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Cited by 78Peroxisome Proliferator-Activated ReceptorsEpigenetics and DNA MethylationNutrition, Genetics, and Disease

Mechanistic Insights Into the Interaction Between Transcription Factors and Epigenetic Modifications and the Contribution to the Development of Obesity

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Huang, Qi, Ma, Chaoyang, Chen, Li, Luo, Dan, Chen, Rui, Liang, Fengxia·2018·Frontiers in Endocrinology
DOI 10.3389/fendo.2018.00370PMC PMC6043677
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Abstract

1 Objective: The development of obesity is inseparable from genetic and epigenetic factors, and transcription factors (TFs) play an essential role in these two mechanisms. This review analyzes the interaction of TFs with epigenetic modifications and the epigenetic mechanisms underlying peroxisome proliferator-activated receptor (PPAR)γ, an important transcription factor, in the development of obesity. 2 Methods: We describe the relationship between TFs and different epigenetic modifications and illustrate the several mechanisms described . Next, we summarize the epigenetic mechanisms of PPARs, an important class of transcription factors involved in obesity, that induce obesity with different triggering factors. Finally, we discuss the mechanisms of epigenetic modification of PPAR-related ligands in lipid metabolism and propose future avenues of research. 3 Results: TFs participate in epigenetic modifications in different forms, causing changes in gene expression. The interactions between the different epigenetic modifications and PPARs are important biological developments that affect fat tissue differentiation, lipogenesis, and lipid metabolism, thereby inducing or inhibiting the development of obesity. We then highlight the need for more research to understand the role of epigenetic modifications and PPARs. 4 Conclusions: Epigenetic mechanisms involved in the regulation of PPARs may be excellent therapeutic targets for obesity treatment. However, there is a need for a deeper understanding of how PPARs and other obesity-related transcription factors interact with epigenetic modifications.

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  • Melatonin has prominent impacts on circadian rhythm, immunity, energy metabolism, and endocrine system.

    “Furthermore, melatonin has prominent impacts on the circadian rhythm, immunity, energy metabolism, and endocrine system. 5,10”

    From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [5]

    The cited paper’s discussion of PPARs and lipid metabolism (section “Participation of PPARs in epigenetic modulation of lipid metabolism”; page unavailable) does not attribute any effects to melatonin. Searches for “melatonin” and for its claimed effects on circadian rhythm, immunity, energy metabolism, and the endocrine system found no passage addressing the claim in our copy. (LLM, conf=0.75)

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Cited by

Sorted by citations

Authors
Huang, Q., Ma, C., Chen, L., Luo, D., Chen, R., & Liang, F.
Affiliations
  • Hubei University of Chinese Medicine (CN)
  • Central Hospital of Wuhan (CN)
  • Huazhong University of Science and Technology (CN)
  • Wuhan Union Hospital (CN)
Corresponding author
Chen, Rui
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2018-07-06
Volume
9
Pages
370-370
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2018.00370
PMC
PMC6043677
OpenAlex
W2810255397
Cited by
78
References
15
Citations by year
2026: 4 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 9 · 2021: 15 · 2020: 9 · 2019: 9 · 2014: 1
FWCI
0.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81574065, 81473787)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
obesity, transcription factors, epigenetic modifications, PPARγ, peroxisome proliferator-activated receptors, lipid metabolism, adipogenesis, lipogenesis, gene expression regulation, PPAR ligands, obesity treatment targets

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