)
Corresponding author: Akasaki, Yuichi
ORCID: Akasaki, Yuichi
Venue: Hypertension Research
Publisher: Springer Science and Business Media LLC
Published: 2019-12-05
Volume: 43
Issue: 5
Pages: 363-371
ISSN: 0916-9636 (ISSN-L)
1348-4214
DOI: 10.1038/s41440-019-0367-7
OpenAlex: W2994537992
Cited by: 30
References: 96
Citations by year: 2026: 6 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 3
FWCI: 0.11
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Hypertension Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: drug abuse, cerebrovascular disease, cardiovascular disease, stimulants, sedatives, hypnotics, narcotics, drug addiction, hyperadrenergic state, ischemic stroke, hemorrhagic stroke, acute coronary syndrome, cardiac arrhythmias, aortic dissection, cardiac hypertrophy, left ventricular dysfunction, differential diagnosis, vasodilators, adrenergic receptor blockers, tachycardia, blood pressure
MeSH terms: Cardiovascular Diseases, Cerebrovascular Disorders, Humans, Illicit Drugs

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Cerebrovascular and cardiovascular diseases caused by drugs of abuse

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