The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
Open accessAbstract
The mammary epithelium comprises two primary cellular lineages, but the degree of heterogeneity within these compartments and their lineage relationships during development remain an open question. Here we report single-cell RNA profiling of mouse mammary epithelial cells spanning four developmental stages in the post-natal gland. Notably, the epithelium undergoes a large-scale shift in gene expression from a relatively homogeneous basal-like program in pre-puberty to distinct lineage-restricted programs in puberty. Interrogation of single-cell transcriptomes reveals different levels of diversity within the luminal and basal compartments, and identifies an early progenitor subset marked by CD55. Moreover, we uncover a luminal transit population and a rare mixed-lineage cluster amongst basal cells in the adult mammary gland. Together these findings point to a developmental hierarchy in which a basal-like gene expression program prevails in the early post-natal gland prior to the specification of distinct lineage signatures, and the presence of cellular intermediates that may serve as transit or lineage-primed cells.
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Cites
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Self-citationMassively parallel digital transcriptional profiling of single cells
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Self-citationReconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
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Single-cell messenger RNA sequencing reveals rare intestinal cell types
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De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
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Cited by
Single-cell transcriptional diversity is a hallmark of developmental potential
Gulati, G. S., Sikandar, S. S., Wesche, D. J., Manjunath, A., Bharadwaj, A., Berger, M. J., Ilagan, F., Kuo, A. H., Hsieh, R. W., Cai, S., et al. (2020) · Science · doi:10.1126/science.aax0249 · Cited by 1,571
Challenges in unsupervised clustering of single-cell RNA-seq data
Kiselev, V. Y., Andrews, T. S., & Hemberg, M. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0088-9 · Cited by 1,160
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Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2018 · Cited by 267
Self-citationObservation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications
Van den Berge, K., Perraudeau, F., Soneson, C., Love, M. I., Risso, D., Vert, J.-P., Robinson, M. D., Dudoit, S., & Clement, L. (2018) · Genome Biology · doi:10.1186/s13059-018-1406-4 · Cited by 228
Metadata
- Authors
- Pal, B., Chen, Y., Vaillant, F., Jamieson, P., Gordon, L., Rios, A. C., Wilcox, S., Fu, N., Liu, K. H., Jackling, F. C., Davis, M. J., Lindeman, G. J., Smyth, G. K., & Visvader, J. E.
- Venue
- Nature Communications
- Published
- 2017-11-20
- Volume
- 8
- Issue
- 1
- Pages
- 1627-1627
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2769379242
- Cited by
- 197
- References
- 13
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pal, B., Chen, Y., Vaillant, F., Jamieson, P., Gordon, L., Rios, A. C., Wilcox, S., Fu, N., Liu, K. H., Jackling, F. C., Davis, M. J., Lindeman, G. J., Smyth, G. K., & Visvader, J. E. (2017). Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling. Nature Communications. https://doi.org/10.1038/s41467-017-01560-x
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