The Serotonin Syndrome
Abstract
The serotonin syndrome is a potentially life-threatening drug reaction that may result from therapeutic medication use, self-poisoning, or interactions between drugs.
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Increase in 5-HT2A neurotransmission is responsible for transient serotonin-related symptoms such as nausea, anxiety, hypertension, tachycardia, visual deficits, motor incoordination, and mild tremors, even at therapeutic doses.
“that is responsible for transient serotoninrelated symptoms such as nausea, anxiety, hypertension, tachycardia, visual deficits, motor incoordination, and mild tremors, even at therapeutic doses.”
From The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges (2024) · cites this paper as [42]
Both psychedelic effects and serotonin syndrome are associated with an increase in 5-HT2A neurotransmission.
“Both psychedelic effects and serotonin syndrome are associated with an increase in 5-HT2A neurotransmission 42,43”
From The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges (2024) · cites this paper as [42]
Serotonin stimulation affects the whole organism, not just the brain, causing vegetative changes including increased systolic and diastolic blood pressure, increased pulse rate, nausea, vomiting, and pupil dilation.
“Serotonin stimulation is known to affect the whole organism not just the brain. It causes vegetative changes such as increase in systolic and diastolic blood pressure, pulse rate, provokes nausea, vomiting, and pupil dilation (Boyer and Shannon, 2005).”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Boyer and Shannon, 2005
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- Authors
- Boyer, E. W., & Shannon, M.
- Affiliations
- Boston Children's Hospital (US)
- ORCID
- Boyer, Edward W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-03-17
- Volume
- 352
- Issue
- 11
- Pages
- 1112-1120
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2123778879
- Cited by
- 1,821
- References
- 49
- Citations by year
- 2026: 47 · 2025: 65 · 2024: 84 · 2023: 53 · 2022: 78 · 2021: 74 · 2020: 92 · 2019: 86 · 2018: 99 · 2017: 96 · 2016: 98 · 2015: 112 · 2014: 121 · 2013: 109 · 2012: 93
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA14929, R21DA014929)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- serotonin syndrome, adverse drug reactions, drug interactions, self-poisoning, serotonin receptor agonists
- MeSH terms
- Algorithms, Antidepressive Agents, Diagnostic Errors, Drug Interactions, Humans, Monoamine Oxidase Inhibitors, Selective Serotonin Reuptake Inhibitors, Serotonin Syndrome, Drug Overdose
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