The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
Open accessAbstract
The roles of long non-coding RNAs in cancer metabolism remain largely unexplored. Here we identify FILNC1 (FoxO-induced long non-coding RNA 1) as an energy stress-induced long non-coding RNA by FoxO transcription factors. FILNC1 deficiency in renal cancer cells alleviates energy stress-induced apoptosis and markedly promotes renal tumor development. We show that FILNC1 deficiency leads to enhanced glucose uptake and lactate production through upregulation of c-Myc. Upon energy stress, FILNC1 interacts with AUF1, a c-Myc mRNA-binding protein, and sequesters AUF1 from binding c-Myc mRNA, leading to downregulation of c-Myc protein. FILNC1 is specifically expressed in kidney, and is downregulated in renal cell carcinoma; also, its low expression correlates with poor clinical outcomes in renal cell carcinoma. Together, our study not only identifies FILNC1 as a negative regulator of renal cancer with potential clinical value, but also reveals a regulatory mechanism by long non-coding RNAs to control energy metabolism and tumor development.
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Metadata
- Authors
- Xiao, Z.-D., Han, L., Lee, H., Zhuang, L., Zhang, Y., Baddour, J., Nagrath, D., Wood, C. G., Gu, J., Wu, X., Liang, H., & Gan, B.
- Venue
- Nature Communications
- Published
- 2017-10-04
- Volume
- 8
- Issue
- 1
- Pages
- 783-783
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2756866387
- Cited by
- 214
- References
- 12
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xiao, Z.-D., Han, L., Lee, H., Zhuang, L., Zhang, Y., Baddour, J., Nagrath, D., Wood, C. G., Gu, J., Wu, X., Liang, H., & Gan, B. (2017). Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nature Communications. https://doi.org/10.1038/s41467-017-00902-z
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