The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Persistence and reversal of plasmid-mediated antibiotic resistance
Open accessAbstract
In the absence of antibiotic-mediated selection, sensitive bacteria are expected to displace their resistant counterparts if resistance genes are costly. However, many resistance genes persist for long periods in the absence of antibiotics. Horizontal gene transfer (primarily conjugation) could explain this persistence, but it has been suggested that very high conjugation rates would be required. Here, we show that common conjugal plasmids, even when costly, are indeed transferred at sufficiently high rates to be maintained in the absence of antibiotics in Escherichia coli . The notion is applicable to nine plasmids from six major incompatibility groups and mixed populations carrying multiple plasmids. These results suggest that reducing antibiotic use alone is likely insufficient for reversing resistance. Therefore, combining conjugation inhibition and promoting plasmid loss would be an effective strategy to limit conjugation-assisted persistence of antibiotic resistance.
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Understanding the mechanisms and drivers of antimicrobial resistance
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Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer
von Wintersdorff, C. J. H., Penders, J., van Niekerk, J. M., Mills, N. D., Majumder, S., van Alphen, L. B., Savelkoul, P. H. M., & Wolffs, P. F. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00173 · Cited by 1,707
Selection of Resistant Bacteria at Very Low Antibiotic Concentrations
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Cited by
The Ecology and Evolution of Pangenomes
Brockhurst, M. A., Harrison, E., Hall, J. P. J., Richards, T., McNally, A., & MacLean, C. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.012 · Cited by 385
Evolution of horizontal transmission in antimicrobial resistance plasmids
Dimitriu, T. (2022) · Microbiology · doi:10.1099/mic.0.001214 · Cited by 72
Metadata
- Authors
- Lopatkin, A. J., Meredith, H. R., Srimani, J. K., Pfeiffer, C., Durrett, R., & You, L.
- Venue
- Nature Communications
- Published
- 2017-11-22
- Volume
- 8
- Issue
- 1
- Pages
- 1689-1689
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2770886876
- Cited by
- 359
- References
- 68
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lopatkin, A. J., Meredith, H. R., Srimani, J. K., Pfeiffer, C., Durrett, R., & You, L. (2017). Persistence and reversal of plasmid-mediated antibiotic resistance. Nature Communications. https://doi.org/10.1038/s41467-017-01532-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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