The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Open accessAbstract
At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from the stroma. This barrier must be breached to allow dissemination of the tumor cells to adjacent tissues. Cancer cells can perforate the BM using proteolysis; however, whether stromal cells play a role in this process remains unknown. Here we show that an abundant stromal cell population, cancer-associated fibroblasts (CAFs), promote cancer cell invasion through the BM. CAFs facilitate the breaching of the BM in a matrix metalloproteinase-independent manner. Instead, CAFs pull, stretch, and soften the BM leading to the formation of gaps through which cancer cells can migrate. By exerting contractile forces, CAFs alter the organization and the physical properties of the BM, making it permissive for cancer cell invasion. Blocking the ability of stromal cells to exert mechanical forces on the BM could therefore represent a new therapeutic strategy against aggressive tumors.
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Citations
Cites
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Compensation mechanism in tumor cell migration
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Cited by
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Mechanoreciprocity in cell migration
van Helvert, S., Storm, C., & Friedl, P. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0012-0 · Cited by 587
Nissen, N. I., Karsdal, M., & Willumsen, N. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1110-6 · Cited by 489
Metadata
- Authors
- Glentis, A., Oertle, P., Mariani, P., Chikina, A., El Marjou, F., Attieh, Y., Zaccarini, F., Lae, M., Loew, D., Dingli, F., Sirven, P., Schoumacher, M., Gurchenkov, B. G., Plodinec, M., & Vignjevic, D. M.
- Venue
- Nature Communications
- Published
- 2017-10-13
- Volume
- 8
- Issue
- 1
- Pages
- 924-924
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2764186557
- Cited by
- 363
- References
- 38
- FWCI
- 15.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Glentis, A., Oertle, P., Mariani, P., Chikina, A., El Marjou, F., Attieh, Y., Zaccarini, F., Lae, M., Loew, D., Dingli, F., Sirven, P., Schoumacher, M., Gurchenkov, B. G., Plodinec, M., & Vignjevic, D. M. (2017). Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane. Nature Communications. https://doi.org/10.1038/s41467-017-00985-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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