The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling
Open accessAbstract
The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel with thermosensitive sol–gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. Cystic cavities are bridged by fibronectin-rich extracellular matrix. The fibrotic extracellular matrix remodeling is mediated by matrix metalloproteinase-9 expressed in macrophages within the fibrotic extracellular matrix. A poly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts with macrophages via histamine receptors, exhibits substantially diminished bridging effects. I-5 injection improves coordinated locomotion, and this functional recovery is accompanied by preservation of myelinated white matter and motor neurons and an increase in axonal reinnervation of the lumbar motor neurons. Our study demonstrates that dynamic interactions between inflammatory cells and injectable biomaterials can induce beneficial extracellular matrix remodeling to stimulate tissue repair following CNS injuries.
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Inflammation and wound healing: the role of the macrophage
Koh, T. J., & DiPietro, L. A. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001943 · Cited by 1,667
Zhu, Y., Soderblom, C., Krishnan, V., Ashbaugh, J., Bethea, J. R., & Lee, J. K. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.024 · Cited by 199
Self-citationKyriakides, T. R., Wulsin, D., Skokos, E. A., Fleckman, P., Pirrone, A., Shipley, J. M., Senior, R. M., & Bornstein, P. (2009) · Matrix Biology · doi:10.1016/j.matbio.2009.01.001 · Cited by 173
Zhang, H., Chang, M., Hansen, C. N., Basso, D. M., & Noble-Haeusslein, L. J. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0038-0 · Cited by 163
Cited by
Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Li, L., Zhang, Y., Mu, J., Chen, J., Zhang, C., Cao, H., & Gao, J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c00929 · Cited by 404
Fan, L., Liu, C., Chen, X., Zheng, L., Zou, Y., Wen, H., Guan, P., Lu, F., Luo, Y., Tan, G., et al. (2022) · Advanced Science · doi:10.1002/advs.202105586 · Cited by 401
Zhou, L., Fan, L., Yi, X., Zhou, Z., Liu, C., Fu, R., Dai, C., Wang, Z., Chen, X., Yu, P., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b04609 · Cited by 391
PEG-based thermosensitive and biodegradable hydrogels
Shi, J., Yu, L., & Ding, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.009 · Cited by 341
Metadata
- Authors
- Hong, L. T. A., Kim, Y.-M., Park, H. H., Hwang, D. H., Cui, Y., Lee, E. M., Yahn, S., Lee, J. K., Song, S.-C., & Kim, B. G.
- Venue
- Nature Communications
- Published
- 2017-09-14
- Volume
- 8
- Issue
- 1
- Pages
- 533-533
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2754420233
- Cited by
- 252
- References
- 4
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hong, L. T. A., Kim, Y.-M., Park, H. H., Hwang, D. H., Cui, Y., Lee, E. M., Yahn, S., Lee, J. K., Song, S.-C., & Kim, B. G. (2017). An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling. Nature Communications. https://doi.org/10.1038/s41467-017-00583-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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