The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury
Abstract
Spinal cord injury is among the most fatal diseases. The complicated inhibitory microenvironment requires comprehensive mitigation. Exosomes derived from mesenchymal stem cells (MSCs) are natural biocarriers of cell paracrine secretions that bear the functions of microenvironment regulation. However, the effective retention, release, and integration of exosomes into the injured spinal cord tissue are poorly defined. Herein, an innovative implantation strategy is established using human MSC-derived exosomes immobilized in a peptide-modified adhesive hydrogel (Exo-pGel). Unlike systemic admistration of exosomes, topical transplantation of the Exo-pGel provides an exosome-encapsulated extracellular matrix to the injured nerve tissue, thereby inducing effecient comprehensive mitigation of the SCI microenvironment. The implanted exosomes exhibit efficient retention and sustained release in the host nerve tissues. The Exo-pGel elicits significant nerve recovery and urinary tissue preservation by effectively mitigating inflammation and oxidation. The Exo-pGel therapy presents a promising strategy for effective treatment of central nervous system diseases based on exosome implantation.
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Cites
ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642
James, S. L., Theadom, A., Ellenbogen, R. G., Bannick, M. S., Montjoy-Venning, W., Lucchesi, L. R., Abbasi, N., Abdulkader, R., Abraha, H. N., Adsuar, J. C., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30415-0 · Cited by 2,001
Cell transplantation therapy for spinal cord injury
Assinck, P., Duncan, G. J., Hilton, B. J., Plemel, J. R., & Tetzlaff, W. (2017) · Nature Neuroscience · doi:10.1038/nn.4541 · Cited by 937
The Biology of Regeneration Failure and Success After Spinal Cord Injury
Tran, A. P., Warren, P. M., & Silver, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00017.2017 · Cited by 884
Regeneration of adult axons in white matter tracts of the central nervous system
Davies, S. J. A., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997) · Nature · doi:10.1038/37776 · Cited by 737
Global neurotrauma research challenges and opportunities
Rubiano, A. M., Carney, N., Chesnut, R., & Puyana, J. C. (2015) · Nature · doi:10.1038/nature16035 · Cited by 519
Kusuma, G. D., Carthew, J., Lim, R., & Frith, J. E. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0349 · Cited by 413
Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0093-5 · Cited by 324
Sun, G., Li, G., Li, D., Huang, W., Zhang, R., Zhang, H., Duan, Y., & Wang, B. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.04.006 · Cited by 314
The Ladder Rung Walking Task: A Scoring System and its Practical Application.
Metz, G. A., & Whishaw, I. Q. (2009) · Journal of Visualized Experiments · doi:10.3791/1204 · Cited by 293
Cited by
Zhang, F.-X., Liu, P., Ding, W., Meng, Q.-B., Su, D.-H., Zhang, Q.-C., Lian, R.-X., Yu, B.-Q., Zhao, M.-D., Dong, J., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121169 · Cited by 328
Shao, J., Zaro, J., & Shen, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s281890 · Cited by 295
Lin, F., Chen, W., Zhou, J., Zhu, J., Yao, Q., Feng, B., Feng, X., Shi, X., Pan, Q., Yu, J., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04708-w · Cited by 206
Self-citationFan, L., Guan, P., Xiao, C., Wen, H., Wang, Q., Liu, C., Luo, Y., Ma, L., Tan, G., Yu, P., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.005 · Cited by 152
M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator
Wang, Y., Lin, Q., Zhang, H., Wang, S., Cui, J., Hu, Y., Liu, J., Li, M., Zhang, K., Zhou, F., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.018 · Cited by 98
Metadata
- Authors
- Li, L., Zhang, Y., Mu, J., Chen, J., Zhang, C., Cao, H., & Gao, J.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-05-07
- Volume
- 20
- Issue
- 6
- Pages
- 4298-4305
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W3023738419
- Cited by
- 404
- References
- 40
- FWCI
- 33.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, L., Zhang, Y., Mu, J., Chen, J., Zhang, C., Cao, H., & Gao, J. (2020). Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury. Nano Letters. https://doi.org/10.1021/acs.nanolett.0c00929
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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